PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18391763-9 2008 Similar findings were observed after administration of a iNOS specific inhibitor, L-N[6]-(1-iminoethyl)lysine (L-NIL). N(6)-(1-iminoethyl)lysine 82-109 nitric oxide synthase 2, inducible Mus musculus 57-61 20176626-6 2010 Since iNOS has been shown to play an important role in sepsis-induced AKI, the iNOS inhibitor L-N(6)-(1-iminoethyl)-lysine (L-NIL) was tested in this in vitro model. N(6)-(1-iminoethyl)lysine 94-122 nitric oxide synthase 2, inducible Mus musculus 79-83 20176626-6 2010 Since iNOS has been shown to play an important role in sepsis-induced AKI, the iNOS inhibitor L-N(6)-(1-iminoethyl)-lysine (L-NIL) was tested in this in vitro model. N(6)-(1-iminoethyl)lysine 124-129 nitric oxide synthase 2, inducible Mus musculus 79-83 24616121-8 2014 In ovariectomized mice cyclicCHAD improved bone mass by both a preventive and a curative treatment protocol, with an effect in line with that of the bisphosphonate alendronate, that was mimicked by the NOS2 inhibitor [L-N6-(1-Iminoethyl)-lysine.2 dihydrochloride]. N(6)-(1-iminoethyl)lysine 218-244 nitric oxide synthase 2, inducible Mus musculus 202-206 19077108-5 2009 In subgroups (n = 6), iNOS was inhibited selectively by L-N6-(1-iminoethyl)-lysine (L-NIL) given either chronically from day 1-3 (3 mg kg(-1) twice daily i.p.) N(6)-(1-iminoethyl)lysine 56-82 nitric oxide synthase 2, inducible Mus musculus 22-26 19077108-5 2009 In subgroups (n = 6), iNOS was inhibited selectively by L-N6-(1-iminoethyl)-lysine (L-NIL) given either chronically from day 1-3 (3 mg kg(-1) twice daily i.p.) N(6)-(1-iminoethyl)lysine 84-89 nitric oxide synthase 2, inducible Mus musculus 22-26 18391763-9 2008 Similar findings were observed after administration of a iNOS specific inhibitor, L-N[6]-(1-iminoethyl)lysine (L-NIL). N(6)-(1-iminoethyl)lysine 111-116 nitric oxide synthase 2, inducible Mus musculus 57-61 16988058-9 2006 Delayed renal IPC increased inducible nitric oxide synthase (iNOS) as well as heat-shock protein 27 synthesis, and the renal protective effects of delayed preconditioning were attenuated by a selective inhibitor of iNOS (l-N(6)[1-iminoethyl]lysine). N(6)-(1-iminoethyl)lysine 221-247 nitric oxide synthase 2, inducible Mus musculus 215-219 18186729-2 2008 l-N(6)-(1-Iminoethyl)-lysine (L-NIL) has been shown to inhibit iNOS in a selective manner, and hence the aim of the present study was to test the hypothesis that treatment with l-NIL may induce a T-cell helper 1 (Th1)-like immune response by Aggregatibacter (Actinobacillus) actinomycetemcomitans lipopolysaccharide (LPS)-stimulated murine spleen cells in vitro. N(6)-(1-iminoethyl)lysine 0-28 nitric oxide synthase 2, inducible Mus musculus 63-67 18186729-2 2008 l-N(6)-(1-Iminoethyl)-lysine (L-NIL) has been shown to inhibit iNOS in a selective manner, and hence the aim of the present study was to test the hypothesis that treatment with l-NIL may induce a T-cell helper 1 (Th1)-like immune response by Aggregatibacter (Actinobacillus) actinomycetemcomitans lipopolysaccharide (LPS)-stimulated murine spleen cells in vitro. N(6)-(1-iminoethyl)lysine 30-35 nitric oxide synthase 2, inducible Mus musculus 63-67 18186729-6 2008 The results showed that treatment with L-NIL suppressed both NO production and iNOS activity but enhanced specific