PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29535810-13 2018 Our results showed that silibinin enhanced TRAIL-induced apoptosis by upregulating DR5 expression through the ROS-ER stress-CaMKII-Sp1 axis. Reactive Oxygen Species 110-113 TNF receptor superfamily member 10b Homo sapiens 83-86 30257253-12 2018 This increase of ROS subsequently induced DR5 expression, and thus increased TRAIL-induced apoptosis in CRC cells. Reactive Oxygen Species 17-20 TNF receptor superfamily member 10b Homo sapiens 42-45 29164887-9 2017 Moreover, we found that PTER induced the expression of DR4 and DR5 through the reactive oxygen species (ROS)/ endoplasmic reticulum (ER) stress/ERK 1/2 and p38/C/EBP-homologous protein (CHOP) signaling pathways. Reactive Oxygen Species 79-102 TNF receptor superfamily member 10b Homo sapiens 63-66 29164887-9 2017 Moreover, we found that PTER induced the expression of DR4 and DR5 through the reactive oxygen species (ROS)/ endoplasmic reticulum (ER) stress/ERK 1/2 and p38/C/EBP-homologous protein (CHOP) signaling pathways. Reactive Oxygen Species 104-107 TNF receptor superfamily member 10b Homo sapiens 63-66 29164887-10 2017 Overall, our results showed that PTER potentiated TRAIL-induced apoptosis via ROS-mediated CHOP activation leading to the expression of DR4 and DR5. Reactive Oxygen Species 78-81 TNF receptor superfamily member 10b Homo sapiens 144-147 29535810-0 2018 Silibinin sensitizes TRAIL-mediated apoptosis by upregulating DR5 through ROS-induced endoplasmic reticulum stress-Ca2+-CaMKII-Sp1 pathway. Reactive Oxygen Species 74-77 TNF receptor superfamily member 10b Homo sapiens 62-65 29535810-6 2018 Furthermore, silibinin increased the production of reactive oxygen species (ROS), which led to the induction of TRAIL-mediated apoptosis through DR5 upregulation. Reactive Oxygen Species 51-74 TNF receptor superfamily member 10b Homo sapiens 145-148 27594528-0 2016 A new brominated chalcone derivative suppresses the growth of gastric cancer cells in vitro and in vivo involving ROS mediated up-regulation of DR5 and 4 expression and apoptosis. Reactive Oxygen Species 114-117 TNF receptor superfamily member 10b Homo sapiens 144-153 29535810-6 2018 Furthermore, silibinin increased the production of reactive oxygen species (ROS), which led to the induction of TRAIL-mediated apoptosis through DR5 upregulation. Reactive Oxygen Species 76-79 TNF receptor superfamily member 10b Homo sapiens 145-148 29535810-12 2018 Accordingly, we showed that ROS/ER stress-induced CaMKII activated Sp1, which is an important transcription factor for DR5 expression. Reactive Oxygen Species 28-31 TNF receptor superfamily member 10b Homo sapiens 119-122 28498435-6 2017 The effects of plumbagin on the expression of DR5, Bax and cFLIP could be partially abolished by the reactive oxygen species (ROS) scavenger NAC. Reactive Oxygen Species 101-124 TNF receptor superfamily member 10b Homo sapiens 46-49 28498435-6 2017 The effects of plumbagin on the expression of DR5, Bax and cFLIP could be partially abolished by the reactive oxygen species (ROS) scavenger NAC. Reactive Oxygen Species 126-129 TNF receptor superfamily member 10b Homo sapiens 46-49 28209994-4 2017 The underlying apoptotic mechanisms involved upregulation of death receptor 5 (DR5) and CCAAT/enhancer binding protein homologous protein, which is related to the endoplasmic reticulum stress response, and is further associated with reactive oxygen species generation and Ca2+ accumulation. Reactive Oxygen Species 233-256 TNF receptor superfamily member 10b Homo sapiens 61-77 28209994-4 2017 The underlying apoptotic mechanisms involved upregulation of death receptor 5 (DR5) and CCAAT/enhancer binding protein homologous protein, which is related to the endoplasmic reticulum stress response, and is further associated with reactive oxygen species generation and Ca2+ accumulation. Reactive Oxygen Species 233-256 TNF receptor superfamily member 10b Homo sapiens 79-82 24919794-9 2014 Hence, HMJ-30-induced endothelial cell apoptosis involved the ROS/JNK-regulated DR5 pathway. Reactive Oxygen Species 62-65 TNF receptor superfamily member 10b Homo sapiens 80-83 26661339-12 2016 CONCLUSIONS AND IMPLICATIONS: ROS generation by decursin selectively activated the PERK/ATF4 axis of the endoplasmic reticulum stress signalling pathway, leading to enhanced TRAIL sensitivity in TRAIL-resistant NSCLC cell lines, partly via up-regulation of DR5. Reactive Oxygen Species 30-33 TNF receptor superfamily member 10b Homo sapiens 257-260 26111475-10 2015 The ROS inhibitor NAC and silencing of DR5 by siRNA transfection inhibited the ability of combination to induce PARP cleavage and generate ROS. Reactive Oxygen Species 139-142 TNF receptor superfamily member 10b Homo sapiens 