PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34002944-0	2021	SMAD4 loss is associated with response to neoadjuvant chemotherapy plus hydroxychloroquine in patients with pancreatic adenocarcinoma.	Hydroxychloroquine	72-90	SMAD family member 4	Homo sapiens	0-5	
34002944-4	2021	We studied whether HCQ treatment in SMAD4 deficient PDA may prevent therapeutic resistance induced by autophagy upregulation.	Hydroxychloroquine	19-22	SMAD family member 4	Homo sapiens	36-41	
34002944-8	2021	The effect of SMAD4 loss on response to HCQ and chemotherapy was studied for association with clinical outcome.	Hydroxychloroquine	40-43	SMAD family member 4	Homo sapiens	14-19	
34002944-12	2021	76% of HCQ-treated patients with SMAD4 loss obtained a histopathologic response greater than or equal to 2A, compared with only 37% with SMAD4 intact (p = 0.006).	Hydroxychloroquine	7-10	SMAD family member 4	Homo sapiens	33-38	
34002944-14	2021	The addition of HCQ to neoadjuvant chemotherapy in patients with PDA may improve treatment response in those with SMAD4 loss.	Hydroxychloroquine	16-19	SMAD family member 4	Homo sapiens	114-119