PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15811372-7	2005	The native ensemble of IL-1beta was characterized using a variety of experimental probes under native (0 M NaCl, guanidine hydrochloride (Gdn-HCl)), moderately destabilized (0 M NaCl, 0.8 M Gdn-HCl), and in moderate salt concentration (0.8 M NaCl, 0 M Gdn-HCl).	Sodium Chloride	107-111	interleukin 1 beta	Homo sapiens	23-31	
11378323-7	2001	We found that 0.5 M NaCl treatment increased mRNA levels of proinflammatory cytokines such as IL-1alpha, IL-6 and IL-8 as well as ICAM-1 in NHEK and IL-1alpha, IL-1beta and IL-6 mRNA levels in NHDF.	Sodium Chloride	20-24	interleukin 1 beta	Homo sapiens	160-168	
12507912-4	2003	Compared to non-CF cells, CF bronchial epithelial cells were characterized by a higher susceptibility to produce elevated IL-8 and RANTES production in an hypertonic NaCl milieu in response to IL-1beta activation.	Sodium Chloride	166-170	interleukin 1 beta	Homo sapiens	193-201	
12115600-3	2002	Indeed, addition of hyperosmotic, pathophysiologically relevant concentrations of NaCl effectively inhibited IL-1beta or TNF-alpha induction of VCAM-1, but not E-selectin, at the level of mRNA and cell surface protein.	Sodium Chloride	82-86	interleukin 1 beta	Homo sapiens	109-117	
8306027-5	1994	Compared with prechallenge values, significant levels of IL-1 beta were detected in all subjects during the immediate reaction (peak, 51.0 +/- 22.4 pg/ml) and LPR (peak, 78.5 +/- 22.6 pg/ml) after antigen challenges (p < 0.01) but not saline challenges.	Sodium Chloride	238-244	interleukin 1 beta	Homo sapiens	57-66	
9264555-8	1997	IL-1beta, but not RA, induced a significant increase in swelling ratio (wet weight in 0.01 M NaCl normalized to wet weight in DMEM) after 8 days in culture, consistent with degradation of the collagen network, and the increase in tissue swelling was inhibited by treatment with TIMP-1 or L-758,354.	Sodium Chloride	93-97	interleukin 1 beta	Homo sapiens	0-8	
9087177-4	1997	In contrast, exposure of PBMC to hyperosmotic conditions (330-410 mOsM) by the addition of NaCl to tissue culture medium induced gene expression for IL-1 alpha, IL-1 beta, and IL-8.	Sodium Chloride	91-95	interleukin 1 beta	Homo sapiens	161-170	
8735570-5	1996	Male lizards were injected with human IL-1 beta (10 ng/g animal), saline, or nothing (control) and the activity level (proportion of lizards above ground) was monitored for 48 h. IL-1 beta-injected lizards showed a decrease in activity compared to saline-injected and control lizards within 2 h after treatment.	Sodium Chloride	66-72	interleukin 1 beta	Homo sapiens	179-188	
8735570-5	1996	Male lizards were injected with human IL-1 beta (10 ng/g animal), saline, or nothing (control) and the activity level (proportion of lizards above ground) was monitored for 48 h. IL-1 beta-injected lizards showed a decrease in activity compared to saline-injected and control lizards within 2 h after treatment.	Sodium Chloride	248-254	interleukin 1 beta	Homo sapiens	179-188	
7552951-6	1995	There were positive correlations between saline aspirate and joint fluid concentrations for NPY-LI and IL-1 beta, and the correlations were stronger for saline aspirates with high joint fluid content.	Sodium Chloride	41-47	interleukin 1 beta	Homo sapiens	103-112	
9843715-5	1998	Titration of NaCl into choline chloride- or sucrose-based media restored 17-kDa IL-1beta production.	Sodium Chloride	13-17	interleukin 1 beta	Homo sapiens	80-88	
1581422-2	1992	Incubation of PAN membrane fragments with radiolabeled IL-1 beta or TNF yielded a significant binding of both cytokines to the membrane (percentage of membrane-bound cytokine after incubation in saline or plasma was 14-17% and 23-46%, respectively).	Sodium Chloride	195-201	interleukin 1 beta	Homo sapiens	55-64	
1581422-4	1992	When plasma was dialyzed against saline the percentage of membrane-bound IL-1 beta and TNF was 63 and 37%, respectively.	Sodium Chloride	33-39	interleukin 1 beta	Homo sapiens	73-82	