39-42 25461556-6 2014 CPT-induced generation of reactive oxygen species (ROS) also preceded the upregulation of DR5 in response to TRAIL. Reactive Oxygen Species 26-49 TNF receptor superfamily member 10b Homo sapiens 90-93 25461556-6 2014 CPT-induced generation of reactive oxygen species (ROS) also preceded the upregulation of DR5 in response to TRAIL. Reactive Oxygen Species 51-54 TNF receptor superfamily member 10b Homo sapiens 90-93 25461556-7 2014 The involvement of ROS in DR5 upregulation confirmed that pretreatment with antioxidants, including N-acetyl-L-cysteine and glutathione, significantly inhibits CPT-TRAIL-induced cell death by suppressing DR5 expression. Reactive Oxygen Species 19-22 TNF receptor superfamily member 10b Homo sapiens 26-29 25017974-8 2014 Moreover, CCT327-induced induction of DR5 and DR4 was mediated by reactive oxygen species (ROS), and N-acetylcysteine (NAC) blocked the induction of DRs by CCT327. Reactive Oxygen Species 66-89 TNF receptor superfamily member 10b Homo sapiens 38-41 25017974-8 2014 Moreover, CCT327-induced induction of DR5 and DR4 was mediated by reactive oxygen species (ROS), and N-acetylcysteine (NAC) blocked the induction of DRs by CCT327. Reactive Oxygen Species 91-94 TNF receptor superfamily member 10b Homo sapiens 38-41 24078627-12 2013 Overall, this study indicates that azadirone can sensitize cancer cells to TRAIL through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 signaling, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins. Reactive Oxygen Species 89-92 TNF receptor superfamily member 10b Homo sapiens 128-131 24401154-7 2014 Moreover, OSU-A9 increased DR5 expression through a reactive oxygen species (ROS)-dependent mechanism. Reactive Oxygen Species 52-75 TNF receptor superfamily member 10b Homo sapiens 27-30 24401154-7 2014 Moreover, OSU-A9 increased DR5 expression through a reactive oxygen species (ROS)-dependent mechanism. Reactive Oxygen Species 77-80 TNF receptor superfamily member 10b Homo sapiens 27-30 24612139-6 2014 Upregulation of DR5 was mediated through the generation of reactive oxygen species (ROS), as ROS scavengers reduced the effect of quercetin on JNK activation, CHOP upregulation, DR induction, TRAIL sensitization, downregulated the expression of cell survival proteins and upregulated the proapoptotic proteins. Reactive Oxygen Species 59-82 TNF receptor superfamily member 10b Homo sapiens 16-19 24612139-6 2014 Upregulation of DR5 was mediated through the generation of reactive oxygen species (ROS), as ROS scavengers reduced the effect of quercetin on JNK activation, CHOP upregulation, DR induction, TRAIL sensitization, downregulated the expression of cell survival proteins and upregulated the proapoptotic proteins. Reactive Oxygen Species 84-87 TNF receptor superfamily member 10b Homo sapiens 16-19 24612139-6 2014 Upregulation of DR5 was mediated through the generation of reactive oxygen species (ROS), as ROS scavengers reduced the effect of quercetin on JNK activation, CHOP upregulation, DR induction, TRAIL sensitization, downregulated the expression of cell survival proteins and upregulated the proapoptotic proteins. Reactive Oxygen Species 93-96 TNF receptor superfamily member 10b Homo sapiens 16-19 24213373-0 2014 Indomethacin sensitizes TRAIL-resistant melanoma cells to TRAIL-induced apoptosis through ROS-mediated upregulation of death receptor 5 and downregulation of survivin. Reactive Oxygen Species 90-93 TNF receptor superfamily member 10b Homo sapiens 119-135 24213373-9 2014 In addition, indomethacin-induced reactive oxygen species (ROS) production preceded upregulation of CHOP and DR5, and consequent sensitization of cells to TRAIL. Reactive Oxygen Species 34-57 TNF receptor superfamily member 10b Homo sapiens 109-112 24213373-9 2014 In addition, indomethacin-induced reactive oxygen species (ROS) production preceded upregulation of CHOP and DR5, and consequent sensitization of cells to TRAIL. Reactive Oxygen Species 59-62 TNF receptor superfamily member 10b Homo sapiens 109-112 23846485-6 2013 Curcumin-induced production of reactive oxygen species did not affect total expression of DR5 but it enhanced mobilization of DR5 to the plasma membrane. Reactive Oxygen Species 31-54 TNF receptor superfamily member 10b Homo sapiens 126-129 23700228-8 2013 Emodin-induced induction of DR5 was mediated through the generation of reactive oxygen species (ROS), as N-acetylcysteine blocked the induction of DR5 and the induction of apoptosis. Reactive Oxygen Species 96-99 TNF receptor superfamily member 10b Homo sapiens 28-31 23135489-6 2013 Collectively, the present study showed that casticin potentiates TRAIL-induced apoptosis through downregulation of cell survival proteins and induction of DR5 mediated by