PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30733805-6 2019 Much emphasis has been placed on the ALDH1A1 and ALDH1A3 members of the ALDH1 family of cytosolic enzymes required for RA biosynthesis. Tretinoin 119-121 aldehyde dehydrogenase 1 family member A1 Homo sapiens 37-44 30292490-0 2019 Expression of retinoic acid signaling components ADH7 and ALDH1A1 is reduced in aniridia limbal epithelial cells and a siRNA primary cell based aniridia model. Tretinoin 14-27 aldehyde dehydrogenase 1 family member A1 Homo sapiens 58-65 30292490-20 2019 These results provide evidence that PAX6 might drive corneal epithelial differentiation by direct or indirect control of retinoic acid signaling processes through ADH7 and ALDH1A1. Tretinoin 121-134 aldehyde dehydrogenase 1 family member A1 Homo sapiens 172-179 29948941-3 2019 ALDH1A1 is also a major regulator of retinoic acid (RA) signaling, which is critical for normal brain homeostasis. Tretinoin 37-50 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-7 29948941-3 2019 ALDH1A1 is also a major regulator of retinoic acid (RA) signaling, which is critical for normal brain homeostasis. Tretinoin 52-54 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-7 30709378-0 2019 Correction to: Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1alpha/VEGF signalling in MCF-7 breast cancer cells. Tretinoin 71-84 aldehyde dehydrogenase 1 family member A1 Homo sapiens 31-38 30541574-0 2018 Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1alpha/VEGF signalling in MCF-7 breast cancer cells. Tretinoin 56-69 aldehyde dehydrogenase 1 family member A1 Homo sapiens 16-23 30541574-15 2018 CONCLUSION: In breast tumors, ALDH1A1 expression primes a permissive microenvironment by promoting tumor angiogenesis via retinoic acid dependent mechanism. Tretinoin 122-135 aldehyde dehydrogenase 1 family member A1 Homo sapiens 30-37 27157616-8 2016 Finally, 2 weeks of daily ATRA treatment were sufficient to inhibit gastric tumor progression in vivo, which was associated with a decrease in CD44, ALDH1, Ki67 and PCNA expression in the remaining tumor cells. Tretinoin 26-30 aldehyde dehydrogenase 1 family member A1 Homo sapiens 149-154 30409702-1 2018 The retinaldehyde dehydrogenase (RALDH) enzymes, RALDH1, RALDH2, and RALDH3, catalyze the irreversible oxidation of retinaldehyde to all-trans-retinoic acid (ATRA). Tretinoin 137-156 aldehyde dehydrogenase 1 family member A1 Homo sapiens 49-55 28677722-2 2017 Enzymes that catalyze the oxidation of retinol to generate atRA, including aldehyde dehydrogenase 1 family (ALDH1)A1, ALDH1A2 and ALDH1A3, exhibit complex expression patterns at different stages of renal development. Tretinoin 59-63 aldehyde dehydrogenase 1 family member A1 Homo sapiens 108-113 28677722-4 2017 In this study, we provide in vitro evidence to demonstrate that Wilms" tumor 1 (WT1) negatively regulates the expression of the atRA synthetic enzymes, ALDH1A1, ALDH1A2 and ALDH1A3, in the 293 cell line, leading to significant blockage of atRA production. Tretinoin 128-132 aldehyde dehydrogenase 1 family member A1 Homo sapiens 152-159 28783931-1 2017 Objective: Retinal dehydrogenase 1 (RALDH1) is a cytosolic enzyme which acts both as a source of retinoic acid (RA) and as a detoxification enzyme. Tretinoin 97-110 aldehyde dehydrogenase 1 family member A1 Homo sapiens 11-34 28783931-1 2017 Objective: Retinal dehydrogenase 1 (RALDH1) is a cytosolic enzyme which acts both as a source of retinoic acid (RA) and as a detoxification enzyme. Tretinoin 97-110 aldehyde dehydrogenase 1 family member A1 Homo sapiens 36-42 28783931-1 2017 Objective: Retinal dehydrogenase 1 (RALDH1) is a cytosolic enzyme which acts both as a source of retinoic acid (RA) and as a detoxification enzyme. Tretinoin 36-38 aldehyde dehydrogenase 1 family member A1 Homo sapiens 11-34 28087752-6 2017 Localisation of RA synthetic (RALDH-1) and degrading (cytochrome P450 subfamily 26 A1 (CYP26A1)) enzymes in human lung was determined by immunofluorescence. Tretinoin 16-18 aldehyde dehydrogenase 1 family member A1 Homo sapiens 30-37 30409702-1 2018 The retinaldehyde dehydrogenase (RALDH) enzymes, RALDH1, RALDH2, and RALDH3, catalyze the irreversible oxidation of retinaldehyde to all-trans-retinoic acid (ATRA). Tretinoin 158-162 aldehyde dehydrogenase 1 family member A1 Homo sapiens 49-55 30166520-11 2018 Second, all-trans retinoic acid (ATRA) suppressed ALDH1 expression, inhibiting NRF2 activation, which led to the attenuation of CSC-like properties in ALDH-H cells but not in ALDH-L cells. Tretinoin 8-31 aldehyde dehydrogenase 1 family member A1 Homo sapiens 50-55 30166520-11 2018 Second, all-trans retinoic acid (ATRA) suppressed ALDH1 expression, inhibiting NRF2 activation, which led to the attenuation of CSC-like properties in ALDH-H cells but not in ALDH-L cells. Tretinoin 33-37 aldehyde dehydrogenase 1 family member A1 Homo sapiens 50-55 28423611-5 2017 ALDH1A3, as well as other members of the ALDH1 subfamily, can function in cells as a retinaldehyde dehydrogenase to generate retinoic acid (RA) from retinal. Tretinoin 125-138 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-5 27443528-11 2016 ATRA treatment led to downregulation of the ALDH1A1, P-gp and BCRP proteins. Tretinoin 0-4 aldehyde dehydrogenase 1 family member A1 Homo sapiens 44-51 27724856-2 2016 The subfamily of aldehyde