PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33160044-7	2021	RESULTS: The results suggested that HCQ in the treatment of RA was mainly associated with 4 targets that are smoothened homolog (SMO), sphingosine kinase (SPHK) 1, SPHK2 and gatty-acid amide hydrolase (FAAH), with their related 3276 proteins" network which regulate ErbB, HIF-1, NF-kappaB, FoxO, chemokines, MAPK, PI3K/Akt pathways and so forth.	Hydroxychloroquine	36-39	AKT serine/threonine kinase 1	Homo sapiens	319-322	
33098839-8	2020	It was found that PI3K/Akt, VEGF, ERBB2 pathways must be given consideration for understanding the role of HCQ and AZM in QT interval prolongation.	Hydroxychloroquine	107-110	AKT serine/threonine kinase 1	Homo sapiens	23-26	
32854577-7	2020	RESULTS: The results suggest that the efficacy of HCQ against SLE is mainly associated with the targets of cyclin-dependent kinase 2 (CDK2), estrogen receptor alpha (ESR1) and CDK1, which regulate PI3K/Akt/GSK3beta as well as interferon (IFN) signaling pathway.	Hydroxychloroquine	50-53	AKT serine/threonine kinase 1	Homo sapiens	202-205	
28708385-9	2017	The enhanced inhibitory actions of CQ-HES compared to HCQ appeared to arise in part from the increased inhibition of ERK and Akt phosphorylation.	Hydroxychloroquine	54-57	AKT serine/threonine kinase 1	Homo sapiens	125-128	
22879389-12	2012	Accordingly, selective triple knockdown of the autophagy genes ATG7, ATG5 and ATG3, and pretreatment with the autophagy inhibitor hydroxychloroquine, efficiently overcame the resistance to Akt/mTOR inhibitors, leading to the activation of the mitochondrial apoptotic pathway.	Hydroxychloroquine	130-148	AKT serine/threonine kinase 1	Homo sapiens	189-192