PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33994369-0 2021 Cisplatin Activates the Growth Inhibitory Signaling Pathways by Enhancing the Production of Reactive Oxygen Species in Non-small Cell Lung Cancer Carrying an EGFR Exon 19 Deletion. Reactive Oxygen Species 92-115 epidermal growth factor receptor Homo sapiens 158-162 33304472-0 2020 EGFR-rich extracellular vesicles derived from highly metastatic nasopharyngeal carcinoma cells accelerate tumour metastasis through PI3K/AKT pathway-suppressed ROS. Reactive Oxygen Species 160-163 epidermal growth factor receptor Homo sapiens 0-4 33304472-4 2020 Here, we demonstrated that epidermal growth factor receptor (EGFR) was highly expressed in tumour tissues of NPC patients with distant metastases and was associated with a decrease in reactive oxygen species (ROS). Reactive Oxygen Species 184-207 epidermal growth factor receptor Homo sapiens 27-59 33304472-4 2020 Here, we demonstrated that epidermal growth factor receptor (EGFR) was highly expressed in tumour tissues of NPC patients with distant metastases and was associated with a decrease in reactive oxygen species (ROS). Reactive Oxygen Species 184-207 epidermal growth factor receptor Homo sapiens 61-65 33304472-4 2020 Here, we demonstrated that epidermal growth factor receptor (EGFR) was highly expressed in tumour tissues of NPC patients with distant metastases and was associated with a decrease in reactive oxygen species (ROS). Reactive Oxygen Species 209-212 epidermal growth factor receptor Homo sapiens 27-59 33304472-4 2020 Here, we demonstrated that epidermal growth factor receptor (EGFR) was highly expressed in tumour tissues of NPC patients with distant metastases and was associated with a decrease in reactive oxygen species (ROS). Reactive Oxygen Species 209-212 epidermal growth factor receptor Homo sapiens 61-65 33304472-7 2020 Mechanistically, EGFR-rich EVs-mediated EGFR overexpression down-regulated intracellular ROS levels through the PI3K/AKT pathway, thus promoting the metastatic potential of poorly metastatic NPC cells. Reactive Oxygen Species 89-92 epidermal growth factor receptor Homo sapiens 17-21 33304472-7 2020 Mechanistically, EGFR-rich EVs-mediated EGFR overexpression down-regulated intracellular ROS levels through the PI3K/AKT pathway, thus promoting the metastatic potential of poorly metastatic NPC cells. Reactive Oxygen Species 89-92 epidermal growth factor receptor Homo sapiens 40-44 31454652-0 2019 High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells. Reactive Oxygen Species 49-72 epidermal growth factor receptor Homo sapiens 15-19 32443749-7 2020 Erlotinib (the EGFR inhibitor) significantly attenuated the EGF-induced T98G invasiveness and metabolic reprogramming of the T98G cells, otherwise illustrated by the increased mitochondrial activity, glycolysis, and ROS production in the EGF-treated cells. Reactive Oxygen Species 216-219 epidermal growth factor receptor Homo sapiens 15-19 31964804-1 2020 Stimulation of plasma membrane receptor tyrosine kinases (RTKs), such as the epidermal growth factor receptor (EGFR), locally increases the abundance of reactive oxygen species (ROS). Reactive Oxygen Species 153-176 epidermal growth factor receptor Homo sapiens 77-109 31964804-1 2020 Stimulation of plasma membrane receptor tyrosine kinases (RTKs), such as the epidermal growth factor receptor (EGFR), locally increases the abundance of reactive oxygen species (ROS). Reactive Oxygen Species 153-176 epidermal growth factor receptor Homo sapiens 111-115 31964804-1 2020 Stimulation of plasma membrane receptor tyrosine kinases (RTKs), such as the epidermal growth factor receptor (EGFR), locally increases the abundance of reactive oxygen species (ROS). Reactive Oxygen Species 178-181 epidermal growth factor receptor Homo sapiens 77-109 31964804-1 2020 Stimulation of plasma membrane receptor tyrosine kinases (RTKs), such as the epidermal growth factor receptor (EGFR), locally increases the abundance of reactive oxygen species (ROS). Reactive Oxygen Species 178-181 epidermal growth factor receptor Homo sapiens 111-115 31852834-9 2020 EGFR amplification was associated with increased reactive oxygen species (ROS) and subsequent increased basal expression of DNA-repair pathways to counterelevated oxidative stress, and thus rendered vulnerability to PARP inhibition. Reactive Oxygen Species 49-72 epidermal growth factor receptor Homo sapiens 0-4 31852834-9 2020 EGFR amplification was associated with increased reactive oxygen species (ROS) and subsequent increased basal expression of DNA-repair pathways to counterelevated oxidative stress, and thus rendered vulnerability to PARP inhibition. Reactive Oxygen Species 74-77 epidermal growth factor receptor Homo sapiens 0-4 30273693-9 2019 The results show that ROS are essential for PAC1 to regulate EGFR and HER2 transactivation as well as proliferation of NSCLC cells. Reactive Oxygen Species 22-25 epidermal growth factor receptor Homo sapiens 61-65 30733286-4 2019 Mechanistically, ROS triggers AhR nuclear accumulation and activation to promote the transcription of both antioxidant enzymes and the epidermal growth factor receptor (EGFR) ligand, amphiregulin (AREG). Reactive Oxygen Species 17-20 epidermal growth factor receptor Homo sapiens 135-167 31491956-2 2019 ROS are known to activate the epidermal growth factor receptor (EGFR), which causes the activation of the Ras/mitogen-activated protein kinases (MAPKs) pathway. Reactive Oxygen Species 0-3 epidermal growth factor receptor Homo sapiens 30-62 31491956-2 2019 ROS are known to activate the epidermal growth factor receptor (EGFR), which causes the activation of the Ras/mitogen-activated protein kinases (MAPKs) pathway. Reactive Oxygen Species 0-3 epidermal growth factor receptor Homo sapiens 64-68 31491956-7 2019 Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression. Reactive Oxygen Species 102-105 epidermal growth factor receptor Homo sapiens 115-119 31491956-8 2019 These results show that lycopene-induced apoptosis and inhibition of proliferation occur via inhibition of ROS-activated EGFR/Ras/ERK and p38 MAPK pathways and NF-kappaB-mediated COX-2 gene expression in AGS cells. Reactive Oxygen Species 107-110 epidermal growth factor receptor Homo sapiens 121-125 32923966-7 2019 ROS are involved in different mechanisms of GPCR transactivation of EGFR. Reactive Oxygen Species 0-3 epidermal growth factor receptor Homo sapiens 68-72 31360122-13 2019 In contrast, in chemoresistant NSCLC, activated Akt promotes EGFR signaling by the positive feedback loop and suppresses CDDP-induced ROS production and apoptosis. Reactive Oxygen Species 134-137 epidermal growth factor receptor Homo sapiens 61-65 31216465-7 2019 Our data identify a role of PARP-1 in controlling ROS levels upon EGFR TKI treatment, with potentially broad implications for therapeutic targeting of the mechanisms that govern the survival of oncogene-driven cancer cells. Reactive Oxygen Species 50-53 epidermal growth factor receptor Homo sapiens 66-70 30733286-4 2019 Mechanistically, ROS triggers AhR nuclear accumulation and activation to promote the transcription of both antioxidant enzymes and the epidermal growth factor receptor (EGFR) ligand, amphiregulin (AREG). Reactive Oxygen Species 17-20 epidermal growth factor receptor Homo sapiens 169-173 30029165-10 2018 These results show that MMP-2 activates the EGFR and triggers downstream signaling pathways increasing ROS formation and promoting vasoconstriction. Reactive Oxygen Species 103-106 epidermal growth factor receptor Homo sapiens 44-48 30431083-0 2019 EGFR mutation decreases FDG uptake in non-small cell lung cancer via the NOX4/ROS/GLUT1 axis. Reactive Oxygen Species 78-81 epidermal growth factor receptor Homo sapiens 0-4 30365122-0 2019 Vorinostat enhances gefitinib-induced cell death through reactive oxygen species-dependent cleavage of HSP90 and its clients in non-small cell lung cancer with the EGFR mutation. Reactive Oxygen Species 57-80 epidermal growth factor receptor Homo sapiens 164-168 30145116-5 2018 On the other hand, single-cell dose-response analysis uncovered a reactive oxygen species-mediated toggle switch between autocatalytically activated monomeric EGFR and the tumor suppressor PTPRG that governs EGFR"s sensitivity to EGF. Reactive Oxygen Species 66-89 epidermal growth factor receptor Homo sapiens 159-163 30145116-5 2018 On the other hand, single-cell dose-response analysis uncovered a reactive oxygen species-mediated toggle switch between autocatalytically activated monomeric EGFR and the tumor suppressor PTPRG that governs EGFR"s sensitivity to EGF. Reactive Oxygen Species 66-89 epidermal growth factor receptor Homo sapiens 208-212 29886055-6 2018 Syringic acid treatment further inhibited intracellular reactive oxygen species and protein-tyrosine phosphatase-kappa activity, a regulator of EGFR activation. Reactive Oxygen Species 56-79 epidermal growth factor receptor Homo sapiens 144-148 29945964-5 2018 Nonsustained ATP production enhanced reactive oxygen species accumulation and subsequent JNK-mediated activation