PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32256360-9 2020 The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay. Uric Acid 59-75 interleukin 6 Homo sapiens 166-170 33460754-7 2021 In addition, AG490 and IL-6 were used in vitro to explore the function of IL-6/STAT3 pathway in the protective effect of MSU. Uric Acid 121-124 interleukin 6 Homo sapiens 74-78 33460754-8 2021 RESULTS: MSW reduced the joint swelling rate in gouty arthritis model and inhibited MSU induced up-regulation of IL-1beta, TNF-alpha, and IL-6 protein levels in serum and synovial fluid. Uric Acid 84-87 interleukin 6 Homo sapiens 138-142 33285354-6 2021 The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased. Uric Acid 71-74 interleukin 6 Homo sapiens 32-36 32148148-0 2021 Uric acid-mediated inflammasome activation in IL-6 primed innate immune cells is regulated by baricitinib. Uric Acid 0-9 interleukin 6 Homo sapiens 46-50 32148148-8 2021 Pretreatment with baricitinib, which blocks IL-6 receptor signalling, prevented MSU-induced cleaved caspase-1 or IL-1beta induction in IL-6-primed neutrophils. Uric Acid 80-83 interleukin 6 Homo sapiens 44-48 32148148-9 2021 Tocilizumab pretreatment also inhibited MSU-mediated IL-1beta production from IL-6-primed neutrophilsConclusions: Priming of human neutrophils with IL-6 promotes uric acid-mediated IL-1beta secretion in the absence of microbial stimulation. Uric Acid 162-171 interleukin 6 Homo sapiens 148-152 32256360-9 2020 The in vitro anti-inflammatory activity was carried out on monosodium urate (MSU) crystal-induced pro-inflammatory cytokines (i.e., interleukin (IL)1alpha, IL-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha) secretion using human peripheral blood mononuclear cells and ELISA technique, and prostaglandin E2 (PGE2)secretion using radioimmunoassay. Uric Acid 77-80 interleukin 6 Homo sapiens 166-170 26163998-6 2015 There were significant correlations in PAH group between IL-6 levels and uric acid, parameters of ventilatory efficiency in cardiopulmonary exercise testing: VE/VO2, VE/VCO2, VE/VCO2 slope and peak PetCO2. Uric Acid 73-82 interleukin 6 Homo sapiens 57-61 31110596-6 2019 Results: Urinary KIM-1, IL-1, IL-6, and TNF-alpha were higher in patients with serum uric acid concentrations >= 6.0 mg/dL. Uric Acid 85-94 interleukin 6 Homo sapiens 30-34 27903743-6 2017 We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants. Uric Acid 14-23 interleukin 6 Homo sapiens 182-186 27903743-6 2017 We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants. Uric Acid 25-41 interleukin 6 Homo sapiens 182-186 27903743-6 2017 We found that uric acid (monosodium urate [MSU]) crystals induce a proinflammatory profile in isolated human term cytotrophoblast cells, with a predominant secretion of IL-1beta and IL-6, a result confirmed in human term placental explants. Uric Acid 43-46 interleukin 6 Homo sapiens 182-186 25649144-7 2016 RESULTS: The production of interleukin (IL)-1beta and IL-6 was higher in patients compared with controls and this correlated with serum urate levels. Uric Acid 136-141 interleukin 6 Homo sapiens 54-58 30095142-5 2019 The 26 selected articles point towards an association between higher levels of uric acid, homocysteine, and interleukin 6 with lower cognitive performance in executive, attentional, and memory domains. Uric Acid 79-88 interleukin 6 Homo sapiens 108-121 29457379-8 2018 Subjects with urate deposits had higher IL-6 (257.2 versus 47.0 pg/ml; P = 0.005), IL-8 (73.2 versus 12.0 pg/ml; P = 0.026), and miR-155 (0.21 versus 0.16; P = 0.015) levels