PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17574068-4	2007	Multifocal ERG may detect macular dysfunction earlier than the currently recommended screening guidelines in patients with potential for macular toxicity from hydroxychloroquine.	Hydroxychloroquine	159-177	ETS transcription factor ERG	Homo sapiens	11-14	
34837219-6	2022	KEY RESULTS: Chloroquine and hydroxychloroquine blocked hERG with IC50 of 1.47+-0.07 muM and 3.78+-0.17 muM respectively, indicating proarrhythmic risk at concentrations effective against SARS-CoV-2 in vitro.	Hydroxychloroquine	29-47	ETS transcription factor ERG	Homo sapiens	56-60	
34837219-8	2022	Acidosis significantly reduced potency of all drugs, whereas increased temperature decreased potency of chloroquine and hydroxychloroquine against hERG but increased potency for azithromycin.	Hydroxychloroquine	120-138	ETS transcription factor ERG	Homo sapiens	147-151	
33345848-0	2021	Off-label use of chloroquine, hydroxychloroquine, azithromycin and lopinavir/ritonavir in COVID-19 risks prolonging the QT interval by targeting the hERG channel.	Hydroxychloroquine	30-48	ETS transcription factor ERG	Homo sapiens	149-153	
33345848-3	2021	Clinically, however, many drugs, including those currently used in COVID-19, such as chloroquine, hydroxychloroquine, azithromycin, and lopinavir/ritonavir, may cause cardiotoxicity by acting on cardiac potassium channels and the hERG channel through their off-target effects.	Hydroxychloroquine	98-116	ETS transcription factor ERG	Homo sapiens	230-234	
34863995-4	2022	We found that R(-)HCQ and S(+)HCQ block human Kir2.1 and hERG potassium channels in the 1 muM-100 muM range with a 2-4 fold enantiomeric separation.	Hydroxychloroquine	18-21	ETS transcription factor ERG	Homo sapiens	57-61	
34863995-4	2022	We found that R(-)HCQ and S(+)HCQ block human Kir2.1 and hERG potassium channels in the 1 muM-100 muM range with a 2-4 fold enantiomeric separation.	Hydroxychloroquine	30-33	ETS transcription factor ERG	Homo sapiens	57-61	
34058295-0	2021	Computational and experimental studies on the inhibitory mechanism of hydroxychloroquine on hERG.	Hydroxychloroquine	70-88	ETS transcription factor ERG	Homo sapiens	92-96	
34058295-7	2021	Molecular docking and patch clamp experiments showed that HCQ could bind to hERG and inhibit the efflux of potassium ion preferentially in the repolarization stage.	Hydroxychloroquine	58-61	ETS transcription factor ERG	Homo sapiens	76-80	
33674391-0	2021	COVID-19 drugs chloroquine and hydroxychloroquine, but not azithromycin and remdesivir, block hERG potassium channels.	Hydroxychloroquine	31-49	ETS transcription factor ERG	Homo sapiens	94-98	
33674391-5	2021	Here we study the effects of chloroquine, hydroxychloroquine, azithromycin, and remdesivir on hERG channels.	Hydroxychloroquine	42-60	ETS transcription factor ERG	Homo sapiens	94-98	
33674391-10	2021	Significance Statement This work demonstrates that among off-label potential COVID-19 treatment drugs chloroquine, hydroxychloroquine, azithromycin, and remdesivir, the former two drugs block hERG potassium channels while the latter two drugs do not.	Hydroxychloroquine	115-133	ETS transcription factor ERG	Homo sapiens	192-196