PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32533263-0 2020 Intracellular ABCB1 as a Possible Mechanism to Explain the Synergistic Effect of Hydroxychloroquine-Azithromycin Combination in COVID-19 Therapy. Hydroxychloroquine 81-99 ATP binding cassette subfamily B member 1 Homo sapiens 14-19 32992777-7 2020 (3) Results: Hydroxychloroquine did not inhibit BCRP or the OATPs tested but inhibited P-gp at concentrations exceeding 10 microM. Hydroxychloroquine 13-31 ATP binding cassette subfamily B member 1 Homo sapiens 87-91 32992777-8 2020 P-gp overexpressing cells were 5.2-fold more resistant to hydroxychloroquine than control cells stressing its substrate characteristics. Hydroxychloroquine 58-76 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 32992777-10 2020 (4) Conclusions: This is the first evidence that hydroxychloroquine"s interaction potential with drug transporters is low, albeit bioavailability of simultaneously orally administered P-gp substrates might be increased by hydroxychloroquine. Hydroxychloroquine 49-67 ATP binding cassette subfamily B member 1 Homo sapiens 184-188 32992777-10 2020 (4) Conclusions: This is the first evidence that hydroxychloroquine"s interaction potential with drug transporters is low, albeit bioavailability of simultaneously orally administered P-gp substrates might be increased by hydroxychloroquine. Hydroxychloroquine 222-240 ATP binding cassette subfamily B member 1 Homo sapiens 184-188 32864162-6 2020 We found several drug-gene variant pairs that may alter the pharmacokinetics of hydroxychloroquine/chloroquine (CYP2C8, CYP2D6, SLCO1A2, and SLCO1B1); azithromycin (ABCB1); ribavirin (SLC29A1, SLC28A2, and SLC28A3); and lopinavir/ritonavir (SLCO1B1, ABCC2, CYP3A). Hydroxychloroquine 80-98 ATP binding cassette subfamily B member 1 Homo sapiens 165-170 31485616-8 2019 Furthermore, HCQ significantly reduced the increase in P-gp expression by inhibiting autophagic activity. Hydroxychloroquine 13-16 ATP binding cassette subfamily B member 1 Homo sapiens 55-59