ROS. Reactive Oxygen Species 195-198 TNF receptor superfamily member 10b Homo sapiens 179-182 23700228-8 2013 Emodin-induced induction of DR5 was mediated through the generation of reactive oxygen species (ROS), as N-acetylcysteine blocked the induction of DR5 and the induction of apoptosis. Reactive Oxygen Species 71-94 TNF receptor superfamily member 10b Homo sapiens 28-31 22681760-9 2012 Snake venom toxin also induced JNK phosphorylation and ROS generation, however, pretreatment of JNK inhibitor and ROS scavenger reversed the inhibitory effect of snake venom toxin on cancer cell proliferation, and reduced the snake venom toxin-induced upregulation of DR4 and DR5 expression. Reactive Oxygen Species 114-117 TNF receptor superfamily member 10b Homo sapiens 276-279 22922338-7 2012 CHOP induction was also reactive oxygen species (ROS)-dependent, as shown by capsazepine"s ability to induce ROS and by the quenching of ROS by N-acetylcysteine or glutathione, which prevented induction of CHOP and DR5 and consequent sensitization to TRAIL. Reactive Oxygen Species 24-47 TNF receptor superfamily member 10b Homo sapiens 215-218 22922338-7 2012 CHOP induction was also reactive oxygen species (ROS)-dependent, as shown by capsazepine"s ability to induce ROS and by the quenching of ROS by N-acetylcysteine or glutathione, which prevented induction of CHOP and DR5 and consequent sensitization to TRAIL. Reactive Oxygen Species 49-52 TNF receptor superfamily member 10b Homo sapiens 215-218 22982206-12 2013 We concluded that VA triggers TRAIL-induced apoptosis by eIF2alpha/CHOP-dependent DR5 induction via ROS generation. Reactive Oxygen Species 100-103 TNF receptor superfamily member 10b Homo sapiens 82-85 23536831-9 2013 Gene silencing of the CCAAT/enhancer binding protein homologous protein (CHOP) and pretreatment with salubrinal, an endoplasmic reticulum (ER) stress inhibitor, attenuated casticin-induced DR5 receptor expression, and apoptosis and ROS production. Reactive Oxygen Species 232-235 TNF receptor superfamily member 10b Homo sapiens 189-192 23536831-12 2013 CONCLUSION/SIGNIFICANCE: Casticin enhances TRAIL-induced apoptosis through the downregulation of cell survival proteins and the upregulation of DR5 receptors through actions on the ROS-ER stress-CHOP pathway. Reactive Oxygen Species 181-184 TNF receptor superfamily member 10b Homo sapiens 144-147 23007278-8 2012 Pretreatment with the c-Jun N-terminal kinase (JNK) inhibitor SP600125 and the reactive oxygen species (ROS) scavenger N-acetylcysteine reduced the SVT and TRAIL-induced upregulation of DR4 and DR5 expression, expression of the apoptosis related protein such as caspase-3 and-9, as well as cell growth inhibitory effects. Reactive Oxygen Species 79-102 TNF receptor superfamily member 10b Homo sapiens 194-197 23007278-8 2012 Pretreatment with the c-Jun N-terminal kinase (JNK) inhibitor SP600125 and the reactive oxygen species (ROS) scavenger N-acetylcysteine reduced the SVT and TRAIL-induced upregulation of DR4 and DR5 expression, expression of the apoptosis related protein such as caspase-3 and-9, as well as cell growth inhibitory effects. Reactive Oxygen Species 104-107 TNF receptor superfamily member 10b Homo sapiens 194-197 22354145-0 2012 AW00179 potentiates TRAIL-mediated death of human lung cancer H1299 cells through ROS-JNK-c-Jun-mediated up-regulation of DR5 and down-regulation of anti-apoptotic molecules. Reactive Oxygen Species 82-85 TNF receptor superfamily member 10b Homo sapiens 122-125 22354145-7 2012 In conclusion, AW00179 has the potential to sensitize H1299 cells to TRAIL-mediated apoptosis through two distinct mechanisms: ROS-JNK-c-Jun-mediated up-regulation of DR5, and down-regulation of anti-apoptotic molecules. Reactive Oxygen Species 127-130 TNF receptor superfamily member 10b Homo sapiens 167-170 22681760-10 2012 CONCLUSIONS: Our results indicated that snake venom toxin could inhibit human colon cancer cell growth, and these effects may be related to ROS and JNK mediated activation of death receptor (DR4 and DR5) signals. Reactive Oxygen Species 140-143 TNF receptor superfamily member 10b Homo sapiens 199-202 22400995-8 2012 DR5 expression after IOA treatment was accompanied by provoking intracellular reactive oxygen species (ROS) generation. Reactive Oxygen Species 78-101 TNF receptor superfamily member 10b Homo sapiens 0-3 22328338-8 2012 Moreover, orlistat induced reactive oxygen species (ROS), and a ROS scavenger diminished the sensitivity to TRAIL through the suppression of CHOP and DR5 expression in both cell lines. Reactive Oxygen Species 76-79 TNF receptor superfamily member 10b Homo sapiens 174-177 22328338-9 2012 These results suggest that there are two pathways of upregulation of DR5 by orlistat, which are