PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29242562-0	2017	ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line.	Reactive Oxygen Species	0-3	NHL repeat containing 2	Homo sapiens	24-30	
29242562-3	2017	Here we show that the NHL-repeat-containing protein 2 (NHLRC2) thioredoxin-like domain protein is cleaved by caspase-8 in ROS-induced apoptosis in the HCT116 human colon cancer cell line.	Reactive Oxygen Species	122-125	NHL repeat containing 2	Homo sapiens	22-53	
29242562-3	2017	Here we show that the NHL-repeat-containing protein 2 (NHLRC2) thioredoxin-like domain protein is cleaved by caspase-8 in ROS-induced apoptosis in the HCT116 human colon cancer cell line.	Reactive Oxygen Species	122-125	NHL repeat containing 2	Homo sapiens	55-61	
29242562-5	2017	Furthermore, the ROS-induced decrease in NHLRC2 protein levels was relieved by the caspase inhibitor z-VAD-fmk.	Reactive Oxygen Species	17-20	NHL repeat containing 2	Homo sapiens	41-47	
29242562-7	2017	Furthermore, siRNA-mediated knockdown of caspase-8 blocked the ROS-induced decrease in NHLRC2 protein levels.	Reactive Oxygen Species	63-66	NHL repeat containing 2	Homo sapiens	87-93	
29242562-8	2017	Both shRNA and CRISPR-Cas9-mediated loss of NHLRC2 resulted in an increased susceptibility of HCT116 cells to ROS-induced apoptosis.	Reactive Oxygen Species	110-113	NHL repeat containing 2	Homo sapiens	44-50	
29242562-9	2017	These results suggest that excess ROS production causes a caspase-8-mediated decrease in NHLRC2 protein levels, leading to apoptotic cell death in colon cancer cells, and indicate an important role of NHLRC2 in the regulation of ROS-induced apoptosis.	Reactive Oxygen Species	34-37	NHL repeat containing 2	Homo sapiens	89-95	
29242562-9	2017	These results suggest that excess ROS production causes a caspase-8-mediated decrease in NHLRC2 protein levels, leading to apoptotic cell death in colon cancer cells, and indicate an important role of NHLRC2 in the regulation of ROS-induced apoptosis.	Reactive Oxygen Species	34-37	NHL repeat containing 2	Homo sapiens	201-207	
29242562-9	2017	These results suggest that excess ROS production causes a caspase-8-mediated decrease in NHLRC2 protein levels, leading to apoptotic cell death in colon cancer cells, and indicate an important role of NHLRC2 in the regulation of ROS-induced apoptosis.	Reactive Oxygen Species	229-232	NHL repeat containing 2	Homo sapiens	201-207