dehydrogenases 1 (ALDH1) isoenzymes, which comprises ALDH1A1, ALDH1A2, and ALDH1A3, is involved in the synthesis of retinoic acid, and has been identified as functional stem cell markers in diverse cancers. Tretinoin 142-155 aldehyde dehydrogenase 1 family member A1 Homo sapiens 17-42 27724856-2 2016 The subfamily of aldehyde dehydrogenases 1 (ALDH1) isoenzymes, which comprises ALDH1A1, ALDH1A2, and ALDH1A3, is involved in the synthesis of retinoic acid, and has been identified as functional stem cell markers in diverse cancers. Tretinoin 142-155 aldehyde dehydrogenase 1 family member A1 Homo sapiens 44-49 27724856-2 2016 The subfamily of aldehyde dehydrogenases 1 (ALDH1) isoenzymes, which comprises ALDH1A1, ALDH1A2, and ALDH1A3, is involved in the synthesis of retinoic acid, and has been identified as functional stem cell markers in diverse cancers. Tretinoin 142-155 aldehyde dehydrogenase 1 family member A1 Homo sapiens 79-86 25742746-0 2015 All-trans retinoic acid downregulates ALDH1-mediated stemness and inhibits tumour formation in ovarian cancer cells. Tretinoin 10-23 aldehyde dehydrogenase 1 family member A1 Homo sapiens 38-43 26305673-9 2015 In conclusion, ALDH1 expression in tumor-associated stromal cells indicates reduced BrCa progression, possibly via RA secretion. Tretinoin 115-117 aldehyde dehydrogenase 1 family member A1 Homo sapiens 15-20 27107124-1 2016 UNLABELLED: A novel bacterial aldehyde dehydrogenase (ALDH) that converts retinal to retinoic acid was first identified in Bacillus cereus The amino acid sequence of ALDH from B. cereus (BcALDH) was more closely related to mammalian ALDHs than to bacterial ALDHs. Tretinoin 85-98 aldehyde dehydrogenase 1 family member A1 Homo sapiens 54-58 27107124-1 2016 UNLABELLED: A novel bacterial aldehyde dehydrogenase (ALDH) that converts retinal to retinoic acid was first identified in Bacillus cereus The amino acid sequence of ALDH from B. cereus (BcALDH) was more closely related to mammalian ALDHs than to bacterial ALDHs. Tretinoin 85-98 aldehyde dehydrogenase 1 family member A1 Homo sapiens 166-170 27107124-2 2016 This enzyme converted not only small aldehydes to carboxylic acids but also the large aldehyde all-trans-retinal to all-trans-retinoic acid with NAD(P)(+) We newly found that BcALDH and human ALDH (ALDH1A1) could reduce all-trans-retinal to all-trans-retinol with NADPH. Tretinoin 120-139 aldehyde dehydrogenase 1 family member A1 Homo sapiens 177-181 27107124-2 2016 This enzyme converted not only small aldehydes to carboxylic acids but also the large aldehyde all-trans-retinal to all-trans-retinoic acid with NAD(P)(+) We newly found that BcALDH and human ALDH (ALDH1A1) could reduce all-trans-retinal to all-trans-retinol with NADPH. Tretinoin 120-139 aldehyde dehydrogenase 1 family member A1 Homo sapiens 198-205 27107124-9 2016 IMPORTANCE: Although mammalian ALDHs have catalyzed the conversion of retinal to retinoic acid with NAD(P)(+) as a cofactor, a bacterial ALDH involved in the conversion is first characterized. Tretinoin 81-94 aldehyde dehydrogenase 1 family member A1 Homo sapiens 31-35 27107124-10 2016 The biotransformation of all-trans-retinal to all-trans-retinoic acid by BcALDH and human ALDH was altered to the biotransformation to all-trans-retinol by a cofactor switch using NADPH. Tretinoin 46-69 aldehyde dehydrogenase 1 family member A1 Homo sapiens 75-79 24285572-6 2015 Proteomics tentatively identified this protein as aldehyde dehydrogenase 1A1 (ALDH1A1), a key enzyme regulating retinoic acid synthesis, and ALDH1A1 protein deficiency in GDFs was confirmed by Western blot. Tretinoin 112-125 aldehyde dehydrogenase 1 family member A1 Homo sapiens 50-76 24285572-6 2015 Proteomics tentatively identified this protein as aldehyde dehydrogenase 1A1 (ALDH1A1), a key enzyme regulating retinoic acid synthesis, and ALDH1A1 protein deficiency in GDFs was confirmed by Western blot. Tretinoin 112-125 aldehyde dehydrogenase 1 family member A1 Homo sapiens 78-85 25793304-13 2015 Taken together, these results suggest that RALDH1 and 2 may play a role in the regulation of postnatal ocular growth in humans through the synthesis of atRA. Tretinoin 152-156 aldehyde dehydrogenase 1 family member A1 Homo sapiens 43-55 25742746-2 2015 Here, we investigated the ALDH1-regulated function and its underlying signalling and tested whether all-trans retinoic acid (ATRA) can suppress ALDH1-regulated tumour behaviour in ovarian cancer cells. Tretinoin 110-123 aldehyde dehydrogenase 1 family member A1 Homo sapiens 144-149 25742746-2 2015 Here, we investigated the ALDH1-regulated function and its underlying signalling and tested whether all-trans retinoic acid (ATRA) can suppress ALDH1-regulated tumour behaviour in ovarian cancer cells. Tretinoin 125-129 aldehyde dehydrogenase 1 family member A1 Homo sapiens 144-149 25742746-8 2015 We conclude that ATRA downregulates ALDH1/FoxM1/Notch1 signalling and suppresses tumour formation in ovarian cancer cells. Tretinoin 17-21 aldehyde dehydrogenase 1 family member A1 Homo sapiens 36-41 25502770-3 2015 While ALDH1A1, ALDH1A2, and ALDH1A3 all form RA, the expression pattern and relative contribution of these enzymes to RA formation in the testis is unknown. Tretinoin 45-47 aldehyde dehydrogenase 1 family member A1 Homo sapiens 6-13 25502770-7 2015 In the absence of cellular retinol binding protein (CRBP)1, ALDH1A1 was predicted to be the main contributor to intratesticular RA formation, but when CRBP1 was present, ALDH1A2 was predicted to be equally important in RA formation as ALDH1A1. Tretinoin 128-130 aldehyde dehydrogenase 1 family member A1 Homo sapiens 60-67 25230277-6 2014 The activation of NEK2 in myeloma cells relied on the ALDH1A1-dependent generation of the retinoid X receptor alpha (RXRalpha) ligand, 9-cis retinoic acid (9CRA) - not the retinoic acid receptor alpha (RARalpha) ligand, all-trans retinoic acid (ATRA). Tretinoin 141-154 aldehyde dehydrogenase 1 family member A1 Homo sapiens 54-61 25427913-6 2015 RA is synthesized from retinaldehyde by the retinaldehyde dehydrogenases, specifically ALDH1A1, ALDH1A2, ALDH1A3, and ALDH8A1. Tretinoin 0-2 aldehyde dehydrogenase 1 family member A1 Homo sapiens 87-94 25230277-6 2014 The activation of NEK2 in myeloma cells relied on the ALDH1A1-dependent generation of the retinoid X receptor alpha (RXRalpha) ligand, 9-cis retinoic acid (9CRA) - not the retinoic acid receptor alpha (RARalpha) ligand, all-trans retinoic acid (ATRA). Tretinoin 245-249 aldehyde dehydrogenase 1 family member A1 Homo sapiens 54-61 24594504-2 2014 We focus on the characterization of the aldehyde dehydrogenase-1 family of enzymes (ALDH1A1, ALDH1A2, ALDH1A3) that catalyze conversion of retinaldehyde to retinoic acid. Tretinoin 156-169 aldehyde dehydrogenase 1 family member A1 Homo sapiens 84-91 24887554-9 2014 We show that the ALDH1A1 isoform, through its function in the retinoic acid metabolism, affects the proliferation and/or early differentiation of stem/progenitor cells and is important for branching morphogenesis. Tretinoin 62-75 aldehyde dehydrogenase 1 family member A1 Homo sapiens 17-24 24524833-5 2014 INTERVENTION(S): Measurement of the three enzymes necessary for retinoic acid biosynthesis, aldehyde dehydrogenase (ALDH) 1A1, 1A2, and 1A3, in testicular tissue by a novel liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) peptide assay. Tretinoin 64-77 aldehyde dehydrogenase 1 family member A1 Homo sapiens 92-125 24374552-0 2014 Aldehyde dehydrogenase 1 activity in the developing human pancreas modulates retinoic acid signalling in mediating islet differentiation and survival. Tretinoin 77-90 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-24 24374552-1 2014 AIMS/HYPOTHESIS: Aldehyde dehydrogenase 1 (ALDH1), a human stem-cell marker, is an enzyme responsible for converting retinaldehydes to retinoic acids (RAs) to modulate cell differentiation. Tretinoin 135-149 aldehyde dehydrogenase 1 family member A1 Homo sapiens 17-41 24374552-1 2014 AIMS/HYPOTHESIS: Aldehyde dehydrogenase 1 (ALDH1), a human stem-cell marker, is an enzyme responsible for converting retinaldehydes to retinoic acids (RAs) to modulate cell differentiation. Tretinoin 135-149 aldehyde dehydrogenase 1 family member A1 Homo sapiens 43-48 23236537-1 2013 ALDH1A1 metabolizes a variety of endogenous and exogenous aldehyde, and also oxidizes retinol to synthesize retinoic acid and modulate cell differentiation. Tretinoin 108-121 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-7 24080087-2 2013 We provide evidence that the retinoic acid-producing enzyme aldehyde dehydrogenase 1a1 (Aldh1a1) is an oncogene suppressor in specific splenic IgG1(+)/CD19(-) and IgG1(+)/CD19(+) B cell populations. Tretinoin 29-42 aldehyde dehydrogenase 1 family member A1 Homo sapiens 60-86 24080087-2 2013 We provide evidence that the retinoic acid-producing enzyme aldehyde dehydrogenase 1a1 (Aldh1a1) is an oncogene suppressor in specific splenic IgG1(+)/CD19(-) and IgG1(+)/CD19(+) B cell populations. Tretinoin 29-42 aldehyde dehydrogenase 1 family member A1 Homo sapiens 88-95 23957476-6 2013 With this cellular assay, we identified potent selective ALDH1A1 inhibitors to explore the role of retinoic acid production in various preclinical disease models. Tretinoin 99-112 aldehyde dehydrogenase 1 family member A1 Homo sapiens 57-64 23614737-5 2013 The authors demonstrated that ALDH1A1 substrate 9-cis retinal and its corresponding product 9-cis retinoic acid potently induced the accumulation of MITF mRNA, tyrosinase mRNA and melanin. Tretinoin 98-111 aldehyde dehydrogenase 1 family member A1 Homo sapiens 30-37 21514413-6 2011 Aberrantly expressed RA signaling molecules included i) the retinol-binding protein CRBP1, which facilitates cellular retinoid uptake; ii) ALDH1A1, capable of activating RA precursors; iii) the RA-degrading enzyme CYP26B1; and iv) the RA-binding protein FABP5, which can inhibit RA-induced differentiation. Tretinoin 21-23 aldehyde dehydrogenase 1 family member A1 Homo sapiens 139-146 23254580-7 2012 Replicon-harboring cells showed higher expression of retinal dehydrogenase 1 (RALDH-1), which converts retinol to retinoic acid, and the cured cells showed higher expression of retinol-binding protein (RBP), which transports retinol from the liver to target tissues. Tretinoin 114-127 aldehyde dehydrogenase 1 family member A1 Homo sapiens 78-85 21704731-7 2012 Retinoic acid is generated from retinaldehyde in adipose tissue by the aldehyde dehydrogenase-1 family of enzymes (Aldh1). Tretinoin 0-13 aldehyde dehydrogenase 1 family member A1 Homo sapiens 115-120 21704731-8 2012 In this review, we discuss the role of Aldh1 enzymes in the generation of retinoic acid during adipogenesis, in the