PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24635079-8 2014 ATRA also induced G1 cell-cycle arrest, inhibited the expression of cyclin D1/cyclin-dependent kinase (CDK)4 and cyclinE/CDK2, and increased the expression of the cyclin-dependent kinase inhibitors p21 and p27. Tretinoin 0-4 interferon alpha inducible protein 27 Homo sapiens 206-209 24646031-3 2014 In many cases, downregulation of CDK activity by ATRA and vitamin D3 is a result of elevated p21- and p27-bound CDKs. Tretinoin 49-53 interferon alpha inducible protein 27 Homo sapiens 102-105 28656276-7 2017 Further investigations indicated that with ATRA-induced expression of RIG-I, levels of phosphorylated (p)AKT-Thr308 and pForkhead Box (FOX) O3A-Thr32 were decreased, the expression levels of cell cycle arrest protein p27 and the apoptotic protein, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), directly transcribed by FOXO3A were increased. Tretinoin 43-47 interferon alpha inducible protein 27 Homo sapiens 217-220 28656276-8 2017 By contrast, following the knockdown of ATRA-induced expression of RIG-I, the levels of pAKT-Thr308 and pFOXO3A-Thr32 were increased, and the protein expression levels of p27 and TRAIL were decreased. Tretinoin 40-44 interferon alpha inducible protein 27 Homo sapiens 171-174 24851929-4 2014 The purpose of this study is to examine whether Cdk5 is involved in ATRA-induced growth arrest of the castration-resistant cancer cell line DU145 through up-regulating Cdk inhibitor protein, p27. Tretinoin 68-72 interferon alpha inducible protein 27 Homo sapiens 191-194 25520935-5 2014 Also, the common cell cycle inhibiting protein, p27, and the new cell cycle regulator, Cdk5, are involved in retinoic acid"s effects. Tretinoin 109-122 interferon alpha inducible protein 27 Homo sapiens 48-51 24851929-7 2014 RESULTS: ATRA treatment inhibited DU145 cell proliferation and significantly increased p27 expression through Cdk5 up-regulation. Tretinoin 9-13 interferon alpha inducible protein 27 Homo sapiens 87-90 24851929-8 2014 Immunocytochemical data showed that a Cdk5 inhibitor reduced ATRA-triggered nuclear distribution of p27 in DU145 cells. Tretinoin 61-65 interferon alpha inducible protein 27 Homo sapiens 100-103 24851929-10 2014 CONCLUSIONS: Our results demonstrate that ATRA induced growth inhibition in castration-resistant prostate cancer cells through activating Cdk5 and p27. Tretinoin 42-46 interferon alpha inducible protein 27 Homo sapiens 147-150 23489885-8 2013 Furthermore, Retinoic acid (RA) treatment confirmed the expression of the multipotent differentiation markers in the SP cells, including TUJ1, pancytokeratin, glial fibrillary acidic protein (GFAP), and p27(Kip1). Tretinoin 13-26 interferon alpha inducible protein 27 Homo sapiens 203-206 23489885-8 2013 Furthermore, Retinoic acid (RA) treatment confirmed the expression of the multipotent differentiation markers in the SP cells, including TUJ1, pancytokeratin, glial fibrillary acidic protein (GFAP), and p27(Kip1). Tretinoin 28-30 interferon alpha inducible protein 27 Homo sapiens 203-206 15492811-0 2004 Expression of p27 and MAPK proteins involved in all-trans retinoic acid-induced apoptosis and cell cycle arrest in matched primary and metastatic melanoma cells. Tretinoin 58-71 interferon alpha inducible protein 27 Homo sapiens 14-17 23518499-6 2013 CDK1 modulates the levels of P27(kip) and AKT phosphorylation in response to ATRA treatment. Tretinoin 77-81 interferon alpha inducible protein 27 Homo sapiens 29-37 21383690-4 2011 RA treatment rapidly induced morphology changes, induced growth arrest at G1/G0 to S transition, decreased cyclin D1 expression and increased p27 expression. Tretinoin 0-2 interferon alpha inducible protein 27 Homo sapiens 142-145 20170512-6 2010 1) The evidence indicated that 4-hydroxytamoxifen, dexamethasone, and various retinoic acids up-regulated expression of p27 in both estrogen