the ROS-CHOP pathway and the ROS-direct pathway. Reactive Oxygen Species 112-115 TNF receptor superfamily member 10b Homo sapiens 81-84 22328338-9 2012 These results suggest that there are two pathways of upregulation of DR5 by orlistat, which are the ROS-CHOP pathway and the ROS-direct pathway. Reactive Oxygen Species 137-140 TNF receptor superfamily member 10b Homo sapiens 81-84 22400995-8 2012 DR5 expression after IOA treatment was accompanied by provoking intracellular reactive oxygen species (ROS) generation. Reactive Oxygen Species 103-106 TNF receptor superfamily member 10b Homo sapiens 0-3 22666346-9 2012 CONCLUSIONS/SIGNIFICANCE: These results suggest that DHA enhances Apo2L/TRAIL-mediated apoptosis in human pancreatic cancer cells through reactive oxygen species-mediated up-regulation of DR5. Reactive Oxygen Species 138-161 TNF receptor superfamily member 10b Homo sapiens 188-191 21660448-12 2012 CONCLUSION: The present study demonstrates that DMF selectively enhances TRAIL-induced apoptosis by ROS-stimulated ER-stress triggering CHOP-mediated DR5 upregulation in HCC. Reactive Oxygen Species 100-103 TNF receptor superfamily member 10b Homo sapiens 150-153 22158615-2 2012 Here we report that stimulation of DR4 and/or DR5 by the agonistic protein KD548-Fc, an Fc-fused DR4/DR5 dual-specific Kringle domain variant, activates plasma membrane-associated Nox1 NADPH oxidase to generate superoxide anion and subsequently accumulates intracellular reactive oxygen species (ROS), leading to sustained c-Jun N-terminal kinase activation and eventual apoptotic cell death in human HeLa and Jurkat tumor cells. Reactive Oxygen Species 271-294 TNF receptor superfamily member 10b Homo sapiens 46-49 22158615-2 2012 Here we report that stimulation of DR4 and/or DR5 by the agonistic protein KD548-Fc, an Fc-fused DR4/DR5 dual-specific Kringle domain variant, activates plasma membrane-associated Nox1 NADPH oxidase to generate superoxide anion and subsequently accumulates intracellular reactive oxygen species (ROS), leading to sustained c-Jun N-terminal kinase activation and eventual apoptotic cell death in human HeLa and Jurkat tumor cells. Reactive Oxygen Species 271-294 TNF receptor superfamily member 10b Homo sapiens 101-104 22158615-2 2012 Here we report that stimulation of DR4 and/or DR5 by the agonistic protein KD548-Fc, an Fc-fused DR4/DR5 dual-specific Kringle domain variant, activates plasma membrane-associated Nox1 NADPH oxidase to generate superoxide anion and subsequently accumulates intracellular reactive oxygen species (ROS), leading to sustained c-Jun N-terminal kinase activation and eventual apoptotic cell death in human HeLa and Jurkat tumor cells. Reactive Oxygen Species 296-299 TNF receptor superfamily member 10b Homo sapiens 46-49 22158615-2 2012 Here we report that stimulation of DR4 and/or DR5 by the agonistic protein KD548-Fc, an Fc-fused DR4/DR5 dual-specific Kringle domain variant, activates plasma membrane-associated Nox1 NADPH oxidase to generate superoxide anion and subsequently accumulates intracellular reactive oxygen species (ROS), leading to sustained c-Jun N-terminal kinase activation and eventual apoptotic cell death in human HeLa and Jurkat tumor cells. Reactive Oxygen Species 296-299 TNF receptor superfamily member 10b Homo sapiens 101-104 22158615-7 2012 Our results suggest that DR4 and DR5 have a capability to activate Nox1 by recruiting RFK, resulting in ROS-mediated apoptotic cell death in tumor cells. Reactive Oxygen Species 104-107 TNF receptor superfamily member 10b Homo sapiens 33-36 22666346-0 2012 Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5. Reactive Oxygen Species 90-93 TNF receptor superfamily member 10b Homo sapiens 120-136 21483669-3 2011 Furthermore, recombinant soluble TRAIL and an agonistic anti-DR5 antibody, AD5-10, treatment stimulates reactive oxygen species (ROS) generation and JNK phosphorylation. Reactive Oxygen Species 104-127 TNF receptor superfamily member 10b Homo sapiens 61-64 21978492-6 2011 PHA665752 treatment also caused increased expression of DR5 via generation of reactive oxygen species, and combination treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and PHA665752 induced significant apoptosis. Reactive Oxygen Species 78-101 TNF receptor superfamily member 10b Homo sapiens 56-59 21362627-7 2011 In addition, reactive oxygen species (ROS) and protein kinase C (PKC) delta appeared to be implicated in UDCA-induced raft-dependent DR5 expression. Reactive Oxygen Species 13-36 TNF receptor superfamily member 10b Homo sapiens 133-136 21362627-7 2011 In addition, reactive oxygen species (ROS) and protein kinase C (PKC) delta appeared to be implicated in UDCA-induced raft-dependent DR5 expression. Reactive Oxygen Species 38-41 TNF