PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12234848-2	2002	The Ambler class B beta-lactamase gene bla(EBR-1) was cloned and expressed in Escherichia coli from E. brevis clinical strain ASS-1, which had reduced susceptibility to expanded-spectrum cephalosporins and carbapenems.	Cephalosporins	187-201	beta-lactamase	Escherichia coli	39-42	
11570857-12	2001	Amino acid sequencing of some beta-lactamases has shown that substitution of only a few amino acids in the bla gene leads to high-level resistance against specific cephalosporins.	Cephalosporins	164-178	beta-lactamase	Escherichia coli	107-110	
12354850-6	2002	The extended-spectrum cephalosporin resistance in these nosocomial E. coli isolates was attributed to the cephamycinase-encoding gene, bla(CMY2).	Cephalosporins	22-35	beta-lactamase	Escherichia coli	135-138	
11257029-8	2001	The gene, bla(KPC-1), was cloned in E. coli and shown to confer resistance to imipenem, meropenem, extended-spectrum cephalosporins, and aztreonam.	Cephalosporins	117-131	beta-lactamase	Escherichia coli	10-13	
32010114-15	2019	Except for one isolate, all were genotypic and phenotypically MDR, and five of them also harbored cephalosporin resistance genes (bla CTX-M- 14, bla SHV- 12, and three bla CMY- 2).	Cephalosporins	98-111	beta-lactamase	Escherichia coli	130-133	
3263690-5	1988	The three beta-lactamases hydrolyzed penicillins and cephalosporins (including cefotaxime and ceftriaxone) and were therefore designated "extended broad-spectrum beta-lactamases" (EBS-Bla).	Cephalosporins	53-67	beta-lactamase	Escherichia coli	184-187	
32366721-0	2020	Comparative Genomic Analysis of Third Generation Cephalosporin-Resistant Escherichia coli Harboring bla CMY-2-Positive IncI1 group, IncB/O/K/Z, and IncC Plasmids Isolated from Healthy Broilers in Japan.	Cephalosporins	49-62	beta-lactamase	Escherichia coli	100-103	
28320396-0	2017	Occurrence of bla DHA-1 mediated cephalosporin resistance in Escherichia coli and their transcriptional response against cephalosporin stress: a report from India.	Cephalosporins	33-46	beta-lactamase	Escherichia coli	14-17	
30010911-0	2018	Co-harboring of cephalosporin (bla)/colistin (mcr) resistance genes among Enterobacteriaceae from flies in Thailand.	Cephalosporins	16-29	beta-lactamase	Escherichia coli	31-34	
30010911-1	2018	The spreading of antimicrobial-resistant Enterobacteriaceae, especially those co-harboring plasmid-mediated cephalosporin (bla) and colistin (mcr) resistance genes, is becoming increasingly problematic.	Cephalosporins	108-121	beta-lactamase	Escherichia coli	123-126	
28320396-0	2017	Occurrence of bla DHA-1 mediated cephalosporin resistance in Escherichia coli and their transcriptional response against cephalosporin stress: a report from India.	Cephalosporins	121-134	beta-lactamase	Escherichia coli	14-17	
28320396-5	2017	The bla DHA-1 transcriptional response was evaluated under different cephalosporin stress by RT PCR.	Cephalosporins	69-82	beta-lactamase	Escherichia coli	4-7	
21393166-7	2011	Two different promoters were found to transcribe bla(CTX-M-15), resulting in different levels of cephalosporin resistance.	Cephalosporins	97-110	beta-lactamase	Escherichia coli	49-52	
23489047-0	2013	Diversity of plasmid replicons encoding the bla(CMY-2) gene in broad-spectrum cephalosporin-resistant Escherichia coli from livestock animals in Japan.	Cephalosporins	78-91	beta-lactamase	Escherichia coli	44-47	
26579110-0	2015	Prevalence of extended-spectrum cephalosporin-resistant Escherichia coli in a farrowing farm: ST1121 clone harboring IncHI2 plasmid contributes to the dissemination of bla CMY-2.	Cephalosporins	32-45	beta-lactamase	Escherichia coli	168-171	
26579110-10	2015	This highlights the role of pEC5207 in co-selection of bla CMY-2-positive isolates under the selective pressure of heavy metals, cephalosporins, and other antimicrobials.	Cephalosporins	129-143	beta-lactamase	Escherichia coli	55-58	
21876060-5	2011	The introduction of bla(SMB-1) into Escherichia coli conferred resistance to a variety of beta-lactam antibiotics, penicillins, cephalosporins, and carbapenems, but not aztreonam, a resistance pattern consistent with those of other MBLs.	Cephalosporins	128-142	beta-lactamase	Escherichia coli	20-23	
12878518-8	2003	The cefaclor-hydrolyzing efficiencies of the ROB-1 variants were strongly decreased in all mutants, suggesting that if bla(ROB-1) mutants were selected by cefaclor, this drug would prevent the further evolution of this beta-lactamase toward molecular forms able to resist extended-spectrum cephalosporins or beta-lactamase inhibitors.	Cephalosporins	290-304	beta-lactamase	Escherichia coli	119-122	
16251286-9	2005	Expression of the cloned bla(SIM-1) gene in Escherichia coli revealed that the encoded enzyme is capable of hydrolyzing a broad array of beta-lactams, including penicillins, narrow- to expanded-spectrum cephalosporins, and carbapenems.	Cephalosporins	203-217	beta-lactamase	Escherichia coli	25-28