PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12839860-0	2003	Drug binding to HERG channels: evidence for a "non-aromatic" binding site for fluvoxamine.	Fluvoxamine	78-89	potassium voltage-gated channel subfamily H member 2	Homo sapiens	16-20	
12839862-0	2003	Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652.	Fluvoxamine	39-50	potassium voltage-gated channel subfamily H member 2	Homo sapiens	12-16	
12839862-3	2003	The objectives of this study were (i) to identify and characterise any inhibitory action on HERG of the selective-serotonin re-uptake inhibitor fluvoxamine, (ii) to then determine whether fluvoxamine shared the consensus molecular determinants of HERG blockade of those drugs so far tested.	Fluvoxamine	144-155	potassium voltage-gated channel subfamily H member 2	Homo sapiens	92-96	
12839862-6	2003	I(HERG) tails, following repolarisation from +20 to -40 mV, were blocked by fluvoxamine with an IC(50) of 3.8 micro M. 3.	Fluvoxamine	76-87	potassium voltage-gated channel subfamily H member 2	Homo sapiens	2-6	
12839862-7	2003	Blockade of wild-type HERG was of extremely rapid onset (within 10 ms) and showed voltage dependence, with fluvoxamine also inducing a leftward shift in voltage-dependent activation of I(HERG).	Fluvoxamine	107-118	potassium voltage-gated channel subfamily H member 2	Homo sapiens	22-26	
12839862-7	2003	Blockade of wild-type HERG was of extremely rapid onset (within 10 ms) and showed voltage dependence, with fluvoxamine also inducing a leftward shift in voltage-dependent activation of I(HERG).	Fluvoxamine	107-118	potassium voltage-gated channel subfamily H member 2	Homo sapiens	187-191	
12839862-11	2003	The S6 mutations, Y652A and F656A, and the pore helix mutant S631A only partially attenuated blockade by fluvoxamine at concentrations causing profound blockade of wild-type HERG.	Fluvoxamine	105-116	potassium voltage-gated channel subfamily H member 2	Homo sapiens	174-178