receptor superfamily member 10b Homo sapiens 133-136 21362627-8 2011 Our results indicate that UDCA-induced apoptosis is mediated by DR5 expression, which is regulated by the raft formation/ROS production/PKCdelta activation pathway and DR5 localization into lipid rafts in gastric cancer cells. Reactive Oxygen Species 121-124 TNF receptor superfamily member 10b Homo sapiens 64-67 21483669-3 2011 Furthermore, recombinant soluble TRAIL and an agonistic anti-DR5 antibody, AD5-10, treatment stimulates reactive oxygen species (ROS) generation and JNK phosphorylation. Reactive Oxygen Species 129-132 TNF receptor superfamily member 10b Homo sapiens 61-64 21127198-12 2011 We observed that DBA-induced induction of DR5 and DR4 was mediated through generation of reactive oxygen species (ROS), as N-acetylcysteine blocked the induction of death receptors and suppression of cell survival proteins by DBA. Reactive Oxygen Species 89-112 TNF receptor superfamily member 10b Homo sapiens 42-45 21127198-12 2011 We observed that DBA-induced induction of DR5 and DR4 was mediated through generation of reactive oxygen species (ROS), as N-acetylcysteine blocked the induction of death receptors and suppression of cell survival proteins by DBA. Reactive Oxygen Species 114-117 TNF receptor superfamily member 10b Homo sapiens 42-45 21078664-11 2011 Overall, our results indicate that nimbolide can sensitize colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species- and ERK-mediated up-regulation of DR5 and DR4, down-regulation of cell survival proteins, and up-regulation of p53 and Bax. Reactive Oxygen Species 140-163 TNF receptor superfamily member 10b Homo sapiens 199-202 21931821-4 2011 Simultaneously, Resveratrol treatment of DLBCL cell lines also caused ROS dependent upregulation of DR5; and interestingly, co-treatment of DLBCL with sub-toxic doses of TRAIL and Resveratrol synergistically induced apoptosis via utilizing DR5, on the other hand, gene silencing of DR5 abolished this effect. Reactive Oxygen Species 70-73 TNF receptor superfamily member 10b Homo sapiens 100-103 20837473-11 2010 Overall, our results show that gossypol enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and the up-regulation of TRAIL death receptors through the ROS-ERK-CHOP-DR5 pathway. Reactive Oxygen Species 186-189 TNF receptor superfamily member 10b Homo sapiens 199-202 20356045-9 2010 Taken together, these data suggested that in addition to the mitochondrial- and Fas receptor-mediated apoptotic pathways involved, ROS-dependent and p53-regulated DR5 expression was also demonstrated to play a pivotal role in the synergistic enhancement of TRAIL-induced apoptosis instigated by 6-DG in Hep G2 cells. Reactive Oxygen Species 131-134 TNF receptor superfamily member 10b Homo sapiens 163-166 20356045-0 2010 6-dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5. Reactive Oxygen Species 97-120 TNF receptor superfamily member 10b Homo sapiens 142-145 19654295-11 2009 Overall, our results show that zerumbone can potentiate TRAIL-induced apoptosis through the reactive oxygen species-mediated activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase leading to DR4 and DR5 induction and resulting in enhancement of the anticancer effects of TRAIL. Reactive Oxygen Species 92-115 TNF receptor superfamily member 10b Homo sapiens 241-244 20356045-6 2010 DR5 expression after 6-DG treatment was accompanied by provoking intracellular reactive oxygen species (ROS) generation. Reactive Oxygen Species 79-102 TNF receptor superfamily member 10b Homo sapiens 0-3 20356045-6 2010 DR5 expression after 6-DG treatment was accompanied by provoking intracellular reactive oxygen species (ROS) generation. Reactive Oxygen Species 104-107 TNF receptor superfamily member 10b Homo sapiens 0-3 20154087-8 2010 We found that celastrol also induced reactive oxygen species (ROS) generation, and ROS sequestration inhibited celastrol-induced expression of CHOP and DR5, and consequent sensitization to TRAIL. Reactive Oxygen Species 83-86 TNF receptor superfamily member 10b Homo sapiens 152-155 19468286-0 2009 An agonistic monoclonal antibody against DR5 induces ROS production, sustained JNK activation and Endo G release in Jurkat leukemia cells. Reactive Oxygen Species 53-56 TNF receptor superfamily member 10b Homo sapiens 41-44 19345731-0 2009 Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Reactive Oxygen Species 56-79 TNF receptor superfamily member 10b Homo sapiens 106-122 19345731-5 2009 Interestingly, a Wit A-induced increase in ROS levels preceded the up-regulation of CHOP and DR5. Reactive Oxygen Species 43-46 TNF receptor superfamily member 10b Homo sapiens 93-96 19345731-6 2009 The involvement of ROS in CHOP-mediated DR5 up-regulation was confirmed by the