regulation of the transcriptional network of PPARgamma in a fat-depot-specific manner, and the important contribution of this autocrine pathway in the development of visceral obesity. Tretinoin 74-87 aldehyde dehydrogenase 1 family member A1 Homo sapiens 39-44 21514413-6 2011 Aberrantly expressed RA signaling molecules included i) the retinol-binding protein CRBP1, which facilitates cellular retinoid uptake; ii) ALDH1A1, capable of activating RA precursors; iii) the RA-degrading enzyme CYP26B1; and iv) the RA-binding protein FABP5, which can inhibit RA-induced differentiation. Tretinoin 170-172 aldehyde dehydrogenase 1 family member A1 Homo sapiens 139-146 21514413-6 2011 Aberrantly expressed RA signaling molecules included i) the retinol-binding protein CRBP1, which facilitates cellular retinoid uptake; ii) ALDH1A1, capable of activating RA precursors; iii) the RA-degrading enzyme CYP26B1; and iv) the RA-binding protein FABP5, which can inhibit RA-induced differentiation. Tretinoin 170-172 aldehyde dehydrogenase 1 family member A1 Homo sapiens 139-146 21436255-7 2011 These effects were recovered to some extent either by RA stimulation or overexpression of any of the Aldh1 enzymes in Aldh1a1(-/-) cells arguing that Aldh1a1 plays a dominant role in autocrine RA production. Tretinoin 193-195 aldehyde dehydrogenase 1 family member A1 Homo sapiens 101-106 21436255-7 2011 These effects were recovered to some extent either by RA stimulation or overexpression of any of the Aldh1 enzymes in Aldh1a1(-/-) cells arguing that Aldh1a1 plays a dominant role in autocrine RA production. Tretinoin 193-195 aldehyde dehydrogenase 1 family member A1 Homo sapiens 150-157 21674038-5 2011 Expression of the three RA-synthesising enzymes, ALDH1A1, 2 and 3 in the fetal ovary and testis was equal to or greater than that in the mesonephros at 8-9 weeks gestation, indicating an intrinsic capacity within the gonad to synthesise RA. Tretinoin 237-239 aldehyde dehydrogenase 1 family member A1 Homo sapiens 49-56 19329942-1 2009 Aldehyde dehydrogenase 1 (ALDH1), a detoxifying enzyme responsible for the oxidation of intracellular aldehydes, was shown to have a function in the early differentiation of stem cells, through its function in oxidizing retinol to retinoic acid. Tretinoin 231-244 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-24 19329942-1 2009 Aldehyde dehydrogenase 1 (ALDH1), a detoxifying enzyme responsible for the oxidation of intracellular aldehydes, was shown to have a function in the early differentiation of stem cells, through its function in oxidizing retinol to retinoic acid. Tretinoin 231-244 aldehyde dehydrogenase 1 family member A1 Homo sapiens 26-31 15597079-1 2004 BACKGROUND: Cytosolic aldehyde dehydrogenase (ALDH1A1) is an important enzyme in the metabolism of acetaldehyde and the synthesis of retinoic acid. Tretinoin 133-146 aldehyde dehydrogenase 1 family member A1 Homo sapiens 46-53 17628022-4 2007 This contrasts with our recent findings about the P/D transition in normal primitive hematopoietic cells, where MAT1 degradation proceeds intrinsically together with granulocytic development, in accord with dynamic expression of aldehyde dehydrogenases (ALDHs) 1A1 and 1B1, which catalyze RA synthesis. Tretinoin 289-291 aldehyde dehydrogenase 1 family member A1 Homo sapiens 229-272 17329364-2 2007 Molecular analyses have previously identified the major RA-synthesising (RALDH1-3) and RA-degrading (CYP26A-C1) enzymes as well as other components involved in RA processing (e.g. CRABP). Tretinoin 56-58 aldehyde dehydrogenase 1 family member A1 Homo sapiens 73-79 17167544-1 2006 Retinal dehydrogenase type 1 (RALDH1) catalyzes the oxidation of all-trans and 9-cis retinal to the respective retinoic acids (RAs), whereas another member of the aldehyde dehydrogenase (ALDH) family, the phenobarbital-induced aldehyde dehydrogenase (PB-ALDH), is very poorly active. Tretinoin 111-125 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-28 17167544-1 2006 Retinal dehydrogenase type 1 (RALDH1) catalyzes the oxidation of all-trans and 9-cis retinal to the respective retinoic acids (RAs), whereas another member of the aldehyde dehydrogenase (ALDH) family, the phenobarbital-induced aldehyde dehydrogenase (PB-ALDH), is very poorly active. Tretinoin 111-125 aldehyde dehydrogenase 1 family member A1 Homo sapiens 30-36 17167544-1 2006 Retinal dehydrogenase type 1 (RALDH1) catalyzes the oxidation of all-trans and 9-cis retinal to the respective retinoic acids (RAs), whereas another member of the aldehyde dehydrogenase (ALDH) family, the phenobarbital-induced aldehyde dehydrogenase (PB-ALDH), is very poorly active. Tretinoin 111-125 aldehyde dehydrogenase 1 family member A1 Homo sapiens 31-35 16837774-7 2006 The results show an increased uptake of atROH in intimal SMCs compared to medial SMCs as well as increased expression of the retinoid-metabolizing enzymes retinol dehydrogenase-5 and retinal dehydrogenase-1 and, in conjunction with this gene expression, increased production of all-trans retinoic acid (atRA). Tretinoin 288-301 aldehyde dehydrogenase 1 family member A1 Homo sapiens 183-206 16837774-7 2006 The results show an increased uptake of atROH in intimal SMCs compared to medial SMCs as well as increased expression of the retinoid-metabolizing enzymes retinol dehydrogenase-5 and retinal dehydrogenase-1 and, in