receptor-positive and negative human breast cancer cells in vitro. Tretinoin 78-92 interferon alpha inducible protein 27 Homo sapiens 120-123 20170512-11 2010 Retinoic acids up-regulated expression of p27 without using either 4E-BP1 or RTKs/PI3K/Akt/AMPK/mTOR protein kinase signaling pathways. Tretinoin 0-14 interferon alpha inducible protein 27 Homo sapiens 42-45 20170512-13 2010 Retinoic acids also up-regulated translation initiation of p27, but without using any of these pathways. Tretinoin 0-14 interferon alpha inducible protein 27 Homo sapiens 59-62 20193324-11 2009 The expression of p27(Kip1) and p21(Waf1) in myeloma cells was up-regulated by RGZ and this change was more apparent when RGZ was used in combination with ATRA. Tretinoin 155-159 interferon alpha inducible protein 27 Homo sapiens 18-21 19035179-6 2008 Western blot displayed that ATRA could decrease the expression of cyclin A, up-regulate the expression of p21 and p27, and down-regulate the expression of p27 related proteins Skp2. Tretinoin 28-32 interferon alpha inducible protein 27 Homo sapiens 114-117 19035179-6 2008 Western blot displayed that ATRA could decrease the expression of cyclin A, up-regulate the expression of p21 and p27, and down-regulate the expression of p27 related proteins Skp2. Tretinoin 28-32 interferon alpha inducible protein 27 Homo sapiens 155-158 16752155-3 2007 RA treatment resulted in an increase of p21, p27 and p53 protein levels and G1 arrest in UM cells, which correlated with significant down-modulation of surface Her2/neu proto-oncogene expression. Tretinoin 0-2 interferon alpha inducible protein 27 Homo sapiens 45-48 15695403-3 2005 RA induces cell accumulation in G(0)-G(1) together with a marked up-regulation of p27(Kip1) by inhibiting ubiquitination and proteasome-dependent degradation of the protein. Tretinoin 0-2 interferon alpha inducible protein 27 Homo sapiens 82-85 15695403-5 2005 Most of RA-induced p27(Kip1) was bound to cyclin D1/cyclin-dependent kinase 4 complexes, probably contributing to the decreased cyclin-dependent kinase 4 kinase activity and pRb hypophosphorylation observed in RA-treated cells. Tretinoin 8-10 interferon alpha inducible protein 27 Homo sapiens 19-22 15695403-5 2005 Most of RA-induced p27(Kip1) was bound to cyclin D1/cyclin-dependent kinase 4 complexes, probably contributing to the decreased cyclin-dependent kinase 4 kinase activity and pRb hypophosphorylation observed in RA-treated cells. Tretinoin 210-212 interferon alpha inducible protein 27 Homo sapiens 19-22 15492811-1 2004 We investigated whether p27 and mitogen-activated protein kinase (MAPK) proteins were involved in all-trans retinoic acid (atRA)-induced apoptosis and cell cycle arrest. Tretinoin 108-121 interferon alpha inducible protein 27 Homo sapiens 24-27 15492811-1 2004 We investigated whether p27 and mitogen-activated protein kinase (MAPK) proteins were involved in all-trans retinoic acid (atRA)-induced apoptosis and cell cycle arrest. Tretinoin 123-127 interferon alpha inducible protein 27 Homo sapiens 24-27 15492811-9 2004 These data indicate that up-regulation of p27 and down-regulation of MAPK proteins were involved in atRA-induced apoptosis and cell cycle arrest in melanoma. Tretinoin 100-104 interferon alpha inducible protein 27 Homo sapiens 42-45 12955881-4 2003 We demonstrate that RA induces growth arrest and differentiation in HepG2 cells by influencing the activities of cyclin-cdk complexes involved in the regulation of G1/S transition and S-phase progression, in particular by modifying the binding of these complexes to p21 and p27 inhibitors. Tretinoin 20-22 interferon alpha inducible protein 27 Homo sapiens 274-277 15256728-3 2004 The expression of p21 and p27 among the CDK inhibitors we examined increased during the differentiation induced with ATRA. Tretinoin 117-121 interferon alpha inducible protein 27 Homo sapiens 26-29 15256728-6 2004 These results