PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7810663-7 1994 Eight minutes after saline administration plasma CCK concentration was 0.9 +/- 0.4 pM; it rose to 4.7 +/- 2.8 pM, 8 min after spermidine (20 mumol). Sodium Chloride 20-26 cholecystokinin Rattus norvegicus 49-52 7800848-5 1994 CCK-8 (2 micrograms/kg) also inhibited the gastric emptying of physiological saline. Sodium Chloride 77-83 cholecystokinin Rattus norvegicus 0-3 8062068-3 1994 In rats drinking hypertonic saline and simultaneously treated with CCK-8, the decrease of vasopressin content was more marked in hypothalamus but somewhat restrained in the neurohypophysis. Sodium Chloride 28-34 cholecystokinin Rattus norvegicus 67-70 8141404-4 1994 When sucrose was infused, all doses of CCK-8 reduced sham feeding of 0.88 M sucrose by 60% or more, but with saline infusions, only the highest dose was effective. Sodium Chloride 109-115 cholecystokinin Rattus norvegicus 39-42 8141404-6 1994 Although 1 microgram/kg CCK-8 was ineffective in the absence of infusions, it significantly reduced intake in combination with both concentrations of glucose and hypertonic (0.6 M) saline. Sodium Chloride 181-187 cholecystokinin Rattus norvegicus 24-27 1415643-8 1992 Near-celiac injection of 30 pmol of CCK-8 produced systemic plasma CCK concentrations averaging 6.5 +/- 1 pM compared with less than 1 pM after saline injection. Sodium Chloride 144-150 cholecystokinin Rattus norvegicus 36-39 8242392-2 1993 Two hours after a single injection of morphine (10 mg/kg, s.c.), CCK mRNA significantly increased in the hypothalamus (0.8-fold) and spinal cord (2-fold) relative to the CCK mRNA content in saline-injected controls. Sodium Chloride 190-196 cholecystokinin Rattus norvegicus 65-68 8457019-8 1993 Finally, in intact rats, CCK significantly inhibited the emptying of physiological saline, and gastric vagotomy abolished this suppression. Sodium Chloride 83-89 cholecystokinin Rattus norvegicus 25-28 1282765-0 1992 Short-term restraint stress and s.c. saline injection alter the tissue levels of substance P and cholecystokinin in the peri-aqueductal grey and limbic regions of rat brain. Sodium Chloride 37-43 cholecystokinin Rattus norvegicus 97-112 1887942-2 1991 We examined the ability of two doses of CCK to inhibit the gastric emptying of 10-ml saline (0.9% NaCl) and glucose (0.125 g/ml) test meals in rats equipped with chronic gastric fistulas before and after surgical removal of the region of the pylorus containing CCK receptors. Sodium Chloride 85-91 cholecystokinin Rattus norvegicus 40-43 1887942-2 1991 We examined the ability of two doses of CCK to inhibit the gastric emptying of 10-ml saline (0.9% NaCl) and glucose (0.125 g/ml) test meals in rats equipped with chronic gastric fistulas before and after surgical removal of the region of the pylorus containing CCK receptors. Sodium Chloride 98-102 cholecystokinin Rattus norvegicus 40-43 1887942-3 1991 Preoperatively, CCK (2 and 8 micrograms/kg) inhibited gastric emptying of both saline and glucose. Sodium Chloride 79-85 cholecystokinin Rattus norvegicus 16-19 3056036-5 1988 The emptying of saline was also delayed by intravenous infusion of CCK-8 (400 pmol.kg-1.h-1). Sodium Chloride 16-22 cholecystokinin Rattus norvegicus 67-70 1694105-2 1990 After prolonged administration of 2% sodium chloride as drinking water (salt-loading), the treatment increased the levels of VP, OXY, TH, GAL, DYN and CCK mRNA in the PVN and SON. Sodium Chloride 37-52 cholecystokinin Rattus norvegicus 151-154 2330072-5 1990 With this paradigm, active sites at which CCK-8 suppressed feeding were defined as sites at which consumption of food for 0-20 min was reduced by 25% or more, or the latency to feed was increased by 3 min or more after the injection of CCK-8, as compared to the effect of the injection of saline, made at the same site. Sodium Chloride 289-295 cholecystokinin Rattus norvegicus 42-45 2622522-6 1989 In addition, following intracardial perfusion of saline for 30 min after pentobarbital anesthesia, the concentrations of CCK-8S-LI increased in