than those without deposition findings. Uric Acid 14-19 interleukin 6 Homo sapiens 40-44 29457379-9 2018 CONCLUSION: In individuals with chronic asymptomatic hyperuricemia, the presence of synovitis and double contour sign by US may represent a subclinical manifestation of monosodium urate crystal nucleation, capable of triggering inflammatory pathways (IL-6 and IL-8) and mechanisms of intercellular communication (miR-155), similar to what is observed in patients with gout. Uric Acid 169-185 interleukin 6 Homo sapiens 251-255 30544373-6 2018 As the UA levels increased, MDA increased significantly and SOD decreased significantly; likewise, IL-6 and TNF-alpha increased significantly as the UA level increased. Uric Acid 149-151 interleukin 6 Homo sapiens 99-103 30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 interleukin 6 Homo sapiens 153-157 30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 interleukin 6 Homo sapiens 289-293 30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 interleukin 6 Homo sapiens 289-293 30544373-8 2018 Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698-3.286, P < .001; OR: 3.261, 95% CI: 1.729-3.857, P < .001; for IL-6 and TNF-alpha, respectively) and MDA (OR: 1.836, 95% CI: 1.283-2.517, P < .01; OR: 2.532, 95% CI: 1.693-3.102, P < .001; for IL-6 and TNF-alpha, respectively) were risk factors for high IL-6 and TNF-alpha and that SOD (OR: 0.517, 95% CI: 0.428-0.763, P < .01; OR: 0.603, 95% CI: 0.415-0.699, P < .001; for IL-6 and TNF-alpha, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Uric Acid 55-57 interleukin 6 Homo sapiens 289-293 29527782-7 2018 Only in T1D boys serum UA was positively correlated with concentrations of subclinical inflammatory markers (CRP, IL-6, TNF-alpha), the indicators of renal function (albumin excretion rate, serum cystatin C level), blood pressure and negatively correlated with anti-inflammatory IL-10. Uric Acid 23-25 interleukin 6 Homo sapiens 114-118 28786993-6 2017 Following uric acid administration, there was an accentuated increase in IL-6 during the oral lipid tolerance test (P<0.001). Uric Acid 10-19 interleukin 6 Homo sapiens 73-77 28786993-9 2017 In health individuals, acute increase in uric acid results in an increased IL-6 response when challenged with lipid load. Uric Acid 41-50 interleukin 6 Homo sapiens 75-79 26301880-3 2015 RESULTS: Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-alpha and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine. Uric Acid 16-18 interleukin 6 Homo sapiens 275-288 26539255-6 2015 RESULTS: UA significantly increased the expressions of IL-6, ICAM-1, TNF-alpha, and MCP-1 and the production of ROS in HUVEC. Uric Acid 9-11 interleukin 6 Homo sapiens 55-59 22153537-8 2012 PAI-1 and IL-6 were significantly correlated with mean arterial pressure, BMI, uric acid, total and LDL-cholesterol. Uric Acid 79-88 interleukin 6 Homo sapiens 10-14 23394103-10 2013 There was a positive correlation between uric acid and inflammatory markers, IL-6 (r = 0.30, p = 0.01), CRP (r = 0.37, p = 0.003), TNF-alpha (r = 0.40, p = 0.001), ICAM-1 (r = 0.53, p = 0.0001), and VCAM-1 (r = 0.45, p = 0.0001). Uric Acid 41-50 interleukin 6 Homo sapiens 77-81 12629765-0 2003 [Interleukin 6 deduces serum urate concentration]. Uric Acid 29-34 interleukin 6 Homo sapiens 1-14 22102722-3 2012 In this study, we found that MSU crystals, through P2Y(6) receptors, stimulated normal human keratinocytes (NHK) to produce IL-1alpha, IL-8/CXCL8, and IL-6. Uric Acid 29-32 interleukin 6 Homo sapiens 151-155 23029307-9 2012 CONCLUSION: The data