conjunction with this gene expression, increased production of all-trans retinoic acid (atRA). Tretinoin 303-307 aldehyde dehydrogenase 1 family member A1 Homo sapiens 183-206 18992716-0 2009 Retinoic acid modulates retinaldehyde dehydrogenase 1 gene expression through the induction of GADD153-C/EBPbeta interaction. Tretinoin 0-13 aldehyde dehydrogenase 1 family member A1 Homo sapiens 24-53 18992716-1 2009 Mammalian class I aldehyde dehydrogenase (ALDH) plays an important role in the biosynthesis of the hormone retinoic acid (RA), which modulates gene expression and cell differentiation. Tretinoin 107-120 aldehyde dehydrogenase 1 family member A1 Homo sapiens 42-46 18992716-1 2009 Mammalian class I aldehyde dehydrogenase (ALDH) plays an important role in the biosynthesis of the hormone retinoic acid (RA), which modulates gene expression and cell differentiation. Tretinoin 122-124 aldehyde dehydrogenase 1 family member A1 Homo sapiens 42-46 18992716-2 2009 RA has been shown to mediate control of human ALDH1 gene expression through modulation of the retinoic acid receptor alpha (RARalpha) and the CCAAT/enhancer binding protein beta (C/EBPbeta). Tretinoin 0-2 aldehyde dehydrogenase 1 family member A1 Homo sapiens 46-51 18992716-7 2009 Treatment with RA increases GADD153 and GADD153-C/EBPbeta interaction resulting in a decreased cellular availability of C/EBPbeta for binding to the Raldh1 CCAAT box. Tretinoin 15-17 aldehyde dehydrogenase 1 family member A1 Homo sapiens 149-155 18992716-8 2009 These data support a model in which high RA levels inhibit Raldh1 gene expression by sequestering C/EBPbeta through its interaction to GADD153. Tretinoin 41-43 aldehyde dehydrogenase 1 family member A1 Homo sapiens 59-65 18502188-6 2008 And during P19 cell neural differentiation induced by all trans-retinoic acid (ATRA) and cell aggregate formation, RALDH1, RALDH2, CYP26A1, and CYP26B1 could be notably upregulated by ATRA, and keeping the high-level expression of RALDH1 and RALDH2 was dependent on the further neural differentiation, but not continuous ATRA induction. Tretinoin 58-77 aldehyde dehydrogenase 1 family member A1 Homo sapiens 115-121 18502188-6 2008 And during P19 cell neural differentiation induced by all trans-retinoic acid (ATRA) and cell aggregate formation, RALDH1, RALDH2, CYP26A1, and CYP26B1 could be notably upregulated by ATRA, and keeping the high-level expression of RALDH1 and RALDH2 was dependent on the further neural differentiation, but not continuous ATRA induction. Tretinoin 79-83 aldehyde dehydrogenase 1 family member A1 Homo sapiens 115-121 18502188-6 2008 And during P19 cell neural differentiation induced by all trans-retinoic acid (ATRA) and cell aggregate formation, RALDH1, RALDH2, CYP26A1, and CYP26B1 could be notably upregulated by ATRA, and keeping the high-level expression of RALDH1 and RALDH2 was dependent on the further neural differentiation, but not continuous ATRA induction. Tretinoin 184-188 aldehyde dehydrogenase 1 family member A1 Homo sapiens 115-121 17916406-4 2007 Our results demonstrate that the only RA isomers detected in RALDH1-expressing or non-expressing cells corresponded to the same steric conformation as the supplied retinoids, indicating a lack of measurable 9-cis/all-trans retinoid-isomerizing activity. Tretinoin 38-40 aldehyde dehydrogenase 1 family member A1 Homo sapiens 61-67 17916406-5 2007 Finally, HeLa cells transfected with RALDH1 derivatives that were retinal isomer-selective in vitro produced only the corresponding RA isomers, establishing these enzymes as useful tools to assess the respective roles of the two RA isomers in vivo. Tretinoin 132-134 aldehyde dehydrogenase 1 family member A1 Homo sapiens 37-43 17407572-13 2007 Lastly, estrogen affects retinoic acid (RA) synthesis and mobilization by regulating expression of CRABP2 and ALDH1A1. Tretinoin 25-38 aldehyde dehydrogenase 1 family member A1 Homo sapiens 110-117 17407572-13 2007 Lastly, estrogen affects retinoic acid (RA) synthesis and mobilization by regulating expression of CRABP2 and ALDH1A1. Tretinoin 40-42 aldehyde dehydrogenase 1 family member A1 Homo sapiens 110-117 16614850-6 2007 The addition of ATRA also exhibited additional inhibitory effects on ALDH activity and increased 4-HC toxicity when added to single siRNA aimed at one of the enzymes. Tretinoin 16-20 aldehyde dehydrogenase 1 family member A1 Homo sapiens 69-73 16614850-7 2007 On the other hand, ATRA had minimal and insignificant additional inhibitory effects on ALDH enzyme activity when added to a combination of siRNAs against both enzymes, but still increased 4-HC toxicity beyond that seen with RNAi-mediated inhibition of both enzymes together. Tretinoin 19-23 aldehyde dehydrogenase 1 family member A1 Homo sapiens 87-91 14506398-1 2003 BACKGROUND: Cytosolic aldehyde dehydrogenase, or ALDH1A1, functions in ethanol detoxification, metabolism of neurotransmitters, and synthesis of retinoic acid. Tretinoin 145-158 aldehyde dehydrogenase 1 family member A1 Homo sapiens 49-56 11306066-4 2001 Simulations of the oxidation of retinol to retinoic acid with mouse ADH4 and human aldehyde dehydrogenase (ALDH1), using rate constants estimated for all steps in the mechanism, suggest that ethanol (50 mM) would modestly decrease production of retinoic acid. Tretinoin 245-258 aldehyde dehydrogenase 1 family member A1 Homo