31305644-0	2017	Erratum: Hypertonic saline protects brain endothelial cells against hypoxia correlated to the levels of estimated glomerular filtration rate and interleukin-1beta: Erratum.	Sodium Chloride	20-26	interleukin 1 beta	Homo sapiens	145-162	
29895944-10	2018	The ELISA results suggested that the concentration of interleukin-1 beta (IL-1beta) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis.	Sodium Chloride	144-148	interleukin 1 beta	Homo sapiens	54-72	
29895944-10	2018	The ELISA results suggested that the concentration of interleukin-1 beta (IL-1beta) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis.	Sodium Chloride	144-148	interleukin 1 beta	Homo sapiens	74-82	
31341381-12	2019	Selective inhibition of COX2 activity decreased osmotic expression of the VEGFA, IL1B, and NLRP3 genes, and blocked the NaCl-induced increase in the cytosolic IL-1beta level.	Sodium Chloride	120-124	interleukin 1 beta	Homo sapiens	159-167	
28288585-4	2017	Previous report in our group demonstrated hypertonic saline (HS) could reduce the release of interleukin-1 beta and tumor necrosis factor-alpha in activated microglia, but the underlying molecular and cellular mechanisms have remained uncertain.	Sodium Chloride	61-63	interleukin 1 beta	Homo sapiens	93-143	
27308826-10	2016	Interestingly, there was a mean increase in all inflammatory cytokines (IL-1beta, IL-6, and IL-8) during the saline treatment from day 1 to week 3, whereas during the Tyloxapol treatment, all cytokines decreased.	Sodium Chloride	109-115	interleukin 1 beta	Homo sapiens	72-80	
27788256-8	2016	High extracellular NaCl induced NLRP3 and pro-IL-1beta gene expression, while the gene expression of further inflammasome-associated proteins (NLRP1, NLRP2, NLRP6, NLRP7, NLRP12, NLRC4, AIM2, ASC, procaspase-1, pro-IL-18) was not altered or below the detection threshold.	Sodium Chloride	19-23	interleukin 1 beta	Homo sapiens	42-54	
27788256-11	2016	High NaCl induced a transient increase of the NLRP3 protein level and a moderate NLRP3 inflammasome activation, as indicated by the transient increase of the cytosolic level of mature IL-1beta.	Sodium Chloride	5-9	interleukin 1 beta	Homo sapiens	184-192	
26044807-4	2015	In the meningitis/saline group IL-1beta and cytokine-induced neutrophil chemoattractant-1 (CINC-1) levels increased at 24 h post-infection; adjuvant treatment with IL-1Ra reversed the increased levels in the hippocampus.	Sodium Chloride	18-24	interleukin 1 beta	Homo sapiens	31-39	
17184753-4	2007	We show that a similar unilateral microinjection of IL1beta (10 ng) into layer VI or onto the surface of the primary somatosensory cortex induced increases in the neuronal activity marker, Fos, relative to the contralateral side that received saline or heat-inactivated IL1beta.	Sodium Chloride	243-249	interleukin 1 beta	Homo sapiens	52-59	
25067987-12	2014	CONCLUSIONS: Hypertonic saline has an immunomodulatory effect on polymorphonuclear cells through the TLR-4 pathway, and the interleukin-1beta-associated pathway is influenced more by hypertonic saline than is the tumor necrosis factor-alpha-associated pathway.	Sodium Chloride	194-200	interleukin 1 beta	Homo sapiens	124-141	
20026325-4	2010	It has been reported that elevated osmolarity achieved by adding sodium chloride to the culture medium of corneal epithelial cells increased the production of IL-1beta, a proinflammation cytokine.	Sodium Chloride	65-80	interleukin 1 beta	Homo sapiens	159-167	
18827361-3	2008	Macrophages stimulated with OL or lipid A sonically dissolved in saline released both interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	Sodium Chloride	65-71	interleukin 1 beta	Homo sapiens	86-103	
18827361-3	2008	Macrophages stimulated with OL or lipid A sonically dissolved in saline released both interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	Sodium Chloride	65-71	interleukin 1 beta	Homo sapiens	105-113	
17172977-7	2007	The addition of NaCl lowered the production of IL-8, TNF-alpha, and IL-1 receptor antagonist by neutrophils, and IL-8 and IL-1beta by mononuclear cells stimulated with LPS.	Sodium Chloride	16-20	interleukin 1 beta	Homo sapiens	122-130