PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23485864-8 2013 Pulsatile GH secretion correlated positively with T concentrations (270-1,170 ng/dl) in the 26 men during saline pulses/saline (P = 0.015, R(2) = 0.24), GHRH pulses/saline (P = 0.020, R(2) = 0.22), and combined GHRH pulses/GHRP-2 (P = 0.016, R(2) = 0.25) infusions. Sodium Chloride 106-112 growth hormone 1 Homo sapiens 10-12 23485864-8 2013 Pulsatile GH secretion correlated positively with T concentrations (270-1,170 ng/dl) in the 26 men during saline pulses/saline (P = 0.015, R(2) = 0.24), GHRH pulses/saline (P = 0.020, R(2) = 0.22), and combined GHRH pulses/GHRP-2 (P = 0.016, R(2) = 0.25) infusions. Sodium Chloride 120-126 growth hormone 1 Homo sapiens 10-12 23485864-8 2013 Pulsatile GH secretion correlated positively with T concentrations (270-1,170 ng/dl) in the 26 men during saline pulses/saline (P = 0.015, R(2) = 0.24), GHRH pulses/saline (P = 0.020, R(2) = 0.22), and combined GHRH pulses/GHRP-2 (P = 0.016, R(2) = 0.25) infusions. Sodium Chloride 120-126 growth hormone 1 Homo sapiens 10-12 23485864-9 2013 Basal nonpulsatile GH secretion correlated with T during saline pulses/GHRP-2 drive (P = 0.020, R(2) = 0.16). Sodium Chloride 57-63 growth hormone 1 Homo sapiens 19-21 15126555-10 2004 stimulated pulsatile, rhythmic, and entropic GH secretion by more than 3-fold on d 1 and more than 1.8-fold on d 14 and 30 (each P < 0.001 vs. saline); 2). Sodium Chloride 146-152 growth hormone 1 Homo sapiens 45-47 15713362-5 2005 The amplitude of the maximum growth hormone (GH) peaks responding to GHRP-2 injection were higher at day 1 than at day 6 of saline or GHRP-2 treatment in both LP and HP steers (P<0.05). Sodium Chloride 124-130 growth hormone 1 Homo sapiens 29-43 15713362-5 2005 The amplitude of the maximum growth hormone (GH) peaks responding to GHRP-2 injection were higher at day 1 than at day 6 of saline or GHRP-2 treatment in both LP and HP steers (P<0.05). Sodium Chloride 124-130 growth hormone 1 Homo sapiens 45-47 15339744-7 2005 GH levels increased to a mean (+/-SE) level of 20.0 +/- 2.3 vs. 0.5 +/- 0.2 microg/l after saline infusion (P < 0.01). Sodium Chloride 91-97 growth hormone 1 Homo sapiens 0-2 12217887-10 2002 Peak GH concentration on the IGF-I + Arg day was ~45% of that on the Sal + Arg day. Sodium Chloride 69-72 growth hormone 1 Homo sapiens 5-7 15001627-4 2004 Administration of E(2) compared with Pl followed by saline infusion: 1) stimulated pulsatile GH secretion ( micro g/liter.6 h), viz., 12 +/- 3.3 (Pl) and 18 +/- 4.6 (E(2)) (mean +/- SEM, paired comparison, P < 0.05); 2) halved the time latency (min) to achieve peak GH secretion after GHRH injection, 24 +/- 2.2 (Pl) and 12 +/- 2.1 (E(2)) (P < 0.01); and 3) did not alter the mass of GH secreted ( micro g/liter) in response to a maximally effective dose of GHRH, 30 +/- 7.2 (Pl) and 37 +/- 11 (E(2)). Sodium Chloride 52-58 growth hormone 1 Homo sapiens 93-95 12217887-11 2002 The effect of arginine on net GH release was calculated as [(Sal + Arg) - (Sal + Sal)] - [(IGF-I + Arg) - (IGF-I + Sal)]. Sodium Chloride 61-64 growth hormone 1 Homo sapiens 30-32 12217887-11 2002 The effect of arginine on net GH release was calculated as [(Sal + Arg) - (Sal + Sal)] - [(IGF-I + Arg) - (IGF-I + Sal)]. Sodium Chloride 75-78 growth hormone 1 Homo sapiens 