of autophagy, which in turn induced EGFR degradation. Reactive Oxygen Species 37-60 epidermal growth factor receptor Homo sapiens 149-153 29123322-0 2017 Hypoxia-induced reactive oxygen species mediate N-cadherin and SERPINE1 expression, EGFR signalling and motility in MDA-MB-468 breast cancer cells. Reactive Oxygen Species 16-39 epidermal growth factor receptor Homo sapiens 84-88 29977314-0 2018 ROS-Mediated Mitochondrial Pathway is Required for Manilkara Zapota (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-kappaB Activities of HeLa Human Cervical Cancer Cells. Reactive Oxygen Species 0-3 epidermal growth factor receptor Homo sapiens 167-171 29548337-4 2018 Furthermore, reactive oxygen species (ROS)-induced oxidative stress from mitochondrial dysfunction or NADPH oxidase (NOX) overactivation and ectopic expression of antioxidative enzymes were also indicated to be involved in EGFR-mediated tumor progression (proliferation, differentiation, migration, and invasion) and drug resistance (EGFR tyrosine kinase inhibitor (TKI)). Reactive Oxygen Species 13-36 epidermal growth factor receptor Homo sapiens 223-227 29548337-4 2018 Furthermore, reactive oxygen species (ROS)-induced oxidative stress from mitochondrial dysfunction or NADPH oxidase (NOX) overactivation and ectopic expression of antioxidative enzymes were also indicated to be involved in EGFR-mediated tumor progression (proliferation, differentiation, migration, and invasion) and drug resistance (EGFR tyrosine kinase inhibitor (TKI)). Reactive Oxygen Species 13-36 epidermal growth factor receptor Homo sapiens 334-338 29548337-4 2018 Furthermore, reactive oxygen species (ROS)-induced oxidative stress from mitochondrial dysfunction or NADPH oxidase (NOX) overactivation and ectopic expression of antioxidative enzymes were also indicated to be involved in EGFR-mediated tumor progression (proliferation, differentiation, migration, and invasion) and drug resistance (EGFR tyrosine kinase inhibitor (TKI)). Reactive Oxygen Species 38-41 epidermal growth factor receptor Homo sapiens 223-227 29548337-4 2018 Furthermore, reactive oxygen species (ROS)-induced oxidative stress from mitochondrial dysfunction or NADPH oxidase (NOX) overactivation and ectopic expression of antioxidative enzymes were also indicated to be involved in EGFR-mediated tumor progression (proliferation, differentiation, migration, and invasion) and drug resistance (EGFR tyrosine kinase inhibitor (TKI)). Reactive Oxygen Species 38-41 epidermal growth factor receptor Homo sapiens 334-338 29548337-7 2018 Oxidation of both the EGFR and downstream phosphatases by ROS enhances EGFR-mediated signaling and promotes tumor progression. Reactive Oxygen Species 58-61 epidermal growth factor receptor Homo sapiens 22-26 29548337-7 2018 Oxidation of both the EGFR and downstream phosphatases by ROS enhances EGFR-mediated signaling and promotes tumor progression. Reactive Oxygen Species 58-61 epidermal growth factor receptor Homo sapiens 71-75 29659325-4 2018 In the present experiment, the possible roles of reactive oxygen species (ROS) in MF-induced EGFR clustering were investigated. Reactive Oxygen Species 74-77 epidermal growth factor receptor Homo sapiens 93-97 29659325-9 2018 However, pretreatment with NAC or PDTC, the scavenger of ROS, not only counteracted the effects of a 50-Hz MF on ROS level and AMS activity, but also inhibited the EGFR clustering induced by MF exposure. Reactive Oxygen Species 57-60 epidermal growth factor receptor Homo sapiens 164-168 29659325-10 2018 CONCLUSIONS: The present and previous data suggest that ROS mediates the MF-induced EGFR clustering via ASMase activation. Reactive Oxygen Species 56-59 epidermal growth factor receptor Homo sapiens 84-88 29589623-6 2018 The nanoconjugated EGF is found to trigger an EGFR-dependent increase in cytoplasmic reactive oxygen species (ROS) levels but no indications of increased mitochondrial ROS levels or mitochondrial membrane damage are detected at early time points of the apoptosis induction. Reactive Oxygen Species 85-108 epidermal growth factor receptor Homo sapiens 46-50 29589623-6 2018 The nanoconjugated EGF is found to trigger an EGFR-dependent increase in cytoplasmic reactive oxygen species (ROS) levels but no indications of increased mitochondrial ROS levels or mitochondrial membrane damage are detected at early time points of the apoptosis induction. Reactive Oxygen Species 110-113 epidermal growth factor receptor Homo sapiens 46-50 28394354-5 2017 Conversely, restricting ROS generation and/or targeting YY1 in lung cancer cells effectively inhibits the EGFR-MnSOD signaling pathway and cell invasiveness induced by MCT-1. Reactive Oxygen Species 24-27 epidermal growth factor receptor Homo sapiens 106-110 29110853-2 2017 Activating mutations of the epidermal growth factor receptor gene (EGFR) are oncogenic drivers in non-small cell lung cancer (NSCLC), but it has remained unknown whether ligand-independent EGFR signaling conferred by EGFR mutation triggers ROS generation in NSCLC cells. Reactive Oxygen Species 240-243 epidermal growth factor receptor Homo sapiens 28-60 29110853-2 2017 Activating mutations of the epidermal growth factor receptor gene (EGFR) are oncogenic drivers in non-small cell lung cancer (NSCLC), but it has remained unknown whether ligand-independent EGFR signaling conferred by EGFR mutation triggers ROS generation in NSCLC cells. Reactive Oxygen Species 240-243 epidermal growth factor receptor Homo sapiens 67-71 29110853-7 2017 RESULTS: EGFR signaling due to EGFR mutation increased ROS levels in transfected HEK293T cells. Reactive Oxygen Species 55-58 epidermal growth factor receptor Homo sapiens 9-13 29110853-7 2017 RESULTS: EGFR signaling due to EGFR mutation increased ROS levels in transfected HEK293T cells. Reactive Oxygen Species 55-58 epidermal growth factor receptor Homo sapiens 31-35 29110853-8 2017 The expression of CD44v isoforms was found to be inversely correlated with basal ROS levels in EGFR mutation-positive NSCLC cell lines. Reactive Oxygen Species 81-84 epidermal growth factor receptor Homo sapiens 95-99 29110853-9 2017 Knockdown of CD44v induced depletion of intracellular GSH and increased ROS levels in EGFR-mutated NSCLC cells that express CD44v at a high level (CD44vhigh). Reactive Oxygen Species 72-75 epidermal growth factor receptor Homo sapiens 86-90 29077771-0 2017 Correction: Correction: Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway. Reactive Oxygen Species 92-115 epidermal growth factor receptor Homo sapiens 126-158 28577939-0 2017 Cigarette smoke extract induces EGFR-TKI resistance via promoting EGFR signaling pathway and ROS generation in NSCLC cell lines. Reactive Oxygen Species 93-96 epidermal growth factor receptor Homo sapiens 32-36 28577939-6 2017 CONCLUSION: Cigarette smoke extract induces EGFR-TKI resistance via promoting EGFR signaling and ROS generation in NSCLC cell lines which could be suppressed by NAC. Reactive Oxygen Species 97-100 epidermal growth factor receptor Homo sapiens 44-48 28222166-0 2017 Correction: Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway. Reactive Oxygen Species 80-103 epidermal growth factor receptor Homo sapiens 114-146 28236592-4 2017 Further experiments revealed the conjugate"s reactive oxygen species (ROS) generating ability, apoptosis inducing activity and involvement in EGFR downstream signaling pathways. Reactive Oxygen Species 45-68 epidermal growth factor receptor Homo sapiens 142-146 28338196-4 2017 The expression of the epidermal growth factor receptor (EGFR) and its downstream signaling pathway extracellular signal-regulated kinase (ERK) protein in H2O2 was detected by Western blot method; moreover, the effect of H2O2 on intracellular reactive oxygen species (ROS) in AGS cells was observed under the fluorescence microscope and quantitative analysis by flow cytometry. Reactive Oxygen Species 242-265 epidermal growth factor receptor Homo sapiens 22-54 28338196-4 2017 The expression of the epidermal growth factor receptor (EGFR) and its downstream signaling pathway extracellular signal-regulated kinase (ERK) protein in H2O2 was detected by Western blot method; moreover, the effect of H2O2 on intracellular reactive oxygen species (ROS) in AGS cells was observed under the fluorescence microscope and quantitative analysis by flow cytometry. Reactive Oxygen Species 242-265 epidermal growth factor receptor Homo sapiens 56-60 28338196-4 2017 The expression of the epidermal growth factor receptor (EGFR) and its downstream signaling pathway extracellular signal-regulated kinase (ERK) protein in H2O2 was detected by Western blot method; moreover, the effect of H2O2 on intracellular reactive oxygen species (ROS) in AGS cells was observed under the fluorescence microscope and quantitative analysis by flow cytometry. Reactive Oxygen Species 267-270 epidermal growth factor receptor Homo sapiens 22-54 28338196-4 2017 The expression of the epidermal growth factor receptor (EGFR) and its downstream signaling pathway extracellular signal-regulated kinase (ERK) protein in H2O2 was detected