PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11023996-10 2000 We conclude that CYP26 expression and RA metabolism are regulated in adult liver not only acutely by RA administration, as may be relevant to retinoid therapy, but under chronic dietary conditions relevant to vitamin A nutrition in humans. Retinoids 142-150 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 17-22 19016711-0 2009 Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid-regulated genes in normal human epidermis. Retinoids 102-110 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 23-28 18769122-8 2008 Several retinoid-regulated genes exhibited much higher mRNA levels in SKRC06 than in SKRC39, even in the absence of drugs; these included crabp2, rargamma and cyp26A1. Retinoids 8-16 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 159-166 18606996-8 2008 These extracts contained retinoids (5.4 nM) as assessed by RA-inducible Cyp26A1-promoter luciferase reporter cell lines. Retinoids 25-34 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 72-79 15703382-5 2005 In addition, synthetic retinoids Am80 (4[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid) and Am580 [4(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphtamido)benzoic acid], which are resistant to CYP26A1 metabolism, can restore the sensitivity of these cells to apoptogens. Retinoids 23-32 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 223-230 11302942-2 2001 The complex mechanistic pattern of retinoid-induced effects on gene expression of CYP26 and intestinal metabolism of all-trans-retinoic acid (RA) was investigated here by studying the effects of retinoid ligands with relative selectivity for binding and transactivation of the retinoid acid receptors, RARs and RXRs, in human intestinal Caco-2 cells. Retinoids 35-43 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 82-87 11302942-2 2001 The complex mechanistic pattern of retinoid-induced effects on gene expression of CYP26 and intestinal metabolism of all-trans-retinoic acid (RA) was investigated here by studying the effects of retinoid ligands with relative selectivity for binding and transactivation of the retinoid acid receptors, RARs and RXRs, in human intestinal Caco-2 cells. Retinoids 195-203 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 82-87 11302942-10 2001 Receptor-selective retinoids showed enhanced effects on induction of CYP26 gene expression and all-trans-retinoic acid metabolism. Retinoids 19-28 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 69-74 17663992-0 2007 Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells. Retinoids 0-8 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 168-175 17510468-0 2007 CYP26 inhibitor R115866 increases retinoid signaling in intimal smooth muscle cells. Retinoids 34-42 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 0-5 17510468-6 2007 Thus, an alternative approach to exogenous retinoid administration could be to increase the intracellular level of all-trans retinoic acid by blocking CYP26-mediated degradation of retinoids. Retinoids 43-51 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 151-156 17510468-6 2007 Thus, an alternative approach to exogenous retinoid administration could be to increase the intracellular level of all-trans retinoic acid by blocking CYP26-mediated degradation of retinoids. Retinoids 181-190 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 151-156 17510468-10 2007 CONCLUSIONS: Blocking of the CYP26-mediated catabolism mimics the effects of exogenously administrated active retinoids on intimal SMCs. Retinoids 110-119 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 29-34 17070795-7 2007 It is proposed that heterogeneous local distribution of retinoids controlled through Raldh2 and Cyp26A1 is responsible for matching the fleshy and the tendinous components of each muscle belly. Retinoids 56-65 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 96-103 16778795-0 2006 Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models. Retinoids 5-13 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 46-51 16194896-4 2005 Other retinoids (retinol, 9-cis-RA, and 13-cis-RA) also induced significant CYP26A1 expression in HepG2 and NB4 cells. Retinoids 6-15 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 76-83 16012519-4 2005 The pattern of retinoid responsiveness for six of 13 target genes (RARbeta2, CYP26A1, CRBP1, RGS16, DUSP6, EGR1) correlated with phenotypic retinoid sensitivity, across a panel of retinoid-sensitive or -resistant lung and breast cancer cell lines. Retinoids 15-23 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 77-84 16012519-4 2005 The pattern of retinoid responsiveness for six of 13 target genes (RARbeta2, CYP26A1, CRBP1, RGS16, DUSP6, EGR1) correlated with phenotypic retinoid sensitivity, across a panel of retinoid-sensitive or -resistant lung and breast cancer cell lines. Retinoids 140-148 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 77-84 16012519-4 2005 The pattern of retinoid responsiveness for six of 13 target genes (RARbeta2, CYP26A1, CRBP1, RGS16, DUSP6, EGR1) correlated with phenotypic retinoid sensitivity, across a panel of retinoid-sensitive or -resistant lung and breast cancer cell lines. Retinoids 140-148 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 77-84 16012519-6 2005 In retinoid-sensitive neuroblastoma, lung and breast cancer cell lines, direct inhibition of retinoid-induced RARbeta2 expression blocked induction of only one of eight retinoid target genes (CYP26A1). Retinoids 93-101 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 192-199 16012519-6 2005 In retinoid-sensitive neuroblastoma, lung and breast cancer cell lines, direct inhibition of retinoid-induced RARbeta2 expression blocked induction of only one of eight retinoid target genes (CYP26A1). Retinoids 93-101 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 