suggest that increased expression of CDK inhibitors, p21 and p27, is necessary for the differentiation of HL-60 cells induced with ATRA. Tretinoin 145-149 interferon alpha inducible protein 27 Homo sapiens 75-78 14980522-0 2004 Retinoic acid causes cell growth arrest and an increase in p27 in F9 wild type but not in F9 retinoic acid receptor beta2 knockout cells. Tretinoin 0-13 interferon alpha inducible protein 27 Homo sapiens 59-62 14980522-5 2004 In F9 Wt cells, cyclin D1, D3, and cyclin E protein levels decreased, while cyclin D2 and p27 levels increased after RA treatment. Tretinoin 117-119 interferon alpha inducible protein 27 Homo sapiens 90-93 14980522-9 2004 Moreover, RA increased the half-life of p27 protein in F9 Wt cells. Tretinoin 10-12 interferon alpha inducible protein 27 Homo sapiens 40-43 14980522-11 2004 Using both genetic and molecular approaches, we have identified some of the molecular mechanisms, such as the large elevation of p27, through which RARbeta(2) mediates these growth inhibitory effects of RA in F9 cells. Tretinoin 148-150 interferon alpha inducible protein 27 Homo sapiens 129-132 11877298-0 2002 Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27(Kip1). Tretinoin 0-13 interferon alpha inducible protein 27 Homo sapiens 177-180 12421932-5 2002 The presence of atRA led to elevated levels of cyclin D3, -E, and -A, decreased levels of p27(Kip1), increased activity of cyclin-dependent kinase 2, and enhanced phosphorylation of the retinoblastoma protein (pRB). Tretinoin 16-20 interferon alpha inducible protein 27 Homo sapiens 90-93 12186376-4 2002 The cell lines (MCF-7, T-47D, ZR-75-1), which expressed both BRCA1 and p27, were extremely sensitive to the inhibitory effect of the combination of TGZ and either ATRA or 9-cis-RA (ED90, 2-5 x 10(-11) M). Tretinoin 163-167 interferon alpha inducible protein 27 Homo sapiens 71-74 12186376-4 2002 The cell lines (MCF-7, T-47D, ZR-75-1), which expressed both BRCA1 and p27, were extremely sensitive to the inhibitory effect of the combination of TGZ and either ATRA or 9-cis-RA (ED90, 2-5 x 10(-11) M). Tretinoin 171-179 interferon alpha inducible protein 27 Homo sapiens 71-74 12012012-7 2002 Our results indicate that ATRA-pretreatment modified the CDDP-induced regulation of CDK2 activity by the CDK inhibitors p21 and p27. Tretinoin 26-30 interferon alpha inducible protein 27 Homo sapiens 128-131 11877298-8 2002 These results thus identify a decrease in c-Myc and cyclin E levels and a posttranscriptional up-regulation of p27(Kip1) as important early changes, and position them in the complex chain of events regulating ATRA-induced cell cycle arrest of myeloid cells. Tretinoin 209-213 interferon alpha inducible protein 27 Homo sapiens 111-114 11595732-4 2001 We found a striking difference between these cells in that while ATRA induces an elevation in the cdk inhibitor p27 in T-47D cells, this is not observed in the ATRA-resistant MCF-7 cells. Tretinoin 65-69 interferon alpha inducible protein 27 Homo sapiens 112-115 11595732-5 2001 Furthermore, we demonstrate that ATRA promotes the ubiquitylation of Skp2, an F-box protein that targets p27 for degradation. Tretinoin 33-37 interferon alpha inducible protein 27 Homo sapiens 105-108 11464914-5 2001 Within 24 hr of RA treatment, there was a 4-fold increase in the expression of p27Kip1, although p27 mRNA levels were unchanged. Tretinoin 16-18 interferon alpha inducible protein 27 Homo sapiens 79-82 11478839-0 2001 Retinoic acid- and bone morphogenetic protein 4-induced apoptosis in P19 embryonal carcinoma cells requires p27. Tretinoin 0-13 interferon alpha inducible protein 27 Homo sapiens 108-111 11478839-8 2001 In contrast, RA and BMP4 induce the Cdk inhibitor p27. Tretinoin 13-15 interferon alpha inducible protein 27 Homo sapiens 50-53 11478839-13 2001 These data support the hypothesis that RA and BMP4 together induce the p27 protein leading to