PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16611671-8 2006 In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C-reactive protein, IL-6, IL-1ra, IL-18, and TNF-alpha, whereas non-significant trends were observed for WBC (P=0.1) and sIL-6r (P=0.2). Uric Acid 45-47 interleukin 18 Homo sapiens 153-158 22058415-0 2011 Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18. Uric Acid 0-9 interleukin 18 Homo sapiens 77-82 21245324-3 2011 In this cohort of subjects with knee osteoarthritis (OA), synovial fluid uric acid was strongly correlated with synovial fluid IL-18 and IL-1beta. Uric Acid 73-82 interleukin 18 Homo sapiens 127-132 21245324-7 2011 The correlation of synovial fluid uric acid with the two cytokines (IL-18 and IL-1beta) known to be produced by uric acid-activated inflammasomes and the association of synovial fluid IL-18 with OA progression, lend strong support to the potential involvement of the innate immune system in OA pathology and OA progression. Uric Acid 34-43 interleukin 18 Homo sapiens 68-73 21245324-7 2011 The correlation of synovial fluid uric acid with the two cytokines (IL-18 and IL-1beta) known to be produced by uric acid-activated inflammasomes and the association of synovial fluid IL-18 with OA progression, lend strong support to the potential involvement of the innate immune system in OA pathology and OA progression. Uric Acid 112-121 interleukin 18 Homo sapiens 68-73 23600826-6 2013 In contrast, IL-18 was up-regulated upon co-stimulation with fatty acids and uric acid. Uric Acid 77-86 interleukin 18 Homo sapiens 13-18 18523012-5 2008 Here, we show that in primary human monocytes microbial components acting on different pathogen-sensing receptors and the danger-associated molecule uric acid are all competent to induce maturation and secretion of IL-1beta and IL-18 through a process that involves as a first event the extracellular release of endogenous ATP. Uric Acid 149-158 interleukin 18 Homo sapiens 228-233 34831052-3 2021 One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Uric Acid 120-125 interleukin 18 Homo sapiens 156-161 16406656-0 2006 Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18. Uric Acid 132-160 interleukin 18 Homo sapiens 7-26 16406656-0 2006 Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18. Uric Acid 132-160 interleukin 18 Homo sapiens 190-195 32911914-2 2020 Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1beta, interleukin-18, and other inflammatory factors. Uric Acid 75-84 interleukin 18 Homo sapiens 267-281 32506648-8 2020 Results showed that UA exposure inhibited cell viability and increased IL-1beta and IL-18 generation in a concentration dependent manner. Uric Acid 20-22 interleukin 18 Homo sapiens 84-89 33693087-7 2019 In macrophages, MSU activates the NLRP3 inflammasome and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1beta and IL-18 secretion. Uric Acid 16-19 interleukin 18 Homo sapiens 143-148 31996020-8 2020 Further, acute uric acid reduction by the administration of benzbromarone in healthy humans for 2 weeks significantly decreased plasma IL-18-an inflammasome-dependent cytokine. Uric Acid 15-24 interleukin 18 Homo sapiens 135-140 32650532-4 2020 Although the mechanism is very complex and needs further explanation, it appears that high levels of cholesterol, urate, and glucose activates NLRP3 inflammasome, which produces IL-1beta, IL-18, and gasdermin D. Uric Acid 114-119 interleukin 18 Homo sapiens 188-193 31707403-10 2019 The expressions of uric acid-induced inflammatory markers IL-1ss and IL-18 were decreased by the inhibitor MCC950. Uric Acid 19-28 interleukin 18 Homo sapiens 69-74 31357788-3 2019 Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1beta and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis. Uric Acid 63-72 interleukin 18 Homo sapiens 264-278 26053021-10 2015 The cytokine determination showed that monocytes from women with PE produced higher endogenous levels of IL-1beta, IL-18 and TNF-alpha compared to the other groups, while the stimulus with MSU led to higher production of these cytokines in preeclamptic group than in the NT group. Uric Acid 189-192 interleukin 18 Homo sapiens 115-120 30833078-4 2019 RESULTS: U937 macrophages treated with MSU crystals showed increased expression of IL-1beta, IL-18, caspase-1, and TXNIP and activation of NF-kappaB signaling, which were strongly inhibited by addition of antioxidants or transfection with TXNIP siRNA. Uric Acid 39-42 interleukin 18 Homo sapiens 93-98 29780394-7 2018 Results showed that uric acid serum concentration was significantly increased in PPMS; in these and in AMS patients, mRNA for NLRP3, ASC, and IL-18 was upregulated as well, but caspase-8 mRNA was upregulated only in PPMS. Uric Acid 20-29 interleukin 18 Homo sapiens 142-147 27219123-1 2016 INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18. Uric Acid 87-103 interleukin 18 Homo sapiens 236-241 27219123-1 2016 INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1beta and IL-18. Uric Acid 105-108 interleukin 18 Homo sapiens 236-241