PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33490900-0 2021 Hydroxychloroquine can impair tumor response to anti-PD1 in subcutaneous mouse models. Hydroxychloroquine 0-18 programmed cell death 1 Mus musculus 53-56 33490900-3 2021 Anti-PD1 therapy-sensitive tumor lines MC38, CT26, and RIL-175 were used to investigate the impact of HCQ on anti-PD1 therapy efficacy. Hydroxychloroquine 102-105 programmed cell death 1 Mus musculus 114-117 33490900-6 2021 Importantly, in all the three tumor models, HCQ treatment significantly impaired the response to anti-PD1 treatment, accompanying diminished in vivo T-cell activation and reduced tumor-infiltrating, antigen-specific CD8+ T cells. Hydroxychloroquine 44-47 programmed cell death 1 Mus musculus 102-105 33490900-2 2021 Here, we evaluate the influence of HCQ treatment on the effect of anti-PD1 tumor immunotherapy. Hydroxychloroquine 35-38 programmed cell death 1 Mus musculus 71-74 32780726-2 2020 Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of CQ derivatives like hydroxychloroquine (HCQ), enhances the antitumor efficacy of anti-PD-1 Ab in melanoma. Hydroxychloroquine 105-123 programmed cell death 1 Mus musculus 171-175 32780726-2 2020 Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of CQ derivatives like hydroxychloroquine (HCQ), enhances the antitumor efficacy of anti-PD-1 Ab in melanoma. Hydroxychloroquine 125-128 programmed cell death 1 Mus musculus 171-175