PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9485169-11 1998 Nine days after ADX, the mean POMC mRNA level was 0.66+/-0.04 pg/microg RNA in the saline-treated animals and increased to 0.98+/-0.08 pg/microg RNA in the dexamethasone-treated animals (p < 0.005). Sodium Chloride 83-89 proopiomelanocortin Rattus norvegicus 30-34 9688689-5 1998 alpha-MSH (100 microg/kg ip) completely prevented the onset of LPS-induced fever during the first 3-4 h after LPS and suppressed fever throughout the next 4 h but did not affect Tb in afebrile rats treated with intraperitoneal saline rather than LPS. Sodium Chloride 227-233 proopiomelanocortin Rattus norvegicus 0-9 7851279-3 1994 Adrenalectomy (48 h after the last drug injection) increased the POMC mRNA level only in the anterior lobe of repeated saline- and amphetamine-treated rats by 59 and 67%, respectively. Sodium Chloride 119-125 proopiomelanocortin Rattus norvegicus 65-69 9367246-11 1997 A single injection of LPS to the 6-saline group resulted in a significant increase in AP POMC mRNA and PVN CRH mRNA at 2 h, while injection of LPS to the 6-LPS group showed no additional increase in these levels. Sodium Chloride 35-41 proopiomelanocortin Rattus norvegicus 89-93 9374199-7 1997 In both saline and NTX-treated lactating subjects, ARC mRNA levels of proDYN, POMC and proENK were significantly decreased compared with the saline or NTX-treated post-lactating subjects (P < 0.01). Sodium Chloride 8-14 proopiomelanocortin Rattus norvegicus 78-82 2938412-2 1985 Intact female rats treated with alpha-MSH on diestrus 2 afternoon exhibited an increase in serum LH levels at 18 hr on proestrus and an elevated number of ova per rat the day of estrus when compared with saline-treated controls. Sodium Chloride 204-210 proopiomelanocortin Rattus norvegicus 32-41 2161741-2 1990 Salt loading with 2% saline causes a decrease in POMC mRNA levels in the IL without affecting levels in the anterior lobe. Sodium Chloride 21-27 proopiomelanocortin Rattus norvegicus 49-53 2838766-3 1988 3H-Spiperone binding showed that (Nle4, D-Phe7)alpha-MSH treatment caused a down regulation of the striatal DA receptors in the lesioned side, contrary to the supersensitivity developed by the corresponding receptors of saline treated rats. Sodium Chloride 220-226 proopiomelanocortin Rattus norvegicus 47-56 4043329-1 1985 In the normal Wistar rat, the plasma alpha-MSH level was raised by hypertonic saline injection (as compared with control rats injected with isotonic saline). Sodium Chloride 78-84 proopiomelanocortin Rattus norvegicus 37-46 4043329-1 1985 In the normal Wistar rat, the plasma alpha-MSH level was raised by hypertonic saline injection (as compared with control rats injected with isotonic saline). Sodium Chloride 149-155 proopiomelanocortin Rattus norvegicus 37-46 8115018-8 1993 The mean POMC mRNA concentration in the MBH was 0.85 +/- 0.04 pg/microgram RNA in the saline group and decreased to 0.62 +/- 0.06 pg/microgram with haloperidol (p < 0.01). Sodium Chloride 86-92 proopiomelanocortin Rattus norvegicus 9-13 28575455-9 2017 The alpha-Melanocyte stimulating hormone and melanocortin 4 receptor protein levels were increased in the central and medial nucleus of the amygdala, paraventricular nucleus, and arcuate nucleus of the hypothalamus in adolescent intermittent ethanol-exposed compared with adolescent intermittent saline-exposed adult rats. Sodium Chloride 296-302 proopiomelanocortin Rattus norvegicus 4-40 7099389-3 1982 injection of 2 microgram of alpha-MSH in ovariectomized (OVX) rats produced a 50% depression of plasma prolactin levels within 10 min, whereas 100 ng of alpha-MSH or saline had no effect. Sodium Chloride 166-172 proopiomelanocortin Rattus norvegicus 28-37 23390842-4 2012 alpha-MSH drops in a concentration of 1 x 10(-4) mg/mL significantly promoted epithelial healing, when compared to the control group treated with 0.9% NaCl. Sodium Chloride 151-155 proopiomelanocortin Rattus norvegicus 0-9 17216604-3 2007 alpha-MSH was administered at a dose of 25 microg rat(-1) day(-1) following GEN or saline injections. Sodium Chloride 83-89 proopiomelanocortin Rattus norvegicus 0-9 18444139-7 2008 Proopiomelanocortin message was reduced in ghrelin-infused and saline-infused TB rats as compared to noninfused TB control rats. Sodium Chloride 63-69 proopiomelanocortin Rattus norvegicus 0-19 17952633-7 2007 The number of viable neurons upon administration of alpha-MSH was significantly higher than upon KA alone (p < 0.05, 119,776 +/- 33,158, KA+alpha-MSH vs. 79,587 +/- 27,554, KA + Saline). Sodium Chloride 181-187 proopiomelanocortin Rattus norvegicus 52-61 17355316-11 2007 Analyses of brains from saline-treated VGX animals revealed a significant induction of Fos in the nucleus tractus solitarii and changes in agouti-related peptide and pro-opiomelanocortin mRNA expression in the hypothalamus compared to their SHAM counterparts, indicating that the vagotomy surgery itself induced a modification of brain