PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11230308-9 2001 Hydralazine alone decreased blood pressure (-27+/-3 mm Hg) and increased mouse renin mRNA 2.4-fold. Hydralazine 0-11 renin Homo sapiens 79-84 21263123-8 2011 Normalization of blood pressure by hydralazine (500 mg/L in drink solutions) attenuated the hydromineral phenotypes and renal renin suppression effects of DOCA-salt but had no effect on the elevated metabolic rate. Hydralazine 35-46 renin Homo sapiens 126-131 2408216-2 1990 However, since traditional vasodilators, such as hydralazine, may cause retention of sodium and water, tachycardia and excessive stimulation of the renin-angiotensin-aldosterone system, they are not suitable for monotherapy. Hydralazine 49-60 renin Homo sapiens 148-153 8682064-8 1995 A study in 804 men with congestive heart failure who received either enalapril or hydralazine plus isosorbide dinitrate showed the greatest reduction in mortality after 2 years in enalapril treated patients with plasma noradrenaline levels > 900 pg.ml-1 or plasma renin levels > 16 ng.ml-1.h-1. Hydralazine 82-93 renin Homo sapiens 267-272 2953239-8 1987 Supine and standing plasma renin activity increased only during long-term treatment with hydralazine. Hydralazine 89-100 renin Homo sapiens 27-32 34515895-4 2021 METHODS: In the present study, we retrospectively assessed the changes in aldosterone, renin, and aldosterone-to-renin values in essential hypertensive participants before and after treatment with either hydralazine (n = 26) or doxazosin (n = 20) or verapamil (n = 15). Hydralazine 204-215 renin Homo sapiens 87-92 34515895-4 2021 METHODS: In the present study, we retrospectively assessed the changes in aldosterone, renin, and aldosterone-to-renin values in essential hypertensive participants before and after treatment with either hydralazine (n = 26) or doxazosin (n = 20) or verapamil (n = 15). Hydralazine 204-215 renin Homo sapiens 113-118 34515895-6 2021 RESULTS: Hydralazine resulted in a borderline significant rise in active plasma renin concentration (19 vs 25 mIU/L, p = 0.067) and a significant fall in the aldosterone-to-renin ratio (38 vs 24, p = 0.017). Hydralazine 9-20 renin Homo sapiens 80-85 34515895-6 2021 RESULTS: Hydralazine resulted in a borderline significant rise in active plasma renin concentration (19 vs 25 mIU/L, p = 0.067) and a significant fall in the aldosterone-to-renin ratio (38 vs 24, p = 0.017). Hydralazine 9-20 renin Homo sapiens 173-178 6387785-3 1984 During sampling, renin release was stimulated in 29 patients with intravenous hydralazine and in 11 with the tourniquet blood trapping test. Hydralazine 78-89 renin Homo sapiens 17-22 6387785-5 1984 Positive renal vein renin ratios (greater than or equal to 1.5) were seen in 52% of the hydralazine group at 0 minutes and in 69% post-hydralazine. Hydralazine 88-99 renin Homo sapiens 20-25 6387785-5 1984 Positive renal vein renin ratios (greater than or equal to 1.5) were seen in 52% of the hydralazine group at 0 minutes and in 69% post-hydralazine. Hydralazine 135-146 renin Homo sapiens 20-25 6338555-8 1983 Hydralazine produced a greater increase in renin, but more variable results. Hydralazine 0-11 renin Homo sapiens 43-48 6394347-8 1984 Hydrallazine also caused a slight increase in plasma renin activity and urinary excretion of noradrenaline. Hydralazine 0-12 renin Homo sapiens 53-58 6293295-5 1982 Hydralazine elevated aldosterone concentration by stimulating the renin-angiotensin system but nifedipine failed to do so despite its effect on the renin-angiotensin system in young individuals. Hydralazine 0-11 renin Homo sapiens 66-71 399592-6 1979 Plasma renin activity was higher in the supine and standing positions with hydrallazine than with oxprenolol alone and with the patients standing this high renin level was prevented by simultaneous treatment with oxprenolol. Hydralazine 75-87 renin Homo sapiens 7-12 6764863-6 1982 Results obtained in patients with renal artery stenosis suggest that stimulation of renin secretion by hydralazine may be of particular advantage