192-199 16012519-7 2005 DNA demethylation, histone acetylation, and exogenous overexpression of RARbeta2 partially restored retinoid-responsive CYP26A1 expression in RA-resistant MDA-MB-231 breast, but not SK-MES-1 lung, cancer cells. Retinoids 100-108 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 120-127 10953040-1 2000 In this study, the expression of CYP26 is examined in relation to retinoid-induced mucosecretory differentiation in human tracheobronchial epithelial (HTBE) cells and compared with that in human lung carcinoma cell lines. Retinoids 66-74 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 33-38 10953040-5 2000 CYP26 mRNA can be induced by the RAR-selective retinoid 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)-benzoic acid (TTAB) but not by the RXR-selective retinoid SR11217 or the anti-activator-protein 1-selective retinoid SR11302. Retinoids 47-55 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 0-5 10953040-5 2000 CYP26 mRNA can be induced by the RAR-selective retinoid 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)-benzoic acid (TTAB) but not by the RXR-selective retinoid SR11217 or the anti-activator-protein 1-selective retinoid SR11302. Retinoids 162-170 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 0-5 10953040-6 2000 RARalpha-, beta-, and gamma-selective retinoids are able to induce CYP26; this induction is inhibited by the RARalpha-selective antagonist Ro41-5253. Retinoids 38-47 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 67-72 9857269-4 1998 Recently, a novel cytochrome P450 enzyme (CYP26) with specific RA 4-hydroxylase activity, which is rapidly induced by RA, has been cloned from man, mouse and zebra fish, fullfilling all requirements of an enzyme which could be of crucial importance in controlling steady-state levels of active retinoids in cells and target tissues, thus protecting against excessive exposure. Retinoids 294-303 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 42-47 10727725-1 2000 CYP26 (P450RAI) catalyzes catabolic retinoic acid (RA) hydroxylation and thereby appears to play a critical role in retinoid signaling pathways during development. Retinoids 116-124 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 0-5 10727725-1 2000 CYP26 (P450RAI) catalyzes catabolic retinoic acid (RA) hydroxylation and thereby appears to play a critical role in retinoid signaling pathways during development. Retinoids 116-124 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 7-14 9564181-2 1998 CYP26 displays specificity toward retinoic acid and it may function as an important regulator or differentiation and a possible modulator of disease states by controlling retinoid concentration and homeostasis. Retinoids 171-179 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 0-5 9857269-5 1998 Besides the putative role of this newly identified CYP26 in contributing to susceptibility of cancer cells to retinoids, the possible function of this gene in early embryonic development is discussed. Retinoids 110-119 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 51-56 31903789-3 2020 In vivo, retinoids induce CYP26 enzyme production in the liver, enhancing their own rapid metabolic clearance, while retinoid resistance in tumour cells themselves is considered to be due in part to increased CYP26 production. Retinoids 9-18 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 26-31 19525031-2 2009 The CYP26 enzyme acts specifically on tRA, but not 13-cis RA (isotretinoin), a retinoid used to treat severe acne. Retinoids 79-87 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 4-9 31903789-3 2020 In vivo, retinoids induce CYP26 enzyme production in the liver, enhancing their own rapid metabolic clearance, while retinoid resistance in tumour cells themselves is considered to be due in part to increased CYP26 production. Retinoids 9-17 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 26-31 31744925-0 2020 Correction to "Induction of CYP26A1 by Metabolites of Retinoic Acid: Evidence That CYP26A1 Is an Important Enzyme in the Elimination of Active Retinoids". Retinoids 143-152 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 28-35 32359660-0 2020 Using the human CYP26A1 gene promoter as a suitable tool for the determination of RAR-mediated retinoid activity. Retinoids 95-103 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 16-23 31744925-0 2020 Correction to "Induction of CYP26A1 by Metabolites of Retinoic Acid: Evidence That CYP26A1 Is an Important Enzyme in the Elimination of Active Retinoids". Retinoids 143-152 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 83-90 26047326-4 2015 The microenvironment expression of cytochrome P450 (CYP)26, a retinoid-metabolizing enzyme was shown to determine normal hematopoietic stem cell fate. Retinoids 62-70 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 35-58 31419517-9 2019 Interestingly, some of these genetic variants result in increased activity of the CYP26 enzymes potentially leading to complex gene-environment interactions due to variability in dietary intake of retinoids. Retinoids 197-206 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 82-87 31419517-10 2019 This review highlights the current knowledge of structure-function of CYP26 enzymes and focuses on their role in human retinoid metabolism in different tissues. Retinoids 119-127 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 70-75 31039331-0 2019 CYP26A1 gene promoter is a useful tool for reporting RAR-mediated retinoid activity. Retinoids 66-74 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 0-7 31039331-2 2019 In this study, we have used a shortened construct form, E4, of the CYP26A1 gene promoter, in a promoter-less vector with either luciferase or red fluorescent protein (RFP) as the reporter gene and have tested its responses to retinoids in transfected HepG2 and HEK293T