PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29228786-4 2017 Here, we demonstrate that oxidative stress, as induced through treatment with 3-morpholinosydnonimine (SIN-1), a spontaneous ROS/RNS generator, drives a reversible loss of AIS protein clustering in primary cortical neurons in vitro. Reactive Oxygen Species 125-128 mitogen-activated protein kinase associated protein 1 Mus musculus 103-108 30571167-8 2018 Mechanistically, Sin1 T86 phosphorylation amplifies mTORC2-mediated downstream signals; it is also required for alphaIIbbeta3-mediated outside-in signaling and plays a role in generating hypoxia/reactive oxygen species through NAD+/Sirt3 (sirtuin 3)/SOD2 (superoxide dismutase 2) pathway. Reactive Oxygen Species 195-218 mitogen-activated protein kinase associated protein 1 Mus musculus 17-21