PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22483968-2 2012 Binding of a non-steroidal anti-inflammatory drug, diclofenac sodium (DCF) and an antibiotic drug, cefotaxime sodium (CFT) belonging to the family of cephalosporins with bovine serum albumin (BSA) has been examined using a combination of isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), steady state and time resolved fluorescence and circular dichroism spectroscopies. Cephalosporins 150-164 albumin Homo sapiens 177-190 23758063-4 2013 We studied the beta-lactamase activity of HSA on clinically significant antibiotics of cephalosporin group in the presence of environmental pollutants by determining specific activity, enzyme kinetics and minimum inhibitory concentrations (MIC). Cephalosporins 87-100 albumin Homo sapiens 42-45 23758063-5 2013 The specific activity of HSA on various cephalosporins was found to be 1181-34 550 times lower than that observed for recombinant CTX-M-15 (used as positive control). Cephalosporins 40-54 albumin Homo sapiens 25-28 23758063-8 2013 The MIC data also showed that HSA is incapable of hydrolysing cephalosporins. Cephalosporins 62-76 albumin Homo sapiens 30-33 23758063-9 2013 The study concludes that HSA is inefficient to cleave antibiotics of cephalosporin group and hence does not contribute to nonmicrobial-based antibiotic resistance. Cephalosporins 69-82 albumin Homo sapiens 25-28 23758063-13 2013 Our results showed that HSA is inefficient in cleaving nitrocefin as compared to a true beta-lactamase (CTX-M-15) and is practically inactive on cephalosporin antibiotics even in the presence pollutants. Cephalosporins 145-158 albumin Homo sapiens 24-27 7132963-0 1982 Study of the interaction between human serum albumin and some cephalosporins. Cephalosporins 62-76 albumin Homo sapiens 39-52 8624497-1 1995 The interaction of a chromogenic cephalosporin, 3-(2, 4 dinitrostyryl)-(6 R, 7 R) -7(2 thienylacetamido)-ceph 3-em-5-carboxylic acid) (nitrocefin) with human serum albumin was studied. Cephalosporins 33-46 albumin Homo sapiens 158-171 7663413-0 1995 Cephalosporin binding sites to human serum albumin and the relation with the N-B transition of this protein. Cephalosporins 0-13 albumin Homo sapiens 37-50 7663413-1 1995 The binding of some cephalosporins to human serum albumin was studied using probes for the so-called I, II, bilirubin and fatty acids binding sites. Cephalosporins 20-34 albumin Homo sapiens 44-57 2779527-1 1989 Ceftriaxone, a cephalosporin, is bound reversibly to defatted human serum albumin from adults, with a first stoichiometric binding constant of 60,000 M-1, as found by equilibrium dialysis at pH 7.4, 37 degrees. Cephalosporins 15-28 albumin Homo sapiens 68-81 4083858-1 1985 The binding of cephalosporins with human serum albumin]. Cephalosporins 15-29 albumin Homo sapiens 47-54 7132963-1 1982 Dialysis and microcalorimetric methods were used to calculate the binding parameters of some cephalosporins to human serum albumin (HSA) and to study the nature of the interactions involved in the binding process. Cephalosporins 93-107 albumin Homo sapiens 117-130 7132963-1 1982 Dialysis and microcalorimetric methods were used to calculate the binding parameters of some cephalosporins to human serum albumin (HSA) and to study the nature of the interactions involved in the binding process. Cephalosporins 93-107 albumin Homo sapiens 132-135 7132963-5 1982 The major binding site for cephalosporins with high HSA affinity is thought to be the electron-rich heterocyle fixed on the methylene at position 3. Cephalosporins 27-41 albumin Homo sapiens 52-55 28976065-0 2018 Probing the interaction of cephalosporin with bovine serum albumin: A structural and comparative perspective. Cephalosporins 27-40 albumin Homo sapiens 53-66 28693993-0 2017 Probing the interaction of cephalosporin antibiotic-ceftazidime with human serum albumin: A biophysical investigation. Cephalosporins 27-40 albumin Homo sapiens 75-88 28693993-3 2017 In the present study, we have explored the mechanism of interaction between cephalosporin antibiotic-ceftazidime (CFD) and human serum albumin (HSA) by spectroscopic and molecular docking studies. Cephalosporins 76-89 albumin Homo sapiens 129-142