IgG2a, IFN-gamma levels, and increased cell proliferation following stimulation with A. actinomycetemcomitans LPS-stimulated cells. N(6)-(1-iminoethyl)lysine 39-44 nitric oxide synthase 2, inducible Mus musculus 79-83 16874658-8 2006 iNOS inhibitors and SNP abrogated these effects but the effect was more pronounced with SMT and L-NIL. N(6)-(1-iminoethyl)lysine 96-101 nitric oxide synthase 2, inducible Mus musculus 0-4 17588258-3 2007 A significant dose-dependent increase in the inducible nitric oxide synthase (NOS2) expression and NO production were observed by various concentrations of TNF-alpha (1, 5, and 10 ng/mL) and LPS (1 and 5 microg/mL) which was completely inhibited by a NOS2 inhibitor, L-N6-(1-iminoethyl) lysine (L-NIL) (1 mM). N(6)-(1-iminoethyl)lysine 267-293 nitric oxide synthase 2, inducible Mus musculus 45-76 17588258-3 2007 A significant dose-dependent increase in the inducible nitric oxide synthase (NOS2) expression and NO production were observed by various concentrations of TNF-alpha (1, 5, and 10 ng/mL) and LPS (1 and 5 microg/mL) which was completely inhibited by a NOS2 inhibitor, L-N6-(1-iminoethyl) lysine (L-NIL) (1 mM). N(6)-(1-iminoethyl)lysine 267-293 nitric oxide synthase 2, inducible Mus musculus 78-82 17588258-3 2007 A significant dose-dependent increase in the inducible nitric oxide synthase (NOS2) expression and NO production were observed by various concentrations of TNF-alpha (1, 5, and 10 ng/mL) and LPS (1 and 5 microg/mL) which was completely inhibited by a NOS2 inhibitor, L-N6-(1-iminoethyl) lysine (L-NIL) (1 mM). N(6)-(1-iminoethyl)lysine 295-300 nitric oxide synthase 2, inducible Mus musculus 45-76 17588258-3 2007 A significant dose-dependent increase in the inducible nitric oxide synthase (NOS2) expression and NO production were observed by various concentrations of TNF-alpha (1, 5, and 10 ng/mL) and LPS (1 and 5 microg/mL) which was completely inhibited by a NOS2 inhibitor, L-N6-(1-iminoethyl) lysine (L-NIL) (1 mM). N(6)-(1-iminoethyl)lysine 295-300 nitric oxide synthase 2, inducible Mus musculus 78-82 17202403-0 2007 Effects of the inducible nitric-oxide synthase inhibitor L-N(6)-(1-iminoethyl)-lysine on microcirculation and reactive nitrogen species generation in the kidney following lipopolysaccharide administration in mice. N(6)-(1-iminoethyl)lysine 57-85 nitric oxide synthase 2, inducible Mus musculus 15-46 17202403-9 2007 The iNOS inhibitor l-N(6)-(1-iminoethyl)-lysine (l-NIL; 3 mg/kg i.p.) N(6)-(1-iminoethyl)lysine 19-47 nitric oxide synthase 2, inducible Mus musculus 4-8 17202403-9 2007 The iNOS inhibitor l-N(6)-(1-iminoethyl)-lysine (l-NIL; 3 mg/kg i.p.) N(6)-(1-iminoethyl)lysine 49-54 nitric oxide synthase 2, inducible Mus musculus 4-8 15998845-5 2005 Both the inducible NO synthase inhibitor L-N(6)-1-iminoethyl-lysine (L-NIL) and the nonselective caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp fluoromethylketone (Z-VAD) prevented renal failure and reversed perfusion deficits. N(6)-(1-iminoethyl)lysine 41-67 nitric oxide synthase 2, inducible Mus musculus 9-30 16551643-3 2006 NO generation by LPS + IFN-gamma was blocked by a specific iNOS blocker, L-N6-(1-iminoethyl)-lysine (L-NIL, 1 mM). N(6)-(1-iminoethyl)lysine 73-99 nitric oxide synthase 2, inducible Mus musculus 59-63 16551643-3 2006 NO generation by LPS + IFN-gamma was blocked by a specific