PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33555842-0 2021 The Therapeutic Value of Hydralazine in Reducing Inflammatory Response, Oxidative Stress and Mortality in Animal Sepsis: Involvement of the PI3K/AKT Pathway. Hydralazine 25-36 AKT serine/threonine kinase 1 Rattus norvegicus 145-148 33555842-13 2021 Additionally, HDZ significantly prevented the increase of Akt activation in the liver and kidney. Hydralazine 14-17 AKT serine/threonine kinase 1 Rattus norvegicus 58-61 33555842-14 2021 HDZ largely mitigated the effects of sepsis by suppressing inflammatory and antioxidant responses via the PI3K/Akt pathway. Hydralazine 0-3 AKT serine/threonine kinase 1 Rattus norvegicus 111-114 31830459-10 2020 In addition, hydralazine also increased p-PI3K, p-AKT, p-eNOS expression and decreased Cleaved Caspase-3, Cleaved Caspase-9 expression in the hearts. Hydralazine 13-24 AKT serine/threonine kinase 1 Rattus norvegicus 50-53 31830459-11 2020 Our results suggest that the cardioprotective effect of hydralazine against I/R injury might be a cooperation of the inhibition of oxidative stress, inflammatory response, apoptosis with the motivation of eNOS phosphorylation via activating the PI3K/AKT signal pathway. Hydralazine 56-67 AKT serine/threonine kinase 1 Rattus norvegicus 250-253