the nucleus accumbens, and decreased in the frontal cortex. Sodium Chloride 49-55 cholecystokinin Rattus norvegicus 121-124 3056036-6 1988 The CCK antagonist L364,718 reversed the effect of peptone in a dose-dependent manner and inhibited the response to exogenous CCK, but the emptying of physiological saline, 50 mM HCl, or hyperosmolal saline remained unchanged. Sodium Chloride 165-171 cholecystokinin Rattus norvegicus 4-7 3056036-6 1988 The CCK antagonist L364,718 reversed the effect of peptone in a dose-dependent manner and inhibited the response to exogenous CCK, but the emptying of physiological saline, 50 mM HCl, or hyperosmolal saline remained unchanged. Sodium Chloride 200-206 cholecystokinin Rattus norvegicus 4-7 3394837-8 1988 In addition to inhibiting intake, CCK inhibited the rate of gastric emptying of saline test meals in 1- and 3-day-old rat pups, and the threshold dosages for this suppression were identical to the thresholds for the inhibition of ingestion. Sodium Chloride 80-86 cholecystokinin Rattus norvegicus 34-37 3337268-3 1988 A 19.3-fold greater dose of CCK-8 (11.6 micrograms.kg body wt-1.h-1) did cause a significant decline in food consumption for the first 4 days compared with saline-infused rats (P less than 0.05) and unoperated controls (P less than 0.01). Sodium Chloride 156-162 cholecystokinin Rattus norvegicus 28-31 2993947-4 1985 Cholecystokinin appreciably inhibited the circulation of serotonin and dopamine in the brain structures in comparison with physiological saline solution. Sodium Chloride 137-143 cholecystokinin Rattus norvegicus 0-15 6300693-10 1983 Acute challenge doses of CCK which induced satiety-related behaviours in saline-infused rats were ineffective in CCK-infused rats. Sodium Chloride 73-79 cholecystokinin Rattus norvegicus 25-28 6329243-7 1984 Peak and tonic responses to sucrose and saline tended to increase after CCK-8 but not NaCl infusions. Sodium Chloride 40-46 cholecystokinin Rattus norvegicus 72-75 22848639-9 2012 Microinjection of L-364,718, LY-288,513 or CCK-8 to saline pretreated rats produced neither a conditioned preference nor aversion, and the induction of CPA by CCK-8 itself after morphine pretreatments was not significant. Sodium Chloride 52-58 cholecystokinin Rattus norvegicus 43-46 26384952-5 2015 When these subthreshold doses of Rb1 and CCK-8 were co-administered, the combination significantly reduced food intake relative to saline controls, and this effect was attenuated by lorglumide, a selective CCK1-receptor antagonist. Sodium Chloride 131-137 cholecystokinin Rattus norvegicus 41-44 7463880-1 1980 In order to elucidate the central action mechanism of cholecystokinin (CCK), effects of this peptide on norepinephrine, dopamine and serotonin contents in the brain were observed in saline control, alpha-methyl-p-tyrosine-, L-DOPA- and pargyline-pretreated rats. Sodium Chloride 182-188 cholecystokinin Rattus norvegicus 71-74 17634201-5 2007 However, when these subthreshold doses of apo AIV and CCK were administered together, the combination produced a significant inhibition of food intake relative to saline controls (P < 0.001), and the duration of the effect was longer than that caused by the administration of either apo AIV or CCK alone. Sodium Chloride 163-169 cholecystokinin Rattus norvegicus 54-57 18600455-5 2009 In saline, a significant decrease in calcium cytosolic response to CCK was observed. Sodium Chloride 3-9 cholecystokinin Rattus norvegicus 67-70 12429561-5 2002 Two days after the final injection of estradiol or vehicle, rats were injected intraperitoneally with 4 microg/kg CCK in 1 ml/kg 0.9 M NaCl or with vehicle alone. Sodium Chloride 135-139 cholecystokinin Rattus norvegicus 114-117 14583742-7 2004 CCK-8s produced anxiogenic-like effect, decreasing the percentage of time spent in open arm (saline=30.3+/-6.6, CCK 0.5 microg=15.2+/-1.8; CCK 1 microg=14.6+/-2.1). Sodium Chloride 93-99 cholecystokinin Rattus norvegicus 0-3 11454330-7 2001 Our results indicate that a mild stressful stimulus such as an intraperitoneal saline injection may have