sapiens 107-112 11872149-0 2002 4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal. Tretinoin 91-104 aldehyde dehydrogenase 1 family member A1 Homo sapiens 108-115 11872149-2 2002 Following the reports that two members of the superfamily of aldehyde dehydrogenase (ALDH) enzymes, ALDH1A1 and ALDH1A2, were capable of catalyzing the oxidation of all-trans retinal to all-trans retinoic acid with submicromolar Km values, we initiated an investigation of the ability of 4-(N,N-dipropylamino)benzaldehyde (DPAB) to inhibit the oxidation of retinal by purified mouse and human ALDH1A1. Tretinoin 186-209 aldehyde dehydrogenase 1 family member A1 Homo sapiens 393-400 10191271-1 1999 Mammalian class I aldehyde dehydrogenase (ALDH1) has been implicated as a retinal dehydrogenase in the biosynthesis of retinoic acid, a modulator of gene expression and cell differentiation. Tretinoin 119-132 aldehyde dehydrogenase 1 family member A1 Homo sapiens 42-47 11306054-6 2001 The recombinant xALDH1 protein exhibited both T(3)-binding activity and ALDH activity converting retinal to retinoic acid (RA), which were similar to those of xCTBP purified from liver cytosol. Tretinoin 108-121 aldehyde dehydrogenase 1 family member A1 Homo sapiens 17-21 11306054-6 2001 The recombinant xALDH1 protein exhibited both T(3)-binding activity and ALDH activity converting retinal to retinoic acid (RA), which were similar to those of xCTBP purified from liver cytosol. Tretinoin 123-125 aldehyde dehydrogenase 1 family member A1 Homo sapiens 17-21 11306066-4 2001 Simulations of the oxidation of retinol to retinoic acid with mouse ADH4 and human aldehyde dehydrogenase (ALDH1), using rate constants estimated for all steps in the mechanism, suggest that ethanol (50 mM) would modestly decrease production of retinoic acid. Tretinoin 43-56 aldehyde dehydrogenase 1 family member A1 Homo sapiens 107-112 11151452-1 2000 Retinal dehydrogenase type 1 (RALDH1) is involved in the biosynthesis of retinoic acid (RA), a modulator of gene expression and cell differentiation. Tretinoin 73-86 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-28 11151452-1 2000 Retinal dehydrogenase type 1 (RALDH1) is involved in the biosynthesis of retinoic acid (RA), a modulator of gene expression and cell differentiation. Tretinoin 73-86 aldehyde dehydrogenase 1 family member A1 Homo sapiens 30-36 11151452-1 2000 Retinal dehydrogenase type 1 (RALDH1) is involved in the biosynthesis of retinoic acid (RA), a modulator of gene expression and cell differentiation. Tretinoin 30-32 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-28 10880953-5 2000 Dehydrogenases catalyzing the reversible oxidation/reduction of retinol and retinal are members of either the alcohol dehydrogenase (ADH) or short-chain dehydrogenase/reductase (SDR) enzyme families, whereas dehydrogenases catalyzing the oxidation of retinal to retinoic acid are members of the aldehyde dehydrogenase (ALDH) family. Tretinoin 262-275 aldehyde dehydrogenase 1 family member A1 Homo sapiens 319-323 10191271-12 1999 Thus our results indicate that Aldh1 can function in retinoic acid synthesis under physiological conditions, but that the closely related Aldh-pb does not share this property. Tretinoin 53-66 aldehyde dehydrogenase 1 family member A1 Homo sapiens 31-36 33550205-0 2021 Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin. Tretinoin 30-43 aldehyde dehydrogenase 1 family member A1 Homo sapiens 58-63 1292933-1 1992 The major cytosolic aldehyde dehydrogenase isozyme (ALDH1) exhibits strong activity for oxidation of retinal to retinoic acid, while the major mitochondrial ALDH2 and the stomach cytosolic ALDH3 have no such activity. Tretinoin 112-125 aldehyde dehydrogenase 1 family member A1 Homo sapiens 52-57 1292933-3 1992 Thus, ALDH1 can efficiently produce retinoic acid from retinal in tissues with low retinal concentrations (< 0.01 mumol/l). Tretinoin 36-49 aldehyde dehydrogenase 1 family member A1 Homo sapiens 6-11 1292933-5 1992 These findings suggest that the major physiological substrate of human ALDH1 is retinal, and that its primary biological role is generation of retinoic acid resulting in modulation of cell differentiation including hormone-mediated development. Tretinoin 143-156 aldehyde dehydrogenase 1 family member A1 Homo sapiens 71-76 34120916-9 2021 We focus on the pivotal role of ALDH1A1, an enzyme expressed by dopaminergic neurons for the detoxification of these neurons, which is under the control of retinoic acid. Tretinoin 156-169 aldehyde dehydrogenase 1 family member A1 Homo sapiens 32-39 35213790-8 2022 Formation velocity of atRA was approximately threefold higher (p = 0.0001) in omental AT (9.8 (7.6, 11.2)) pmol/min/mg) than subcutaneous AT (3.2 (2.1, 4.0) pmol/min/mg) and correlated with ALDH1A2 expression in omental AT (beta-coefficient = 3.07, p = 0.0007) and with ALDH1A1 expression in subcutaneous AT (beta-coefficient = 0.13, p = 0.003). Tretinoin 22-26 aldehyde dehydrogenase 1 family member A1 Homo sapiens 270-277 35213790-10 2022 Our findings suggest that ALDH1A2 is the primary mediator of atRA formation in omental AT, whereas ALDH1A1 is the principal atRA-synthesizing enzyme in subcutaneous AT. Tretinoin 124-128 aldehyde dehydrogenase 1 family member A1 Homo sapiens 99-106 35574006-2 2022 The synthesis of retinoic acid from retinal in the seminiferous epithelium