iNOS blocker, L-N6-(1-iminoethyl)-lysine (L-NIL, 1 mM). N(6)-(1-iminoethyl)lysine 101-106 nitric oxide synthase 2, inducible Mus musculus 59-63 14770040-5 2004 iNOS was inhibited using intraperitoneal L-N(6)-(1-iminoethyl)lysine (L-NIL; 5 mg/kg). N(6)-(1-iminoethyl)lysine 41-68 nitric oxide synthase 2, inducible Mus musculus 0-4 14770040-5 2004 iNOS was inhibited using intraperitoneal L-N(6)-(1-iminoethyl)lysine (L-NIL; 5 mg/kg). N(6)-(1-iminoethyl)lysine 70-75 nitric oxide synthase 2, inducible Mus musculus 0-4 14770040-9 2004 Pharmacologic inhibition of iNOS activity using L-NIL or genetic ablation of the iNOS gene ameliorated LPS-induced changes in TJ protein expression and gut mucosal barrier function. N(6)-(1-iminoethyl)lysine 48-53 nitric oxide synthase 2, inducible Mus musculus 28-32 11254581-8 2001 Parasitemia was cleared and tissue amastigotes became undetectable in these mice even in the presence of the iNOS inhibitor L-NIL. N(6)-(1-iminoethyl)lysine 124-129 nitric oxide synthase 2, inducible Mus musculus 109-113 12896879-6 2004 Treatment of endotoxemic mice with an isoform-selective iNOS inhibitor [l-N(6)-(1-iminoethyl)lysine; l-NIL] ameliorated LPS-induced changes in TJ protein expression and preserved bronchoalveolar epithelial barrier function. N(6)-(1-iminoethyl)lysine 72-99 nitric oxide synthase 2, inducible Mus musculus 56-60 12946943-6 2004 Pharmacological inhibition of iNOS activity using l-N6-(1-iminoethyl)lysine (5 mg/kg) or genetic ablation of iNOS ameliorated LPS-induced changes in hepatobiliary barrier function, and these strategies partially preserved TJ protein expression and localization. N(6)-(1-iminoethyl)lysine 50-75 nitric oxide synthase 2, inducible Mus musculus 30-34 12556364-11 2003 Specific inhibition of inducible nitric oxide synthase (iNOS), l-N(6)-(1-iminoethyl)-lysine, reversed the renal protective effect on GFR and RBF observed with antioxidant treatment during endotoxemia. N(6)-(1-iminoethyl)lysine 63-91 nitric oxide synthase 2, inducible Mus musculus 23-54 12556364-11 2003 Specific inhibition of inducible nitric oxide synthase (iNOS), l-N(6)-(1-iminoethyl)-lysine, reversed the renal protective effect on GFR and RBF observed with antioxidant treatment during endotoxemia. N(6)-(1-iminoethyl)lysine 63-91 nitric oxide synthase 2, inducible Mus musculus 56-60 12217856-8 2002 Addition of the iNOS-selective inhibitor L-N(6)-(1-iminoethyl) lysine, reduced both J(v) and J(HCO3) significantly in wild-type, but not in iNOS knockout, mice. N(6)-(1-iminoethyl)lysine 41-69 nitric oxide synthase 2, inducible Mus musculus 16-20 12217856-8 2002 Addition of the iNOS-selective inhibitor L-N(6)-(1-iminoethyl) lysine, reduced both J(v) and J(HCO3) significantly in wild-type, but not in iNOS knockout, mice. N(6)-(1-iminoethyl)lysine 41-69 nitric oxide synthase 2, inducible Mus musculus 140-144 12682064-9 2003 Pharmacological inhibition of NOS by l-NNA or l-N6-(1-iminoethyl) lysine (l-NIL, a specific inhibitor of iNOS) mitigates the kidney protection afforded by 30 min of ischemic preconditioning. N(6)-(1-iminoethyl)lysine 46-72 nitric oxide synthase 2, inducible Mus musculus 105-109 12682064-9 2003 Pharmacological inhibition of NOS by l-NNA or l-N6-(1-iminoethyl) lysine (l-NIL, a specific inhibitor of iNOS) mitigates the kidney protection afforded by 30 min of ischemic