PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28356734-8 2017 These proteoliposomes were able to generate reactive oxygen species (ROS) in an activated reconstituted cell-free NADPH oxidase activation assay in the presence of recombinant p47 phox , p67 phox and Rac, the cytosolic components of the NADPH oxidase complex. Reactive Oxygen Species 44-67 CD33 molecule Homo sapiens 187-190 31907986-0 2020 Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging. Reactive Oxygen Species 110-133 CD33 molecule Homo sapiens 46-57 28356734-8 2017 These proteoliposomes were able to generate reactive oxygen species (ROS) in an activated reconstituted cell-free NADPH oxidase activation assay in the presence of recombinant p47 phox , p67 phox and Rac, the cytosolic components of the NADPH oxidase complex. Reactive Oxygen Species 69-72 CD33 molecule Homo sapiens 187-190 27569996-8 2016 Furthermore, the GPI-80 CV in the CD16hi population was correlated inversely with the proliferative ability of T cells and the GPI-80 MFI of the CD33hi population was correlated with reactive oxygen species production. Reactive Oxygen Species 183-206 CD33 molecule Homo sapiens 145-149 27313830-7 2016 eMPs contained Nox1, Nox2, Nox4, p47(phox), p67(phox), and p22(phox) and they produced ROS which was inhibited by the Nox inhibitor, apocynin. Reactive Oxygen Species 87-90 CD33 molecule Homo sapiens 44-47 22562603-2 2012 The source of ROS is an enzymatic complex (the NADPH oxidase), comprising a membrane-associated heterodimer (flavocytochrome b (558)), consisting of subunits Nox2 and p22(phox), and four cytosolic components (p47(phox), p67(phox), p40(phox), and Rac). Reactive Oxygen Species 14-17 CD33 molecule Homo sapiens 220-223 24406248-8 2014 Mechanistically, ATRA caused the generation of reactive oxygen species (ROS) through increased expression of NADPH oxidase subunits (p47(phox) and p67(phox)) to facilitate ATRA-induced GSK-3beta activation and cell apoptosis. Reactive Oxygen Species 47-70 CD33 molecule Homo sapiens 147-150 24406248-8 2014 Mechanistically, ATRA caused the generation of reactive oxygen species (ROS) through increased expression of NADPH oxidase subunits (p47(phox) and p67(phox)) to facilitate ATRA-induced GSK-3beta activation and cell apoptosis. Reactive Oxygen Species 72-75 CD33 molecule Homo sapiens 147-150 23999600-10 2014 gp120-expanded CD33(+) MDSCs inhibited IFN-gamma release from autologous T cells, which was restored upon ROS and iNOS inhibition. Reactive Oxygen Species 106-109 CD33 molecule Homo sapiens 15-19 22532027-7 2012 In addition, knockdown of p67(phox) could abolish ATO-induced ROS production. Reactive Oxygen Species 62-65 CD33 molecule Homo sapiens 26-29 11433301-1 2001 The production of reactive oxygen species (ROS) by neutrophils has a vital role in defence against a range of infectious agents, and is driven by the assembly of a multi-protein complex containing a minimal core of five proteins: the two membrane-bound subunits of cytochrome b(558) (gp91(phox) and p22(phox)) and three soluble factors (GTP-Rac, p47(phox) and p67(phox) (refs 1, 2). Reactive Oxygen Species 18-41 CD33 molecule Homo sapiens 360-363 22235113-8 2012 Confocal microscopy demonstrated a ROS-containing endosomal compartment that co-labeled with gp91(phox), p40(phox), p67(phox), and Rab5, but not with the secondary granule marker CD66b. Reactive Oxygen Species 35-38 CD33 molecule Homo sapiens 116-119 21953144-6 2012 HCV core-treated CD33(+) cells exhibit a CD14(+) CD11b(+/low) HLADR(-/low) phenotype with up-regulated expression of p47(phox) , a component of the NOX2 complex critical for reactive oxygen species (ROS) production. Reactive Oxygen Species 174-197 CD33 molecule Homo sapiens 17-21 21953144-6 2012 HCV core-treated CD33(+) cells exhibit a CD14(+) CD11b(+/low) HLADR(-/low) phenotype with up-regulated expression of p47(phox) , a component of the NOX2 complex critical for reactive oxygen species (ROS) production. Reactive Oxygen Species 199-202 CD33 molecule Homo sapiens 17-21 21953144-10 2012 CONCLUSION: These results suggest that HCV promotes the accumulation of CD33(+) MDSC, resulting in ROS-mediated suppression of T-cell responsiveness. Reactive Oxygen Species 99-102 CD33 molecule Homo sapiens 72-76 17913709-1 2007 Nox activator 1 (NoxA1) is a homologue of p67(phox) that acts in conjunction with Nox organizer 1 (NoxO1) to regulate reactive oxygen species (ROS) production by the NADPH oxidase Nox1. Reactive Oxygen Species 118-141 CD33 molecule Homo sapiens 42-45 17913709-1 2007 Nox activator 1 (NoxA1) is a homologue of p67(phox) that acts in conjunction with Nox organizer 1 (NoxO1) to regulate reactive oxygen species (ROS) production by the NADPH oxidase Nox1. Reactive Oxygen Species 143-146 CD33 molecule Homo sapiens 42-45 22365599-3 2012 exploit the interactive interface between Rac GTPase and its effector p67(phox) to specifically inhibit reactive oxygen species production without perturbing other Rac-mediated cellular processes. Reactive Oxygen Species 104-127 CD33 molecule Homo sapiens 70-73 20708598-2 2011 It becomes active when membrane-bound cytochrome b(558), the redox core, is assembled with cytosolic p47(phox), p67(phox), p40(phox), and rac proteins to produce superoxide, the precursor for generation of toxic reactive oxygen species. Reactive Oxygen Species 212-235 CD33 molecule Homo sapiens 112-115 11433301-1 2001 The production of reactive oxygen species (ROS) by neutrophils has a vital role in defence against a range of infectious agents, and is driven by the assembly of a multi-protein complex containing a minimal core of five proteins: the two membrane-bound subunits of cytochrome b(558) (gp91(phox) and p22(phox)) and three soluble factors (GTP-Rac, p47(phox) and p67(phox) (refs 1, 2). Reactive Oxygen Species 43-46 CD33 molecule Homo sapiens 360-363 33048872-6 2020 RESULTS: We demonstrate that HOTAIRM1 and HOXA1 expressions are reciprocally upregulated and are responsible for increased levels of immunosuppressive molecules, such as arginase 1 (Arg1), inducible nitric oxide synthase (iNOS), signal transducer and activator of transcription 3 (STAT3), and reactive oxygen species (ROS), in CD33 myeloid cells derived from PLHIV on ART. Reactive Oxygen Species 293-316 CD33 molecule Homo sapiens 327-331 33048872-6 2020 RESULTS: We demonstrate that HOTAIRM1 and HOXA1 expressions are reciprocally upregulated and are responsible for increased levels of immunosuppressive molecules, such as arginase 1 (Arg1), inducible nitric oxide synthase (iNOS), signal transducer and activator of transcription 3 (STAT3), and reactive oxygen species (ROS), in CD33 myeloid cells derived from PLHIV on ART. Reactive Oxygen Species 318-321 CD33 molecule Homo sapiens 327-331