is a result of the action of aldehyde dehydrogenases termed ALDH1A1, ALDH1A2, and ALDH1A3. Tretinoin 17-30 aldehyde dehydrogenase 1 family member A1 Homo sapiens 135-142 9890568-3 1999 To understand the role of human liver cytosolic aldehyde dehydrogenase (ALDH1) in retinoic acid synthesis, we examined the ability of ALDH 1 to catalyze the oxidation of the naturally occurring retinal isomers. Tretinoin 82-95 aldehyde dehydrogenase 1 family member A1 Homo sapiens 72-77 9394035-17 1997 Erythrocyte ALDH-1-effected oxidation of other aldehydes to their corresponding acids, e.g. retinaldehyde to retinoic acid, may also be of pharmacological and/or physiological significance since a wide variety of aldehydes are known to be substrates for ALDH-1. Tretinoin 109-122 aldehyde dehydrogenase 1 family member A1 Homo sapiens 12-18 9394035-17 1997 Erythrocyte ALDH-1-effected oxidation of other aldehydes to their corresponding acids, e.g. retinaldehyde to retinoic acid, may also be of pharmacological and/or physiological significance since a wide variety of aldehydes are known to be substrates for ALDH-1. Tretinoin 109-122 aldehyde dehydrogenase 1 family member A1 Homo sapiens 254-260 7615557-2 1995 Human cytosolic aldehyde dehydrogenase 1 (ALDH1) plays a role in the biosynthesis of retinoic acid that is a modulator for gene expression and cell differentiation. Tretinoin 85-98 aldehyde dehydrogenase 1 family member A1 Homo sapiens 42-47 35412614-5 2022 We show that one such target gene, ALDH1A1, which regulates a key step in retinoic acid biosynthesis, is consistently upregulated with PBRM1 loss in ccRCC cell lines and primary tumors, as well as non-malignant cells. Tretinoin 74-87 aldehyde dehydrogenase 1 family member A1 Homo sapiens 35-42 35078784-0 2022 Targeting S100A9-ALDH1A1-retinoic acid signaling to suppress brain relapse in EGFR-mutant lung cancer. Tretinoin 25-38 aldehyde dehydrogenase 1 family member A1 Homo sapiens 17-24 35056791-1 2022 Aldehyde dehydrogenase-1a1 (ALDH1a1), the enzyme responsible for the oxidation of retinal into retinoic acid, represents a key therapeutic target for the treatment of debilitating disorders such as cancer, obesity, and inflammation. Tretinoin 95-108 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-26 35056791-1 2022 Aldehyde dehydrogenase-1a1 (ALDH1a1), the enzyme responsible for the oxidation of retinal into retinoic acid, represents a key therapeutic target for the treatment of debilitating disorders such as cancer, obesity, and inflammation. Tretinoin 95-108 aldehyde dehydrogenase 1 family member A1 Homo sapiens 28-35 33744437-4 2021 Disulfiram also inhibits ALDH1a1, another member of the aldehyde dehydrogenases that catalyzes the oxidation of retinal into retinoic acid. Tretinoin 125-138 aldehyde dehydrogenase 1 family member A1 Homo sapiens 25-32 33355213-2 2021 atRA is predominantly synthesized from retinaldehyde by aldehyde dehydrogenase 1A1 (ALDH1A1) but aldehyde oxidase (AOX) may also contribute to atRA biosynthesis. Tretinoin 0-4 aldehyde dehydrogenase 1 family member A1 Homo sapiens 56-82 33355213-2 2021 atRA is predominantly synthesized from retinaldehyde by aldehyde dehydrogenase 1A1 (ALDH1A1) but aldehyde oxidase (AOX) may also contribute to atRA biosynthesis. Tretinoin 0-4 aldehyde dehydrogenase 1 family member A1 Homo sapiens 84-91 33355213-7 2021 The two enzymes were identified as AOX and ALDH1A1 based on inhibition of atRA formation by AOX inhibitor hydralazine (20-50% inhibition) and ALDH1A1 inhibitor WIN18,446 (50-80% inhibition). Tretinoin 74-78 aldehyde dehydrogenase 1 family member A1 Homo sapiens 43-50 33355213-9 2021 The formation velocity of atRA in the presence of NAD+ correlated significantly with the expression of ALDH1A1 and AOX protein. Tretinoin 26-30 aldehyde dehydrogenase 1 family member A1 Homo sapiens 103-110 33355213-10 2021 Taken together the data show that both AOX and ALDH1A1 contribute to atRA biosynthesis in the human liver with ALDH1A1 being the high affinity low capacity enzyme and AOX the low affinity high capacity enzyme. Tretinoin 69-73 aldehyde dehydrogenase 1 family member A1 Homo sapiens 47-54 33355213-10 2021 Taken together the data show that both AOX and ALDH1A1 contribute to atRA biosynthesis in the human liver with ALDH1A1 being the high affinity low capacity enzyme and AOX the low affinity high capacity enzyme. Tretinoin 69-73 aldehyde dehydrogenase 1 family member A1 Homo sapiens 111-118 33495566-0 2021 PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling. Tretinoin 73-86 aldehyde dehydrogenase 1 family member A1 Homo sapiens 21-28 33495566-4 2021 ALDH1A1 regulates variety of cellular processes by catalyzing the conversion of retinaldehyde to retinoic acid. Tretinoin 97-110 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-7 33495566-6 2021 PRMT3 inhibits the enzymatic activity of ALDH1A1 and negatively regulates the expression of retinoic acid responsive genes in a methyltransferase activity independent manner. Tretinoin 92-105 aldehyde dehydrogenase 1 family member A1 Homo sapiens 41-48 32695508-4 2020 ALDH1 has a role in early stem cell differentiation through its function in the oxidation of retinol to retinoic acid, proposed to be a strong candidate for breast cancer stem cells. Tretinoin 104-117 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-5 32293355-3 2020 All-trans