PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28736555-0 2017 beta-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1beta Production. beta-Glucans 0-11 interleukin 1 beta Homo sapiens 100-108 29170665-8 2017 Our results show that the beta-glucan fungal cell wall carbohydrate stimulated B-lymphocytes to secrete IL-1beta in a process partially mediated by Dectin-1 activation via SYK and the transcription factors NF-kappaB and AP-1. beta-Glucans 26-37 interleukin 1 beta Homo sapiens 104-112 28736555-3 2017 We show that beta-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large beta-glucan-stimulated DC generate significantly more IL-1beta, IL-6, and IL-23 compared to those stimulated with the smaller beta-glucans. beta-Glucans 13-24 interleukin 1 beta Homo sapiens 178-186 28736555-3 2017 We show that beta-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large beta-glucan-stimulated DC generate significantly more IL-1beta, IL-6, and IL-23 compared to those stimulated with the smaller beta-glucans. beta-Glucans 124-135 interleukin 1 beta Homo sapiens 178-186 20421639-11 2010 In conclusion, our results show that beta-glucans are recognized by membrane-associated dectin-1 and cytoplasmic NLRP3 inflammasome resulting in IL-1beta gene transcription and IL-1beta secretion in human macrophages, respectively. beta-Glucans 37-49 interleukin 1 beta Homo sapiens 145-153 27121946-5 2016 It was demonstrated that beta-glucan induced the activation of nuclear factor (NF)-kappaB and markedly increased the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) in macrophages. beta-Glucans 25-36 interleukin 1 beta Homo sapiens 171-189 27121946-5 2016 It was demonstrated that beta-glucan induced the activation of nuclear factor (NF)-kappaB and markedly increased the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) in macrophages. beta-Glucans 25-36 interleukin 1 beta Homo sapiens 191-199 22817337-7 2012 In most cases, oat beta-glucan resulted in a dose-dependent increase in pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in lung and peritoneal macrophages with and without exposure to HSV-1 infection. beta-Glucans 19-30 interleukin 1 beta Homo sapiens 100-108 20421639-4 2010 We show that beta-glucans activate the transcription of the proinflammatory cytokine IL-1beta through a dectin-1-dependent pathway in human macrophages. beta-Glucans 13-25 interleukin 1 beta Homo sapiens 85-93 28736555-5 2017 Furthermore, we show that the capacity to induce phagocytosis, and the relative IL-1beta production determined by beta-glucan size, regulates the composition of the cytokine milieu generated from DC. beta-Glucans 114-125 interleukin 1 beta Homo sapiens 80-88 23637950-4 2013 PRINCIPAL FINDINGS: Serum-differentiated macrophages stimulated with beta-glucans showed a low production of TNFalpha and IL-1beta, a high production of IL-6 and IL-23, and a delayed induction of cyclooxygenase-2 and PGE2 biosynthesis that resembled the responses elicited by crystals and those produced when phagosomal degradation of the phagocytic cargo increases ligand access to intracellular pattern recognition receptors. beta-Glucans 69-81 interleukin 1 beta Homo sapiens 122-130 20421639-5 2010 Moreover, dectin-1 receptor associated Syk tyrosine kinase was essential for beta-glucan induced IL-1beta mRNA expression. beta-Glucans 77-88 interleukin 1 beta Homo sapiens 97-105 20421639-11 2010 In conclusion, our results show that beta-glucans are recognized by membrane-associated dectin-1 and cytoplasmic NLRP3 inflammasome resulting in IL-1beta gene transcription and IL-1beta secretion in human macrophages, respectively. beta-Glucans 37-49 interleukin 1 beta Homo sapiens 177-185 20421639-6 2010 In contrast to LPS, beta-glucans also strongly activated the secretion of IL-1beta. beta-Glucans 20-32 interleukin 1 beta Homo sapiens 74-82 20421639-7 2010 This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages. beta-Glucans 5-16 interleukin 1 beta Homo sapiens 27-35 20421639-7 2010 This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages. beta-Glucans 5-16 interleukin 1 beta Homo sapiens 180-188 20421639-7 2010 This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages. beta-Glucans 151-163 interleukin 1 beta Homo sapiens 27-35 20421639-7 2010 This beta-glucan triggered IL-1beta release was abolished by cytochalasin D, an inhibitor of phagocytosis, demonstrating that cytosolic recognition of beta-glucans is required for IL-1beta response in human macrophages. beta-Glucans 151-163 interleukin 1 beta Homo sapiens 180-188 20421639-8 2010 RNA interference-mediated gene knockdown experiments demonstrated that cytoplasmic NLRP3 inflammasome is essential for beta-glucan-induced IL-1beta secretion. beta-Glucans 119-130 interleukin 1 beta Homo sapiens 139-147 19222370-8 2009 N-mannan-linked residues, chitin, and beta-glucan from C. albicans are important for IL-1beta stimulation. beta-Glucans 38-49 interleukin 1 beta Homo sapiens 85-93 18802048-6 2008 Our results suggest that gliadin and beta-glucan stimulate IL-23 secretion through induction of the IL-1 signaling pathway and reveal for the first time that the IL-1 system regulates IL-23 production. beta-Glucans 37-48 interleukin 1 beta Homo sapiens 100-104