PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30187704-1 2018 PURPOSE: Cefaclor, a second-generation oral cephalosporin, is known to cause IgE-mediated hypersensitivity. Cephalosporins 44-57 immunoglobulin heavy constant epsilon Homo sapiens 77-80 25374747-1 2014 Cephalosporins can cause a range of hypersensitivity reactions, including IgE-mediated, immediate reactions. Cephalosporins 0-14 immunoglobulin heavy constant epsilon Homo sapiens 74-77 25930196-0 2015 IgE-mediated hypersensitivity to cephalosporins: Cross-reactivity and tolerability of alternative cephalosporins. Cephalosporins 33-47 immunoglobulin heavy constant epsilon Homo sapiens 0-3 25930196-0 2015 IgE-mediated hypersensitivity to cephalosporins: Cross-reactivity and tolerability of alternative cephalosporins. Cephalosporins 98-112 immunoglobulin heavy constant epsilon Homo sapiens 0-3 25930196-1 2015 BACKGROUND: Studies regarding the cross-reactivity and tolerability of alternative cephalosporins in large samples of subjects with an IgE-mediated hypersensitivity to cephalosporins are lacking. Cephalosporins 83-97 immunoglobulin heavy constant epsilon Homo sapiens 135-138 25930196-1 2015 BACKGROUND: Studies regarding the cross-reactivity and tolerability of alternative cephalosporins in large samples of subjects with an IgE-mediated hypersensitivity to cephalosporins are lacking. Cephalosporins 168-182 immunoglobulin heavy constant epsilon Homo sapiens 135-138 25374747-4 2014 Nevertheless, skin testing with diluted solutions of cephalosporins can be valuable in confirming IgE-mediated hypersensitivity reactions. Cephalosporins 53-67 immunoglobulin heavy constant epsilon Homo sapiens 98-101 25374747-7 2014 In selected cases of inconclusive results in both skin tests and IgE assays, a graded challenge or induction of drug tolerance with the implicated cephalosporin should be performed. Cephalosporins 147-160 immunoglobulin heavy constant epsilon Homo sapiens 65-68 19494517-1 2009 BACKGROUND: Cephalosporins can induce severe or life-threatening IgE-mediated reactions in some individuals. Cephalosporins 12-26 immunoglobulin heavy constant epsilon Homo sapiens 65-68 20888035-0 2010 IgE-mediated hypersensitivity to cephalosporins: cross-reactivity and tolerability of penicillins, monobactams, and carbapenems. Cephalosporins 33-47 immunoglobulin heavy constant epsilon Homo sapiens 0-3 19494517-9 2009 CONCLUSION: A positive skin test to cephalosporin implies the presence of drug-specific IgE antibodies. Cephalosporins 36-49 immunoglobulin heavy constant epsilon Homo sapiens 88-91 18762521-11 2008 CONCLUSIONS: Extremely few nonimmediate manifestations associated with cephalosporin therapy are actually hypersensitivity reactions, whereas most immediate reactions to cephalosporins are IgE-mediated. Cephalosporins 170-184 immunoglobulin heavy constant epsilon Homo sapiens 189-192 3300459-5 1987 The results of in-vivo challenges of patients with IgE to penicillin suggest the incidence of reactivity of cephalosporins in patients allergic to penicillin is less than generally appreciated. Cephalosporins 108-122 immunoglobulin heavy constant epsilon Homo sapiens 51-54 17017928-0 2006 IgE-mediated hypersensitivity to cephalosporins. Cephalosporins 33-47 immunoglobulin heavy constant epsilon Homo sapiens 0-3 17017928-1 2006 Like penicillins, cephalosporins may cause IgE-mediated reactions such as urticaria, angioedema, and anaphylactic shock, which occur because of sensitization to determinants shared with penicillins or to unique cephalosporin haptens. Cephalosporins 18-32 immunoglobulin heavy constant epsilon Homo sapiens 43-46 17017928-1 2006 Like penicillins, cephalosporins may cause IgE-mediated reactions such as urticaria, angioedema, and anaphylactic shock, which occur because of sensitization to determinants shared with penicillins or to unique cephalosporin haptens. Cephalosporins 18-31 immunoglobulin heavy constant epsilon Homo sapiens 43-46 17017928-5 2006 As far as in vitro tests are concerned, IgE assays for cephalosporins, specifically sepharose-radioimmunoassays, are a potentially useful tool in evaluating immediate reactions and could be used as complementary tests. Cephalosporins 55-69 immunoglobulin heavy constant epsilon Homo sapiens 40-43 17017928-6 2006 In selected cases displaying negative results in both skin tests and IgE assays, a graded challenge with the implicated cephalosporin can be performed. Cephalosporins 120-133 immunoglobulin heavy constant epsilon Homo sapiens 69-72 17017928-7 2006 Cephalosporin IgE-mediated hypersensitivity may be a transient condition; therefore, allergologic exams should be repeated in patients with negative initial allergologic work-ups, including challenges. Cephalosporins 0-13 immunoglobulin heavy constant epsilon Homo sapiens 14-17 12141712-4 2002 METHODS: Specific serum IgE antibodies to several cephalosporins were monitored in a 52-year-old man after a selective systemic anaphylaxis attributable to cefuroxime, who showed a good tolerance to penicillin V during a single-blind, placebo-controlled challenge. Cephalosporins 50-64 immunoglobulin heavy constant epsilon Homo sapiens 24-27 2083978-0 1990 Drugs as allergens: an immunoassay for detecting IgE antibodies to cephalosporins. Cephalosporins 67-81 immunoglobulin heavy constant epsilon Homo sapiens 49-52 2083978-1 1990 A radioimmunoassay employing cephalothin linked to a solid phase has been developed for the detection of cephalosporin-reactive IgE antibodies. Cephalosporins 105-118 immunoglobulin heavy constant epsilon Homo sapiens 128-131 11746950-1 2001 IgE antibodies in the sera of subjects allergic to beta-lactam antibiotics detect a spectrum of specificities ranging from side-chain groups to an entire penicillin or cephalosporin molecule. Cephalosporins 168-181 immunoglobulin heavy constant epsilon Homo sapiens 0-3 9131470-2 1996 Subjects allergic to the widely used cephalosporin antibiotic cefaclor have serum immuno globulin (Ig) E antibodies that react with the drug. Cephalosporins 37-50 immunoglobulin heavy constant epsilon Homo sapiens 82-104