by Western blot method; moreover, the effect of H2O2 on intracellular reactive oxygen species (ROS) in AGS cells was observed under the fluorescence microscope and quantitative analysis by flow cytometry. Reactive Oxygen Species 267-270 epidermal growth factor receptor Homo sapiens 56-60 27942670-8 2017 We thus revealed the mechanisms controlling ROS production, notably the activity modulation of the ROS-producing enzyme NADPH oxidase by fast (<10 s) EGFR transactivation, and measured quantitatively their kinetic parameters through a minimal analytical model. Reactive Oxygen Species 44-47 epidermal growth factor receptor Homo sapiens 153-157 28137309-6 2017 ROS have been implicated in IR-induced EMT, via activation of several EMT transcription factors-including Snail, HIF-1, ZEB1, and STAT3-that are activated by signalling pathways, including those of TGF-beta, Wnt, Hedgehog, Notch, G-CSF, EGFR/PI3K/Akt, and MAPK. Reactive Oxygen Species 0-3 epidermal growth factor receptor Homo sapiens 237-241 27942670-8 2017 We thus revealed the mechanisms controlling ROS production, notably the activity modulation of the ROS-producing enzyme NADPH oxidase by fast (<10 s) EGFR transactivation, and measured quantitatively their kinetic parameters through a minimal analytical model. Reactive Oxygen Species 99-102 epidermal growth factor receptor Homo sapiens 153-157 28081539-11 2017 Accordingly, ROS levels were increased in suspended cells, resulting in the activation of Src and EGFR. Reactive Oxygen Species 13-16 epidermal growth factor receptor Homo sapiens 98-102 28081539-15 2017 CONCLUSIONS: NOX4 upregulation confers anoikis resistance by ROS-mediated activation of EGFR and Src, and by maintaining EGFR levels, which is critical for cell survival. Reactive Oxygen Species 61-64 epidermal growth factor receptor Homo sapiens 88-92 27846303-0 2016 Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway. Reactive Oxygen Species 68-91 epidermal growth factor receptor Homo sapiens 102-134 27846303-8 2016 In conclusion, the ROS-dependent phosphorylation of EGFR/MAPK is an important signaling pathway for AF-induced inhibition of RPE cell survival, and AF may have the potential for treatment of abnormal survival of RPE cells in PVR. Reactive Oxygen Species 19-22 epidermal growth factor receptor Homo sapiens 52-56 27450723-0 2016 ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis. Reactive Oxygen Species 111-114 epidermal growth factor receptor Homo sapiens 21-25 27744404-10 2016 Ang II- or EGF-triggered reactive oxygen species production was significantly reduced in shRNA-EGFR-injected hearts compared with that in the shRNA-SCR group. Reactive Oxygen Species 25-48 epidermal growth factor receptor Homo sapiens 95-99 27650496-2 2016 Activation of EGFR is regulated by redox-dependent processes involving reversible cysteine oxidation by reactive oxygen species (ROS) and involves both ligand-dependent and -independent mechanisms, but the precise source(s) of ROS and the molecular mechanisms that control tyrosine kinase activity are incompletely understood. Reactive Oxygen Species 104-127 epidermal growth factor receptor Homo sapiens 14-18 27650496-2 2016 Activation of EGFR is regulated by redox-dependent processes involving reversible cysteine oxidation by reactive oxygen species (ROS) and involves both ligand-dependent and -independent mechanisms, but the precise source(s) of ROS and the molecular mechanisms that control tyrosine kinase activity are incompletely understood. Reactive Oxygen Species 129-132 epidermal growth factor receptor Homo sapiens 14-18 27650496-2 2016 Activation of EGFR is regulated by redox-dependent processes involving reversible cysteine oxidation by reactive oxygen species (ROS) and involves both ligand-dependent and -independent mechanisms, but the precise source(s) of ROS and the molecular mechanisms that control tyrosine kinase activity are incompletely understood. Reactive Oxygen Species 227-230 epidermal growth factor receptor Homo sapiens 14-18 26747779-9 2016 We established that LPS induced p42/p44 MAPK activation via a c-Src/NADPH oxidase/ROS/EGFR, PDGFR/PI3K/Akt-dependent pathway in these cells. Reactive Oxygen Species 82-85 epidermal growth factor receptor Homo sapiens 86-90 27195063-5 2016 These results suggest an important role for NADPH oxidase in the initiation/promotion of neuronal degeneration by increasing ROS in close proximity to protein machineries, including those for ZNRF1 and EGFR, thereby promoting neuronal degeneration. Reactive Oxygen Species 125-128 epidermal growth factor receptor Homo sapiens 202-206 26815118-8 2016 Production of ROS was inhibited by both the NADPH oxidase 1 (NOX1) inhibitor STK301831 and NOX1 knock-down, which also impaired TACE/ADAM17 activation and thus EGFR phosphorylation. Reactive Oxygen Species 14-17 epidermal growth factor receptor Homo sapiens 160-164 27594973-9 2016 The downregulation of EGFR, GRB2, and PTPN11 will reduce the production of reactive oxygen species and protect against oxidative stress-induced injury for intestine. Reactive Oxygen Species 75-98 epidermal growth factor receptor Homo sapiens 22-26 26528827-4 2016 RESULTS: The basal ROS levels in EGFR(T790M)-containing TKI-resistant NSCLC cell lines were substantially high. Reactive Oxygen Species 19-22 epidermal growth factor receptor Homo sapiens 33-38 26528827-12 2016 CONCLUSION: Targeting EGFR by elevating ROS and redox imbalance is a potential new strategy to develop a new EGFR inhibitor for TKI-resistant patients with a wide therapeutic window between EGFR(T790M) and EGFR(WT). Reactive Oxygen Species 40-43 epidermal growth factor receptor Homo sapiens 22-26 26528827-12 2016 CONCLUSION: Targeting EGFR by elevating ROS and redox imbalance is a potential new strategy to develop a new EGFR inhibitor for TKI-resistant patients with a wide therapeutic window between EGFR(T790M) and EGFR(WT). Reactive Oxygen Species 40-43 epidermal growth factor receptor Homo sapiens 109-113 26528827-12 2016 CONCLUSION: Targeting EGFR by elevating ROS and redox imbalance is a potential new strategy to develop a new EGFR inhibitor for TKI-resistant patients with a wide therapeutic window between EGFR(T790M) and EGFR(WT). Reactive Oxygen Species 40-43 epidermal growth factor receptor Homo sapiens 109-113 26528827-12 2016 CONCLUSION: Targeting EGFR by elevating ROS and redox imbalance is a potential new strategy to develop a new EGFR inhibitor for TKI-resistant patients with a wide therapeutic window between EGFR(T790M) and EGFR(WT). Reactive Oxygen Species 40-43 epidermal growth factor receptor Homo sapiens 109-113 26904167-9 2016 Thus, taken together, our findings suggested that TGF-beta and hypoxia/reoxygenation promoted tumor progression and radioresistance of A549 cells through ROS-mediated activation of Nrf2 and EGFR. Reactive Oxygen Species 154-157 epidermal growth factor receptor Homo sapiens 190-194 26409771-0 2015 Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway. Reactive Oxygen Species 72-75 epidermal growth factor receptor Homo sapiens 27-31 26286833-6 2016 Our results show that ROS production induced by Bcl-w activates Src, which then binds to and phosphorylates EGFR, leading to stimulation of the PI3K-dependent invasion pathway. Reactive Oxygen Species 22-25 epidermal growth factor receptor Homo sapiens 108-112 25562511-5 2015 Reactive oxygen species generated by dual oxidase 2 stabilize tyrosine phosphorylation of epidermal growth factor receptor and induce MUC3 and MUC5AC through persistent activation of extracellular signal-regulated kinases 1/2-protein kinase C. Knocking down dual oxidase 2 by selective RNA targeting (siRNA) reduced epidermal growth factor receptor phosphorylation, and MUC3 and MUC5AC gene expression. Reactive Oxygen Species 0-23 epidermal growth factor receptor Homo sapiens 90-122 25671776-8 2015 Although mitochondrial dysfunction seems to mediate the aldosterone-induced mesangial apoptosis, the ROS dependent epithelial growth factor receptor (EGFR) transactivation is probably responsible for aldosterone-induced mesangial mitosis and proliferation. Reactive Oxygen Species 101-104 epidermal growth factor receptor Homo sapiens 115-148 25671776-8 2015 Although mitochondrial dysfunction seems to mediate the aldosterone-induced mesangial apoptosis, the ROS dependent epithelial growth factor receptor (EGFR) transactivation is probably responsible for aldosterone-induced mesangial mitosis and proliferation. Reactive Oxygen Species 101-104 epidermal growth factor receptor Homo sapiens 150-154 26300055-12 2015 ROS increment was responsible for the PKC-alpha activation that provoked EGFR transactivation and consequential phosphorylation of ERK1/2. Reactive Oxygen Species 0-3 epidermal growth factor receptor Homo sapiens 73-77 26079889-3 2015 Noteworthy, we have previously demonstrated that EGFR/Rac1/reactive oxygen species (ROS)/matrix metalloproteinase 9 (MMP-9) is a key signaling cascade regulating MUC5AC production in airway cells challenged with LPS. Reactive Oxygen Species 59-82 epidermal growth factor receptor Homo sapiens 49-53 