PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10025664-0 1999 Identification of a cis-acting element in the rat alpha-fetoprotein gene and its specific binding proteins in F9 cells during retinoic acid-induced differentiation. Tretinoin 126-139 alpha-fetoprotein Rattus norvegicus 50-67 10025664-2 1999 Following retinoic acid (RA) treatment, alpha-fetoprotein (AFP), a differentiation marker, is expressed and secreted. Tretinoin 10-23 alpha-fetoprotein Rattus norvegicus 40-57 10025664-2 1999 Following retinoic acid (RA) treatment, alpha-fetoprotein (AFP), a differentiation marker, is expressed and secreted. Tretinoin 10-23 alpha-fetoprotein Rattus norvegicus 59-62 10025664-2 1999 Following retinoic acid (RA) treatment, alpha-fetoprotein (AFP), a differentiation marker, is expressed and secreted. Tretinoin 25-27 alpha-fetoprotein Rattus norvegicus 40-57 10025664-2 1999 Following retinoic acid (RA) treatment, alpha-fetoprotein (AFP), a differentiation marker, is expressed and secreted. Tretinoin 25-27 alpha-fetoprotein Rattus norvegicus 59-62 7539613-0 1995 9-cis-retinoic acid is more effective than all-trans-retinoic acid in upregulating expression of the alpha-fetoprotein gene. Tretinoin 43-66 alpha-fetoprotein Rattus norvegicus 101-118 9268491-6 1997 However, when these cells were induced by retinoic acid to differentiate, Ca2+-dependent PC-PLC and gamma-GT activities decreased significantly, together with alpha-fetoprotein expression. Tretinoin 42-55 alpha-fetoprotein Rattus norvegicus 159-176 8945636-3 1996 alpha-Fetoprotein (AFP), a hepatocyte differentiation, maturation, and carcinogenesis marker, is transcriptionally upregulated by RA in McA-RH8994 hepatoma cells. Tretinoin 130-132 alpha-fetoprotein Rattus norvegicus 0-17 8945636-3 1996 alpha-Fetoprotein (AFP), a hepatocyte differentiation, maturation, and carcinogenesis marker, is transcriptionally upregulated by RA in McA-RH8994 hepatoma cells. Tretinoin 130-132 alpha-fetoprotein Rattus norvegicus 19-22 8945636-10 1996 CAT assays demonstrated that overexpression of RXRalpha conferred the best RA response, consistent with our previous observation that 9-cis-RA is more potent than all-trans-RA for inducing the expression of the AFP gene. Tretinoin 75-77 alpha-fetoprotein Rattus norvegicus 211-214 7539613-1 1995 In McA-RH 8994 rat hepatoma cells, all-trans-retinoic acid (t-RA) induces expression of the alpha-fetoprotein (AFP) and albumin genes and results in a phenotype similar to differentiated fetal hepatocytes. Tretinoin 35-58 alpha-fetoprotein Rattus norvegicus 92-109 7539613-1 1995 In McA-RH 8994 rat hepatoma cells, all-trans-retinoic acid (t-RA) induces expression of the alpha-fetoprotein (AFP) and albumin genes and results in a phenotype similar to differentiated fetal hepatocytes. Tretinoin 35-58 alpha-fetoprotein Rattus norvegicus 111-114 7539613-1 1995 In McA-RH 8994 rat hepatoma cells, all-trans-retinoic acid (t-RA) induces expression of the alpha-fetoprotein (AFP) and albumin genes and results in a phenotype similar to differentiated fetal hepatocytes. Tretinoin 60-64 alpha-fetoprotein Rattus norvegicus 92-109 7539613-1 1995 In McA-RH 8994 rat hepatoma cells, all-trans-retinoic acid (t-RA) induces expression of the alpha-fetoprotein (AFP) and albumin genes and results in a phenotype similar to differentiated fetal hepatocytes. Tretinoin 60-64 alpha-fetoprotein Rattus norvegicus 111-114 7539613-2 1995 The present study elucidated the mechanism involved in AFP gene regulation mediated by retinoic acid. Tretinoin 87-100 alpha-fetoprotein Rattus norvegicus 55-58 7539613-5 1995 Northern blots and transfection assays using the 7.3 kb full-length regulatory region of the AFP gene demonstrated that c-RA was more effective than t-RA in regulating expression of the AFP gene. Tretinoin 149-153 alpha-fetoprotein Rattus norvegicus 93-96 7539613-5 1995 Northern blots and transfection assays using the 7.3 kb full-length regulatory region of the AFP gene demonstrated that c-RA was more effective than t-RA in regulating expression of the AFP gene. Tretinoin 149-153 alpha-fetoprotein Rattus norvegicus 186-189 7539613-7 1995 In contrast, t-RA at a concentration of 10(-7) M exerted no significant effect; 10(-6) to 10(-5) M t-RA was needed to affect AFP gene expression. Tretinoin 99-103 alpha-fetoprotein Rattus norvegicus 125-128 7525384-0 1994 Identification of a retinoic acid response element upstream of the rat alpha-fetoprotein gene. Tretinoin 20-33 alpha-fetoprotein Rattus norvegicus 71-88 7525384-8 1994 Furthermore, responsiveness of AFP-RARE1 to RA was independent of orientation. Tretinoin 35-37 alpha-fetoprotein Rattus norvegicus 31-34 7525384-9 1994 These studies present a novel target for RA action by identifying a RARE in the AFP gene. Tretinoin 41-43 alpha-fetoprotein Rattus norvegicus 80-83 1379951-0 1992 The effects of retinoic acid on the expression of alpha-fetoprotein and albumin genes in rat hepatoma cell lines. Tretinoin 15-28 alpha-fetoprotein Rattus norvegicus 50-67 1379951-3 1992 In the present study, we demonstrated that retinoic acid, whose receptors belong to the steroid/thyroid hormone receptor gene family, also enhanced the expression of alpha-fetoprotein and albumin gene in McA-RH 8994 cells, but had no effect on alpha-fetoprotein gene expression in McA-RH 7777 cells. Tretinoin 43-56 alpha-fetoprotein Rattus norvegicus 166-183 1379951-3 1992 In the present study, we demonstrated that retinoic acid, whose receptors belong to the steroid/thyroid hormone receptor gene family, also enhanced the expression of alpha-fetoprotein and albumin gene in McA-RH 8994 cells, but had no effect on alpha-fetoprotein gene expression in McA-RH 7777 cells. Tretinoin 43-56 alpha-fetoprotein Rattus norvegicus 244-261 1379951-5 1992 Actinomycin D inhibited the retinoic acid mediated increase in alpha-fetoprotein and albumin mRNA expression. Tretinoin 28-41 alpha-fetoprotein Rattus norvegicus 63-80 6199027-1 1984 Regulation of the biosynthesis of alpha-fetoprotein and albumin was studied in a temperature-sensitive fetal rat hepatocyte line (RLA209-15) which exhibits a differentiated phenotype when grown at 40 degrees C. Retinoic acid inhibited alpha-fetoprotein production but increased albumin production. Tretinoin 211-224 alpha-fetoprotein Rattus norvegicus 34-51