Rb activation and ultimately apoptosis. Tretinoin 39-41 interferon alpha inducible protein 27 Homo sapiens 71-74 11063125-0 2000 Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27. Tretinoin 0-13 interferon alpha inducible protein 27 Homo sapiens 155-158 11063125-2 2000 In the present study, we provide a functional link between RA and p27 function in the control of neuronal differentiation in NT2/D1 cells. Tretinoin 59-61 interferon alpha inducible protein 27 Homo sapiens 66-69 11063125-3 2000 We report that RA enhances p27 expression, which results in increased association with cyclin E/cyclin-dependent kinase 2 complexes and suppression of their activity; however, antisense clones, which have greatly reduced RA-dependent p27 inducibility (NT2-p27AS), continue to synthesize DNA and are unable to differentiate properly in response to RA as determined by lack of neurite outgrowth and by the failure to modify surface antigens. Tretinoin 15-17 interferon alpha inducible protein 27 Homo sapiens 27-30 11063125-4 2000 As to the mechanism involved in RA-dependent p27 upregulation, our data support the concept that RA reduces p27 protein degradation through the ubiquitin/proteasome-dependent pathway. Tretinoin 32-34 interferon alpha inducible protein 27 Homo sapiens 45-48 11063125-4 2000 As to the mechanism involved in RA-dependent p27 upregulation, our data support the concept that RA reduces p27 protein degradation through the ubiquitin/proteasome-dependent pathway. Tretinoin 32-34 interferon alpha inducible protein 27 Homo sapiens 108-111 11063125-4 2000 As to the mechanism involved in RA-dependent p27 upregulation, our data support the concept that RA reduces p27 protein degradation through the ubiquitin/proteasome-dependent pathway. Tretinoin 97-99 interferon alpha inducible protein 27 Homo sapiens 45-48 11063125-4 2000 As to the mechanism involved in RA-dependent p27 upregulation, our data support the concept that RA reduces p27 protein degradation through the ubiquitin/proteasome-dependent pathway. Tretinoin 97-99 interferon alpha inducible protein 27 Homo sapiens 108-111 10090931-0 1999 1,25-Dihydroxyvitamin D3 induces differentiation of a retinoic acid-resistant acute promyelocytic leukemia cell line (UF-1) associated with expression of p21(WAF1/CIP1) and p27(KIP1). Tretinoin 54-67 interferon alpha inducible protein 27 Homo sapiens 173-176 10896783-6 2000 Evaluation of the kinase activity of cyclin-Cdk complexes showed that RA increases p27(Kip1) expression in CH27 cells leading to markedly reduced cyclin A/Cdk2 kinase activity and slightly reduced cyclin E/Cdk2 kinase activity, with no effect on cyclin D/Cdk4 and cyclin D/Cdk6 activities. Tretinoin 70-72 interferon alpha inducible protein 27 Homo sapiens 83-86 10896783-0 2000 Retinoic acid-mediated G1 arrest is associated with induction of p27(Kip1) and inhibition of cyclin-dependent kinase 3 in human lung squamous carcinoma CH27 cells. Tretinoin 0-13 interferon alpha inducible protein 27 Homo sapiens 65-68 10896783-3 2000 Here we report that RA mediated the dose- and time-dependent growth arrest in G1 phase, accompanied by the up-regulation of p27(Kip1) and the down-regulation of the cyclin-dependent kinase 3 (Cdk3) and p21(CIP1/Waf1) proteins. Tretinoin 20-22 interferon alpha inducible protein 27 Homo sapiens 124-127 10090931-14 1999 Interestingly, the combination of 1, 25(OH)2D3 and RA markedly enhanced the levels of p27(KIP1) transcript and protein as compared with levels induced by 1, 25(OH)2D3 alone. Tretinoin 51-53 interferon alpha inducible protein 27 Homo sapiens 86-89 9366521-8 1997 Interestingly, when U343 cells are growth arrested by p16, p21 or p27 induction and treated simultaneously with RA, a dramatic morphological change occurs, cells acquiring multiple long, tapering processes reminiscent of primary astrocytes. Tretinoin 112-114 interferon alpha inducible protein 27 Homo sapiens 66-69