25562511-6 2015 Extracellular reactive oxygen species produced by dual oxidase 2, upon stimulation by epidermal growth factor, stabilize epidermal growth factor receptor phosphorylation and activate extracellular signal-regulated kinases 1/2-protein kinase C which induce MUC5AC and MUC3. Reactive Oxygen Species 14-37 epidermal growth factor receptor Homo sapiens 121-153 25562511-5 2015 Reactive oxygen species generated by dual oxidase 2 stabilize tyrosine phosphorylation of epidermal growth factor receptor and induce MUC3 and MUC5AC through persistent activation of extracellular signal-regulated kinases 1/2-protein kinase C. Knocking down dual oxidase 2 by selective RNA targeting (siRNA) reduced epidermal growth factor receptor phosphorylation, and MUC3 and MUC5AC gene expression. Reactive Oxygen Species 0-23 epidermal growth factor receptor Homo sapiens 316-348 24724551-0 2014 Activation of sperm EGFR by light irradiation is mediated by reactive oxygen species. Reactive Oxygen Species 61-84 epidermal growth factor receptor Homo sapiens 20-24 25477514-0 2015 Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development. Reactive Oxygen Species 129-152 epidermal growth factor receptor Homo sapiens 27-59 25477514-10 2015 Furthermore, inhibition of AREG or EGFR restored capacity of ROS generation and decreased SOD2 expression. Reactive Oxygen Species 61-64 epidermal growth factor receptor Homo sapiens 35-39 25477514-14 2015 In summary, the present study suggests that ligand-dependent constitutive activation of EGFR causes reduced ROS generation and increased antioxidant expression, leading to development of apoptosis resistance, contributing to Cr(VI)-induced tumorigenesis. Reactive Oxygen Species 108-111 epidermal growth factor receptor Homo sapiens 88-92 25338626-0 2015 Reactive oxygen species-mediated activation of the Src-epidermal growth factor receptor-Akt signaling cascade prevents bortezomib-induced apoptosis in hepatocellular carcinoma cells. Reactive Oxygen Species 0-23 epidermal growth factor receptor Homo sapiens 55-87 25338626-8 2015 The ROS scavenger N-acetyl-L-cysteine inhibits bortezomib-induced ROS production and abrogates the phosphorylation of Src, epidermal growth factor receptor and Akt. Reactive Oxygen Species 4-7 epidermal growth factor receptor Homo sapiens 123-155 25338626-10 2015 The present study concluded that ROS mediated the activation of the Src-EGFR-Akt cascade by bortezomib. Reactive Oxygen Species 33-36 epidermal growth factor receptor Homo sapiens 72-76 24963595-0 2014 Verrucarin A induces apoptosis through ROS-mediated EGFR/MAPK/Akt signaling pathways in MDA-MB-231 breast cancer cells. Reactive Oxygen Species 39-42 epidermal growth factor receptor Homo sapiens 52-56 24963595-8 2014 Collectively, these results indicate that VA-induces ROS elevation in cancer cells, which results in the activation of p38MAPK and inhibition of EGFR/Akt/ERK signaling cascade and, ultimately, cancer cell death. Reactive Oxygen Species 53-56 epidermal growth factor receptor Homo sapiens 145-149 24724551-4 2014 Here, we showed that this effect of light on HAM is mediated by ROS-dependent activation of the epidermal growth factor receptor (EGFR). Reactive Oxygen Species 64-67 epidermal growth factor receptor Homo sapiens 96-128 24724551-4 2014 Here, we showed that this effect of light on HAM is mediated by ROS-dependent activation of the epidermal growth factor receptor (EGFR). Reactive Oxygen Species 64-67 epidermal growth factor receptor Homo sapiens 130-134 24724551-5 2014 Interestingly, ROS-mediated HAM even when the EGFR was activated by EGF, the physiological ligand of EGFR. Reactive Oxygen Species 15-18 epidermal growth factor receptor Homo sapiens 46-50 24724551-5 2014 Interestingly, ROS-mediated HAM even when the EGFR was activated by EGF, the physiological ligand of EGFR. Reactive Oxygen Species 15-18 epidermal growth factor receptor Homo sapiens 101-105 23688012-5 2014 Recent experimental studies indicate that chronically elevated leptin transactivates the EGFR through the mechanisms requiring reactive oxygen species and cytosolic tyrosine kinase, c-Src. Reactive Oxygen Species 127-150 epidermal growth factor receptor Homo sapiens 89-93 24635018-5 2014 RESULTS AND INNOVATION: There is an inverse correlation between MnSOD expression and UV-induced activation of epidermal growth factor receptor (EGFR), as determined by phosphorylation at Tyr1068, both in vitro and in vivo, which correlates with increased ROS production (as measured by dihydroethidium fluorescence). Reactive Oxygen Species 255-258 epidermal growth factor receptor Homo sapiens 110-142 24635018-5 2014 RESULTS AND INNOVATION: There is an inverse correlation between MnSOD expression and UV-induced activation of epidermal growth factor receptor (EGFR), as determined by phosphorylation at Tyr1068, both in vitro and in vivo, which correlates with increased ROS production (as measured by dihydroethidium fluorescence). Reactive Oxygen Species 255-258 epidermal growth factor receptor Homo sapiens 144-148 24126683-4 2013 The present study shows that PN promoted the phosphorylation of EGF receptor (phospho-EGFR) at Tyr1173, an event which was observed already at 1 h of incubation with 25 microM PN and reached a peak at 8-16 h. This effect seemed to be a consequence of ROS production, because N-acetylcysteine (NAC), a powerful ROS scavenger, prevented the increment of phospho-EGFR levels. Reactive Oxygen Species 251-254 epidermal growth factor receptor Homo sapiens 86-90 24126683-4 2013 The present study shows that PN promoted the phosphorylation of EGF receptor (phospho-EGFR) at Tyr1173, an event which was observed already at 1 h of incubation with 25 microM PN and reached a peak at 8-16 h. This effect seemed to be a consequence of ROS production, because N-acetylcysteine (NAC), a powerful ROS scavenger, prevented the increment of phospho-EGFR levels. Reactive Oxygen Species 310-313 epidermal growth factor receptor Homo sapiens 86-90 24126683-7 2013 Therefore, EGFR phosphorylation can exert a key role in the production of superoxide anion and ROS induced by PN in MDA-MB-231 cells. Reactive Oxygen Species 95-98 epidermal growth factor receptor Homo sapiens 11-15 23872073-6 2013 Reactive oxygen species (ROS)-dependent mechanisms initiated by TGF-beta1 were critical for EGFR(Y845) and p53(Ser15) phosphorylation and target gene expression. Reactive Oxygen Species 0-23 epidermal growth factor receptor Homo sapiens 92-101 23872073-6 2013 Reactive oxygen species (ROS)-dependent mechanisms initiated by TGF-beta1 were critical for EGFR(Y845) and p53(Ser15) phosphorylation and target gene expression. Reactive Oxygen Species 25-28 epidermal growth factor receptor Homo sapiens 92-101 23063463-4 2013 ROS generation in response to TGF-beta1 stimulation is rapid and precedes PAI-1 induction; engagement of non-SMAD (e.g., EGFR, Src kinase, MAP kinases, p53) and SMAD2/3 pathways are both required for PAI-1 expression and are ROS-dependent. Reactive Oxygen Species 0-3 epidermal growth factor receptor Homo sapiens 121-125 24020587-8 2013 In addition, SAL induced cell proliferation in estrogen receptor (ER)-negative MCF-10A cells, and the proliferation was inhibited by an antioxidant N-acetylcysteine and an epidermal growth factor receptor (EGFR) inhibitor AG1478, suggesting that reactive oxygen species may participate in the proliferation of MCF-10A cells via EGFR activation. Reactive Oxygen Species 246-269 epidermal growth factor receptor Homo sapiens 206-210 23597419-10 2013 Genetic variation in 24 ROS-related genes, including EGFR, CENPE, APEX1, and GSTP1, was associated with mRNA expression of 14 genes previously linked to fibrosis (P<=.005). Reactive Oxygen Species 24-27 epidermal growth factor receptor Homo sapiens 53-57 23411410-0 2013 Electromagnetic fields induce neural differentiation of human bone marrow derived mesenchymal stem cells via ROS mediated EGFR activation. Reactive Oxygen Species 109-112 epidermal growth factor receptor Homo sapiens 122-126 23411410-7 2013 Moreover, pretreatment with a ROS scavenger, N-acetylcystein, and an EGFR inhibitor, AG-1478, prevented the phosphorylation of EGFR and downstream molecules. Reactive Oxygen Species 30-33 epidermal growth factor receptor Homo sapiens 127-131 24081029-0 2013 Inactive ERBB receptors cooperate with reactive oxygen species to suppress cancer progression. Reactive Oxygen Species 39-62 epidermal growth factor receptor Homo sapiens 9-13 23909633-5 2013 In the present review we mainly focus on our three latest contributions to the understanding of this signalling pathway triggered by myocardial stretch: 1) The finding that an increased production of reactive oxygen species (ROS) from mitochondrial origin is critical in the activation of the NHE-1 and therefore in the genesis of the SFR; 2) the demonstration of a key role played by the transactivation of the epidermal growth factor receptor; and 3) the involvement of mineralocorticoid receptors (MR) activation in the stretch-triggered cascade leading to the SFR. Reactive Oxygen Species 200-223 epidermal