prior to renal vein sampling. Hydralazine 103-114 renin Homo sapiens 84-89 7004877-5 1980 In a second child with renin-induced hypertension since the firth month of life, treatment wiht hydralazine, clonidine and hydrochlorothiazide was in part effective, but failure to thrive was progressive. Hydralazine 96-107 renin Homo sapiens 23-28 228024-3 1979 Plasma renin activity increased significantly with hydralazine and was unchanged during prazosin administration. Hydralazine 51-62 renin Homo sapiens 7-12 228024-5 1979 Plasma renin activity and heart rate increased during hypoglycemia; the increases were greater in patients taking prazosin or hydralazine. Hydralazine 126-137 renin Homo sapiens 7-12 399592-7 1979 With the patients supine, combination of oxprenolol with hydrallazine resulted in a mean plasma renin activity which was less than half that with hydrallazine alone, although this difference was not statistically significant. Hydralazine 57-69 renin Homo sapiens 96-101 5942939-0 1966 On the role of hydralazine in renal hemodynamics and secretion of renin. Hydralazine 15-26 renin Homo sapiens 66-71 45015-6 1979 2) It is likely that renin activated by Cl and Hydr partially blunts their hypotensive activity. Hydralazine 47-51 renin Homo sapiens 21-26 893737-3 1977 However, in each of four patients who had high supine baseline plasma renin activity, propranolol enhanced the fall in blood pressure caused by hydralazine. Hydralazine 144-155 renin Homo sapiens 70-75 893737-7 1977 Pretreating with propranolol weakens homeostatic defenses against hydralazine such as rises in pulse rate and plasma renin activity. Hydralazine 66-77 renin Homo sapiens 117-122 893737-9 1977 In patients with high supine plasma renin activity, propranolol potentiates the fall in blood pressure induced by hydralazine, perhaps because the hypertension in such patients is renin dependent. Hydralazine 114-125 renin Homo sapiens 180-185 1199814-0 1975 Effect of alprenolol and hydralazine on plasma renin concentration in patients with arterial hypertension. Hydralazine 25-36 renin Homo sapiens 47-52 1199814-1 1975 The effect of alprenolol alone and in combination with hydralazine on plasma renin concentration has been studied in 25 patients with arterial hypertension. Hydralazine 55-66 renin Homo sapiens 77-82 4746367-0 1973 [Plasma renin activity in venous renal blood and its stimulation by hydralazine and theophylline (author"s transl)]. Hydralazine 68-79 renin Homo sapiens 8-13 4918551-0 1970 Observation on the mechanism of renin release by hydralazine in hypertensive patients. Hydralazine 49-60 renin Homo sapiens 32-37 5804376-0 1969 Post-hydralazine renin release in the diagnosis of renovascular hypertension. Hydralazine 5-16 renin Homo sapiens 17-22 875465-0 1977 Physiologic mechanisms of bupicomide- and hydralazine-induced increase in plasma renin activity in hypertensive patients. Hydralazine 42-53 renin Homo sapiens 81-86 875465-1 1977 A study was made of the possible mechanisms underlying bupicomide- and hydralazine-induced increase of plasma renin activity. Hydralazine 71-82 renin Homo sapiens 110-115 875465-7 1977 Plasma renin activity during bupicomide and hydralazine administration correlated positively with control plasma renin activity (r = 0.98, P less than 0.001). Hydralazine 44-55 renin Homo sapiens 113-118 875465-9 1977 We conclude that control plasma renin activity is a major determinant of change in plasma renin activity during administration of bupicomide or hydralazine. Hydralazine 144-155 renin Homo sapiens 32-37 875465-9 1977 We conclude that control plasma renin activity is a major determinant of change in plasma renin activity during administration of bupicomide or hydralazine. Hydralazine 144-155 renin Homo sapiens 90-95 875465-10 1977 Both an increase in sympathetic activity and a decrease in perfusion pressure may contribute to the bupicomide- and hydralazine-induced increase in plasma renin activity, possibly by a baroreceptor-mediated increase in adrenergic tone. Hydralazine 116-127 renin Homo sapiens 155-160