PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12688550-9 2003 In contrast, L-NMMA, an inhibitor of nitric oxide synthase, abolished the effects of IL-1beta on ATP content and KBR, as well as on NO production. omega-N-Methylarginine 13-19 interleukin 1 beta Rattus norvegicus 85-93 15201138-7 2004 N(G)-monomethyl-l-arginine, a known inhibitor of inducible nitric oxide synthetase (iNOS), markedly inhibited IL-1beta-induced iNOS gene expression, NO release, caspase-3 and caspase-6 activation, lamin B degradation, and loss of metabolic cell viability, indicating that the observed IL-1beta-induced effects on nuclear lamin B involve the intermediacy of NO. omega-N-Methylarginine 0-26 interleukin 1 beta Rattus norvegicus 110-118 15201138-7 2004 N(G)-monomethyl-l-arginine, a known inhibitor of inducible nitric oxide synthetase (iNOS), markedly inhibited IL-1beta-induced iNOS gene expression, NO release, caspase-3 and caspase-6 activation, lamin B degradation, and loss of metabolic cell viability, indicating that the observed IL-1beta-induced effects on nuclear lamin B involve the intermediacy of NO. omega-N-Methylarginine 0-26 interleukin 1 beta Rattus norvegicus 285-293 12465160-9 2002 L-NMMA and CuDips completely corrected the suppressive effect of IL-1beta on proteoglycan synthesis, unlike with IL-17. omega-N-Methylarginine 0-6 interleukin 1 beta Rattus norvegicus 65-73 11955955-6 2002 KT5720, an inhibitor of protein kinase A, and N(G)-monomethyl-L-arginine, an inhibitor of NO synthase, abrogated cilostazol-enhanced IL-1beta-stimulated NO production and apoptosis. omega-N-Methylarginine 46-72 interleukin 1 beta Rattus norvegicus 133-141 11259370-5 2001 Moreover, inhibition of IL-1b-induced endogenous NO formation by the NO-synthase (NOS) inhibitor L-NMMA markedly attenuated MIP-2 protein expression. omega-N-Methylarginine 97-103 interleukin 1 beta Rattus norvegicus 24-29 12082283-4 2002 Using L-NMMA (1 mM), as a NO synthase inhibitor, and CuDips (10 microM), as a SOD mimetic, we provide evidence that the inhibitory potency of IL-1beta on proteoglycan synthesis and its stimulating effect on COX-2 activity depend both on NO and O2-* production. omega-N-Methylarginine 6-12 interleukin 1 beta Rattus norvegicus 142-150 10365824-12 1999 N(G)-monomethyl-L-arginine, an inhibitor of nitric oxide synthase, abolished the effects of IL-1beta on the ATP levels and ketone body ratio, as well as on the nitric oxide production. omega-N-Methylarginine 0-26 interleukin 1 beta Rattus norvegicus 92-100 11003621-9 2000 The NOS inhibitor N(G)-monomethyl-L-arginine (NMA) inhibited the protective effects of IL-1beta and IFN-gamma. omega-N-Methylarginine 18-44 interleukin 1 beta Rattus norvegicus 87-95 11003621-9 2000 The NOS inhibitor N(G)-monomethyl-L-arginine (NMA) inhibited the protective effects of IL-1beta and IFN-gamma. omega-N-Methylarginine 46-49 interleukin 1 beta Rattus norvegicus 87-95 10953999-9 2000 Treatment with IL-1beta reduced the AGEs-stimulated intracellular oxidant level through increased NO production, whilst inhibition of NO production by L-NMMA reduced the inhibitory effect of IL-1beta. omega-N-Methylarginine 151-157 interleukin 1 beta Rattus norvegicus 191-199 11798681-5 1999 RESULTS: IL-1 beta induced a significant increase in nitrite production, a decrease of islet cell DNA and insulin content and reduction of cell activity (MTT, P < 0.001); these changes were blocked by L-NMMA (P < 0.001). omega-N-Methylarginine 204-210 interleukin 1 beta Rattus norvegicus 9-18 10342285-8 1999 After a treatment with interleukin-1 beta for 24 hr, contractile effects of phenylephrine (1 microM-10 microM) were markedly inhibited in the presence of L-NMMA (100 microM) applied to inhibit NO synthesis. omega-N-Methylarginine 154-160 interleukin 1 beta Rattus norvegicus 23-41 9751495-4 1998 N(G)-monomethyl-L-arginine inhibited the IL-1beta-induced increase in HO-1. omega-N-Methylarginine 0-26 interleukin 1 beta Rattus norvegicus 41-49 9576743-5 1998 Treatment of INS-1 cells