30-32 11158008-9 2001 Administration of E(2) elevated the geometric mean basal (saline-infused) GH secretory burst mass by 2.1-fold (95% confidence interval, 1.4- to 3.1-fold) compared with placebo ingestion (geometric mean ratios; P < 0.001). Sodium Chloride 58-64 growth hormone 1 Homo sapiens 74-76 9159285-9 1997 Concentrations of GH increased in saline-pretreated ewes following injections of clonidine or GHRH (P < .01). Sodium Chloride 34-40 growth hormone 1 Homo sapiens 18-20 10887057-0 2000 On the mechanism of growth hormone-induced stimulation of renal acidification in humans: effect of dietary NaCl. Sodium Chloride 107-111 growth hormone 1 Homo sapiens 20-34 8924193-8 1996 Except for one subject, who developed pronounced side effects, human growth hormone showed a surge following saline that was inhibited following citalopram. Sodium Chloride 109-115 growth hormone 1 Homo sapiens 69-83 9024267-7 1997 During saline treatment, the secretory patterns of both GH and ectopic GHRH were pulsatile; however, there was no correlation between changes in plasma GHRH and GH concentrations. Sodium Chloride 7-13 growth hormone 1 Homo sapiens 56-58 9024267-7 1997 During saline treatment, the secretory patterns of both GH and ectopic GHRH were pulsatile; however, there was no correlation between changes in plasma GHRH and GH concentrations. Sodium Chloride 7-13 growth hormone 1 Homo sapiens 71-73 8858219-13 1996 This effect of GH was much more pronounced during IGF-I: NEFA rose from 702 +/- 267 (saline) and 885 +/- 236 (IGF-I) to 963 +/- 215 (saline) (p < 0.05) and 1815 +/- 586 mumol/l (IGF-I) (p < 0.02), respectively; after 5 h, 3-OH-butyrate rose from 242 +/- 234 (saline) and 340 +/- 280 (IGF-I) to 678 +/- 638 (saline) (p < 0.02) and 1115 +/- 578 mumol/l (IGF-I) (p < 0.02) respectively. Sodium Chloride 85-91 growth hormone 1 Homo sapiens 15-17 8858219-13 1996 This effect of GH was much more pronounced during IGF-I: NEFA rose from 702 +/- 267 (saline) and 885 +/- 236 (IGF-I) to 963 +/- 215 (saline) (p < 0.05) and 1815 +/- 586 mumol/l (IGF-I) (p < 0.02), respectively; after 5 h, 3-OH-butyrate rose from 242 +/- 234 (saline) and 340 +/- 280 (IGF-I) to 678 +/- 638 (saline) (p < 0.02) and 1115 +/- 578 mumol/l (IGF-I) (p < 0.02) respectively. Sodium Chloride 133-139 growth hormone 1 Homo sapiens 15-17 8858219-13 1996 This effect of GH was much more pronounced during IGF-I: NEFA rose from 702 +/- 267 (saline) and 885 +/- 236 (IGF-I) to 963 +/- 215 (saline) (p < 0.05) and 1815 +/- 586 mumol/l (IGF-I) (p < 0.02), respectively; after 5 h, 3-OH-butyrate rose from 242 +/- 234 (saline) and 340 +/- 280 (IGF-I) to 678 +/- 638 (saline) (p < 0.02) and 1115 +/- 578 mumol/l (IGF-I) (p < 0.02) respectively. Sodium Chloride 133-139 growth hormone 1 Homo sapiens 15-17 8858219-13 1996 This effect of GH was much more pronounced during IGF-I: NEFA rose from 702 +/- 267 (saline) and 885 +/- 236 (IGF-I) to 963 +/- 215 (saline) (p < 0.05) and 1815 +/- 586 mumol/l (IGF-I) (p < 0.02), respectively; after 5 h, 3-OH-butyrate rose from 242 +/- 234 (saline) and 340 +/- 280 (IGF-I) to 678 +/- 638 (saline) (p < 0.02) and 1115 +/- 578 mumol/l (IGF-I) (p < 0.02) respectively. Sodium Chloride 133-139 growth hormone 1 Homo sapiens 15-17 7921207-1 1994 We have evaluated parameters of the serum growth hormone (GH) concentration