PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15025563-14	2004	Re-expression of these proteins restored calcium- and RA (retinoic acid)-responsive involucrin expression in these cells.	Tretinoin	58-71	involucrin	Homo sapiens	84-94	
9397150-7	1998	A similar pattern was observed for TGase protein, but, RA, which, by itself, reduced INV, markedly enhanced the ability of 1,25(OH)2D3 to raise INV levels, possibly by inhibiting 1,25(OH)2D3-stimulated TGase activity and cross-linking of soluble INV into the insoluble cornified envelope (CE).	Tretinoin	55-57	involucrin	Homo sapiens	85-88	
9397150-7	1998	A similar pattern was observed for TGase protein, but, RA, which, by itself, reduced INV, markedly enhanced the ability of 1,25(OH)2D3 to raise INV levels, possibly by inhibiting 1,25(OH)2D3-stimulated TGase activity and cross-linking of soluble INV into the insoluble cornified envelope (CE).	Tretinoin	55-57	involucrin	Homo sapiens	144-147	
9397150-7	1998	A similar pattern was observed for TGase protein, but, RA, which, by itself, reduced INV, markedly enhanced the ability of 1,25(OH)2D3 to raise INV levels, possibly by inhibiting 1,25(OH)2D3-stimulated TGase activity and cross-linking of soluble INV into the insoluble cornified envelope (CE).	Tretinoin	55-57	involucrin	Homo sapiens	144-147	
1590919-1	1992	Treatment of the human esophageal cancer cell line EC8712 with retinoic acid (RA) stopped the cell growth significantly and gave rise to terminal differentiation of the cells characterized by increased expression of involucrin gene.	Tretinoin	63-76	involucrin	Homo sapiens	216-226	
8959344-0	1996	Regulation of involucrin gene expression by retinoic acid and glucocorticoids.	Tretinoin	44-57	involucrin	Homo sapiens	14-24	
8959344-3	1996	Dexamethasone enhanced, and retinoic acid decreased, endogenous involucrin mRNA expression in cells treated with these ligands.	Tretinoin	28-41	involucrin	Homo sapiens	64-74	
8959344-4	1996	Functional interactions between each ligand were observed; all-trans or 9-cis retinoic acid reduced dexamethasone enhancement of involucrin expression.	Tretinoin	78-91	involucrin	Homo sapiens	129-139	
8959344-11	1996	Based on these data, we suggest that suppression of involucrin promoter activity by retinoic acid may be mediated through interaction with the AP1 transcriptional complex.	Tretinoin	84-97	involucrin	Homo sapiens	52-62	
1590919-1	1992	Treatment of the human esophageal cancer cell line EC8712 with retinoic acid (RA) stopped the cell growth significantly and gave rise to terminal differentiation of the cells characterized by increased expression of involucrin gene.	Tretinoin	78-80	involucrin	Homo sapiens	216-226	
2463259-8	1989	In normal epidermal cells, the suppressive effect of retinoic acid was much more evident with particulate transglutaminase than involucrin levels.	Tretinoin	53-66	involucrin	Homo sapiens	128-138	
1675998-9	1991	In contrast, retinoic acid suppressed in these cells the level of involucrin, transglutaminase Type I, and SQ37 mRNA.	Tretinoin	13-26	involucrin	Homo sapiens	66-76	
19120344-8	2009	RESULTS: RA induced HB-EGF and involucrin expression in a concentration-dependent manner, whereas it inhibited keratin 10 expression.	Tretinoin	9-11	involucrin	Homo sapiens	31-41	
19120344-10	2009	However, when R115866 was combined with low concentrations of RA, HB-EGF and involucrin expression was induced.	Tretinoin	62-64	involucrin	Homo sapiens	77-87