PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25774279-1	2014	BACKGROUND: Extended spectrum beta-lactamase (ESBL) are gram-negative bacteria that produce the enzyme, beta-lactamase, which can break down commonly used antibiotics, such as penicillin and cephalosporins, making infections with ESBL producing bacteria more difficult to treat.	Cephalosporins	191-205	CTX-M-15	Klebsiella pneumoniae	46-50	
28751669-2	2017	Indeed, K. pneumoniae is the enterobacterial species most concerned by both resistance to extended-spectrum cephalosporins, due to extended-spectrum beta-lactamase (ESBL) production, and resistance to carbapenems, i.e. the beta-lactams with the broadest activity.	Cephalosporins	108-122	CTX-M-15	Klebsiella pneumoniae	131-163	
28751669-2	2017	Indeed, K. pneumoniae is the enterobacterial species most concerned by both resistance to extended-spectrum cephalosporins, due to extended-spectrum beta-lactamase (ESBL) production, and resistance to carbapenems, i.e. the beta-lactams with the broadest activity.	Cephalosporins	108-122	CTX-M-15	Klebsiella pneumoniae	165-169	
25774279-1	2014	BACKGROUND: Extended spectrum beta-lactamase (ESBL) are gram-negative bacteria that produce the enzyme, beta-lactamase, which can break down commonly used antibiotics, such as penicillin and cephalosporins, making infections with ESBL producing bacteria more difficult to treat.	Cephalosporins	191-205	CTX-M-15	Klebsiella pneumoniae	230-234	
21565630-2	2011	BACKGROUND AND AIMS: Extended-spectrum beta-lactamase (ESBLs) production is still the most frequent mechanism of resistance to cephalosporins in gram-negative bacteria.	Cephalosporins	127-141	CTX-M-15	Klebsiella pneumoniae	21-53	
23767198-1	2012	BACKGROUND: The emergence and subsequent widespread dissemination of bacterial resistance to a variety of beta-lactam antibiotics by the elaboration of ESBL (Extended Spectrum Beta Lactamase) poses a serious threat to the effective use of beta lactam antibiotics and cephalosporins.	Cephalosporins	267-281	CTX-M-15	Klebsiella pneumoniae	152-156	
23767198-1	2012	BACKGROUND: The emergence and subsequent widespread dissemination of bacterial resistance to a variety of beta-lactam antibiotics by the elaboration of ESBL (Extended Spectrum Beta Lactamase) poses a serious threat to the effective use of beta lactam antibiotics and cephalosporins.	Cephalosporins	267-281	CTX-M-15	Klebsiella pneumoniae	158-190	
21393158-0	2011	Radical reduction of cephalosporin use at a tertiary hospital after educational antibiotic intervention during an outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae.	Cephalosporins	21-34	CTX-M-15	Klebsiella pneumoniae	126-158	
21393158-1	2011	OBJECTIVES: During an outbreak of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae at our hospital, we performed an educational antibiotic intervention aimed at reducing prescriptions of second- and third-generation cephalosporins and preventing increased use of fluoroquinolones and carbapenems.	Cephalosporins	239-253	CTX-M-15	Klebsiella pneumoniae	34-66	
10588311-1	1999	The increasing use of broader-spectrum cephalosporins in the first half of the 1990s has become one of the major factors responsible for the high rate of selection of extended-spectrum beta-lactamase (ESBL)-producing microorganisms in Polish hospitals.	Cephalosporins	39-53	CTX-M-15	Klebsiella pneumoniae	167-199	
17657040-0	2002	Extended spectrum beta lactamase (ESBL) mediated resistance to third generation cephalosporins among Klebsiella pneumoniae in Chennai.	Cephalosporins	80-94	CTX-M-15	Klebsiella pneumoniae	0-32	
17657040-0	2002	Extended spectrum beta lactamase (ESBL) mediated resistance to third generation cephalosporins among Klebsiella pneumoniae in Chennai.	Cephalosporins	80-94	CTX-M-15	Klebsiella pneumoniae	34-38	
16938422-2	2006	The RLC classify as ESBL producers those strains for which any MIC of cephalosporins is 3-fold lower in the presence of 2 mug/mL of clavulanate.	Cephalosporins	70-84	CTX-M-15	Klebsiella pneumoniae	20-24	
15828446-0	2005	Extended Spectrum Beta-Lactamase-producing Klebsiella pneumoniae outbreaks during a third generation cephalosporin restriction policy.	Cephalosporins	101-114	CTX-M-15	Klebsiella pneumoniae	0-32	
14582562-1	2003	With the overuse of expanded-spectrum cephalosporins, especially ceftazidime, outbreaks of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae and Escherichia coli infections have been reported.	Cephalosporins	38-52	CTX-M-15	Klebsiella pneumoniae	91-123	
10588311-1	1999	The increasing use of broader-spectrum cephalosporins in the first half of the 1990s has become one of the major factors responsible for the high rate of selection of extended-spectrum beta-lactamase (ESBL)-producing microorganisms in Polish hospitals.	Cephalosporins	39-53	CTX-M-15	Klebsiella pneumoniae	201-205	
30825700-0	2019	Infections by OXA-48-like-producing Klebsiella pneumoniae non-co-producing extended-spectrum beta-lactamase: Can they be successfully treated with cephalosporins?	Cephalosporins	147-161	CTX-M-15	Klebsiella pneumoniae	75-107	
30825700-2	2019	However, very few clinical experiences of treating extended-spectrum beta-lactamase (ESBL)-negative OXA-48 producers with cephalosporins have been published.	Cephalosporins	122-136	CTX-M-15	Klebsiella pneumoniae	51-83