PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21924056-14	2011	The levels of expression of RyR2 were significantly decreased in HF group and increased in the group treated with carvedilol and the group treated with carvedilol and Radix astragali.	Carvedilol	114-124	ryanodine receptor 2, cardiac	Mus musculus	28-32	
34352124-6	2021	Furthermore, pharmacologically shortening the RyR2 open time with R-carvedilol rescued these AD-related deficits in 3xTG mice.	Carvedilol	66-78	ryanodine receptor 2, cardiac	Mus musculus	46-50	
34090936-6	2021	Consistent with previous in vivo studies, our in vitro studies using optimized brain slices also showed that limiting the open duration of the ryanodine receptor 2 (RyR2) by the RyR2 mutation E4872Q or by the R-carvedilol enantiomer prevented and rescued neuronal hyperactivity of hippocampal CA1 neurons from 5xFAD mice.	Carvedilol	209-221	ryanodine receptor 2, cardiac	Mus musculus	143-163	
32966798-5	2020	Pharmacologically limiting RyR2 open time with the R-carvedilol enantiomer (but not racemic carvedilol) prevents and rescues neuronal hyperactivity, memory impairment, and neuron loss even in late stages of AD.	Carvedilol	51-63	ryanodine receptor 2, cardiac	Mus musculus	27-31	
32966798-5	2020	Pharmacologically limiting RyR2 open time with the R-carvedilol enantiomer (but not racemic carvedilol) prevents and rescues neuronal hyperactivity, memory impairment, and neuron loss even in late stages of AD.	Carvedilol	53-63	ryanodine receptor 2, cardiac	Mus musculus	27-31	
21924056-14	2011	The levels of expression of RyR2 were significantly decreased in HF group and increased in the group treated with carvedilol and the group treated with carvedilol and Radix astragali.	Carvedilol	152-162	ryanodine receptor 2, cardiac	Mus musculus	28-32	
21924056-16	2011	Carvedilol and Radix astragali can increase expression of RyR2 mRNA and inhibit Ca(2+) leak by restoring the binding of FKBP12.6 back to RyR in HF to improve cardiac function and prevent left ventricle from remodeling.	Carvedilol	0-10	ryanodine receptor 2, cardiac	Mus musculus	58-62