PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32780726-2 2020 Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of CQ derivatives like hydroxychloroquine (HCQ), enhances the antitumor efficacy of anti-PD-1 Ab in melanoma. Hydroxychloroquine 105-123 palmitoyl-protein thioesterase 1 Mus musculus 32-64 32780726-2 2020 Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of CQ derivatives like hydroxychloroquine (HCQ), enhances the antitumor efficacy of anti-PD-1 Ab in melanoma. Hydroxychloroquine 105-123 palmitoyl-protein thioesterase 1 Mus musculus 66-70 32780726-2 2020 Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of CQ derivatives like hydroxychloroquine (HCQ), enhances the antitumor efficacy of anti-PD-1 Ab in melanoma. Hydroxychloroquine 125-128 palmitoyl-protein thioesterase 1 Mus musculus 32-64 32780726-2 2020 Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of CQ derivatives like hydroxychloroquine (HCQ), enhances the antitumor efficacy of anti-PD-1 Ab in melanoma. Hydroxychloroquine 125-128 palmitoyl-protein thioesterase 1 Mus musculus 66-70 32780726-8 2020 Ppt1 inhibition by HCQ, or DC661, induced cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING), tank-binding kinase 1 (TBK1) pathway activation and the secretion of interferon beta (IFN-beta) in macrophages which was a key component for augmented T cell-mediated cytotoxicity. Hydroxychloroquine 19-22 palmitoyl-protein thioesterase 1 Mus musculus 0-4