PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9706420-6	1998	The serum MMP-3 level in patients with SLE at admission showed direct correlations with serum uric acid, total cholesterol (p < 0.001), triglyceride, the white blood cell count, and the neutrophil count (p < 0.05), as well as inverse correlations with the total protein (p < 0.01), and IgG (p < 0.05).	Uric Acid	94-103	matrix metallopeptidase 3	Homo sapiens	10-15	
14730623-11	2004	In this cascade, Pyk-2, Src, and p38 kinases transduce MSU-induced NO production and MMP-3 expression.	Uric Acid	55-58	matrix metallopeptidase 3	Homo sapiens	85-90	
32896590-9	2021	RESULTS: MMP-3 was significantly increased in rat serum, synovial fluid, cartilages and chondrocytes treated with high-level uric acid.	Uric Acid	125-134	matrix metallopeptidase 3	Homo sapiens	9-14	
32896590-11	2021	Furthermore, high-level uric acid contributed to the degradation of proteoglycan via the activation of MMP-3.	Uric Acid	24-33	matrix metallopeptidase 3	Homo sapiens	103-108	
32896590-13	2021	CONCLUSION: Our study showed that MMP-3 was enhanced by high levels of uric acid, which promoted proteoglycan degradation, and induced MSU crystallization in turn.	Uric Acid	71-80	matrix metallopeptidase 3	Homo sapiens	34-39	
30994184-1	2021	BACKGROUND: Atherosclerosis is as a systemic inflammatory disease associated with the activation of many mediators, including matrix metalloproteinases (MMPs), and may be amplified by abnormal high serum uric acid (UA) concentration (hyperuricemia, HU).	Uric Acid	204-213	matrix metallopeptidase 3	Homo sapiens	153-157	
30994184-2	2021	The aim of the study was to determine the relationship between serum UA concentration and activity of MMPs and their correlation with the hypertension-mediated organ damage (HMOD) intensity.	Uric Acid	69-71	matrix metallopeptidase 3	Homo sapiens	102-106	
30994184-7	2021	Among the studied metalloproteinases only MMP-3 activity positively correlated with serum UA concentration independently of age, body mass index and serum lipids (R2 = 0.11, p = 0.048).	Uric Acid	90-92	matrix metallopeptidase 3	Homo sapiens	42-47	
30994184-8	2021	Multivariate regression analysis showed positive association between IMT and BP, UA concentration and MMP-3 activity, independently of waist circumference and serum lipids (R2 = 0.328, p < 0.002).	Uric Acid	81-83	matrix metallopeptidase 3	Homo sapiens	102-107	
30994184-10	2021	CONCLUSIONS: The present results may support the thesis that UA and the increased by UA activity of MMPs may take part in the development of HMOD, especially IMT.	Uric Acid	85-87	matrix metallopeptidase 3	Homo sapiens	100-104