result that pretreatment with an antioxidant, NAC or catalase, inhibited Wit A-induced up-regulation of both CHOP and DR5. Reactive Oxygen Species 19-22 TNF receptor superfamily member 10b Homo sapiens 40-43 19345731-6 2009 The involvement of ROS in CHOP-mediated DR5 up-regulation was confirmed by the result that pretreatment with an antioxidant, NAC or catalase, inhibited Wit A-induced up-regulation of both CHOP and DR5. Reactive Oxygen Species 19-22 TNF receptor superfamily member 10b Homo sapiens 197-200 18523266-13 2008 These findings reveal that proteasome inhibitor-mediated NF-kappaB and ROS-dependent p53 activation are contributed to intronic regulation of DR5 transcription, and resulted in the subsequent enhancement of TRAIL-induced apoptosis in human lung cancer cells. Reactive Oxygen Species 71-74 TNF receptor superfamily member 10b Homo sapiens 142-145 18974136-12 2008 Interestingly, baicalein induced reactive oxygen species (ROS) and a ROS scavenger prevented DR5 expression and TRAIL sensitization in PC3 but not SW480 cells. Reactive Oxygen Species 69-72 TNF receptor superfamily member 10b Homo sapiens 93-96 18523266-0 2008 Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: involvement of NF-kappa B and reactive oxygen species-mediated p53 activation. Reactive Oxygen Species 124-147 TNF receptor superfamily member 10b Homo sapiens 89-92 19010914-7 2008 Up-regulation of TRAIL-R2 expression was dependent on a protein kinase Calpha/c-Jun-NH(2)-kinase 2/c-Jun signaling pathway activated by perifosine through reactive oxygen species production. Reactive Oxygen Species 155-178 TNF receptor superfamily member 10b Homo sapiens 17-25 18852146-6 2008 A mechanistic study showed the contributions of reactive oxygen species (ROS) and intracellular calcium in CHOP and DR5 gene up-regulation. Reactive Oxygen Species 48-71 TNF receptor superfamily member 10b Homo sapiens 116-119 18852146-6 2008 A mechanistic study showed the contributions of reactive oxygen species (ROS) and intracellular calcium in CHOP and DR5 gene up-regulation. Reactive Oxygen Species 73-76 TNF receptor superfamily member 10b Homo sapiens 116-119 18852146-11 2008 In summary, the effect of up-regulation of DR5 by 15dPGJ(2) in colon cancer cells is independent of PPAR-gamma and p53 but relies on CHOP induction through gene transcription involving ROS and calcium. Reactive Oxygen Species 185-188 TNF receptor superfamily member 10b Homo sapiens 43-46 17440103-3 2007 Our data show that sanguinarine treatment of PEL cells results in up-regulation of death receptor 5 (DR5) expression via generation of reactive oxygen species (ROS) and causes activation of caspase-8 and truncation of Bid (tBid). Reactive Oxygen Species 135-158 TNF receptor superfamily member 10b Homo sapiens 83-99 18164688-9 2008 Taken together, the results of this study demonstrate that rosiglitazone enhances TRAIL-induced apoptosis in various cancer cells by ROS-mediated DR5 up-regulation and down-regulation of c-FLIPs. Reactive Oxygen Species 133-136 TNF receptor superfamily member 10b Homo sapiens 146-149 18164688-0 2008 Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Reactive Oxygen Species 100-123 TNF receptor superfamily member 10b Homo sapiens 150-166 18164688-4 2008 We found that treatment with rosiglitazone significantly induces DR5 expression at both its mRNA and its protein levels, accompanying the generation of reactive oxygen species (ROS). Reactive Oxygen Species 152-175 TNF receptor superfamily member 10b Homo sapiens 65-68 18164688-4 2008 We found that treatment with rosiglitazone significantly induces DR5 expression at both its mRNA and its protein levels, accompanying the generation of reactive oxygen species (ROS). Reactive Oxygen Species 177-180 TNF receptor superfamily member 10b Homo sapiens 65-68 18164688-6 2008 Pretreatment with GSH significantly inhibited rosiglitazone-induced DR5 up-regulation and the cell death induced by the combined treatment with rosiglitazone and TRAIL, suggesting that ROS mediate rosiglitazone-induced DR5 up-regulation, contributing to TRAIL-mediated apoptosis. Reactive Oxygen Species 185-188 TNF receptor superfamily member 10b Homo sapiens 68-71 18164688-6 2008 Pretreatment with GSH significantly inhibited rosiglitazone-induced DR5 up-regulation and the cell death induced by the combined treatment with rosiglitazone and TRAIL, suggesting that ROS mediate rosiglitazone-induced DR5 up-regulation, contributing to TRAIL-mediated apoptosis. Reactive Oxygen Species 185-188 TNF receptor superfamily member 10b Homo sapiens 219-222 17440103-3 2007 Our data show that sanguinarine treatment of PEL cells results in up-regulation of death receptor 5 (DR5) expression via generation of reactive oxygen species (ROS) and