growth factor receptor Homo sapiens 412-451 23909633-5 2013 In the present review we mainly focus on our three latest contributions to the understanding of this signalling pathway triggered by myocardial stretch: 1) The finding that an increased production of reactive oxygen species (ROS) from mitochondrial origin is critical in the activation of the NHE-1 and therefore in the genesis of the SFR; 2) the demonstration of a key role played by the transactivation of the epidermal growth factor receptor; and 3) the involvement of mineralocorticoid receptors (MR) activation in the stretch-triggered cascade leading to the SFR. Reactive Oxygen Species 225-228 epidermal growth factor receptor Homo sapiens 412-451 23481041-7 2013 We demonstrate that reactive oxygen species and especially decrease in pH generated during exposure to LEF are involved in EGFR ligandless activation. Reactive Oxygen Species 20-43 epidermal growth factor receptor Homo sapiens 123-127 23344263-9 2013 Inhibition of EGFR-ERK/AKT by gefitinib activates FOXO3a, which in turn reduces reactive oxygen species (ROS) and ROS-mediated CID. Reactive Oxygen Species 80-103 epidermal growth factor receptor Homo sapiens 14-18 23344263-9 2013 Inhibition of EGFR-ERK/AKT by gefitinib activates FOXO3a, which in turn reduces reactive oxygen species (ROS) and ROS-mediated CID. Reactive Oxygen Species 105-108 epidermal growth factor receptor Homo sapiens 14-18 23344263-9 2013 Inhibition of EGFR-ERK/AKT by gefitinib activates FOXO3a, which in turn reduces reactive oxygen species (ROS) and ROS-mediated CID. Reactive Oxygen Species 114-117 epidermal growth factor receptor Homo sapiens 14-18 23344263-10 2013 To overcome this, we showed that SAHA and erastin, the inducers of ROS-mediated CID, strongly enhanced the effect of cisplatin in WT EGFR cells. Reactive Oxygen Species 67-70 epidermal growth factor receptor Homo sapiens 133-137 22773695-10 2012 Taken together, we demonstrated that ATPgammaS stimulated activation of NADPH oxidase, resulting in generation of ROS, which then activated the downstream c-Src/EGFR/PI3K/Akt/NF-kappaB/p300 cascade to regulate the expression of COX-2 and synthesis of PGE(2) in A549 cells. Reactive Oxygen Species 114-117 epidermal growth factor receptor Homo sapiens 161-165 22687878-5 2012 We show that reactive oxygen species (ROS), known to damage cellular macromolecules and to modulate signaling cascades in a variety of human diseases including cancers, appear to play a critical role in mediating EGFR TKI-resistance. Reactive Oxygen Species 13-36 epidermal growth factor receptor Homo sapiens 213-217 22687878-5 2012 We show that reactive oxygen species (ROS), known to damage cellular macromolecules and to modulate signaling cascades in a variety of human diseases including cancers, appear to play a critical role in mediating EGFR TKI-resistance. Reactive Oxygen Species 38-41 epidermal growth factor receptor Homo sapiens 213-217 22781707-11 2012 Taken together, these findings indicate that indoxyl sulfate enhances Ang II signaling through reactive oxygen species-induced EGFR expression. Reactive Oxygen Species 95-118 epidermal growth factor receptor Homo sapiens 127-131 22773695-6 2012 The increase of ROS level resulted in activation of the c-Src/epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/nuclear factor (NF)-kappaB cascade. Reactive Oxygen Species 16-19 epidermal growth factor receptor Homo sapiens 56-94 22773695-6 2012 The increase of ROS level resulted in activation of the c-Src/epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/nuclear factor (NF)-kappaB cascade. Reactive Oxygen Species 16-19 epidermal growth factor receptor Homo sapiens 96-100 21898403-6 2012 Inhibition of PKA in HaCaT-MC1R cells resulted in a marked increase of ROS production after UVA irradiation; (4) the ability of HaCaT-MC1R cells to produce UVA-ROS was restored by inhibiting epidermal growth factor receptor (EGFR) or extracellular signal-regulated kinases (ERK) activity before UVA exposure. Reactive Oxygen Species 160-163 epidermal growth factor receptor Homo sapiens 191-223 21898403-6 2012 Inhibition of PKA in HaCaT-MC1R cells resulted in a marked increase of ROS production after UVA irradiation; (4) the ability of HaCaT-MC1R cells to produce UVA-ROS was restored by inhibiting epidermal growth factor receptor (EGFR) or extracellular signal-regulated kinases (ERK) activity before UVA exposure. Reactive Oxygen Species 160-163 epidermal growth factor receptor Homo sapiens 225-229 21412256-9 2011 These results suggest that cis-UCA exerts its effects on human keratinocytes via intracellular ROS generation that modulates EGFR signaling and subsequently induces PGE(2) synthesis and apoptotic cell death. Reactive Oxygen Species 95-98 epidermal growth factor receptor Homo sapiens 125-129 21321939-5 2011 EV71-induced ROS generation was mediated through activation of integrin beta1, an epidermal growth factor receptor (EGFR), Rac1 and NADPH oxidase which revealed by using selective pharmacological inhibitors or transfection with respective siRNAs. Reactive Oxygen Species 13-16 epidermal growth factor receptor Homo sapiens 116-120 21914790-8 2011 EGFR activation by menadione was associated with reversible protein tyrosine phosphatase inhibition, which seemed to be mediated by ROS generation as exposure to antioxidants prevented both menadione-induced ROS generation and phosphatase inhibition. Reactive Oxygen Species 132-135 epidermal growth factor receptor Homo sapiens 0-4 21914790-8 2011 EGFR activation by menadione was associated with reversible protein tyrosine phosphatase inhibition, which seemed to be mediated by ROS generation as exposure to antioxidants prevented both menadione-induced ROS generation and phosphatase inhibition. Reactive Oxygen Species 208-211 epidermal growth factor receptor Homo sapiens 0-4 22215616-0 2012 Angiotensin II induces epithelial-to-mesenchymal transition in renal epithelial cells through reactive oxygen species/Src/caveolin-mediated activation of an epidermal growth factor receptor-extracellular signal-regulated kinase signaling pathway. Reactive Oxygen Species 94-117 epidermal growth factor receptor Homo sapiens 157-189 22215616-6 2012 Thus, this report provides the first evidence that reactive oxygen species (ROS)/Src-dependent activation of persistent Cav-EGFR-ERK signaling mediates renal tubular cell dedifferentiation and identifies a novel molecular mechanism that may be involved in progressive renal injury caused by chronic exposure to Ang II. Reactive Oxygen Species 51-74 epidermal growth factor receptor Homo sapiens 124-128 22215616-6 2012 Thus, this report provides the first evidence that reactive oxygen species (ROS)/Src-dependent activation of persistent Cav-EGFR-ERK signaling mediates renal tubular cell dedifferentiation and identifies a novel molecular mechanism that may be involved in progressive renal injury caused by chronic exposure to Ang II. Reactive Oxygen Species 76-79 epidermal growth factor receptor Homo sapiens 124-128 21708247-0 2011 NADPH-oxidase-dependent reactive oxygen species mediate EGFR transactivation by FPRL1 in WKYMVm-stimulated human lung cancer cells. Reactive Oxygen Species 24-47 epidermal growth factor receptor Homo sapiens 56-60 21308480-3 2011 MUC5AC expression is regulated by epidermal growth factor receptor (EGFR) which can be activated by reactive oxygen species (ROS). Reactive Oxygen Species 100-123 epidermal growth factor receptor Homo sapiens 34-66 21308480-3 2011 MUC5AC expression is regulated by epidermal growth factor receptor (EGFR) which can be activated by reactive oxygen species (ROS). Reactive Oxygen Species 100-123 epidermal growth factor receptor Homo sapiens 68-72 21308480-3 2011 MUC5AC expression is regulated by epidermal growth factor receptor (EGFR) which can be activated by reactive oxygen species (ROS). Reactive Oxygen Species 125-128 epidermal growth factor receptor Homo sapiens 34-66 21557328-3 2011 TGFalpha-dependent ERK oscillations mediated through the epidermal growth factor receptor (EGFR) are inhibited by low dose X-irradiation (10 cGy) and low concentrations of hydrogen peroxide (0.32-3.26 microM H(2)O(2)) used as a model reactive oxygen species (ROS). Reactive Oxygen Species 234-257 epidermal growth factor receptor Homo sapiens 91-95 21308480-3 2011 MUC5AC expression is regulated by epidermal growth factor receptor (EGFR) which can be activated by reactive oxygen species (ROS). Reactive Oxygen Species 125-128 epidermal growth factor receptor Homo sapiens 68-72 21308480-6 2011 The aim of our study was to examine the role of HA and CD44 in ROS-induced EGFR activation and MUC5AC expression. Reactive Oxygen Species 63-66 epidermal growth factor receptor Homo sapiens 75-79 21308480-8 2011 ROS-induced EGFR phosphorylation, which was activated by tissue kallekrein (TK) activation and EGF release. Reactive Oxygen Species 0-3 epidermal growth factor receptor Homo sapiens 12-16 21308480-9 2011 We found ROS promoted CD44 co-immunoprecipitation with EGFR and MUC5AC up-regulation. Reactive Oxygen Species 9-12 epidermal