cells. Retinoids 226-235 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 67-74 28754309-6 2017 Here, we discuss accumulating evidence suggesting that cytochrome P450 (CYP26), the primary retinoid-inactivating enzyme, plays a critical role in the integration of two of these molecular programs: the retinoid and Hedgehog pathways. Retinoids 92-100 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 72-77 28754309-6 2017 Here, we discuss accumulating evidence suggesting that cytochrome P450 (CYP26), the primary retinoid-inactivating enzyme, plays a critical role in the integration of two of these molecular programs: the retinoid and Hedgehog pathways. Retinoids 203-211 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 72-77 26047326-9 2015 Our data suggest that stromal CYP26 activity creates retinoid low sanctuaries in the BM that protect AML cells from systemic atRA therapy. Retinoids 53-61 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 30-35 25492813-12 2015 These data support the role of CYP26A1 to clear bioactive retinoids, and suggest that the enzyme forming active 4-oxo-atRA may be important in modulating retinoid action. Retinoids 58-67 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 31-38 25492813-0 2015 Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Retinoids 128-137 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 13-20 25492813-0 2015 Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Retinoids 128-137 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 68-75 25492813-3 2015 Hence, CYP26A1, the main atRA hydroxylase, may function either to deplete bioactive retinoids or to form active metabolites. Retinoids 84-93 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 7-14 25492813-12 2015 These data support the role of CYP26A1 to clear bioactive retinoids, and suggest that the enzyme forming active 4-oxo-atRA may be important in modulating retinoid action. Retinoids 58-66 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 31-38 24043786-9 2013 Accordingly, we found that bone marrow stromal cell CYP26 was also able to inactivate retinoids in serum, preventing RA signaling. Retinoids 86-95 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 52-57 25236354-6 2014 PCR analysis revealed a significant upregulation of retinoid-regulated genes such as CYP26A1 and STRA6 in LRAT KD cells, suggesting their possible involvement in mediating retinoid resistance in melanoma cells. Retinoids 52-60 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 85-92 25236354-6 2014 PCR analysis revealed a significant upregulation of retinoid-regulated genes such as CYP26A1 and STRA6 in LRAT KD cells, suggesting their possible involvement in mediating retinoid resistance in melanoma cells. Retinoids 172-180 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 85-92 20658618-6 2010 RESULTS: Treatment of NB cells with retinoids induced expression of several genes including the retinoid metabolizing enzymes CYP26A1 and CYP26B1. Retinoids 36-45 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 126-133 20606468-1 2011 AIM: The cytochrome P450 enzymes of the CYP26 family are involved in the catabolism of the biologically active retinoid all-trans-retinoic acid (atRA). Retinoids 111-119 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 40-45 20606468-9 2011 Inhibition of this loop with a CYP26 inhibitor increased retinoid signaling. Retinoids 57-65 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 31-36 20682464-7 2010 The results support a cooperative model in which the functioning of multiple RAREs may account for the strong inducibility of CYP26A1 in liver, which, in turn, may be important physiologically for restoring retinoid homeostasis when the concentration of RA rises. Retinoids 207-215 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 126-133 23071109-13 2012 The stereoselectivity observed in CYP26A1 function will aid in better understanding of the active site features of the enzyme and the disposition of biologically active retinoids. Retinoids 169-178 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 34-41 22542753-7 2012 HepaRG hepatocytes were also shown to up-regulate the expression of CYP26A1 mRNA in response to retinoid treatment. Retinoids 96-104 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 68-75 20658618-6 2010 RESULTS: Treatment of NB cells with retinoids induced expression of several genes including the retinoid metabolizing enzymes CYP26A1 and CYP26B1. Retinoids 36-44 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 126-133 19294396-3 2009 Here, we examined the effects of RA and the CYP26 inhibitors, liarozole and talarozole, on retinoid metabolism and RA-regulated genes in organotypic epidermis. Retinoids 91-99 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 44-49 19294396-0 2009 Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis. Retinoids 128-136 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 50-55 19294396-9 2009 The present study shows that CYP26A1 expression is extremely sensitive to both exogenous RA and increased endogenous RA levels, i.e. due to CYP26 inhibition, and thus an excellent biomarker for retinoid signalling in organotypic epidermis. Retinoids 194-202 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 29-36 19294396-9 2009 The present study shows that CYP26A1 expression is extremely sensitive to both exogenous RA and increased endogenous RA levels, i.e. due to CYP26 inhibition, and thus an excellent biomarker for retinoid signalling in organotypic epidermis. Retinoids 194-202 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 29-34 19147277-8 2009 The effect of EBBP on retinoid-responsive transcription appeared to be limited to genes with the retinoic acid response element (betaRARE) regulatory sequence, such as CYP26A1. Retinoids 22-30 cytochrome P450 family 26 subfamily A member 1 Homo sapiens 168-175