causes activation of caspase-8 and truncation of Bid (tBid). Reactive Oxygen Species 135-158 TNF receptor superfamily member 10b Homo sapiens 101-104 17440103-3 2007 Our data show that sanguinarine treatment of PEL cells results in up-regulation of death receptor 5 (DR5) expression via generation of reactive oxygen species (ROS) and causes activation of caspase-8 and truncation of Bid (tBid). Reactive Oxygen Species 160-163 TNF receptor superfamily member 10b Homo sapiens 83-99 17440103-3 2007 Our data show that sanguinarine treatment of PEL cells results in up-regulation of death receptor 5 (DR5) expression via generation of reactive oxygen species (ROS) and causes activation of caspase-8 and truncation of Bid (tBid). Reactive Oxygen Species 160-163 TNF receptor superfamily member 10b Homo sapiens 101-104 34582654-0 2021 Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis. Reactive Oxygen Species 77-80 TNF receptor superfamily member 10b Homo sapiens 29-32 16452234-0 2006 Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. Reactive Oxygen Species 148-171 TNF receptor superfamily member 10b Homo sapiens 198-201 15987718-0 2005 Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). Reactive Oxygen Species 110-133 TNF receptor superfamily member 10b Homo sapiens 159-175 15987718-0 2005 Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). Reactive Oxygen Species 110-133 TNF receptor superfamily member 10b Homo sapiens 177-180 15987718-5 2005 We found that treatment with curcumin significantly induces death receptor 5 (DR5) expression both at its mRNA and protein levels, accompanying the generation of the reactive oxygen species (ROS). Reactive Oxygen Species 166-189 TNF receptor superfamily member 10b Homo sapiens 60-76 15987718-5 2005 We found that treatment with curcumin significantly induces death receptor 5 (DR5) expression both at its mRNA and protein levels, accompanying the generation of the reactive oxygen species (ROS). Reactive Oxygen Species 166-189 TNF receptor superfamily member 10b Homo sapiens 78-81 15987718-5 2005 We found that treatment with curcumin significantly induces death receptor 5 (DR5) expression both at its mRNA and protein levels, accompanying the generation of the reactive oxygen species (ROS). Reactive Oxygen Species 191-194 TNF receptor superfamily member 10b Homo sapiens 60-76 15987718-5 2005 We found that treatment with curcumin significantly induces death receptor 5 (DR5) expression both at its mRNA and protein levels, accompanying the generation of the reactive oxygen species (ROS). Reactive Oxygen Species 191-194 TNF receptor superfamily member 10b Homo sapiens 78-81 15987718-7 2005 Taken together, the present study demonstrates that curcumin enhances TRAIL-induced apoptosis by ROS-mediated DR5 upregulation. Reactive Oxygen Species 97-100 TNF receptor superfamily member 10b Homo sapiens 110-113 34599545-0 2021 CSC-3436 sensitizes triple negative breast cancer cells to TRAIL-induced apoptosis through ROS-mediated p38/CHOP/death receptor 5 signaling pathways. Reactive Oxygen Species 91-94 TNF receptor superfamily member 10b Homo sapiens 113-129 34599545-7 2021 In addition, the induction of DR5 by CSC-3436 was found to be dependent on the modulation of reactive oxygen species (ROS)/p38/C/EBP-homologous protein (CHOP) signaling pathways. Reactive Oxygen Species 93-116 TNF receptor superfamily member 10b Homo sapiens 30-33 34599545-7 2021 In addition, the induction of DR5 by CSC-3436 was found to be dependent on the modulation of reactive oxygen species (ROS)/p38/C/EBP-homologous protein (CHOP) signaling pathways. Reactive Oxygen Species 118-121 TNF receptor superfamily member 10b Homo sapiens 30-33 34599545-8 2021 Overall, our results indicated that CSC-3436 could potentiate the apoptotic effects of TRAIL through down-regulation of cell survival proteins and upregulation of DR5 via the ROS-mediated upregulation of CHOP protein. Reactive Oxygen Species 175-178 TNF receptor superfamily member 10b Homo sapiens 163-166 33841136-14 2021 DR5 upregulation induced by alternol required the production of reactive oxygen species (ROS). Reactive Oxygen Species 64-87 TNF receptor superfamily member 10b Homo sapiens 0-3 33857626-0 2021 Sodium fluoride activates the extrinsic apoptosis via regulating NOX4/ROS-mediated p53/DR5 signaling pathway in lung cells both in vitro and in vivo. Reactive Oxygen Species 70-73 TNF receptor superfamily member 10b Homo sapiens 87-90 33857626-8 2021 Specifically, NOX4 knockdown inhibited NaF-induced the activation of p53/DR5 axis by reducing NOX4-derived ROS production. Reactive Oxygen Species 107-110 TNF receptor superfamily member 10b Homo sapiens 73-76 34479917-7 2021 Furthermore, paclitaxel induced ROS-mediated DNA damage that