PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24324142-4 2014 TGF-beta rapidly and sequentially activated phospholipase D1, phosphatidylinositol-4-phosphate 5-kinase 1alpha, and NADPH oxidase 4 (NOX4) to produce reactive oxygen species, driving internalization of betaENaC, the subunit responsible for cell-surface stability of the alphabetagammaENaC complex. Reactive Oxygen Species 150-173 phospholipase D1 Homo sapiens 44-60 27809301-6 2016 In low glucose cultures, the blockade of fatty acid oxidation (FAO) by PLD1 inhibition suppresses adenosine triphosphate (ATP) production and increases reactive oxygen species (ROS), leading to cancer cell death. Reactive Oxygen Species 152-175 phospholipase D1 Homo sapiens 71-75 27809301-6 2016 In low glucose cultures, the blockade of fatty acid oxidation (FAO) by PLD1 inhibition suppresses adenosine triphosphate (ATP) production and increases reactive oxygen species (ROS), leading to cancer cell death. Reactive Oxygen Species 177-180 phospholipase D1 Homo sapiens 71-75 19258390-8 2009 However, our data describe a role for PLD1-induced DAG as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling. Reactive Oxygen Species 119-122 phospholipase D1 Homo sapiens 38-42 17640750-7 2007 PLD1 enhanced COX-2 expression by CoCl(2) via reactive oxygen species (ROS), p38 MAPK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhanced CoCl(2)-induced COX-2 expression via ROS and p38 MAPK, but not ERK, PKC-delta, and PKA. Reactive Oxygen Species 46-69 phospholipase D1 Homo sapiens 0-4 17640750-7 2007 PLD1 enhanced COX-2 expression by CoCl(2) via reactive oxygen species (ROS), p38 MAPK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhanced CoCl(2)-induced COX-2 expression via ROS and p38 MAPK, but not ERK, PKC-delta, and PKA. Reactive Oxygen Species 71-74 phospholipase D1 Homo sapiens 0-4 17640750-7 2007 PLD1 enhanced COX-2 expression by CoCl(2) via reactive oxygen species (ROS), p38 MAPK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhanced CoCl(2)-induced COX-2 expression via ROS and p38 MAPK, but not ERK, PKC-delta, and PKA. Reactive Oxygen Species 186-189 phospholipase D1 Homo sapiens 0-4