PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12862445-0	2003	Structural analogues of the bimetallic reaction center in acetyl CoA synthase: a Ni--Ni model with bound CO.	Carbon Monoxide	105-107	acyl-CoA synthetase short chain family member 2	Homo sapiens	58-77	
25416390-4	2014	Use of CO as metabolic fuel for microbes relies on enzymes like carbon monoxide dehydrogenase (CODH) and acetyl-CoA synthase (ACS), which catalyze conversions resembling processes that eventually initiated the dawn of life.CODHs catalyze the (reversible) oxidation of CO with water to CO2 and come in two different flavors with unprecedented active site architectures.	Carbon Monoxide	7-9	acyl-CoA synthetase short chain family member 2	Homo sapiens	105-124	
25416390-4	2014	Use of CO as metabolic fuel for microbes relies on enzymes like carbon monoxide dehydrogenase (CODH) and acetyl-CoA synthase (ACS), which catalyze conversions resembling processes that eventually initiated the dawn of life.CODHs catalyze the (reversible) oxidation of CO with water to CO2 and come in two different flavors with unprecedented active site architectures.	Carbon Monoxide	7-9	acyl-CoA synthetase short chain family member 2	Homo sapiens	126-129	
25416390-7	2014	Ni- and Fe-containing CODHs are frequently associated with ACS, where the CODH component reduces CO2 to CO and ACS condenses CO with a methyl group and CoA to acetyl-CoA.Our current state of knowledge on how the three enzymes catalyze these reactions will be summarized and the different strategies of CODHs to achieve the same task within different active site architectures compared.	Carbon Monoxide	22-24	acyl-CoA synthetase short chain family member 2	Homo sapiens	59-62	
25416390-7	2014	Ni- and Fe-containing CODHs are frequently associated with ACS, where the CODH component reduces CO2 to CO and ACS condenses CO with a methyl group and CoA to acetyl-CoA.Our current state of knowledge on how the three enzymes catalyze these reactions will be summarized and the different strategies of CODHs to achieve the same task within different active site architectures compared.	Carbon Monoxide	22-24	acyl-CoA synthetase short chain family member 2	Homo sapiens	111-114	
23713976-7	2013	This is the basis for directional transport of CO from the production site (C-cluster of CODH subunit) to the utilization site (A-cluster of ACS subunit).	Carbon Monoxide	47-49	acyl-CoA synthetase short chain family member 2	Homo sapiens	141-144	
22616859-4	2012	In this pathway, CODH converts CO2 into CO and ACS generates acetyl-CoA in a reaction involving Ni CO, methyl-Ni and acetyl-Ni as catalytic intermediates.	Carbon Monoxide	17-19	acyl-CoA synthetase short chain family member 2	Homo sapiens	47-50	
22616859-4	2012	In this pathway, CODH converts CO2 into CO and ACS generates acetyl-CoA in a reaction involving Ni CO, methyl-Ni and acetyl-Ni as catalytic intermediates.	Carbon Monoxide	31-33	acyl-CoA synthetase short chain family member 2	Homo sapiens	47-50	
22616859-5	2012	A 70 A (1 A=0.1 nm) channel guides CO, generated at the active site of CODH, to a CO "cage" near the ACS active site to sequester this reactive species and assure its rapid availability to participate in a kinetically coupled reaction with an unstable Ni(I) state that was recently trapped by photolytic, rapid kinetic and spectroscopic studies.	Carbon Monoxide	35-37	acyl-CoA synthetase short chain family member 2	Homo sapiens	101-104	
23394607-0	2013	Different modes of carbon monoxide binding to acetyl-CoA synthase and the role of a conserved phenylalanine in the coordination environment of nickel.	Carbon Monoxide	19-34	acyl-CoA synthetase short chain family member 2	Homo sapiens	46-65	
11827525-1	2002	CO dehydrogenase/acetyl-CoA synthase (CODH/ACS), a key enzyme in the Wood-Ljungdahl pathway of anaerobic CO(2) fixation, is a bifunctional enzyme containing CODH, which catalyzes the reversible two-electron oxidation of CO to CO(2), and ACS, which catalyzes acetyl-CoA synthesis from CoA, CO, and a methylated corrinoid iron-sulfur protein (CFeSP).	Carbon Monoxide	0-2	acyl-CoA synthetase short chain family member 2	Homo sapiens	38-46	
11827525-1	2002	CO dehydrogenase/acetyl-CoA synthase (CODH/ACS), a key enzyme in the Wood-Ljungdahl pathway of anaerobic CO(2) fixation, is a bifunctional enzyme containing CODH, which catalyzes the reversible two-electron oxidation of CO to CO(2), and ACS, which catalyzes acetyl-CoA synthesis from CoA, CO, and a methylated corrinoid iron-sulfur protein (CFeSP).	Carbon Monoxide	0-2	acyl-CoA synthetase short chain family member 2	Homo sapiens	43-46	
11827525-2	2002	ACS contains an active site nickel iron-sulfur cluster that forms a paramagnetic adduct with CO, called the nickel iron carbon (NiFeC) species, which we have hypothesized to be a key intermediate in acetyl-CoA synthesis.	Carbon Monoxide	93-95	acyl-CoA synthetase short chain family member 2	Homo sapiens	0-3	
10684606-7	2000	To gain a better understanding of how CO production and utilization are coordinated, we have studied an isotopic exchange reaction between labeled CO(2) and the carbonyl group of acetyl-CoA with the CODH/ACS from Clostridium thermoaceticum.	Carbon Monoxide	38-40	acyl-CoA synthetase short chain family member 2	Homo sapiens	204-207	
33017144-4	2020	The results indicate that the ACS reaction proceeds first through a methyl radical transfer from cobalamin (Cbl) to Nip randomly accompanying with the CO binding.	Carbon Monoxide	151-153	acyl-CoA synthetase short chain family member 2	Homo sapiens	30-33	
34835373-4	2021	Genomic analyses have shown that these methanogens lack genes for carbon monoxide dehydrogenase/acetyl-CoA synthase (Codh/Acs), one of the oldest enzymes that catalyzes the central step in the Wood-Ljungdahl pathway.	Carbon Monoxide	66-81	acyl-CoA synthetase short chain family member 2	Homo sapiens	117-125