with L-NMMA, an inhibitor of iNOS, provides the same degree of protection against IL-1beta or supernatants from LPS-activated rat PBMC as MnSOD overexpression, supporting the idea that MnSOD protects INS-1 cells by interfering with the normal IL-1beta-mediated increase in iNOS. omega-N-Methylarginine 30-36 interleukin 1 beta Rattus norvegicus 107-115 9696008-4 1998 The inhibition of DNA synthesis by IL-1beta was completely abrogated when NO production was inhibited by N-monomethyl-L-arginine (NMA), a competitive inhibitor of iNOS. omega-N-Methylarginine 105-128 interleukin 1 beta Rattus norvegicus 35-43 9696008-4 1998 The inhibition of DNA synthesis by IL-1beta was completely abrogated when NO production was inhibited by N-monomethyl-L-arginine (NMA), a competitive inhibitor of iNOS. omega-N-Methylarginine 130-133 interleukin 1 beta Rattus norvegicus 35-43 9576743-5 1998 Treatment of INS-1 cells with L-NMMA, an inhibitor of iNOS, provides the same degree of protection against IL-1beta or supernatants from LPS-activated rat PBMC as MnSOD overexpression, supporting the idea that MnSOD protects INS-1 cells by interfering with the normal IL-1beta-mediated increase in iNOS. omega-N-Methylarginine 30-36 interleukin 1 beta Rattus norvegicus 268-276 9253947-4 1997 An inhibitor of nitric oxide (NO) synthase, N(G)-monomethyl-L-arginine (L-NMMA, 100 microM), prevented the inhibitory effect of interleukin-1beta. omega-N-Methylarginine 44-70 interleukin 1 beta Rattus norvegicus 128-145 9310350-8 1997 To investigate the role of NO in the IL-1beta- or LPS-mediated suppression of P450 2C11, N-monomethyl-L-arginine (NMA) was administered at concentrations ranging from 30 to 300 microM. omega-N-Methylarginine 114-117 interleukin 1 beta Rattus norvegicus 37-45 9253947-4 1997 An inhibitor of nitric oxide (NO) synthase, N(G)-monomethyl-L-arginine (L-NMMA, 100 microM), prevented the inhibitory effect of interleukin-1beta. omega-N-Methylarginine 72-78 interleukin 1 beta Rattus norvegicus 128-145 9253947-10 1997 Addition of L-NMMA (1 mM) during the 24 h treatment prevented NO production and preserved the sodium nitroprusside-induced cGMP generation by interleukin-1beta. omega-N-Methylarginine 12-18 interleukin 1 beta Rattus norvegicus 142-159 9185761-12 1997 Relaxation of Ito cells by IL-1beta treatment was inhibited by L-NMMA in a dose-dependent manner, but was enhanced by SNAP. omega-N-Methylarginine 63-69 interleukin 1 beta Rattus norvegicus 27-35 8603098-7 1996 Furthermore, interleukin-1beta markedly stimulated nitric oxide formation in hepatocytes, and this increase was blocked by NG-monomethyl-L-arginine (a nitric oxide synthase inhibitor) and by interleukin-1 receptor antagonist. omega-N-Methylarginine 123-147 interleukin 1 beta Rattus norvegicus 13-30 9130760-6 1997 The IL-1beta-stimulated NO production was inhibited by the NOS inhibitor, L-NMMA, whose effects were reversed by L-arginine. omega-N-Methylarginine 74-80 interleukin 1 beta Rattus norvegicus 4-12 9013984-10 1997 IL-1beta also induced NO production in these cells, which was inhibited by NG-monomethyl-L-arginine. omega-N-Methylarginine 75-99 interleukin 1 beta Rattus norvegicus 0-8 9010260-4 1997 Total DNA synthesis was significantly reduced in the presence of IL-1beta and TNF-alpha, and this effect was completely reversed by N(G)-monomethyl-L-arginine (L-NMMA), an inhibitor of iNOS. omega-N-Methylarginine 132-158 interleukin 1 beta Rattus norvegicus 65-73 9010260-4 1997 Total DNA synthesis was significantly reduced in the presence of IL-1beta and TNF-alpha, and this effect was completely reversed by N(G)-monomethyl-L-arginine (L-NMMA), an inhibitor of iNOS. omega-N-Methylarginine 160-166 interleukin 1 beta Rattus norvegicus 65-73 8603098-8 1996 NG-monomethyl-L-arginine reversed inhibition of the ATP increase, decrease in the ketone body ratio, and increase in lactate production, which were induced by interleukin-1beta. omega-N-Methylarginine 0-24 interleukin 1 beta Rattus norvegicus 159-176 7538649-6 1995 The NO