response to saline and 1-, 10- and 100-micrograms intravenous bolus doses of amide analogue of GH-releasing hormone (GHRH (1-29)NH2) given in random order to 10 adult male volunteers of median body weight 68 (60-90)kg. Sodium Chloride 88-94 growth hormone 1 Homo sapiens 42-56 8787952-4 1995 Mean incremental change of serum GH from value at time 0 was 47.5 +/- 5.5 and 41.5 +/- 4.1 micrograms/l after saline + Hex and GH + Hex, respectively. Sodium Chloride 110-116 growth hormone 1 Homo sapiens 33-35 8514857-7 1993 During saline infusion, GH secretion rates remained elevated. Sodium Chloride 7-13 growth hormone 1 Homo sapiens 24-26 8013941-1 1994 Our recent data show that acute and sustained hypercortisolism decreases circulating growth hormone (GH) levels in acromegaly with respect to saline infusion. Sodium Chloride 142-148 growth hormone 1 Homo sapiens 101-103 7693566-6 1993 GH secretion was evaluated after 45 min iv infusion of porcine galanin (0.5 mg in 100 ml of saline) from 0 to 45 min combined with a 60 min iv infusion of a) saline (100 ml) or b) MCP (10 mg in 100 ml of saline) from -15 to 45 min. Sodium Chloride 92-98 growth hormone 1 Homo sapiens 0-2 1398470-2 1992 On several nonconsecutive days, we investigated the GH response to saline serum, 100, 200 (twice) and 400 micrograms of TRH administration. Sodium Chloride 67-73 growth hormone 1 Homo sapiens 52-54 1281259-6 1992 GHRH-induced GH secretion was evaluated during a 40-minute intravenous (IV) infusion of saline (100 mL) or porcine galanin (12.5 micrograms/min in 100 mL saline). Sodium Chloride 88-94 growth hormone 1 Homo sapiens 0-2 1592874-4 1992 GHRH-induced GH secretion was evaluated after 30-min iv infusion of saline (100 mL) or arginine (30 g) in 100 mL saline. Sodium Chloride 68-74 growth hormone 1 Homo sapiens 0-2 1592874-4 1992 GHRH-induced GH secretion was evaluated after 30-min iv infusion of saline (100 mL) or arginine (30 g) in 100 mL saline. Sodium Chloride 113-119 growth hormone 1 Homo sapiens 0-2 1592874-5 1992 After saline administration, steroid-treated patients showed a blunted GH response to GHRH (GH peak, 8.7 +/- 2.4 micrograms/L) compared to that of normal subjects (GH peak, 23.8 +/- 3.9 micrograms/L). Sodium Chloride 6-12 growth hormone 1 Homo sapiens 71-73 1592874-5 1992 After saline administration, steroid-treated patients showed a blunted GH response to GHRH (GH peak, 8.7 +/- 2.4 micrograms/L) compared to that of normal subjects (GH peak, 23.8 +/- 3.9 micrograms/L). Sodium Chloride 6-12 growth hormone 1 Homo sapiens 86-88 1592874-5 1992 After saline administration, steroid-treated patients showed a blunted GH response to GHRH (GH peak, 8.7 +/- 2.4 micrograms/L) compared to that of normal subjects (GH peak, 23.8 +/- 3.9 micrograms/L). Sodium Chloride 6-12 growth hormone 1 Homo sapiens 86-88 1375312-6 1992 During saline infusion, steroid-treated patients showed a blunted GH response to GHRH (GH peak, 8.1 +/- 2.8 micrograms/L), as compared with normal subjects (GH peak, 23.8 +/- 3.9 micrograms/L). Sodium Chloride 7-13 growth hormone 1 Homo sapiens 66-68 1375312-6 1992 During saline infusion, steroid-treated patients showed a blunted GH response to GHRH (GH peak, 8.1 +/- 2.8 micrograms/L), as compared with normal subjects (GH peak, 23.8 +/- 3.9 micrograms/L). Sodium Chloride 7-13 