PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33343385-9 2020 extract compared to saline administration, which was accompanied by downregulation of the proinflammatory cytokines interleukin (IL)-1beta and IL-6. Sodium Chloride 20-26 interleukin 6 Mus musculus 143-147 27405597-4 2016 Here we show that methane-rich saline (MS) ip treatment (16 ml/kg) alleviated endotoxin shock, bacteria-induced sepsis and dextran-sulfate-sodium-induced colitis in mice via decreased production of TNF-alpha and IL-6. Sodium Chloride 31-37 interleukin 6 Mus musculus 212-216 30897196-10 2019 In cultured Met-5A, additional NaCl in the medium upregulated IL-6 as well as vascular endothelial growth factor-A, associated with increased expression and nuclear translocation of tonicity-responsive enhancer binding protein (TonEBP). Sodium Chloride 31-35 interleukin 6 Mus musculus 62-66 29767573-11 2018 Consistent with our hypothesis, mice that received the IL-6 trans-signaling-specific inhibitor sgp130Fc, a fusion protein of the soluble extracellular portion of gp130 with the constant portion of the mouse IgG1 antibody, showed attenuation of CH-induced increases in right ventricular systolic pressure, right ventricular and pulmonary arterial remodeling as compared to vehicle (saline)-treated control mice. Sodium Chloride 381-387 interleukin 6 Mus musculus 55-59 29713131-11 2018 NaCl aggravates peritoneal macrophage inflammation by promoting the expressions of interleukin (IL)-1, IL-6 and mouse inducible nitric oxide synthase. Sodium Chloride 0-4 interleukin 6 Mus musculus 103-107 29030272-10 2018 In mice subjected to IL-6 injection, the fasting-induced PXR, PPARalpha and PGC-1alpha mRNA responses were lower than after saline injection. Sodium Chloride 124-130 interleukin 6 Mus musculus 21-25 27747134-10 2016 While saline and microbead injection increased Bcl-xl and Socs3 mRNA in both WT and IL-6-/- mice, IL-6-/- deficiency led to smaller increases for both Bcl-xl and Socs3. Sodium Chloride 6-12 interleukin 6 Mus musculus 84-88 26918466-6 2016 In saline-treated mice fed control diet, aging increased the proportion of microglia that stained for MHC class II (<3% for adults vs. 23% for aged), IL-1beta (<2% for adults vs. 25% for aged), and IL-6 (<2% for adults vs. 25% for aged), indicating an age-related increase in proinflammatory microglia. Sodium Chloride 3-9 interleukin 6 Mus musculus 204-208 26918466-7 2016 In saline-treated aged mice fed luteolin, the proportion of microglia that stained for MHC class II, IL-1beta, and IL-6 was reduced by nearly half (to 12%, 13%, and 12%, respectively). Sodium Chloride 3-9 interleukin 6 Mus musculus 115-119 25449670-10 2015 Collectively, our data demonstrate that acidified saline injection increases intramuscular IL-1 and IL-6, but not TNF; that intramuscular pre-treatment with an NF-kappaB inhibitor blocks mechanical hypersensitivity; and that genetic manipulation of the IL-1 and IL-6, but not TNF systems, prevents mechanical hypersensitivity following musculoskeletal sensitization. Sodium Chloride 50-56 interleukin 6 Mus musculus 100-104 25449670-10 2015 Collectively, our data demonstrate that acidified saline injection increases intramuscular IL-1 and IL-6, but not TNF; that intramuscular pre-treatment with an NF-kappaB inhibitor blocks mechanical hypersensitivity; and that genetic manipulation of the IL-1 and IL-6, but not TNF systems, prevents mechanical hypersensitivity following musculoskeletal sensitization. Sodium Chloride 50-56 interleukin 6 Mus musculus 262-266 21696761-16 2012 When applying IPA analysis, six main canonical pathways were constantly dysregulated in the same significance order in both the saline and LPS group at 4, 24, and 48 h. These were: Toll-like receptor and NF-kappaB signaling, hepatic cholestasis, interleukin-6, and LPS-mediated MAPK signaling pathways, and pattern recognition receptors of bacterial pathway. Sodium Chloride 128-134 interleukin 6 Mus musculus 246-259 23277090-8 2013 Twenty-four hours post-injection (0.33 mg/kg LPS or Saline) we found a LPS-induced upregulation of whole brain TNFalpha, IL-1beta, and IL-10 mRNA, and increased IL-1beta and IL-6 in the spleen and liver; these effects were not attenuated by VWR. Sodium Chloride 52-58 interleukin 6 Mus musculus 174-178 23031399-6 2012 Incision after saline or escalating morphine treatment upregulated skin IL-1beta, IL-6, G-CSF and MIP-1alpha levels in ppt-A(-/-) and wt mice similarly. Sodium Chloride 15-21 interleukin 6 Mus musculus 82-86 25010770-8 2014 Meanwhile, transplantation of IL-6-expressing Lewis Lung Carcinoma cells caused cachexia in mice, which then received either MR16-1 or 0.9% saline. Sodium Chloride 140-146 interleukin 6 Mus musculus 30-34 23852503-6 2013 In vivo studies of mice pretreated with saline or 100 mug/kg of IL-11 at 12 and 2 h before 10-Gy total body irradiation (TBI) demonstrated that G-CSF and IL-6 were significantly upregulated, whereas IL-2 and IL-4 were reduced. Sodium Chloride 40-46 interleukin 6 Mus musculus 154-158 19705479-5 2009 Saline/LPS treatment was associated with