PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29109438-4	2017	VSIG4 activates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, mitochondrial reactive oxygen species secretion, and macrophage inhibition.	Reactive Oxygen Species	241-264	V-set and immunoglobulin domain containing 4	Mus musculus	0-5	
34856328-0	2021	Up-regulation of VSIG4 alleviates kidney transplantation-associated acute kidney injury through suppressing inflammation and ROS via regulation of AKT signaling.	Reactive Oxygen Species	125-128	V-set and immunoglobulin domain containing 4	Mus musculus	17-22	
34856328-7	2021	Oxidative stress and reactive oxygen species (ROS) accumulation in renal tissues were also mitigated by exogenous VSIG4 in CI/KT mice through improving nuclear factor-erythroid 2 related factor 2 (Nrf2) nuclear expression.	Reactive Oxygen Species	21-44	V-set and immunoglobulin domain containing 4	Mus musculus	114-119	
34856328-7	2021	Oxidative stress and reactive oxygen species (ROS) accumulation in renal tissues were also mitigated by exogenous VSIG4 in CI/KT mice through improving nuclear factor-erythroid 2 related factor 2 (Nrf2) nuclear expression.	Reactive Oxygen Species	46-49	V-set and immunoglobulin domain containing 4	Mus musculus	114-119	
34856328-8	2021	The inhibitory effects of VSIG4 on inflammation, ROS generation and cell death were confirmed in OGD/R-treated macrophages, which further ameliorated oxidative damage and apoptosis in podocytes.	Reactive Oxygen Species	49-52	V-set and immunoglobulin domain containing 4	Mus musculus	26-31