PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26125760-5	2015	Flow cytometry was applied to detect changes in apoptosis of RPMI8226/DOX cells (stained with annexin-V/propidium iodide) caused by inhibition by hydroxychloroquine and 3-methyladenine on autophagy.	Hydroxychloroquine	146-164	annexin A5	Homo sapiens	94-103	
30041771-7	2018	Studies in vitro have shown that HCQ is able to restore the placental expression of Annexin V, which has an anticoagulant effect and to prevent the placental injury induced by APL.	Hydroxychloroquine	33-36	annexin A5	Homo sapiens	84-93	
21871597-0	2011	Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression.	Hydroxychloroquine	0-18	annexin A5	Homo sapiens	103-113	
21871597-2	2011	We recently showed that the antimalarial drug, hydroxychloroquine, dissociates antiphospholipid immune complexes and restores annexin A5 binding to planar phospholipid bilayer.	Hydroxychloroquine	47-65	annexin A5	Homo sapiens	126-136	
21871597-6	2011	RESULTS: Hydroxychloroquine reversed the effects of the antiphospholipid antibodies on the syncytiotrophoblasts by markedly reducing immunoglobulin-G binding and restoring annexin A5 expression.	Hydroxychloroquine	9-27	annexin A5	Homo sapiens	172-182	
19965621-0	2010	Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug.	Hydroxychloroquine	0-18	annexin A5	Homo sapiens	32-42	
19965621-8	2010	HCQ reversed the effect of antiphospholipid antibodies on AnxA5 and restored AnxA5 binding to PLBs, an effect corroborated by atomic force microscopy.	Hydroxychloroquine	0-3	annexin A5	Homo sapiens	58-63	
19965621-8	2010	HCQ reversed the effect of antiphospholipid antibodies on AnxA5 and restored AnxA5 binding to PLBs, an effect corroborated by atomic force microscopy.	Hydroxychloroquine	0-3	annexin A5	Homo sapiens	77-82	
19965621-9	2010	Similar reversals of antiphospholipid-induced abnormalities were measured on the surfaces of human umbilical vein endothelial cells and syncytialized trophoblast cell lines, wherein HCQ reduced the binding of antiphospholipid antibodies, increased cell-surface AnxA5 concentrations, and prolonged plasma coagulation to control levels.	Hydroxychloroquine	182-185	annexin A5	Homo sapiens	261-266	
19965621-10	2010	In addition, HCQ increased the AnxA5 anticoagulant activities of APS patient plasmas.	Hydroxychloroquine	13-16	annexin A5	Homo sapiens	31-36	
19965621-11	2010	In conclusion, HCQ reversed antiphospholipid-mediated disruptions of AnxA5 on PLBs and cultured cells, and in APS patient plasmas.	Hydroxychloroquine	15-18	annexin A5	Homo sapiens	69-74	
20353989-4	2010	Recently, we reported that hydroxychloroquine, a synthetic antimalarial drug, can reverse this antibody-mediated process through two mechanisms: (1) by inhibiting the formation of aPL IgG-beta2glycoprotein I complexes; and (2) by promoting the formation of a second layer of AnxA5 crystal "patches" over areas where the immune complexes had disrupted AnxA5 crystallization.	Hydroxychloroquine	27-45	annexin A5	Homo sapiens	275-280	
20353989-4	2010	Recently, we reported that hydroxychloroquine, a synthetic antimalarial drug, can reverse this antibody-mediated process through two mechanisms: (1) by inhibiting the formation of aPL IgG-beta2glycoprotein I complexes; and (2) by promoting the formation of a second layer of AnxA5 crystal "patches" over areas where the immune complexes had disrupted AnxA5 crystallization.	Hydroxychloroquine	27-45	annexin A5	Homo sapiens	351-356