PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27225954-2 2016 The first goal of this study was to establish the time frame during which prostanoids participate in ANG II-salt HTN. Salts 108-112 angiogenin Rattus norvegicus 101-104 27225954-9 2016 On the basis of our results, we propose that activation of the brain prostanoid synthesis pathway both upstream and downstream from COX at early stages plays an important role in the development of the neurogenic component of ANG II-salt HTN. Salts 233-237 angiogenin Rattus norvegicus 226-229 27245181-7 2016 In rats subjected to a low-salt diet for 7 days, continuous infusion of Ang 1-7 (576 mug/kg per day) resulted in a lesser rise in aldosterone (salt deplete+Ang 1-7, 16.4+-4.8 ng/dL) compared with rats receiving vehicle (salt deplete+vehicle, 27.6+-5.3 ng/dL; P<0.01) but did not modify plasma renin activity. Salts 27-31 angiogenin Rattus norvegicus 72-79 27245181-7 2016 In rats subjected to a low-salt diet for 7 days, continuous infusion of Ang 1-7 (576 mug/kg per day) resulted in a lesser rise in aldosterone (salt deplete+Ang 1-7, 16.4+-4.8 ng/dL) compared with rats receiving vehicle (salt deplete+vehicle, 27.6+-5.3 ng/dL; P<0.01) but did not modify plasma renin activity. Salts 27-31 angiogenin Rattus norvegicus 72-77 27245181-7 2016 In rats subjected to a low-salt diet for 7 days, continuous infusion of Ang 1-7 (576 mug/kg per day) resulted in a lesser rise in aldosterone (salt deplete+Ang 1-7, 16.4+-4.8 ng/dL) compared with rats receiving vehicle (salt deplete+vehicle, 27.6+-5.3 ng/dL; P<0.01) but did not modify plasma renin activity. Salts 143-147 angiogenin Rattus norvegicus 72-79 27245181-7 2016 In rats subjected to a low-salt diet for 7 days, continuous infusion of Ang 1-7 (576 mug/kg per day) resulted in a lesser rise in aldosterone (salt deplete+Ang 1-7, 16.4+-4.8 ng/dL) compared with rats receiving vehicle (salt deplete+vehicle, 27.6+-5.3 ng/dL; P<0.01) but did not modify plasma renin activity. Salts 143-147 angiogenin Rattus norvegicus 72-77 25862832-3 2015 Here, we hypothesized that ANG II-salt HTN would be accompanied by altered PVN SK channel activity, which may contribute to sympathoexcitation in vivo. Salts 34-38 angiogenin Rattus norvegicus 27-30 25862832-5 2015 In contrast, rats with ANG II-salt HTN demonstrated significantly attenuated SSNA, RSNA, and MAP (P < 0.05) responses to PVN-injected apamin compared with NS control rats. Salts 30-34 angiogenin Rattus norvegicus 23-26 25862832-10 2015 We conclude that reduced SK channel function in the PVN is involved in the sympathoexcitation associated with ANG II-salt HTN. Salts 117-121 angiogenin Rattus norvegicus 110-113 24124187-4 2013 Here we tested the hypothesis that RVLM vasomotor neurons have exaggerated resting discharge in rats with ANG II-salt hypertension. Salts 113-117 angiogenin Rattus norvegicus 106-109 24694383-0 2014 CNS neuroplasticity and salt-sensitive hypertension induced by prior treatment with subpressor doses of ANG II or aldosterone. Salts 24-28 angiogenin Rattus norvegicus 104-107 24075738-3 2013 As increased salt intake promotes inflammation and oxidative stress, we hypothesized that excess dietary salt would promote diastolic dysfunction in transgenic females under conditions of excess tissue Ang II and circulating aldosterone levels. Salts 105-109 angiogenin Rattus norvegicus 202-205 20212262-8 2010 This study showed that TG rats with increased circulating levels of Ang-(1-7) are protected against cardiac dysfunction and fibrosis and also present an attenuated increase in blood pressure after DOCA-salt hypertension. Salts 202-206 angiogenin Rattus norvegicus 68-76 21900456-0 2012 AT1 receptor-mediated augmentation of angiotensinogen, oxidative stress, and inflammation in ANG II-salt hypertension. Salts 100-104 angiogenin Rattus norvegicus 93-96 21803946-1 2011 This study determined the effect of ANG-(1-7) on salt-induced suppression of endothelium-dependent vasodilatation in the mesenteric arteries of male Sprague-Dawley rats. Salts 49-53 angiogenin Rattus norvegicus 36-44 21803946-5 2011 Acute preincubation with ANG-(1-7) and chronic infusion of ANG-(1-7) ameliorated the elevated superoxide levels in rats fed a high-salt diet, but the expression of Cu/Zn SOD and Mn SOD enzyme proteins in the vessel wall was unaffected by ANG-(1-7) infusion. Salts 