PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7829693-2	1994	METHODS: Changes in proinsulin secretion or cleavage were assessed by measuring serum intact proinsulin and immunoreactive insulin concentrations in three models of acid base and calcium disturbance: (1) subacute changes in acid base status in six volunteers who received oral placebo, ammonium chloride, or sodium bicarbonate for three five day periods; (2) acute changes in calcium concentration in eight subjects who received 25 mmol oral calcium; (3) chronic changes in calcium concentration in seven patients with primary hyperparathyroidism and five with pseudohypoparathyroidism.	Ammonium Chloride	286-303	insulin	Homo sapiens	20-30	
8063854-1	1994	By quantitative immunoelectron microscopy and HPLC, we have studied the effect of disrupting pH gradients, by ammonium chloride, on proinsulin conversion in the insulin-producing B-cells of the islets of langerhans.	Ammonium Chloride	110-127	insulin	Homo sapiens	132-142	
2169515-9	1990	Ammonium chloride, however, strongly attenuated the serum deprivation response and the inhibitory effect of insulin.	Ammonium Chloride	0-17	insulin	Homo sapiens	108-115	
7046731-6	1982	Chloroquine (3-50 microM), bacitracin (0.1-10 mM) and NH4Cl (1-10 mM) inhibited insulin degradation as soon as this became detectable and caused an increase in the association of insulin to hepatocytes after 20 min.	Ammonium Chloride	54-59	insulin	Homo sapiens	80-87	
2656861-9	1989	The processing of HI both at the plasma membrane and intracellularly was inhibited by chloroquine, monensin, and NH4Cl, suggesting that both intracellular pH changes and endocytic and exocytic events may be required for these compartments to process insulin.	Ammonium Chloride	113-118	insulin	Homo sapiens	250-257	
2653825-5	1989	Methylamine, ammonium chloride and dansyl cadaverine but not chloroquine reduce the total amount of insulin endocytosed.	Ammonium Chloride	13-30	insulin	Homo sapiens	100-107	
3068222-11	1988	Plasma insulin concentration decreased (P less than .05) 26 to 46% during NH4Cl infusion and increased (P less than .05) 89 to 122% during POST.	Ammonium Chloride	74-79	insulin	Homo sapiens	7-14	
6089756-1	1984	Treatment of hepatocytes with either NH4Cl (10mM) or fructose (10mM) blocks insulin"s activation of the "dense-vesicle" cyclic AMP phosphodiesterase.	Ammonium Chloride	37-42	insulin	Homo sapiens	76-83	
7000584-4	1980	Agents believed to inhibit intralysosomal degradation of various proteins also inhibited the degradation of 125I-insulin by H4 cells (chloroquine, ammonium chloride, procaine, and lidocaine); inhibitors of energy production (dinitrophenol, sodium cyanide) inhibited degradation; an agent which inhibits microtubule function (vinblastine) blocked insulin degradation; and methylamine, reported to prevent receptor aggregation,2 also interfered with insulin processing.	Ammonium Chloride	147-164	insulin	Homo sapiens	113-120