triggered the activation of the extrinsic pathway of apoptosis via the up-regulation of death receptor (DR5) and caspase-8 activation. Reactive Oxygen Species 32-35 TNF receptor superfamily member 10b Homo sapiens 165-168 33937072-7 2021 The results demonstrate that the elevating ROS can up-regulate the expression of DR5, resulting in apoptosis via mitochondrial pathway. Reactive Oxygen Species 43-46 TNF receptor superfamily member 10b Homo sapiens 81-84 33841136-14 2021 DR5 upregulation induced by alternol required the production of reactive oxygen species (ROS). Reactive Oxygen Species 89-92 TNF receptor superfamily member 10b Homo sapiens 0-3 33841136-15 2021 Removing ROS inhibited the induction of DR5 and blocked the antiapoptotic proteins induced by alternol. Reactive Oxygen Species 9-12 TNF receptor superfamily member 10b Homo sapiens 40-43 32506763-0 2020 ROS-mediated PERK-eIF2alpha-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling. Reactive Oxygen Species 0-3 TNF receptor superfamily member 10b Homo sapiens 126-129 33240775-4 2020 Mechanistically, curcumol directly targets NQO2 to cause reactive oxygen species (ROS) generation, which triggers endoplasmic reticulum (ER) stress-C/EBP homologous protein (CHOP) death receptor (DR5) signaling, sensitizing NSCLC cell to TRAIL-induced apoptosis. Reactive Oxygen Species 82-85 TNF receptor superfamily member 10b Homo sapiens 196-199 32506763-10 2020 Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity. Reactive Oxygen Species 42-45 TNF receptor superfamily member 10b Homo sapiens 189-192 31019655-13 2019 Meanwhile, ROS scavenger NAC, JNK inhibitor SP600125, and p53 inhibitor PFTalpha were used to verify that autophagy-mediated upregulation of DR5 was regulated by the SNX-2112-stimulated activation of the ROS-JNK-p53 signaling pathway. Reactive Oxygen Species 11-14 TNF receptor superfamily member 10b Homo sapiens 141-144 32124960-13 2020 Overall, the present study provided evidence that ICA sensitized tumor cells to TRAIL-induced apoptosis via ROS-, ERK- and CHOP-mediated upregulation of DR5 and DR4. Reactive Oxygen Species 108-111 TNF receptor superfamily member 10b Homo sapiens 153-156 30692634-5 2019 Overexpression of RUNX3 increased DR5 expression via induction of the reactive oxygen species (ROS)-endoplasmic reticulum (ER) stress-effector CHOP. Reactive Oxygen Species 70-93 TNF receptor superfamily member 10b Homo sapiens 34-37 30692634-5 2019 Overexpression of RUNX3 increased DR5 expression via induction of the reactive oxygen species (ROS)-endoplasmic reticulum (ER) stress-effector CHOP. Reactive Oxygen Species 95-98 TNF receptor superfamily member 10b Homo sapiens 34-37 31019655-0 2019 Hsp90 Inhibitor SNX-2112 Enhances TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via the ROS-Mediated JNK-p53-Autophagy-DR5 Pathway. Reactive Oxygen Species 97-100 TNF receptor superfamily member 10b Homo sapiens 128-131 31019655-13 2019 Meanwhile, ROS scavenger NAC, JNK inhibitor SP600125, and p53 inhibitor PFTalpha were used to verify that autophagy-mediated upregulation of DR5 was regulated by the SNX-2112-stimulated activation of the ROS-JNK-p53 signaling pathway. Reactive Oxygen Species 204-207 TNF receptor superfamily member 10b Homo sapiens 141-144 30359578-5 2018 The upregulation of DR5 expression by C27OAs strictly depends on transactivation of C/EBP homology protein, which is regulated through the p38 MAPK pathway, rather than p53 and intracellular reactive oxygen species status. Reactive Oxygen Species 191-214 TNF receptor superfamily member 10b Homo sapiens 20-23 29964331-7 2018 Moreover, inhibition of reactive oxygen species by N-acetyl-L-cysteine efficiently blocked BIX-01294-induced DR5 upregulation by inhibiting ATF4/CHOP expression, leading to diminished sensitization to TRAIL. Reactive Oxygen Species 24-47 TNF receptor superfamily member 10b Homo sapiens 109-112 29964331-8 2018 These findings suggest that BIX-01294 sensitizes breast cancer cells to TRAIL by upregulating ATF4/CHOP-dependent DR5 expression with a reactive oxygen species-dependent manner. Reactive Oxygen Species 136-159 TNF receptor superfamily member 10b Homo sapiens 114-117 29964331-0 2018 Inhibition of euchromatin histone-lysine N-methyltransferase 2 sensitizes breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through reactive oxygen species-mediated activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway activation. Reactive Oxygen Species 161-184 TNF receptor superfamily member 10b Homo sapiens 253-269 29800641-0 2018 Isoalantolactone induces apoptosis through reactive oxygen species-dependent upregulation of death receptor 5 in human esophageal cancer cells. Reactive Oxygen Species 43-66 TNF receptor superfamily member 10b Homo sapiens 93-109