growth hormone 1 Homo sapiens 81-83 1375312-6 1992 During saline infusion, steroid-treated patients showed a blunted GH response to GHRH (GH peak, 8.1 +/- 2.8 micrograms/L), as compared with normal subjects (GH peak, 23.8 +/- 3.9 micrograms/L). Sodium Chloride 7-13 growth hormone 1 Homo sapiens 81-83 2026752-4 1991 During the saline infusion, spontaneous GH peaks occurred at variable times in four of the six subjects. Sodium Chloride 11-17 growth hormone 1 Homo sapiens 40-42 1371576-4 1992 GAL induced an increase of GH (GAL v saline, area under curve [AUC], mean +/- SEM: 316.5 +/- 73.9 v 93.2 +/- 20.9 micrograms/L/h, P less than .05), but failed to modify both PRL and insulin secretion. Sodium Chloride 37-43 growth hormone 1 Homo sapiens 27-29 2026752-9 1991 The GH secretion rates during the infusion period (0900-1430 h) were 2.40 +/- 0.68, 2.47 +/- 0.61, 7.67 +/- 1.86, and 14.75 +/- 2.32 on the saline and GHRP (0.1, 0.3, and 1.0 micrograms/kg.h) infusion days, respectively (P less than 0.05, 1.0 micrograms/kg.h vs. saline). Sodium Chloride 140-146 growth hormone 1 Homo sapiens 4-6 2026752-9 1991 The GH secretion rates during the infusion period (0900-1430 h) were 2.40 +/- 0.68, 2.47 +/- 0.61, 7.67 +/- 1.86, and 14.75 +/- 2.32 on the saline and GHRP (0.1, 0.3, and 1.0 micrograms/kg.h) infusion days, respectively (P less than 0.05, 1.0 micrograms/kg.h vs. saline). Sodium Chloride 263-269 growth hormone 1 Homo sapiens 4-6 2026752-10 1991 The GH secretion rates after the iv GHRP bolus were 18.28 +/- 3.81, 19.01 +/- 2.03, 11.70 +/- 2.55, and 7.86 +/- 0.80 on the saline and GHRP (0.1, 0.3, and 1.0 micrograms/kg.h) infusion days, respectively (P less than 0.05, 1.0 micrograms/kg.h vs. saline). Sodium Chloride 125-131 growth hormone 1 Homo sapiens 4-6 2026752-10 1991 The GH secretion rates after the iv GHRP bolus were 18.28 +/- 3.81, 19.01 +/- 2.03, 11.70 +/- 2.55, and 7.86 +/- 0.80 on the saline and GHRP (0.1, 0.3, and 1.0 micrograms/kg.h) infusion days, respectively (P less than 0.05, 1.0 micrograms/kg.h vs. saline). Sodium Chloride 248-254 growth hormone 1 Homo sapiens 4-6 1671389-8 1991 GHRH induced a clear GH release during saline infusion in both groups, significantly higher in group B (43.6 +/- 4.8 micrograms/L) than in group A (20.1 +/- 6.1 micrograms/L; P less than 0.02 vs. A), and only a slight increase during met-GH infusions (10.4 +/- 4.1 micrograms/L in group A; 16.7 +/- 4.2 micrograms/L in group B; P = NS). Sodium Chloride 39-45 growth hormone 1 Homo sapiens 0-2 2508484-7 1989 In experiment 2 responses of GH, insulin, and glucose to saline, glucose, arginine, and GRF infusions varied (P less than 0.05) between and within lines relative to control values. Sodium Chloride 57-63 growth hormone 1 Homo sapiens 29-31 2198432-6 1990 GHRH induced a clear GH release during saline infusion (46.6 +/- 2.70 micrograms/L) and a scanty GH release during met-GH infusion (9.3 +/- 1.52 micrograms/L; P less than .01). Sodium Chloride 39-45 growth hormone 1 Homo sapiens 0-2 2505955-4 1989 In these, and in patients with microprolactinoma, GH responses after GRF (P less than 0.001 vs saline) were variable. Sodium Chloride 95-101 growth hormone 1 Homo sapiens 50-52 2502553-4 1989 The serum GH response to GHRH during NaCl infusion was significantly lower in the TPN subjects than in the