PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22522748-2	2012	We report a method using cryopreserved human hepatocytes and the time-dependent AO inhibitor hydralazine (K(I) = 83 +- 27 muM, k(inact) = 0.063 +- 0.007 min(-1)), which estimates the contribution of AO metabolism relative to total hepatic clearance.	Hydralazine	93-104	latexin	Homo sapiens	122-125	
22522748-8	2012	Overall, these findings demonstrate that hydralazine, at a concentration of 25 to 50 muM, can be used in human hepatocyte incubations to estimate the contribution of AO to the hepatic clearance of drugs and other compounds.	Hydralazine	41-52	latexin	Homo sapiens	85-88	
29018032-8	2017	The in situ hydralazine N-acetylation rates differed significantly with respect to NAT2 genotype after incubation with 10 (P = 0.002) or 100 microM (P = 0.0015) hydralazine and were higher after incubation with 100 muM (10-fold) than with 10 muM (4.5-fold) hydralazine.	Hydralazine	12-23	latexin	Homo sapiens	215-218	
30448524-2	2019	In this study, however, hydralazine was found to inhibit CYP1A2, 2B6, 2D6, and 3A in human suspension hepatocytes under reaction phenotyping assay conditions, at concentrations that chemically knocked out most of the AO activities (>=50 muM).	Hydralazine	24-35	latexin	Homo sapiens	240-243	
31710239-4	2020	Results: The tested compounds revealed potent to mild activity with EC50 values 0.339-114.300 muM compared with hydralazine EC50 = 18.210 muM.	Hydralazine	112-123	latexin	Homo sapiens	138-141	
29018032-3	2017	After recombinant expression in yeast, human NAT2 exhibited an apparent Lineweaver-Burk constant (K-m) value (20.1 +- 8.8 muM) for hydralazine over 20-fold lower than the apparent K-m value (456 +- 57 muM) for recombinant human NAT1 (P = 0.0016).	Hydralazine	131-142	latexin	Homo sapiens	122-125	
29018032-8	2017	The in situ hydralazine N-acetylation rates differed significantly with respect to NAT2 genotype after incubation with 10 (P = 0.002) or 100 microM (P = 0.0015) hydralazine and were higher after incubation with 100 muM (10-fold) than with 10 muM (4.5-fold) hydralazine.	Hydralazine	12-23	latexin	Homo sapiens	242-245	
29018032-3	2017	After recombinant expression in yeast, human NAT2 exhibited an apparent Lineweaver-Burk constant (K-m) value (20.1 +- 8.8 muM) for hydralazine over 20-fold lower than the apparent K-m value (456 +- 57 muM) for recombinant human NAT1 (P = 0.0016).	Hydralazine	131-142	latexin	Homo sapiens	201-204	
29018032-6	2017	Hydralazine NAT activities in vitro differed significantly with respect to NAT2 genotype at 1000 (P = 0.0319), 100 (P = 0.002), and 10 muM hydralazine (P = 0.0029).	Hydralazine	0-11	latexin	Homo sapiens	135-138