131-135 angiogenin Rattus norvegicus 25-33 21803946-5 2011 Acute preincubation with ANG-(1-7) and chronic infusion of ANG-(1-7) ameliorated the elevated superoxide levels in rats fed a high-salt diet, but the expression of Cu/Zn SOD and Mn SOD enzyme proteins in the vessel wall was unaffected by ANG-(1-7) infusion. Salts 131-135 angiogenin Rattus norvegicus 59-67 21803946-5 2011 Acute preincubation with ANG-(1-7) and chronic infusion of ANG-(1-7) ameliorated the elevated superoxide levels in rats fed a high-salt diet, but the expression of Cu/Zn SOD and Mn SOD enzyme proteins in the vessel wall was unaffected by ANG-(1-7) infusion. Salts 131-135 angiogenin Rattus norvegicus 59-67 20576679-8 2010 In conclusion, ANG II AT1 receptor blockade in dDAVP-treated rats on a low-salt diet was associated with decreased urine concentration and decreased inner medullary AQP2, p-AQP2, and AQP3 expression, suggesting that AT1 receptor activation plays a significant role in regulating aquaporin expression and modulating urine concentration in vivo. Salts 75-79 angiogenin Rattus norvegicus 15-18 23176108-1 2013 AIM: To elucidate the role of the O(2)(-), H(2)O(2) or NO pathways in aortic angiotensin (Ang)II-induced vasoconstriction in Dahl salt-sensitive (SS) rats compared with control SS-13(BN) rats on a normal or hypercaloric diet. Salts 130-134 angiogenin Rattus norvegicus 90-93 21813872-8 2011 These data suggest that activation of the JAK/STAT pathway is critical for the development of ANG II-induced hypertension by mediating its effects on renal sodium excretory capability, but the physiological control of blood pressure by ANG II with a low-salt diet does not require JAK2 activation. Salts 254-258 angiogenin Rattus norvegicus 94-97 16027079-0 2005 [Effects of high salt diet on blood pressure, renal morphology and osteopontin expression in Sprague-Dawley rat with Ang II-induced renal injury]. Salts 17-21 angiogenin Rattus norvegicus 117-120 19946038-0 2010 Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Salts 47-51 angiogenin Rattus norvegicus 18-26 19684181-3 2009 In salt-fed rats, relaxation of MCA in response to these vasodilator stimuli was restored by chronic (3 days) intravenous infusion of either ANG II (5 ngxkg(-1)xmin(-1)) or epidermal growth factor (EGF; 2 microg/h). Salts 3-7 angiogenin Rattus norvegicus 141-144 17616753-11 2007 Furthermore, the attenuated erectile function of DOCA-salt hypertensive rats was fully restored by ANG-(1-7) administration. Salts 54-58 angiogenin Rattus norvegicus 99-107 16027079-1 2005 OBJECTIVE: To investigate the effect of high-salt diet on blood pressure, renal morphology and osteopontin (OPN) expression in Sprague-Dawley rat with Ang II-induced renal injury. Salts 45-49 angiogenin Rattus norvegicus 151-154 16027079-13 2005 CONCLUSIONS: High salt diet could aggravate the renal injury of the rats with Ang II-induced renal injury that may be independent of blood pressure change. Salts 18-22 angiogenin Rattus norvegicus 78-81 12482748-2 2003 Plasma ANG II and ANG I in salt-depleted SHR were elevated sevenfold compared with peptide levels measured in sodium-replete SHR, whereas plasma ANG-(1-7) was twofold greater in salt-depleted SHR compared with salt-replete SHR. Salts 27-31 angiogenin Rattus norvegicus 7-10 15780097-7 2005 Ang-(1-7) receptor blockade elicited significant decreases in glomerular filtration rate (GFR), renal plasma flow (RPF), and sodium excretion in 2K1C rats, and in salt-depleted TGR and HanSD. Salts 163-167 angiogenin Rattus norvegicus 0-3 15780097-10 2005 CONCLUSION: These findings suggest that under conditions of normal intrarenal RAS activity and increased intrarenal Ang II action by infusion of Ang II or by insertion of a renin gene in salt-replete conditions, Ang-(1-7) is not an important factor in the regulation of renal function. Salts 187-191 angiogenin Rattus norvegicus 116-119 15486030-9 2005 These results indicate that ANG II suppression secondary to elevated dietary salt intake impairs vascular relaxation and Ca2+ regulation by prostacyclin. Salts 77-81 angiogenin Rattus norvegicus 28-31 15614030-6 2004 RESULTS: After a normal or high salt diet, Ang-(1-7) significantly decreased maximal Ang II-induced vascular constrictions by 40-50%. Salts 32-36 angiogenin Rattus norvegicus 43-46 12482748-2 2003 Plasma ANG II and