preconditioning. N(6)-(1-iminoethyl)lysine 74-79 nitric oxide synthase 2, inducible Mus musculus 105-109 12895524-3 2003 In the wild type mice, intrathecal administration of L-N(6)-(1-iminoethyl)-lysine, a selective iNOS inhibitor, significantly inhibited thermal hyperalgesia in the late phase but not in the early phase of carrageenan inflammation. N(6)-(1-iminoethyl)lysine 53-81 nitric oxide synthase 2, inducible Mus musculus 95-99 11506742-5 2001 Moreover, nitric oxide (NO) was also involved in the downregulation of LPS-induced IL-1 by IFN, as addition of the inducible nitric oxide synthase (iNOS) inhibitor L-N(6)-(1-iminoethyl)lysine (NIL) negated the effect. N(6)-(1-iminoethyl)lysine 164-191 nitric oxide synthase 2, inducible Mus musculus 115-146 11506742-5 2001 Moreover, nitric oxide (NO) was also involved in the downregulation of LPS-induced IL-1 by IFN, as addition of the inducible nitric oxide synthase (iNOS) inhibitor L-N(6)-(1-iminoethyl)lysine (NIL) negated the effect. N(6)-(1-iminoethyl)lysine 164-191 nitric oxide synthase 2, inducible Mus musculus 148-152 11254581-9 2001 Inhibition of iNOS in the chronic phase of the infection, i.e., from day 60 to day 120 p.i., with L-NIL did not result in a reappearance of parasitemia. N(6)-(1-iminoethyl)lysine 98-103 nitric oxide synthase 2, inducible Mus musculus 14-18 10583588-2 1999 Continuous treatment with 5 mm or 10 mm l-N6-(1-imino-ethyl)-lysine (L-NIL), a selective NOS2-inhibitor, in acidified drinking water for up to 7 weeks consistently reduced infection-induced nitrate/nitrite to background levels in mycobacteria-infected BALB/c mice. N(6)-(1-iminoethyl)lysine 40-67 nitric oxide synthase 2, inducible Mus musculus 89-93 10544183-7 1999 During excisional wound repair, mice were treated with L-N(6)-(1-iminoethyl)lysine (L-NIL), a selective inhibitor of iNOS enzymatic activity. N(6)-(1-iminoethyl)lysine 55-82 nitric oxide synthase 2, inducible Mus musculus 117-121 10544183-7 1999 During excisional wound repair, mice were treated with L-N(6)-(1-iminoethyl)lysine (L-NIL), a selective inhibitor of iNOS enzymatic activity. N(6)-(1-iminoethyl)lysine 84-89 nitric oxide synthase 2, inducible Mus musculus 117-121 10899065-7 2000 L-N(6)-(1-iminoethyl)lysine, a selective inhibitor of inducible NO synthase (NOS2), obliterated the protective effects of FGF-2. N(6)-(1-iminoethyl)lysine 0-27 nitric oxide synthase 2, inducible Mus musculus 77-81 10594757-3 1999 During excisional repair, mice were treated with L-N6-(1-iminoethyl)lysine (L-NIL), a selective inhibitor of iNOS enzymatic activity. N(6)-(1-iminoethyl)lysine 49-74 nitric oxide synthase 2, inducible Mus musculus 109-113 10594757-3 1999 During excisional repair, mice were treated with L-N6-(1-iminoethyl)lysine (L-NIL), a selective inhibitor of iNOS enzymatic activity. N(6)-(1-iminoethyl)lysine 76-81 nitric oxide synthase 2, inducible Mus musculus 109-113 10583588-2 1999 Continuous treatment with 5 mm or 10 mm l-N6-(1-imino-ethyl)-lysine (L-NIL), a selective NOS2-inhibitor, in acidified drinking water for up to 7 weeks consistently reduced infection-induced nitrate/nitrite to background levels in mycobacteria-infected BALB/c mice. N(6)-(1-iminoethyl)lysine 69-74 nitric oxide synthase 2, inducible Mus musculus 89-93 9427324-3 1997 The i-NOS inhibitor L-N6-(1-iminoethyl)-lysine (NIL, 600 microM) suppressed