growth factor receptor Homo sapiens 55-59 21308480-11 2011 All the effects were inhibited by blocking CD44 or EGFR, suggesting that CD44 plays a critical role in ROS-induced MUC5AC up-regulation. Reactive Oxygen Species 103-106 epidermal growth factor receptor Homo sapiens 51-55 21308480-12 2011 These results show that ROS depolymerizes hyaluronan into fragments, and these fragments bind their receptor CD44 to induce TK activation, which cleaves EGF precursors into mature EGF to activate its receptor EGFR. Reactive Oxygen Species 24-27 epidermal growth factor receptor Homo sapiens 209-213 21557328-3 2011 TGFalpha-dependent ERK oscillations mediated through the epidermal growth factor receptor (EGFR) are inhibited by low dose X-irradiation (10 cGy) and low concentrations of hydrogen peroxide (0.32-3.26 microM H(2)O(2)) used as a model reactive oxygen species (ROS). Reactive Oxygen Species 234-257 epidermal growth factor receptor Homo sapiens 57-89 21557328-3 2011 TGFalpha-dependent ERK oscillations mediated through the epidermal growth factor receptor (EGFR) are inhibited by low dose X-irradiation (10 cGy) and low concentrations of hydrogen peroxide (0.32-3.26 microM H(2)O(2)) used as a model reactive oxygen species (ROS). Reactive Oxygen Species 259-262 epidermal growth factor receptor Homo sapiens 57-89 21557328-3 2011 TGFalpha-dependent ERK oscillations mediated through the epidermal growth factor receptor (EGFR) are inhibited by low dose X-irradiation (10 cGy) and low concentrations of hydrogen peroxide (0.32-3.26 microM H(2)O(2)) used as a model reactive oxygen species (ROS). Reactive Oxygen Species 259-262 epidermal growth factor receptor Homo sapiens 91-95 20566383-1 2010 The G-protein coupled receptor (GPCR) fMLP receptor (FPR) and the two receptors tyrosine kinase (RTK), the nerve growth factor (NGF) receptor TrkA and the epidermal growth factor (EGF) receptor (EGFR) are involved in reactive oxygen species (ROS), matrix metalloproteinase-9 (MMP-9) production and CD11b membrane integrin upregulation. Reactive Oxygen Species 217-240 epidermal growth factor receptor Homo sapiens 155-193 21300668-6 2011 Moreover, inhibition of epidermal growth factor receptor kinase activation with AG-1478 abrogated equol-stimulated mitochondrial reactive oxygen species generation and subsequent kinase and eNOS activation. Reactive Oxygen Species 129-152 epidermal growth factor receptor Homo sapiens 24-56 21300668-7 2011 Our findings suggest that equol-stimulated mitochondrial reactive oxygen species modulate endothelial redox signaling and NO release involving transactivation of epidermal growth factor receptor kinase and reorganization of the F-actin cytoskeleton. Reactive Oxygen Species 57-80 epidermal growth factor receptor Homo sapiens 162-194 20962773-0 2011 Reactive oxygen species mediate inflammatory cytokine release and EGFR-dependent mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin. Reactive Oxygen Species 0-23 epidermal growth factor receptor Homo sapiens 66-70 20566383-1 2010 The G-protein coupled receptor (GPCR) fMLP receptor (FPR) and the two receptors tyrosine kinase (RTK), the nerve growth factor (NGF) receptor TrkA and the epidermal growth factor (EGF) receptor (EGFR) are involved in reactive oxygen species (ROS), matrix metalloproteinase-9 (MMP-9) production and CD11b membrane integrin upregulation. Reactive Oxygen Species 242-245 epidermal growth factor receptor Homo sapiens 155-193 19855084-6 2010 The phosphorylation and internalization of EGFR were associated with this ROS generation. Reactive Oxygen Species 74-77 epidermal growth factor receptor Homo sapiens 43-47 19855084-7 2010 ECG decreased the phosphorylation and internalization of EGFR at the cell surface of NHNE cells, resulting in the attenuation of exogenous H(2)O(2)-induced intracellular ROS generation and MUC5AC overexpression. Reactive Oxygen Species 170-173 epidermal growth factor receptor Homo sapiens 57-61 20123015-9 2010 Inhibition of Src kinase activity and ROS may inhibit the EGFR activation. Reactive Oxygen Species 38-41 epidermal growth factor receptor Homo sapiens 58-62 20815772-4 2010 The effects of ROS on both BRAK and IL-8 expression were attenuated by pre-treatment with N-acetyl-L-cysteine (NAC), epidermal growth factor receptor (EGFR), and mitogen-activated protein kinase (MAPK) inhibitors. Reactive Oxygen Species 15-18 epidermal growth factor receptor Homo sapiens 117-149 20153715-6 2010 EGFR activation by plumbagin, juglone and menadione was attenuated by a superoxide dismutase mimetic, indicating that ROS-related mechanisms contribute to EGFR activation by these naphthoquinones. Reactive Oxygen Species 118-121 epidermal growth factor receptor Homo sapiens 0-4 20153715-6 2010 EGFR activation by plumbagin, juglone and menadione was attenuated by a superoxide dismutase mimetic, indicating that ROS-related mechanisms contribute to EGFR activation by these naphthoquinones. Reactive Oxygen Species 118-121 epidermal growth factor receptor Homo sapiens 155-159 19168439-3 2009 alpha(1)-ARs promote p66Shc-YY(239/240) phosphorylation via a ROS-dependent mechanism that is localized to caveolae and requires epidermal growth factor receptor (EGFR) and PKCepsilon activity. Reactive Oxygen Species 62-65 epidermal growth factor receptor Homo sapiens 129-161 19339632-13 2009 Finally, we examined the role of reactive oxygen species (ROS) in Aldo-induced transactivation of the EGFR. Reactive Oxygen Species 33-56 epidermal growth factor receptor Homo sapiens 102-106 19339632-13 2009 Finally, we examined the role of reactive oxygen species (ROS) in Aldo-induced transactivation of the EGFR. Reactive Oxygen Species 58-61 epidermal growth factor receptor Homo sapiens 102-106 19166869-2 2009 Previous studies in this laboratory have shown that benzo[a]pyrene quinones (BPQs), 1,6-BPQ and 3,6-BPQ, are able to induce epidermal growth factor receptor (EGFR) cell signaling through the production of reactive oxygen species. Reactive Oxygen Species 205-228 epidermal growth factor receptor Homo sapiens 124-156 19166869-2 2009 Previous studies in this laboratory have shown that benzo[a]pyrene quinones (BPQs), 1,6-BPQ and 3,6-BPQ, are able to induce epidermal growth factor receptor (EGFR) cell signaling through the production of reactive oxygen species. Reactive Oxygen Species 205-228 epidermal growth factor receptor Homo sapiens 158-162 19501047-6 2009 Our results also indicate that signaling events downstream of EGFR involved PI3K-dependent activation of Rac1, which mediated the NADPH-generated reactive oxygen species responsible for MMP-9 secretion and activation. Reactive Oxygen Species 146-169 epidermal growth factor receptor Homo sapiens 62-66 19501047-7 2009 Finally, we observed that EGFR/PI3K/Rac1/NADPH/ROS/MMP-9 regulate MUC5AC production in LPS-challenged NCI-H292 cells. Reactive Oxygen Species 47-50 epidermal growth factor receptor Homo sapiens 26-30 19188434-11 2009 CONCLUSIONS: High glucose, likely through ROS, impairs the EGFR-phosphatidylinositol 3-kinase/Akt pathway, resulting in delayed corneal epithelial wound healing. Reactive Oxygen Species 42-45 epidermal growth factor receptor Homo sapiens 59-63 19168439-3 2009 alpha(1)-ARs promote p66Shc-YY(239/240) phosphorylation via a ROS-dependent mechanism that is localized to caveolae and requires epidermal growth factor receptor (EGFR) and PKCepsilon activity. Reactive Oxygen Species 62-65 epidermal growth factor receptor Homo sapiens 163-167 19234179-5 2009 Pretreatment of KB cells with antioxidants vitamin C and N-acetylcysteine or the pharmacological inhibitor PD168393 specific for the epidermal growth factor receptor all inhibited UVB-induced ROS as well as PAF-R agonists, yet had no effect on fMLP-mediated PAF-R agonist production. Reactive Oxygen Species 192-195 epidermal growth factor receptor Homo sapiens 133-165 18757307-4 2009 We have previously shown that ROS-induced MUC5AC expression in NHBE cells is dependent on hyaluronan depolymerization and epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK) activation. Reactive Oxygen Species 30-33 epidermal growth factor receptor Homo sapiens 122-154 18757307-4 2009 We have previously shown that ROS-induced MUC5AC expression in NHBE cells is dependent on hyaluronan depolymerization and epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK) activation. Reactive Oxygen Species 30-33 epidermal growth factor receptor Homo sapiens 156-160 18757307-6 2009 We found that ROS promotes CD44/EGFR interaction, EGFR/MAPK activation, and MUC5B up-regulation that are prevented by blocking CD44 and/or EGFR. Reactive Oxygen Species 14-17 epidermal growth factor receptor Homo sapiens 32-36 18757307-6 2009 We found that ROS promotes CD44/EGFR interaction, EGFR/MAPK activation, and MUC5B up-regulation that are prevented by blocking CD44 and/or EGFR. Reactive Oxygen Species 14-17 epidermal growth factor receptor Homo sapiens 50-54 18757307-6 2009 We found that ROS promotes CD44/EGFR interaction, EGFR/MAPK activation, and MUC5B up-regulation that are prevented by blocking CD44 and/or EGFR. Reactive Oxygen