PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20670210-5 2010 In mice, after intravenous administration of tandutinib, the mean plasma AUC values in the Bcrp1(-/-) mice and Mdr1a/b(-/-) mice was 1.53- and 1.20-fold greater than that of the wild type (WT) mice, respectively. tandutinib 45-55 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 91-96 20670210-10 2010 P-gp affected oral absorption and brain penetration of tandutinib to a greater extent than Bcrp, but Bcrp contribution to systemic clearance of tandutinib was greater than P-gp. tandutinib 144-154 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 101-105 20670210-9 2010 This finding illustrates that P-gp and Bcrp play a role in oral absorption, systemic clearance, and brain penetration of tandutinib in the rodents. tandutinib 121-131 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 39-43