PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9520946-6	1998	In contrast to IL-8, the TNF-alpha-induced HRPE MCP-1 gene expression was only slightly enhanced by GHSA.	ghsa	100-104	C-C motif chemokine ligand 2	Homo sapiens	48-53	
11381075-7	2001	Combined inhibition of MEK by U0126, p38 by SB202190, and Janus kinase (jak) by AG490 revealed that GHSA stimulation of IL-8 production was predominately mediated by MEK and to a lesser extent by p38 pathways, whereas activation of MEK, p38, and jak was required for maximal MCP-1 induction.	ghsa	100-104	C-C motif chemokine ligand 2	Homo sapiens	275-280	
11381075-9	2001	CONCLUSIONS: GHSA stimulates hRPE IL-8 and MCP-1 production through divergent and overlapping, but not identical, intracellular signaling cascades.	ghsa	13-17	C-C motif chemokine ligand 2	Homo sapiens	43-48	
9472473-6	1998	RESULTS: GHSA at 500 micrograms/ml concentration induced a significant increase in keratocyte IL-8 and MCP-1 protein secretion over the 24 h time course.	ghsa	9-13	C-C motif chemokine ligand 2	Homo sapiens	103-108	
9472473-9	1998	The levels of GHSA (500 micrograms/ml)-induced keratocyte IL-8 and MCP-1 expression were similar to that induced by IL-1 beta (0.02 ng/ml) and TNF-alpha (2.0 ng/ml).	ghsa	14-18	C-C motif chemokine ligand 2	Homo sapiens	67-72	
8830798-4	1996	Enzyme-linked immunoassay GHSA (500 micrograms/mL)-treated hRPE cells secreted levels of IL-8 and MCP-1 detectable within 4 h and reached 26.0 +/- 1.3 and 42.2 0.4 ng/10(6) cells/mL after 24 h, respectively.	ghsa	26-30	C-C motif chemokine ligand 2	Homo sapiens	98-103	
8830798-5	1996	Induction of IL-8 and MCP-1 by GHSA at concentrations ranging from 62.5 to 3,000 micrograms/mL exhibited dose-dependent kinetics.	ghsa	31-35	C-C motif chemokine ligand 2	Homo sapiens	22-27	
8830798-6	1996	The GHSA-induced chemokine secretion by hRPE was almost completely inhibited by actinomycin D and cycloheximide, suggesting that de novo mRNA and protein synthesis are necessary for the GHSA-induced IL-8 and MCP-1 production.	ghsa	4-8	C-C motif chemokine ligand 2	Homo sapiens	208-213	
8830798-6	1996	The GHSA-induced chemokine secretion by hRPE was almost completely inhibited by actinomycin D and cycloheximide, suggesting that de novo mRNA and protein synthesis are necessary for the GHSA-induced IL-8 and MCP-1 production.	ghsa	186-190	C-C motif chemokine ligand 2	Homo sapiens	208-213	
8830798-7	1996	Northern blot analysis of GHSA-induced hRPE IL-8 and MCP-1 mRNA expression corresponded to the time- and dose-dependent increases measured by enzyme-linked immunosorbent assay.	ghsa	26-30	C-C motif chemokine ligand 2	Homo sapiens	53-58	
8830798-8	1996	High concentrations of glucose (20 mM; 360 mg/dl) increased GHSA-induced hRPE IL-8 and MCP-1 secretion, whereas added insulin (0.5 ng/mL) inhibited IL-8 but not MCP-1 protein secretion and mRNA expression.	ghsa	60-64	C-C motif chemokine ligand 2	Homo sapiens	87-92