PA subjects. Sodium Chloride 37-41 growth hormone 1 Homo sapiens 10-12 2502553-6 1989 The mean integrated areas under the GH response-time curve after GHRH treatment were 3963 +/- 2086 min/micrograms.L following NaCl infusion and 413 +/- 64 min/micrograms.L following Met-hGH infusion in PA subjects; they were 1127 +/- 500 min/micrograms.L following NaCl infusion and 1456 +/- 682 min/micrograms.L during Met-hGH infusion in the TPN subjects. Sodium Chloride 126-130 growth hormone 1 Homo sapiens 36-38 2502553-6 1989 The mean integrated areas under the GH response-time curve after GHRH treatment were 3963 +/- 2086 min/micrograms.L following NaCl infusion and 413 +/- 64 min/micrograms.L following Met-hGH infusion in PA subjects; they were 1127 +/- 500 min/micrograms.L following NaCl infusion and 1456 +/- 682 min/micrograms.L during Met-hGH infusion in the TPN subjects. Sodium Chloride 265-269 growth hormone 1 Homo sapiens 36-38 2502553-8 1989 These results suggest that hyperalimentation induces a metabolic background which inhibits GH secretion, as manifested by a diminished serum GH response to GHRH administered after NaCl infusion. Sodium Chloride 180-184 growth hormone 1 Homo sapiens 91-93 2502553-8 1989 These results suggest that hyperalimentation induces a metabolic background which inhibits GH secretion, as manifested by a diminished serum GH response to GHRH administered after NaCl infusion. Sodium Chloride 180-184 growth hormone 1 Homo sapiens 141-143 2513149-9 1989 The timing of the next GH pulse could be predicted equally well after TRH and saline from the overnight secretory profile using autocorrelation. Sodium Chloride 78-84 growth hormone 1 Homo sapiens 23-25 6341144-4 1983 When oral glucose was ingested 5 h after initiating the growth hormone infusion, plasma glucose rose by 2-2.5 mmol/l above control (saline infusion) values and the area under the glucose curve increased twofold (p less than 0.005). Sodium Chloride 132-138 growth hormone 1 Homo sapiens 56-70 2892113-4 1988 Compared to control experiments, in which saline was administered intranasally, overnight increases in plasma glucose concentrations were reduced in all subjects by nearly 70% (48 +/- 19 v 148 +/- 26 mg/dL, P less than .01), plasma growth hormone was maintained at basal levels throughout the night (less than 2 v 8 to 12 ng/mL, P less than .01), and the analog was well tolerated. Sodium Chloride 42-48 growth hormone 1 Homo sapiens 232-246 3081329-3 1986 Under pentobarbital anesthesia, 10 micrograms hpGRF dissolved in 0.3 ml saline were injected iv, which increased the plasma GH level from 19.8 +/- 3.6 (mean +/- SE) to 846.0 +/- 40.5 ng/ml in 10 min. Sodium Chloride 72-78 growth hormone 1 Homo sapiens 124-126 3080467-5 1986 The GH response to the supramaximal dose of GHRH was greater after saline infusion than after GHRH infusion, and the GH response to insulin-induced hypoglycemia was significantly greater after GHRH infusion compared with the responses on the other 3 study days. Sodium Chloride 67-73 growth hormone 1 Homo sapiens 4-6 3080467-5 1986 The GH response to the supramaximal dose of GHRH was greater after saline infusion than after GHRH infusion, and the GH response to insulin-induced hypoglycemia was significantly greater after GHRH infusion compared with the responses on the other 