PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30820314-10 2019 Finally, we determined that hypoxia and ROS blocked the interaction between PI3K and Stathmin1 to activate disassembly of microtubules. Reactive Oxygen Species 40-43 stathmin 1 Homo sapiens 85-94 30820314-11 2019 Conclusion: Thus, our data demonstrate that hypoxia induced the production of ROS and damaged EC function by destroying the microtubular structure through the PI3K/stathmin1 pathway. Reactive Oxygen Species 78-81 stathmin 1 Homo sapiens 164-173 21622897-10 2011 Functional studies showed that ROS markedly up-regulated expression of ITGB3, which in turn promoted an aggressive phenotype in SW480 cells, with concomitant up-regulated expression of STMN1. Reactive Oxygen Species 31-34 stathmin 1 Homo sapiens 185-190 21622897-13 2011 Furthermore, STMN1 expression and the PI3K-Akt-mTOR pathway were found to be involved in ROS-induced and ITGB3-mediated migration and invasion of colorectal cancer cells. Reactive Oxygen Species 89-92 stathmin 1 Homo sapiens 13-18