PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33493612-5	2021	Smad signaling was also suppressed by atRA treatment in these cells, and RNA immunoprecipitation analyses revealed that Smad2 can directly interact with Meg3 in MEPM cells following atRA treatment.	Tretinoin	38-42	SMAD family member 2	Mus musculus	120-125	
34166781-6	2021	Moreover, Smad2 was found to interact directly with Meg3, and atRA treatment significantly enriched Meg3 in Smad2-immunoprecipitated samples.	Tretinoin	62-66	SMAD family member 2	Mus musculus	108-113	
33493612-5	2021	Smad signaling was also suppressed by atRA treatment in these cells, and RNA immunoprecipitation analyses revealed that Smad2 can directly interact with Meg3 in MEPM cells following atRA treatment.	Tretinoin	182-186	SMAD family member 2	Mus musculus	120-125	
30460049-11	2017	We also found atRA inhibited phosphorylation of Smad2 compared with untreated group (P < .05).	Tretinoin	14-18	SMAD family member 2	Mus musculus	48-53	
29972949-8	2017	Moreover, atRA decreased the levels of p-Smad2 and Smad4 in embryonic palate mesenchymal cells, whereas the expression of Smad7 was significantly increased at GD14 and GD15.	Tretinoin	10-14	SMAD family member 2	Mus musculus	41-46	
29926545-0	2019	The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor beta1.	Tretinoin	15-28	SMAD family member 2	Mus musculus	71-78	
29926545-2	2019	We investigated the effect of RA and the role of these signaling molecules on the phosphorylation of Smad2/3 (p-Smad2/3) induced by TGF-beta1.	Tretinoin	30-32	SMAD family member 2	Mus musculus	101-108	
29926545-2	2019	We investigated the effect of RA and the role of these signaling molecules on the phosphorylation of Smad2/3 (p-Smad2/3) induced by TGF-beta1.	Tretinoin	30-32	SMAD family member 2	Mus musculus	101-106	
19388084-0	2009	Smad2/3 is involved in growth inhibition of mouse embryonic palate mesenchymal cells induced by all-trans retinoic acid.	Tretinoin	106-119	SMAD family member 2	Mus musculus	0-7	
19388084-8	2009	The protein expression levels of p21, Smad2/3, phospho-Smad2, and phospho-Smad3 were increased, while phospho-Rb was decreased in MEPM after atRA treatment on GD 10.	Tretinoin	141-145	SMAD family member 2	Mus musculus	38-45	
19388084-8	2009	The protein expression levels of p21, Smad2/3, phospho-Smad2, and phospho-Smad3 were increased, while phospho-Rb was decreased in MEPM after atRA treatment on GD 10.	Tretinoin	141-145	SMAD family member 2	Mus musculus	38-43	
19388084-13	2009	Our study demonstrated that Smad2/3 regulation of p21 was partly required for atRA-induced cell cycle perturbations in MEPM cells.	Tretinoin	78-82	SMAD family member 2	Mus musculus	28-33	
19255510-4	2009	We found that atRA suppressed chondrogenesis and Smad2/3 phosphorylation regardless of the presence of TGF-beta3.	Tretinoin	14-18	SMAD family member 2	Mus musculus	49-56	
19255510-5	2009	Functional assays indicated that TGF-beta3 treatment or co-transfection of expressing Smad2/3 vectors suppressed atRA-induced RARE-tk-Luc activity.	Tretinoin	113-117	SMAD family member 2	Mus musculus	86-93	
16410076-8	2006	Further study showed that atRA inhibited phosphorylation of Smad2 and Smad3 and increased Smad7 expression.	Tretinoin	26-30	SMAD family member 2	Mus musculus	60-65	
17634193-6	2007	RA rescue of the lung phenotype was associated with low levels of Smad2 phosphorylation and downregulation of Tgfbeta targets in Raldh2-null foreguts.	Tretinoin	0-2	SMAD family member 2	Mus musculus	66-71	
15799023-6	2005	RESULTS: Endogenous TGFbetaRII and Smad2 are downregulated in the inner ear following in utero atRA treatment.	Tretinoin	95-99	SMAD family member 2	Mus musculus	35-40