the nitrite accumulation and the increase in Mn-SOD-like immunoreactivity in activated cells without significant effect on the level of i-NOS-like immunoreactivity. N(6)-(1-iminoethyl)lysine 20-46 nitric oxide synthase 2, inducible Mus musculus 4-9 9725234-8 1998 A highly specific inhibitor of the inducible nitric oxide synthase (iNOS), L-N6-(1-iminoethyl)lysine, dihydrochloride, also inhibited the action of MIF, suggesting an important role for iNOS in the antiparasitic properties of MIF. N(6)-(1-iminoethyl)lysine 75-100 nitric oxide synthase 2, inducible Mus musculus 35-66 9725234-8 1998 A highly specific inhibitor of the inducible nitric oxide synthase (iNOS), L-N6-(1-iminoethyl)lysine, dihydrochloride, also inhibited the action of MIF, suggesting an important role for iNOS in the antiparasitic properties of MIF. N(6)-(1-iminoethyl)lysine 75-100 nitric oxide synthase 2, inducible Mus musculus 68-72 9725234-8 1998 A highly specific inhibitor of the inducible nitric oxide synthase (iNOS), L-N6-(1-iminoethyl)lysine, dihydrochloride, also inhibited the action of MIF, suggesting an important role for iNOS in the antiparasitic properties of MIF. N(6)-(1-iminoethyl)lysine 75-100 nitric oxide synthase 2, inducible Mus musculus 186-190 7525961-0 1994 L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. N(6)-(1-iminoethyl)lysine 0-25 nitric oxide synthase 2, inducible Mus musculus 52-83 8750736-3 1995 L-N6-(1-iminoethyl)-lysine potently inhibited the activity of inducible NO-synthase in primary macrophages. N(6)-(1-iminoethyl)lysine 0-26 nitric oxide synthase 2, inducible Mus musculus 62-83 8750736-5 1995 In vivo, L-N6-(1-iminoethyl)-lysine (0.4-9 mM in the drinking water) suppressed inducible NO-synthase activity and caused a dramatic exacerbation of leishmaniasis, despite a counterregulatory increase of inducible NO-synthase protein in the tissue. N(6)-(1-iminoethyl)lysine 9-35 nitric oxide synthase 2, inducible Mus musculus 80-101 8750736-5 1995 In vivo, L-N6-(1-iminoethyl)-lysine (0.4-9 mM in the drinking water) suppressed inducible NO-synthase activity and caused a dramatic exacerbation of leishmaniasis, despite a counterregulatory increase of inducible NO-synthase protein in the tissue. N(6)-(1-iminoethyl)lysine 9-35 nitric oxide synthase 2, inducible Mus musculus 204-225 8750736-8 1995 We conclude that L-N6-(1-iminoethyl)-lysine should be used instead of NG-monomethyl-L-arginine for potent suppression of inducible NO-synthase in vitro and in vivo. N(6)-(1-iminoethyl)lysine 17-43 nitric oxide synthase 2, inducible Mus musculus 121-142 7525961-1 1994 L-N6-(1-Iminoethyl)lysine (L-NIL) has been synthesized and is shown to be both a potent and selective inhibitor of mouse inducible nitric oxide synthase (miNOS). N(6)-(1-iminoethyl)lysine 0-25 nitric oxide synthase 2, inducible Mus musculus 121-152 7525961-1 1994 L-N6-(1-Iminoethyl)lysine (L-NIL) has been synthesized and is shown to be both a potent and selective inhibitor of mouse inducible nitric oxide synthase (miNOS). N(6)-(1-iminoethyl)lysine 27-32 nitric oxide synthase 2, inducible Mus musculus 121-152 34314655-3 2021 One hour before SL-CLP surgery, mice were treated with N6-(1-Iminoethyl)-lysine (L-NIL, 5 mg/kg, i.p), a selective inhibitor of iNOS. N(6)-(1-iminoethyl)lysine 55-79 nitric oxide synthase 2, inducible Mus musculus 128-132