Species 14-17 epidermal growth factor receptor Homo sapiens 50-54 18757307-9 2009 This ROS-induced MUC5B expression requires CD44 as well as EGFR and MAPK activation. Reactive Oxygen Species 5-8 epidermal growth factor receptor Homo sapiens 59-63 19234179-8 2009 These studies suggest that UVB-induced systemic immunosuppression is due to epidermal growth factor receptor-mediated ROS which results in PAF-R agonist formation. Reactive Oxygen Species 118-121 epidermal growth factor receptor Homo sapiens 76-108 18577517-16 2008 EGFR-Akt interaction promoted by HA was responsible for the increased production of ROS and HA-promoted cell motility. Reactive Oxygen Species 84-87 epidermal growth factor receptor Homo sapiens 0-4 19116140-6 2009 Our results also indicate that signaling events downstream of EGF receptor involved PI3K- and Src-dependent activation of Rac1, which mediated the NADPH-generated reactive oxygen species responsible for MMP-2 secretion and activation. Reactive Oxygen Species 163-186 epidermal growth factor receptor Homo sapiens 62-74 19049666-2 2008 Low concentration of ouabain binding to Na(+)/K(+)-ATPase activates Src/epidermal growth factor receptor complex to initiate multiple signal pathways, which include PLC/IP3/CICR, PI3K, reactive oxygen species (ROS), PLC/DG/PKC/Raf/MEK/ERK1/2, and Ras/Raf/MEK/ERK1/2 pathways. Reactive Oxygen Species 185-208 epidermal growth factor receptor Homo sapiens 72-104 19049666-2 2008 Low concentration of ouabain binding to Na(+)/K(+)-ATPase activates Src/epidermal growth factor receptor complex to initiate multiple signal pathways, which include PLC/IP3/CICR, PI3K, reactive oxygen species (ROS), PLC/DG/PKC/Raf/MEK/ERK1/2, and Ras/Raf/MEK/ERK1/2 pathways. Reactive Oxygen Species 210-213 epidermal growth factor receptor Homo sapiens 72-104 18577517-0 2008 CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2. Reactive Oxygen Species 166-189 epidermal growth factor receptor Homo sapiens 5-37 18577517-17 2008 In summary, HA promotes CD44-EGFR interaction, which in turn activates PKC signaling, involving Akt, Rac1, Phox, and the production of ROS, FAK, and MMP-2, to enhance melanoma cell motility. Reactive Oxygen Species 135-138 epidermal growth factor receptor Homo sapiens 29-33 17637750-4 2008 EGFR transactivation required the activation of SFKs and the production of ROS via NADPH oxidase, but was not dependent on metalloproteases or the release of EGF-like ligands. Reactive Oxygen Species 75-78 epidermal growth factor receptor Homo sapiens 0-4 18271921-9 2008 Although, the mutational patterns in equivalent human lesions were not completely coincident, this first report of Egfr mutations in an experimental lung tumor model suggests that X-rays or other factors producing oxygen radicals could cause EGFR mutations in some proportion of lung cancers in humans. Reactive Oxygen Species 214-229 epidermal growth factor receptor Homo sapiens 115-119 18271921-9 2008 Although, the mutational patterns in equivalent human lesions were not completely coincident, this first report of Egfr mutations in an experimental lung tumor model suggests that X-rays or other factors producing oxygen radicals could cause EGFR mutations in some proportion of lung cancers in humans. Reactive Oxygen Species 214-229 epidermal growth factor receptor Homo sapiens 242-246 18375743-9 2008 We conclude that multiple TLR ligands induce airway epithelial cell production of IL-8 and VEGF via a Duox1--> ROS--> TACE--> TGF-alpha--> EGFR phosphorylation pathway. Reactive Oxygen Species 114-117 epidermal growth factor receptor Homo sapiens 151-155 18259192-5 2008 In particular, we show that ROS are responsible for the redox-mediated activation of Src that trans-phosphorylates epidermal growth factor receptor (EGFR) in a ligand-independent manner. Reactive Oxygen Species 28-31 epidermal growth factor receptor Homo sapiens 115-147 18259192-5 2008 In particular, we show that ROS are responsible for the redox-mediated activation of Src that trans-phosphorylates epidermal growth factor receptor (EGFR) in a ligand-independent manner. Reactive Oxygen Species 28-31 epidermal growth factor receptor Homo sapiens 149-153 17881465-9 2007 Together, these data suggest that the ROS-EGFR-JNK pathway is involved in transducing the proliferative effect of ANG II in cultured HMCs. Reactive Oxygen Species 38-41 epidermal growth factor receptor Homo sapiens 42-46 16820949-4 2006 Collectively, our data demonstrate that UV-induced desmoglein-2 down-regulation is mediated reactive oxygen species which are generated through EGFR activation and Rac2/NADPH oxidase activation, suggesting that antioxidants may be applied for protection against UV-induced cataract. Reactive Oxygen Species 92-115 epidermal growth factor receptor Homo sapiens 144-148 17623008-5 2007 This study provides evidence that radio waves induce ERK1/2 activation downstream of the EGF (epidermal growth factor) receptor, which is in turn activated by the release of reactive oxygen species. Reactive Oxygen Species 174-197 epidermal growth factor receptor Homo sapiens 94-127 17875416-7 2007 Hyperosmolarity-induced ROS formation then leads to a Src-family kinase Yes-mediated activation of the epidermal growth factor receptor (EGFR) and to an activation of the c-Jun-N-terminal kinase (JNK). Reactive Oxygen Species 24-27 epidermal growth factor receptor Homo sapiens 103-135 17875416-7 2007 Hyperosmolarity-induced ROS formation then leads to a Src-family kinase Yes-mediated activation of the epidermal growth factor receptor (EGFR) and to an activation of the c-Jun-N-terminal kinase (JNK). Reactive Oxygen Species 24-27 epidermal growth factor receptor Homo sapiens 137-141 17142770-12 2006 Thus, LPS accelerates wound repair in airway epithelial cells via a novel TLR-4-->protein kinase C alphabeta-->dual oxidase 1-->reactive oxygen species-->TACE-->TGF-alpha-->EGFR phosphorylation pathway. Reactive Oxygen Species 137-160 epidermal growth factor receptor Homo sapiens 191-195 17475774-7 2007 The death induced by inhibition of EGFR or Src in normal primary prostate cells is not mediated through or dependent on caspase activation, but depends on the induction of reactive oxygen species. Reactive Oxygen Species 172-195 epidermal growth factor receptor Homo sapiens 35-39 17023263-3 2006 The NADPH oxidase antagonist diphenylene iodonium chloride and the EGFR inhibitor AG1487 prevent UVB-mediated ROS generation, the activation of the Ask-1-p38 MAPK stress response pathway, and apoptosis, evidencing the link existing between the early plasma membrane-generated ROS and the activation of a lethal cascade initiated by Ask-1. Reactive Oxygen Species 110-113 epidermal growth factor receptor Homo sapiens 67-71 17023263-3 2006 The NADPH oxidase antagonist diphenylene iodonium chloride and the EGFR inhibitor AG1487 prevent UVB-mediated ROS generation, the activation of the Ask-1-p38 MAPK stress response pathway, and apoptosis, evidencing the link existing between the early plasma membrane-generated ROS and the activation of a lethal cascade initiated by Ask-1. Reactive Oxygen Species 276-279 epidermal growth factor receptor Homo sapiens 67-71 16424381-6 2006 ROS-induced EGFR activation resulted in GC proliferation and increased MUC5AC gene and protein expression. Reactive Oxygen Species 0-3 epidermal growth factor receptor Homo sapiens 12-16 16424381-11 2006 In conclusion, ROS-induced GC metaplasia in normal human bronchial epithelial cells is associated with HA depolymerization and EGF processing by TK followed by EGFR signaling, suggesting that increases in TK activity could contribute to GC metaplasia and mucus hypersecretion in diseases such as asthma and chronic bronchitis. Reactive Oxygen Species 15-18 epidermal growth factor receptor Homo sapiens 160-164 16553950-12 2006 CONCLUSION: Collectively, our data demonstrate that in HASMC LTD4 stimulation of a Gi/o coupled CysLT1-R triggers the transactivation of the EGF-R through the intervention of PI3K and ROS. Reactive Oxygen Species 184-187 epidermal growth factor receptor Homo sapiens 141-146 16734756-5 2006 This complex process with a NADPH oxidase-derived reactive oxygen species signal as an important upstream event, allows via Yes, JNK and epidermal growth factor-receptor activation for CD95 tyrosine phosphorylation as a prerequisite for CD95 targeting to the plasma membrane and formation of the death inducing signalling complex. Reactive Oxygen Species 50-73 epidermal growth factor receptor Homo sapiens 137-169 16166300-5 2005 Production of ROS resulted in EGF receptor (EGFR) and Akt1 phosphorylation in HB-EGF-expressing cells. Reactive Oxygen Species 14-17 epidermal growth factor receptor Homo sapiens 30-42 16148149-6 2005 We hypothesize that HNE activates TACE via ROS generation, resulting in cleavage of pro-TGF-alpha, EGFR activation, and MUC5AC mucin expression in airway epithelial cells. Reactive Oxygen Species 43-46 epidermal growth factor receptor Homo sapiens 99-103 16166300-5 2005 Production of ROS resulted in EGF receptor (EGFR) and Akt1 phosphorylation in HB-EGF-expressing cells. Reactive