retinoic acid (ATRA) has been shown to be a potential targeted therapy against CSCs due to its ability to inhibit ALDH1A1 activity. Tretinoin 0-23 aldehyde dehydrogenase 1 family member A1 Homo sapiens 124-131 32293355-8 2020 Treatment with ATRA was found to significantly reduce the increased expression of ALDH1A1 and CD44 and the IC50 values for gefitinib in A549GSC and H1650GSC cells, and ATRA could directly inhibit active ALDH1A1 as compared to DEAB. Tretinoin 15-19 aldehyde dehydrogenase 1 family member A1 Homo sapiens 82-89 32293355-8 2020 Treatment with ATRA was found to significantly reduce the increased expression of ALDH1A1 and CD44 and the IC50 values for gefitinib in A549GSC and H1650GSC cells, and ATRA could directly inhibit active ALDH1A1 as compared to DEAB. Tretinoin 15-19 aldehyde dehydrogenase 1 family member A1 Homo sapiens 203-210 32293355-8 2020 Treatment with ATRA was found to significantly reduce the increased expression of ALDH1A1 and CD44 and the IC50 values for gefitinib in A549GSC and H1650GSC cells, and ATRA could directly inhibit active ALDH1A1 as compared to DEAB. Tretinoin 168-172 aldehyde dehydrogenase 1 family member A1 Homo sapiens 82-89 32293355-8 2020 Treatment with ATRA was found to significantly reduce the increased expression of ALDH1A1 and CD44 and the IC50 values for gefitinib in A549GSC and H1650GSC cells, and ATRA could directly inhibit active ALDH1A1 as compared to DEAB. Tretinoin 168-172 aldehyde dehydrogenase 1 family member A1 Homo sapiens 203-210 32293355-9 2020 CONCLUSION: Our findings suggest that combination treatment with ATRA prevents gefitinib-induced enrichment of ALDH1A1bright/CD44high CSCs and enhances gefitinib-induced growth inhibition of NSCLC/ADC cells. Tretinoin 65-69 aldehyde dehydrogenase 1 family member A1 Homo sapiens 111-118 32293355-3 2020 All-trans retinoic acid (ATRA) has been shown to be a potential targeted therapy against CSCs due to its ability to inhibit ALDH1A1 activity. Tretinoin 25-29 aldehyde dehydrogenase 1 family member A1 Homo sapiens 124-131 32293355-7 2020 Using DEAB as the positive control, direct inhibitory effect of ATRA on ALDH1A1 activity was determined by ALDEFLUOR assay, RESULTS: GSCs showed higher expression of ALDH1A1 and CD44 and IC50 values for gefitinib than their respective parental cells, suggesting that gefitinib can lead to propagation of CSC-enriched gefitinib-resistant cells. Tretinoin 64-68 aldehyde dehydrogenase 1 family member A1 Homo sapiens 72-79 32293355-7 2020 Using DEAB as the positive control, direct inhibitory effect of ATRA on ALDH1A1 activity was determined by ALDEFLUOR assay, RESULTS: GSCs showed higher expression of ALDH1A1 and CD44 and IC50 values for gefitinib than their respective parental cells, suggesting that gefitinib can lead to propagation of CSC-enriched gefitinib-resistant cells. Tretinoin 64-68 aldehyde dehydrogenase 1 family member A1 Homo sapiens 166-173 31187490-0 2020 ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression. Tretinoin 62-75 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-7 31187490-6 2020 Notably, CSC marker aldehyde dehydrogenase 1A1 (ALDH1A1), a critical enzyme that synthesizes retinoic acid (RA), was abundantly expressed in PDCs. Tretinoin 93-106 aldehyde dehydrogenase 1 family member A1 Homo sapiens 20-46 31187490-6 2020 Notably, CSC marker aldehyde dehydrogenase 1A1 (ALDH1A1), a critical enzyme that synthesizes retinoic acid (RA), was abundantly expressed in PDCs. Tretinoin 93-106 aldehyde dehydrogenase 1 family member A1 Homo sapiens 48-55 31187490-6 2020 Notably, CSC marker aldehyde dehydrogenase 1A1 (ALDH1A1), a critical enzyme that synthesizes retinoic acid (RA), was abundantly expressed in PDCs. Tretinoin 108-110 aldehyde dehydrogenase 1 family member A1 Homo sapiens 20-46 31187490-6 2020 Notably, CSC marker aldehyde dehydrogenase 1A1 (ALDH1A1), a critical enzyme that synthesizes retinoic acid (RA), was abundantly expressed in PDCs. Tretinoin 108-110 aldehyde dehydrogenase 1 family member A1 Homo sapiens 48-55 31187490-7 2020 ALDH1A1 inhibitors and shRNAs repressed both PDC proliferation and spheroid formation, whereas all-trans RA could rescue ALDH1A1 shRNA-suppressed spheroid formation. Tretinoin 105-107 aldehyde dehydrogenase 1 family member A1 Homo sapiens 121-128 33132350-1 2020 Aldehyde dehydrogenase 1A1 (ALDH1A1) in intestinal epithelial cells (IECs) plays a critical role in regulating immune responses through the production of retinoic acid (RA). Tretinoin 154-167 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-26 33132350-1 2020 Aldehyde dehydrogenase 1A1 (ALDH1A1) in intestinal epithelial cells (IECs) plays a critical role in regulating immune responses through the production of retinoic acid (RA). Tretinoin 154-167 aldehyde dehydrogenase 1 family member A1 Homo sapiens 28-35 33132350-1 2020 Aldehyde dehydrogenase 1A1 (ALDH1A1) in intestinal epithelial cells (IECs) plays a critical role in regulating immune responses through the production of retinoic acid (RA). Tretinoin 169-171 aldehyde dehydrogenase 1 family member A1 Homo sapiens 0-26 33132350-1 2020 Aldehyde dehydrogenase 1A1 (ALDH1A1) in intestinal epithelial cells (IECs) plays a critical role in regulating immune responses through the production of retinoic acid (RA). Tretinoin 169-171 aldehyde dehydrogenase 1 family member A1 Homo sapiens 28-35