activity in areas involved in regulating appetite. Sodium Chloride 24-30 proopiomelanocortin Rattus norvegicus 166-186 10865075-8 2000 alpha-MSH and beta-MSH injected ICV into fasted rats at doses of 1, 3 and 6 nmol resulted in a decrease in food intake, (2 h food intake: alpha-MSH 6 nmol, 1.7+/-0.3 g; beta-MSH 6 nmol, 1.5+/-0.3 g vs. saline 6.0+/-0.5 g, P<0.001). Sodium Chloride 202-208 proopiomelanocortin Rattus norvegicus 0-9 11979051-3 2002 Intraparaventricular nuclear (iPVN) injection of [Nle(4),D-Phe(7)]-alpha-MSH (NDP-MSH) (a long-acting alpha-MSH analogue) increased plasma adrenocorticotropic hormone (ACTH) (10 min post-injection: 25.0 +/- 3.9 vs. saline 10.9 +/- 2.0, p < 0.05) and plasma corticosterone (10 min post-injection: 174.1 +/- 14.2 vs. saline 124.7 +/- 16.3 ng/ml, p < 0.05). Sodium Chloride 215-221 proopiomelanocortin Rattus norvegicus 67-76 11979051-3 2002 Intraparaventricular nuclear (iPVN) injection of [Nle(4),D-Phe(7)]-alpha-MSH (NDP-MSH) (a long-acting alpha-MSH analogue) increased plasma adrenocorticotropic hormone (ACTH) (10 min post-injection: 25.0 +/- 3.9 vs. saline 10.9 +/- 2.0, p < 0.05) and plasma corticosterone (10 min post-injection: 174.1 +/- 14.2 vs. saline 124.7 +/- 16.3 ng/ml, p < 0.05). Sodium Chloride 318-324 proopiomelanocortin Rattus norvegicus 67-76 10938261-3 2000 Chronic alpha-MSH infusion reduced cumulative food intake by 10.7% (P < 0.05 vs. saline) and body weight by 4.3% (P < 0.01 vs. saline), which in turn lowered plasma insulin levels by 29.3% (P < 0.05 vs. saline). Sodium Chloride 84-90 proopiomelanocortin Rattus norvegicus 8-17 10938261-3 2000 Chronic alpha-MSH infusion reduced cumulative food intake by 10.7% (P < 0.05 vs. saline) and body weight by 4.3% (P < 0.01 vs. saline), which in turn lowered plasma insulin levels by 29.3% (P < 0.05 vs. saline). Sodium Chloride 133-139 proopiomelanocortin Rattus norvegicus 8-17 10938261-3 2000 Chronic alpha-MSH infusion reduced cumulative food intake by 10.7% (P < 0.05 vs. saline) and body weight by 4.3% (P < 0.01 vs. saline), which in turn lowered plasma insulin levels by 29.3% (P < 0.05 vs. saline). Sodium Chloride 133-139 proopiomelanocortin Rattus norvegicus 8-17 10938261-5 2000 Central alpha-MSH infusion acutely activated neurons in forebrain areas such as the hypothalamic paraventricular nucleus, as measured by a 254% increase in c-Fos-like immunoreactivity (P < 0.01 vs. saline), as well as satiety pathways in the hindbrain. Sodium Chloride 201-207 proopiomelanocortin Rattus norvegicus 8-17 16814468-5 2006 Stimulation of the cells with glutamate and high K+ saline induced a significant increase in the plasma membrane area covered with alpha-MSH deposits compared to control cells incubated with glutamate and CNQX, a glutamate channel blocker. Sodium Chloride 52-58 proopiomelanocortin Rattus norvegicus 131-140 16195498-1 2006 Gamma-melanocyte stimulating hormone (gamma-MSH) is a circulating natriuretic peptide hormone derived from proopiomelanocortin (POMC); its concentration in plasma and pituitary POMC mRNA abundance, increase in rats ingesting a high-sodium diet (HSD, 8% NaCl) compared with a low-sodium diet (LSD, 0.07% NaCl). Sodium Chloride 253-257 proopiomelanocortin Rattus norvegicus 128-132 16195498-1 2006 Gamma-melanocyte stimulating hormone (gamma-MSH) is a circulating natriuretic peptide hormone derived from proopiomelanocortin (POMC); its concentration in plasma and pituitary POMC mRNA abundance, increase in rats ingesting a high-sodium diet (HSD, 8% NaCl) compared with a low-sodium diet (LSD, 0.07% NaCl). Sodium Chloride 303-307 proopiomelanocortin Rattus norvegicus 128-132 15082867-4 2004 at 5 min of critical hypotension produced a long-lasting pressor effect with a 100% survival rate at 2 h. The action was accompanied by 34.5% and 28.9% higher plasma concentrations of ACTH and alpha-MSH, respectively, in comparison to concentrations in the saline-injected group as measured 20 min after treatment. Sodium Chloride 257-263 proopiomelanocortin Rattus norvegicus 193-202 14568996-1 2003 Gamma-melanocyte-stimulating hormone (gamma-MSH) is a natriuretic peptide derived from proopiomelanocortin (POMC) in the pituitary neurointermediate lobe (NIL); its plasma concentration in rats doubles after ingestion of a high (HSD; 8% NaCl) compared with a low sodium diet (LSD; 0.07%). Sodium Chloride 237-241 proopiomelanocortin Rattus norvegicus 108-112 12576179-8 2003 In the anterior pituitary, levels of both proopiomelanocortin (POMC) and CRH-receptor 1 (R1) mRNAs were significantly higher than saline controls on the 14th day of chronic "binge" cocaine and were at control levels on the 4th day of withdrawal. Sodium Chloride 130-136 proopiomelanocortin Rattus norvegicus 42-61 10865075-9 2000 Desacetyl alpha-MSH did not reduce food intake at low doses but was significant at 25 nmol (2 h food intake: desacetyl-alpha-MSH 6.1+/-1.0 g vs. saline 9.5+/-1.4 g, P<0.05). Sodium Chloride 145-151 proopiomelanocortin Rattus norvegicus 10-19