synthase inhibitors NG-nitro-L-arginine or NG-monomethyl-L-arginine, or the NO scavenger oxyhaemoglobin prevented the IL-1 beta-induced increase of cGMP. omega-N-Methylarginine 50-74 interleukin 1 beta Rattus norvegicus 125-134 7544689-8 1995 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes. omega-N-Methylarginine 42-66 interleukin 1 beta Rattus norvegicus 27-36 7544689-8 1995 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes. omega-N-Methylarginine 42-66 interleukin 1 beta Rattus norvegicus 150-159 7540548-10 1995 Moreover, the addition of NG-monomethyl-L-arginine, a NO synthase inhibitor, reversed both IL-1 beta stimulation of NO production and suppression of apoptosis, suggesting a mediatory role of NO in these IL-1 beta effects. omega-N-Methylarginine 26-50 interleukin 1 beta Rattus norvegicus 91-100 7540548-10 1995 Moreover, the addition of NG-monomethyl-L-arginine, a NO synthase inhibitor, reversed both IL-1 beta stimulation of NO production and suppression of apoptosis, suggesting a mediatory role of NO in these IL-1 beta effects. omega-N-Methylarginine 26-50 interleukin 1 beta Rattus norvegicus 203-212 8178348-6 1994 Production of nitrite by islet cells in the presence of IL-1 beta was inhibited in cultures also containing 2 mM L-NG-monomethyl-Arginine (L-NMMA) (3.4 +/- 0.4 microM, n = 9, P = 0.09 vs. control). omega-N-Methylarginine 139-145 interleukin 1 beta Rattus norvegicus 56-65 7517798-9 1994 NG-mono-methyl-L-arginine, an NOS inhibitor, completely blocked the IL-1 beta-induced NOx production, whose effect was reversed by L-arginine but not by D-arginine. omega-N-Methylarginine 0-25 interleukin 1 beta Rattus norvegicus 68-77 8020588-6 1994 Inhibition of the nitric oxide synthase activity by NG-monomethyl-L-arginine prevented IL-1 beta-induced nitric oxide generation and apoptotic cell killing. omega-N-Methylarginine 52-76 interleukin 1 beta Rattus norvegicus 87-96 7534490-8 1994 IL-1 beta-induced NO synthesis was significantly inhibited by NG-monomethyl-L-arginine, cycloheximide, actinomycin D, dexamethasone, and TGF-beta. omega-N-Methylarginine 62-86 interleukin 1 beta Rattus norvegicus 0-9 8178348-8 1994 Addition of 2 mM L-NMMA to islet cultures in the presence of IL-1 beta (20 IU/ml) (n = 9) restored insulin release to normal (from 6 +/- 2 to 38 +/- 9 microU, P > or = 0.6), suggesting that NO mediates the inhibitory effect of IL-1 beta on beta-cell function. omega-N-Methylarginine 17-23 interleukin 1 beta Rattus norvegicus 61-70 8178348-8 1994 Addition of 2 mM L-NMMA to islet cultures in the presence of IL-1 beta (20 IU/ml) (n = 9) restored insulin release to normal (from 6 +/- 2 to 38 +/- 9 microU, P > or = 0.6), suggesting that NO mediates the inhibitory effect of IL-1 beta on beta-cell function. omega-N-Methylarginine 17-23 interleukin 1 beta Rattus norvegicus 230-239 8119136-4 1994 Also, the cytokine combination of IL-1 beta, tumor necrosis factor-alpha, and interferon-gamma induced a 10-fold increase in NO production by RIN cells, and L-NG-monomethyl arginine, an inhibitor of NO synthase, produced a dose-dependent inhibition of cytokine-induced NO production, DNA fragmentation, and cell destruction. omega-N-Methylarginine 157-181 interleukin 1 beta Rattus norvegicus 34-43 7507826-6 1994 Only 1 mM N-methyl arginine, an inhibitor of nitric oxide synthase, completely protected all three parameters of beta-cell function from damage by IL-1 beta. omega-N-Methylarginine 10-27 interleukin 1 beta Rattus norvegicus 147-156 8440413-4 1993 We demonstrate that a 1-h pretreatment of islets with IL-1 beta followed by an 8-h incubation in the absence of this cytokine results in inhibition of glucose-stimulated insulin secretion (50%), which is completely prevented by pretreatment of islets with the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (NMMA). omega-N-Methylarginine 292-316 interleukin 1 beta Rattus norvegicus 54-63 7522298-3 1994 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine or transforming growth factor beta (TGF-beta) completely inhibited the IL-1 beta-induced NO and cGMP production in cardiac myocytes. omega-N-Methylarginine 42-66 interleukin 1 beta Rattus norvegicus 27-36 7522298-3 1994 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine or transforming growth factor beta (TGF-beta) completely inhibited the IL-1 beta-induced NO and cGMP production in cardiac myocytes. omega-N-Methylarginine 42-66 interleukin 1 beta Rattus norvegicus 138-147 7505613-7 1993 IL-1 beta-induced nitrite and PGE2 production is attenuated by the NOS inhibitor NG-monomethyl-L-arginine (NMMA), but NMMA has no inhibitory effect on the expression of either iCOX or iNOS as determined by immunoprecipitation. omega-N-Methylarginine 81-105 interleukin 1 beta Rattus norvegicus 0-9 7505613-7 1993 IL-1 beta-induced nitrite and PGE2 production is attenuated by the NOS inhibitor NG-monomethyl-L-arginine (NMMA), but NMMA has no inhibitory effect on the expression of either iCOX or iNOS as determined by immunoprecipitation. omega-N-Methylarginine 107-111 interleukin 1 beta Rattus norvegicus 0-9 7686532-5 1993 NG-Monomethyl L-arginine completely blocked the interleukin-1 beta-induced NO2-/NO3- production, the effect of which was reversed by L-arginine but not by D-arginine. omega-N-Methylarginine 0-24 interleukin 1 beta Rattus norvegicus 48-66 8440413-4 1993 We demonstrate that a 1-h pretreatment of islets with IL-1 beta followed by an 8-h incubation in the absence of this cytokine results in inhibition of glucose-stimulated insulin secretion (50%), which is completely prevented by pretreatment of islets with the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (NMMA). omega-N-Methylarginine 318-322 interleukin 1 beta Rattus norvegicus 54-63 8440413-5 1993 The production of nitric oxide by islets under these pulse conditions is demonstrated by IL-1 beta-induced nitrite and electron paramagnetic resonance-detectable iron-nitrosyl complex formation, both of which are prevented by NMMA. omega-N-Methylarginine 226-230 interleukin 1 beta Rattus norvegicus 89-98 1334975-5 1992 Pretreatment of beta-cells, purified by FACS with IL-1 beta results in a 40% inhibition of glucose-stimulated insulin secretion that is prevented by the nitric oxide synthase inhibitor, NG-monomethyl-L-arginine (NMMA). omega-N-Methylarginine 186-210 interleukin 1 beta Rattus norvegicus 50-59 1334975-10 1992 This is further demonstrated by IL-1 beta-induced inhibition of glucose oxidation by purified beta-cells, mitochondrial aconitase activity of dispersed islet cells, and mitochondrial aconitase activity of Rin-m5F cells, all of which are prevented by NMMA. omega-N-Methylarginine 250-254 interleukin 1 beta Rattus norvegicus 32-41 1334975-5 1992 Pretreatment of beta-cells, purified by FACS with IL-1 beta results in a 40% inhibition of glucose-stimulated insulin secretion that is prevented by the nitric oxide synthase inhibitor, NG-monomethyl-L-arginine (NMMA). omega-N-Methylarginine 212-216 interleukin 1 beta Rattus norvegicus 50-59 1334975-6 1992 IL-1 beta induces the formation of nitric oxide by purified beta-cells as evidenced by the accumulation of cGMP, which is blocked by NMMA. omega-N-Methylarginine 133-137 interleukin 1 beta Rattus norvegicus 0-9 1720090-7 1991 Both Meth-arg and N alpha-p-tosyl-L-lysine chloromethyl ketone (0.1 mM), a protease inhibitor, could completely counteract the IL-1 beta-induced increases in nitrite production and inhibition of aconitase activity and glucose oxidation rates. omega-N-Methylarginine 5-13 interleukin 1 beta Rattus norvegicus 127-136 1282674-5 1992 Release of NO, induced by IL-1 beta, is dependent upon the availability of the substrate, L-arginine, and is suppressed by a competitive inhibitor, NG-monomethyl-L-arginine. omega-N-Methylarginine 148-172 interleukin 1 beta Rattus norvegicus 26-35 20046028-9 2009 When l-NMMA was added to the medium with IL-1beta and TNF-alpha, changes to PAR-2 by these cytokine recovered. omega-N-Methylarginine 5-11 interleukin 1 beta Rattus norvegicus 41-49