suggest that compared to inflammatory markers such as CRP and IL-6 serum uric acid levels may predict future CVD risk in patients with stable CHD with a risk increase even at levels considered normal. Uric Acid 94-103 interleukin 6 Homo sapiens 83-87 21946433-4 2011 Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6, the chemokine CXCL8 and the matrix metalloproteinase (MMP)-1 from both normal and RA-FLS (all P<0.05). Uric Acid 0-16 interleukin 6 Homo sapiens 103-107 21946433-5 2011 Moreover, the additive or synergistic effect on the release of IL-6, CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-alpha or IL-1beta. Uric Acid 164-180 interleukin 6 Homo sapiens 63-67 17599452-0 2007 Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years. Uric Acid 14-23 interleukin 6 Homo sapiens 69-82 17599452-7 2007 The relation between UA and CRP persisted after adjustment for baseline IL-6. Uric Acid 21-23 interleukin 6 Homo sapiens 72-76 17599452-8 2007 Subjects with high UA at baseline had a progressively higher probability of developing clinically relevant increased IL-6 (>2.5 pg/ml) and CRP (>3 mg/L) during 3 years. Uric Acid 19-21 interleukin 6 Homo sapiens 117-121 16611671-8 2006 In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C-reactive protein, IL-6, IL-1ra, IL-18, and TNF-alpha, whereas non-significant trends were observed for WBC (P=0.1) and sIL-6r (P=0.2). Uric Acid 45-47 interleukin 6 Homo sapiens 139-143 15235923-14 2004 Monocytes or neutrophils exposed to urate crystals produce tumor necrosis factor alpha, interleukin-1 (IL-1), IL-6, and IL-8. Uric Acid 36-41 interleukin 6 Homo sapiens 110-114 11844003-11 2001 CRP and IL-6 were important confounders in the relationship between serum uric acid and overall mortality. Uric Acid 74-83 interleukin 6 Homo sapiens 8-12 10685834-0 2000 Interleukin 6 reduces serum urate concentrations. Uric Acid 28-33 interleukin 6 Homo sapiens 0-13 35314903-12 2022 Also, the in vitro experiment showed that UA induced epithelial-to-mesenchymal transition (EMT) and production of IL-1, IL-6, and TGF-beta in A549 cells. Uric Acid 42-44 interleukin 6 Homo sapiens 120-124 9886724-8 1998 In patients with chronic heart failure, serum uric acid concentrations correlated with circulating levels of sTNFR1 (r=0.74), interleukin-6 (r=0.66), sTNFR2 (r=0.63), TNFa (r=0.60) (all P<0.001), and ICAM-1 (r=0.41, P<0.01). Uric Acid 46-55 interleukin 6 Homo sapiens 126-139 9886724-9 1998 In stepwise regression analyses, serum uric acid emerged as the strongest predictor of ICAM-1, interleukin-6, TNF, sTNFR1 and sTNFR2, independent of diuretic dose, age, body mass index, alcohol intake, serum creatinine, plasma insulin and glucose, and insulin sensitivity. Uric Acid 39-48 interleukin 6 Homo sapiens 95-108 34716863-9 2021 To assess the function of JAK2/STAT3 signaling, HUVECs were treated with UA, and the phosphorylation levels of JAK2, STAT3, IL-6 and SOCS3 were increased by a high concentration of UA. Uric Acid 181-183 interleukin 6 Homo sapiens 124-128 2554932-3 1989 In this study, we demonstrated that monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, and to a lesser extent, hydroxyapatite crystals, increased IL-6 production by synoviocytes and monocytes in vitro. Uric Acid 36-52 interleukin 6 Homo sapiens 171-175 2554932-3 1989 In this study, we demonstrated that monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, and to a lesser extent, hydroxyapatite crystals, increased IL-6 production by synoviocytes and monocytes in vitro. Uric Acid 54-57 interleukin 6 Homo sapiens 171-175