long-lasting effects on CCK-ergic transmission in the PFC. Sodium Chloride 79-85 cholecystokinin Rattus norvegicus 129-132 12065614-6 2002 When analyzed as a function of time after cocaine treatment, these increases were sustained and were significantly different from CCK levels of saline-treated rats. Sodium Chloride 144-150 cholecystokinin Rattus norvegicus 130-133 8672081-10 1996 Na+ dependence of secretagogue (CCK-OP)-stimulated amylase secretion was investigated in digitonin permeabilized rat pancreatic acini and was higher in acini incubated in Na+ containing buffer (30 mm NaCl/105 mm KCl buffer; 6.4 +/- 0.4% of total amylase above basal) compared to buffer without Na+ (0 mm NaCl/135 mm KCl buffer; 4.7 +/- 0.4% of total amylase above basal, P < 0.03). Sodium Chloride 200-204 cholecystokinin Rattus norvegicus 32-35 10644635-2 2000 Intraperitoneal injection of 0.250-2.0 microg/kg cholecystokinin (CCK) significantly inhibited gastric emptying of a 5-ml NaCl load in LF rats by 26.2-55. Sodium Chloride 122-126 cholecystokinin Rattus norvegicus 49-64 10644635-2 2000 Intraperitoneal injection of 0.250-2.0 microg/kg cholecystokinin (CCK) significantly inhibited gastric emptying of a 5-ml NaCl load in LF rats by 26.2-55. Sodium Chloride 122-126 cholecystokinin Rattus norvegicus 66-69 9510141-4 1998 Treatment with loxiglumide (Loxi-3 and Loxi-4) or CCK-8 for 6 days (CCK-4) or with a high dose of loxiglumide for the first 3 days (Loxi-2) significantly suppressed the recovery of pancreatic weight and DNA content compared to saline treatment or to the untreated normal control rats. Sodium Chloride 227-233 cholecystokinin Rattus norvegicus 50-53 9510141-4 1998 Treatment with loxiglumide (Loxi-3 and Loxi-4) or CCK-8 for 6 days (CCK-4) or with a high dose of loxiglumide for the first 3 days (Loxi-2) significantly suppressed the recovery of pancreatic weight and DNA content compared to saline treatment or to the untreated normal control rats. Sodium Chloride 227-233 cholecystokinin Rattus norvegicus 68-71 11294747-1 2001 Serotonin [5-hydroxytryptamine (5-HT)] and CCK injected into the lateral parabrachial nucleus (LPBN) inhibit NaCl and water intake. Sodium Chloride 109-113 cholecystokinin Rattus norvegicus 43-46 11294747-9 2001 CCK-8 combined with methysergide (4 microg) reduced the effect of methysergide on NaCl intake. Sodium Chloride 82-86 cholecystokinin Rattus norvegicus 0-3 11294747-10 2001 The data suggest that functional interactions between 5-HT and CCK in the LPBN may be important for exerting inhibitory control of NaCl intake. Sodium Chloride 131-135 cholecystokinin Rattus norvegicus 63-66 11108253-5 2000 Fasting blunted the satiety response to 3.0 microg/kg CCK, such that 30-min food intake was suppressed by 65.1% (relative to saline-treated controls) in fasted rats vs. 85.9% in the fed state (P < 0.05). Sodium Chloride 125-131 cholecystokinin Rattus norvegicus 54-57 9791058-1 1998 The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II or by a combined treatment with subcutaneous furosemide (Furo) + captopril (Cap). Sodium Chloride 201-205 cholecystokinin Rattus norvegicus 125-128 9791058-11 1998 Taken together, these results suggest that CCK actions in the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states. Sodium Chloride 108-112 cholecystokinin Rattus norvegicus 43-46 8672081-10 1996 Na+ dependence of secretagogue (CCK-OP)-stimulated amylase secretion was investigated in digitonin permeabilized rat pancreatic acini and was higher in acini incubated in Na+ containing buffer (30 mm NaCl/105 mm KCl buffer; 6.4 +/- 0.4% of total amylase above basal) compared to buffer without Na+ (0 mm NaCl/135 mm KCl buffer; 4.7 +/- 0.4% of total amylase above basal, P < 0.03). Sodium Chloride 304-308 cholecystokinin Rattus norvegicus 32-35 8740446-5 1996 Northern blot analysis revealed that the levels of CCK mRNA in the frontal cortex and the hippocampus of 3 or 6 mg/kg MAP-treated rats were significantly decreased, compared to the saline-treated controls. Sodium Chloride 181-187 cholecystokinin Rattus norvegicus 51-54