3 study days. Sodium Chloride 67-73 growth hormone 1 Homo sapiens 44-46 2863915-1 1985 Pituitary growth hormone (GH) responses during a 10-h iv infusion of saline or human GH-releasing factor (hGRF-44) at 500 ng/kg/h, followed by an iv bolus injection of hGRF-44 at 2 micrograms/kg body weight, were studied in 10 patients with GH deficiency. Sodium Chloride 69-75 growth hormone 1 Homo sapiens 10-24 3930225-4 1985 The mean +/- SEM integrated amount of GH secreted was 107 +/- 38.2 ng/ml.h in response to hGRF infusion, which was greater than the value of 25.4 +/- 3.5 ng/ml.h obtained during saline infusion. Sodium Chloride 178-184 growth hormone 1 Homo sapiens 38-40 6422486-5 1984 Serum GH concentration was also increased in two of six subjects following saline infusion in the evening. Sodium Chloride 75-81 growth hormone 1 Homo sapiens 6-8 1278844-9 1976 The growth-hormone response to an arginine stimulus was lower after alcohol than after saline in all subjects. Sodium Chloride 87-93 growth hormone 1 Homo sapiens 4-18 119798-3 1979 When oral clonidine administration was associated to a slow thyrotropin releasing hormone (TRH) infusion (1 mg dissolved in 400 ml of 0.9% saline solution, at a constant rate during 150 min) the plasma GH response was significantly inhibited when compared with that observed after clonidine alone. Sodium Chloride 139-145 growth hormone 1 Homo sapiens 202-204 1100541-6 1975 and oral administration of 10 mg of diazepam, the peak GH levels, reached in 30 and 60 minutes (19.6+/-2.9 and 15.2+/-3.2ng/ml, respectively), were significantly higher than those during saline and placebo periods (4.3+/-0.8 and 5.9+/-1.1 ng/ml, respectively). Sodium Chloride 187-193 growth hormone 1 Homo sapiens 55-57 4793673-0 1973 [Growth hormone release in unstable diabetes: tests with saline, arginine, glucagon, and epinephrine (author"s transl)]. Sodium Chloride 57-63 growth hormone 1 Homo sapiens 1-15 14131399-2 1964 Human growth hormone was prepared from acetone-dried pituitary powder by hot glacial acetic acid extraction and subsequent precipitation by sodium chloride and cold acetone. Sodium Chloride 140-155 growth hormone 1 Homo sapiens 6-20 4594581-6 1974 The "paradoxical" rise in growth hormone seen in these patients during the saline infusion was suppressed by GHRIH. Sodium Chloride 75-81 growth hormone 1 Homo sapiens 26-40 4187998-0 1969 Growth hormone responses to saline and L-arginine. Sodium Chloride 28-34 growth hormone 1 Homo sapiens 0-14 4173259-0 1968 Corticosteroid and growth-hormone response to synthetic lysine-vasopressin, natural vasopressin, saline solution, and venepuncture. Sodium Chloride 97-103 growth hormone 1 Homo sapiens 19-33 16742415-4 1966 Crude growth hormone was purified by gel filtration on Sephadex, resulting in a product that is soluble in water or 0.5% sodium chloride. Sodium Chloride 121-136 growth hormone 1 Homo sapiens 6-20 27256533-4 2016 The growth hormone group and control group received daily subcutaneous injections of rhGH and equivalent volumes of saline, respectively. Sodium Chloride 116-122 growth hormone 1 Homo sapiens 4-18 25832546-6 2015 Additional experiments of human growth hormone melting in the presence of histidine, lysine, and sodium chloride were performed. Sodium Chloride 97-112 growth hormone 1 Homo sapiens 32-46