Oxygen Species 14-17 epidermal growth factor receptor Homo sapiens 44-48 15389789-9 2005 CONCLUSIONS: The simultaneous use of EGFR inhibitor and compound releasing NO(*) might lead to a synergy in the ceramide and ROS production which might cause cellular membrane damages resulting in a massive apoptotic/necrotic death of metastatic PC cells. Reactive Oxygen Species 125-128 epidermal growth factor receptor Homo sapiens 37-41 15829704-8 2005 Exogenously administered reactive oxygen species (ROS) were found to activate ERK1/ERK2 via the EGFR and src tyrosine kinase activity and pretreatment of cells with the antioxidant N-acetylcysteine (NAC) and the NADPH oxidase inhibitor DPI abrogated albumin-induced activation of ERK1/ERK2. Reactive Oxygen Species 25-48 epidermal growth factor receptor Homo sapiens 96-100 15829704-8 2005 Exogenously administered reactive oxygen species (ROS) were found to activate ERK1/ERK2 via the EGFR and src tyrosine kinase activity and pretreatment of cells with the antioxidant N-acetylcysteine (NAC) and the NADPH oxidase inhibitor DPI abrogated albumin-induced activation of ERK1/ERK2. Reactive Oxygen Species 50-53 epidermal growth factor receptor Homo sapiens 96-100 15976327-4 2005 METHODS AND RESULTS: Knockdown of Cav1 protein by small interfering RNA (siRNA) inhibits Ang II-stimulated Rac1 activation and membrane translocation, H2O2 production, ROS-dependent epidermal growth factor receptor (EGF-R) transactivation, and subsequent phosphorylation of Akt without affecting ROS-independent extracellular signal-regulated kinase 1/2 phosphorylation. Reactive Oxygen Species 168-171 epidermal growth factor receptor Homo sapiens 182-214 15123705-0 2004 Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells. Reactive Oxygen Species 0-23 epidermal growth factor receptor Homo sapiens 100-132 14988406-0 2004 Role of hyaluronan and reactive oxygen species in tissue kallikrein-mediated epidermal growth factor receptor activation in human airways. Reactive Oxygen Species 23-46 epidermal growth factor receptor Homo sapiens 77-109 12966092-7 2003 Experiments with the Src inhibitor, PP2, and the antioxidant N-acetyl-L-cysteine revealed critical roles for Src and reactive oxygen species as upstream mediators of EGFR transactivation in response to PPAR ligands. Reactive Oxygen Species 117-140 epidermal growth factor receptor Homo sapiens 166-170 15009100-10 2004 Our data identify anthralin-induced reactive oxygen species and, more specifically, H(2)O(2) as an important upstream mediator required for ligand-independent epidermal growth factor receptor phosphorylation and downstream signaling. Reactive Oxygen Species 36-59 epidermal growth factor receptor Homo sapiens 159-191 14633709-4 2003 Using a model of epidermal growth factor (EGF) withdrawal in MCF-10A, we hypothesized that production of reactive oxygen species by BPQs could lead to the activation of the EGF receptor (EGFR). Reactive Oxygen Species 105-128 epidermal growth factor receptor Homo sapiens 173-185 14633709-4 2003 Using a model of epidermal growth factor (EGF) withdrawal in MCF-10A, we hypothesized that production of reactive oxygen species by BPQs could lead to the activation of the EGF receptor (EGFR). Reactive Oxygen Species 105-128 epidermal growth factor receptor Homo sapiens 187-191 14521055-6 2003 The inhibition of ROS generation by DPI declined EGF-dependent activation of EGF receptor and STAT factors to basal level. Reactive Oxygen Species 18-21 epidermal growth factor receptor Homo sapiens 77-89 14521055-8 2003 We have postulated that EGF-induced ROS generation is a very important initial event promoting physiological activation of EGF receptor and subsequent STAT factor activation. Reactive Oxygen Species 36-39 epidermal growth factor receptor Homo sapiens 123-135 10641711-3 1999 We have recently shown that exposure of human keratinocytes to physiologic doses of ultraviolet B radiation (UVB) activates epidermal growth factor receptor (EGFR)/extracellular-regulated kinase 1 and 2 (ERK1/2), and p38 signaling pathways via reactive oxygen species. Reactive Oxygen Species 244-267 epidermal growth factor receptor Homo sapiens 124-156 11182298-1 2001 We have recently shown that exposure of human keratinocytes to physiologic doses of ultraviolet B (UVB) activates epidermal growth factor receptor (EGFR)/extracellular-regulated kinases 1 and 2 (ERK1/2) and p38 signaling pathways via reactive oxygen species, an effect that can be modulated by antioxidants. Reactive Oxygen Species 234-257 epidermal growth factor receptor Homo sapiens 114-146 11182298-1 2001 We have recently shown that exposure of human keratinocytes to physiologic doses of ultraviolet B (UVB) activates epidermal growth factor receptor (EGFR)/extracellular-regulated kinases 1 and 2 (ERK1/2) and p38 signaling pathways via reactive oxygen species, an effect that can be modulated by antioxidants. Reactive Oxygen Species 234-257 epidermal growth factor receptor Homo sapiens 148-152 11304462-0 2001 Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells. Reactive Oxygen Species 76-99 epidermal growth factor receptor Homo sapiens 0-32 11304462-4 2001 Here, we provide novel evidence that ROS are critical mediators of EGF-R transactivation by Ang II. Reactive Oxygen Species 37-40 epidermal growth factor receptor Homo sapiens 67-72 11162642-5 2001 These data indicate that ROS mediate Ang II-induced EGF receptor transactivation, a critical mechanism for ERK-dependent growth in VSMCs. Reactive Oxygen Species 25-28 epidermal growth factor receptor Homo sapiens 52-64 11031201-3 2000 Both of these reactive oxygen species serve as second messengers to activate multiple intracellular proteins and enzymes, including the epidermal growth factor receptor, c-Src, p38 mitogen-activated protein kinase, Ras, and Akt/protein kinase B. Reactive Oxygen Species 14-37 epidermal growth factor receptor Homo sapiens 136-168 10641711-3 1999 We have recently shown that exposure of human keratinocytes to physiologic doses of ultraviolet B radiation (UVB) activates epidermal growth factor receptor (EGFR)/extracellular-regulated kinase 1 and 2 (ERK1/2), and p38 signaling pathways via reactive oxygen species. Reactive Oxygen Species 244-267 epidermal growth factor receptor Homo sapiens 158-162 34520834-7 2021 Under the laser irradiation, APFHG can significantly increase the production of the intracellular reactive oxygen species and produce a synergistic therapeutic effect in inhibition of cellular growth and induction of cell cycle arrest and apoptosis on both Gef-sensitive and Gef-resistant EGFR-mutant NSCLC cells through PDT/molecular targeted therapy. Reactive Oxygen Species 98-121 epidermal growth factor receptor Homo sapiens 289-293 35381015-3 2022 Therefore, we conducted this study to find out what ROS and their modified product are associated with eGFR in type 2 diabetes mellitus (T2DM) patients. Reactive Oxygen Species 52-55 epidermal growth factor receptor Homo sapiens 103-107 34157521-1 2021 This review examines the concerted role of Epidermal Growth Factor Receptor (EGFR) and integrins in regulating Reactive oxygen species (ROS) production through different signaling pathways. Reactive Oxygen Species 111-134 epidermal growth factor receptor Homo sapiens 43-75 34157521-1 2021 This review examines the concerted role of Epidermal Growth Factor Receptor (EGFR) and integrins in regulating Reactive oxygen species (ROS) production through different signaling pathways. Reactive Oxygen Species 136-139 epidermal growth factor receptor Homo sapiens 43-75 35218706-2 2022 We previously reported that reactive oxygen species (ROS) generated by NADPH oxidases induces EGFR-dependent phosphorylation and activation of ZNRF1 ubiquitin ligase in neurons, which promotes neuronal cell death and neurite degeneration. Reactive Oxygen Species 28-51 epidermal growth factor receptor Homo sapiens 94-98 35218706-2 2022 We previously reported that reactive oxygen species (ROS) generated by NADPH oxidases induces EGFR-dependent phosphorylation and activation of ZNRF1 ubiquitin ligase in neurons, which promotes neuronal cell death and neurite degeneration. Reactive Oxygen Species 53-56 epidermal growth factor receptor Homo sapiens 94-98 35568782-14 2022 Scavenging of reactive oxygen species (ROS) ameliorated the enhanced EGFR activation in LR cells. Reactive Oxygen Species 14-37 epidermal growth factor receptor Homo sapiens 69-73 35568782-14 2022 Scavenging of reactive oxygen species (ROS) ameliorated the enhanced EGFR activation in LR cells. Reactive Oxygen Species 39-42 epidermal growth factor receptor Homo sapiens 69-73 35568782-15 2022 Lenvatinib resistance was induced by enhanced EGFR activation, possibly via ROS accumulation, in lenvatinib- resistant cells. Reactive Oxygen Species 76-79 epidermal growth factor receptor Homo sapiens 46-50 35126111-0 2021 FGFC1 Selectively Inhibits Erlotinib-Resistant Non-Small Cell Lung Cancer via Elevation of ROS Mediated by the EGFR/PI3K/Akt/mTOR Pathway. Reactive Oxygen Species 91-94 epidermal growth factor receptor Homo sapiens 111-115