a 33% reduction in maximal force and elevated serum TNF-alpha and IL-6. Sodium Chloride 0-6 interleukin 6 Mus musculus 107-111 21116691-6 2011 RESULTS: A hydrodynamic injection of saline induced a significant production of interleukin (IL)-6. Sodium Chloride 37-43 interleukin 6 Mus musculus 80-98 20223119-11 2009 The expression level of TNFalpha, IL-1beta, IL-6 mRNA on hepatocytes in polypeptide treated mice was significantly lower (1.26 +/- 0.37, 0.98 +/- 0.21, 0.43 +/- 0.17, 87.43 +/- 16.7 respectively) than that in the saline treated ones (1.98 +/- 0.56, 1.24 +/- 0.35, 0.64 +/- 0.25 and 236.11 +/- 32.7, respectively) (P < 0.01). Sodium Chloride 213-219 interleukin 6 Mus musculus 44-48 12573707-3 2003 Generally, right cortices had higher interleukin-1beta and interleukin-6 levels than left cortices for both saline and lipopolysaccharide-treated mice. Sodium Chloride 108-114 interleukin 6 Mus musculus 59-72 19291858-9 2009 The most striking differences observed between saline and R(+)-verapamil pretreated animals on combination therapy included down-regulation of TNF-alpha, higher levels of IL-6, and decreased IFN-gamma concentrations. Sodium Chloride 47-53 interleukin 6 Mus musculus 171-175 16166341-8 2006 However, all wild-type mice, whether treated with saline or imipenem, died by 42 h after CLP and had significant hypothermia, metabolic acidosis, and high plasma concentrations of the cytokines interleukin-6, macrophage inflammatory protein-2, and keratinocyte-derived chemokine. Sodium Chloride 50-56 interleukin 6 Mus musculus 194-207 18162079-16 2008 In the lung, IL-6 and IL-10 was significantly increased in alcohol-exposed infected mice compared to saline-treated infected mice. Sodium Chloride 101-107 interleukin 6 Mus musculus 13-17 12573707-5 2003 For the saline-treated mice: in their left cortices, interleukin-1beta levels were higher for ambidextrous mice than for right-pawed mice (P<0.05); in their right cortices, interleukin-6 levels were higher for ambidextrous mice than for right-/left-pawed mice, and right-pawed mice have higher levels of interleukin-6 than left-pawed mice (P<0.01). Sodium Chloride 8-14 interleukin 6 Mus musculus 176-189 12573707-5 2003 For the saline-treated mice: in their left cortices, interleukin-1beta levels were higher for ambidextrous mice than for right-pawed mice (P<0.05); in their right cortices, interleukin-6 levels were higher for ambidextrous mice than for right-/left-pawed mice, and right-pawed mice have higher levels of interleukin-6 than left-pawed mice (P<0.01). Sodium Chloride 8-14 interleukin 6 Mus musculus 307-320 11391686-7 2001 RESULTS: Anti-IL-6 Ab (with saline or etoposide) induced tumor apoptosis and regression ( approximately 60% compared to initial tumor size). Sodium Chloride 28-34 interleukin 6 Mus musculus 14-18 1451333-6 1992 Interestingly, the addition of combinations of IL-1 and IL-6 increased the proliferation of T cells in response to KLH presented by either saline- or poly(I:C)-treated M phi. Sodium Chloride 139-145 interleukin 6 Mus musculus 56-60 34970349-12 2022 In addition the protein expression levels of RIP1 and RIP3 and the cytokines NF-kappaB, TNF-alpha, IL-1beta and IL-6 were downregulated compared with the TBI group, which demonstrated that hydrogen-rich saline-induced inhibition of necroptosis and neuroinflammation ameliorated neuronal death following TBI. Sodium Chloride 203-209 interleukin 6 Mus musculus 112-116 35191221-7 2022 RESULTS: Mice exposed to enhanced levels of IL-6 during endurance exercise bouts showed superior improvements in endurance performance (33% more work and 12% greater peak power compared with baseline), fatigue resistance in situ (P = 0.0014 vs. Sed+Saline; P = 0.0199 vs. Sed+IL-6; and P = 0.0342 vs. Ex+Saline), motor coordination (rotarod performance, P = 0.0428), and gait (gait speed, P = 0.0053) following training. Sodium Chloride 249-255 interleukin 6 Mus musculus 44-48 2681491-4 1989 Feline HGF/IL-6 was eluted into the fractions corresponding to a molecular weight of 30,000-40,000 in gel filtration, and into the fractions at a salt concentration of 0.2-0.3 M NaCl in anion exchange chromatography. Sodium Chloride 178-182 interleukin 6 Mus musculus 11-15 10996474-1 2000 This study examines the effects of repeated amitriptyline and desipramine administration (10 mg/kg, IP) on the immunoreactivity of saline-injected C57BL/6 mice, as evaluated by the ability of splenocytes to reduce a tetrazolium salt to formazan (MTT test), to proliferate, and to produce cytokines, such as interleukin (IL)-1, IL-2, IL-4, IL-6, IL-10 and interferon gamma (IFN-gamma). Sodium Chloride 131-137 interleukin 6 Mus musculus 339-343 11003212-7 2000 In the saline-treated group, IL-6 circulating and hepatic levels rose after burn injury (p < 0.03). Sodium Chloride 7-13 interleukin 6 Mus musculus 29-33 11003212-9 2000 IL-6 hepatic production after burn injury was higher in the mice with a BAL of 300 mg/dl than in those with a BAL of 100 mg/dl and the saline-treated group (p = 0.001). Sodium Chloride 135-141 interleukin 6 Mus musculus 0-4