ANG I in salt-depleted SHR were elevated sevenfold compared with peptide levels measured in sodium-replete SHR, whereas plasma ANG-(1-7) was twofold greater in salt-depleted SHR compared with salt-replete SHR. Salts 27-31 angiogenin Rattus norvegicus 18-21 12482748-8 2003 The ANG II antibody increased blood pressure to the greatest extent in salt-depleted SHR pretreated with only losartan (+11 +/- 2 mmHg) and to the least extent in salt-depleted SHR previously treated with the combination of losartan, PD-123319, and [d-Ala(7)]ANG-(1-7) (+7 +/- 1 mmHg; P < 0.01). Salts 71-75 angiogenin Rattus norvegicus 4-7 12482748-8 2003 The ANG II antibody increased blood pressure to the greatest extent in salt-depleted SHR pretreated with only losartan (+11 +/- 2 mmHg) and to the least extent in salt-depleted SHR previously treated with the combination of losartan, PD-123319, and [d-Ala(7)]ANG-(1-7) (+7 +/- 1 mmHg; P < 0.01). Salts 163-167 angiogenin Rattus norvegicus 4-7 12482748-10 2003 Our results demonstrate that ANG II and ANG-(1-7) act through non-AT(1) receptors to oppose the vasoconstrictor actions of ANG II in salt-depleted SHR. Salts 133-137 angiogenin Rattus norvegicus 29-32 12372775-4 2002 In the renal cortex and medulla, RA, ANG I, and ANG II levels were also increased by diminution of dietary salt content but, in contrast to plasma, ANG II levels increased much more than RA or ANG I levels [5.4 (cortex)- and 4.7 (medulla)-fold compared with HS rats]. Salts 107-111 angiogenin Rattus norvegicus 48-51 12372775-4 2002 In the renal cortex and medulla, RA, ANG I, and ANG II levels were also increased by diminution of dietary salt content but, in contrast to plasma, ANG II levels increased much more than RA or ANG I levels [5.4 (cortex)- and 4.7 (medulla)-fold compared with HS rats]. Salts 107-111 angiogenin Rattus norvegicus 48-51 12372776-8 2002 Our results suggest that the increase in renal ANG II levels after salt restriction results mainly from an uptake of ANG II, via AT(1) receptors. Salts 67-71 angiogenin Rattus norvegicus 47-50 10564122-2 1999 Because the renin-ANG system plays a central role in blood pressure regulation and electrolyte balance, it may be closely involved in the phenomenon of salt sensitivity. Salts 152-156 angiogenin Rattus norvegicus 18-21 10666081-0 2000 Elevated salt intake impairs dilation of rat skeletal muscle resistance arteries via ANG II suppression. Salts 9-13 angiogenin Rattus norvegicus 85-88 1558208-3 1992 Chronic peripheral administration of ANG II produced a salt appetite in SD but not in F344 rats; ANG III was ineffective in both strains. Salts 55-59 angiogenin Rattus norvegicus 37-40 7994452-1 1994 Exogenous angiotensin I (ANG I) was degraded to mainly des-Asp-ANG I instead of ANG II in the hypothalamic homogenate of the Sprague Dawley (SD), Wistar Kyoto (WKY), left renal artery stenosed hypertensive SD (LRAS), deoxycorticosterone acetate/salt-induced hypertensive SD (DOCA-salt) and spontaneously hypertensive rats (SHR). Salts 245-249 angiogenin Rattus norvegicus 25-28 7973802-1 1994 Intravenous infusion of various doses of Ang II caused significant increases of the salt intake in S-D rats as a result of natriuretic action of the drug. Salts 84-88 angiogenin Rattus norvegicus 41-44 31587572-6 2019 During the developmental stage of Ang II-salt hypertension, L-PGDS expression was higher in cerebrospinal fluid, and PGD2 levels were increased in the choroid plexus, cerebrospinal fluid, and the cardioregulatory brain region rostral ventrolateral medulla. Salts 41-45 angiogenin Rattus norvegicus 34-37 31587572-9 2019 Blockade of DP1R with BWA868C, however, increased the magnitude of Ang II-salt hypertension and significantly increased neurogenic pressor activity. Salts 74-78 angiogenin Rattus norvegicus 67-70 31587572-10 2019 In summary, we establish that the development of Ang II-salt hypertension requires increased COX- and L-PGDS-derived PGD2 production in the brain, making L-PGDS a possible target for treating neurogenic hypertension. Salts 56-60 angiogenin Rattus norvegicus 49-52 3390713-9 1988 The mechanism that underlies the production of salt appetite by aldosterone and Ang II may at least partially consist of mineralocorticoid-induced increases in the number of Ang receptors in discrete brain regions. Salts 47-51 angiogenin Rattus norvegicus 80-83