PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34653733-6 2021 The up-regulation of Srxn1 markedly decreased HG-evoked apoptosis, reactive oxygen species (ROS) generation and pro-inflammatory cytokine release in RGCs. Reactive Oxygen Species 67-90 sulfiredoxin 1 Homo sapiens 21-26 26721593-0 2016 Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damage. Reactive Oxygen Species 74-97 sulfiredoxin 1 Homo sapiens 0-12 26721593-3 2016 Here we show that ROS-mediated selective death of tumor cells can be caused by inhibiting sulfiredoxin (Srx), which reduces hyperoxidized peroxiredoxins, leading to their reactivation. Reactive Oxygen Species 18-21 sulfiredoxin 1 Homo sapiens 90-102 26721593-3 2016 Here we show that ROS-mediated selective death of tumor cells can be caused by inhibiting sulfiredoxin (Srx), which reduces hyperoxidized peroxiredoxins, leading to their reactivation. Reactive Oxygen Species 18-21 sulfiredoxin 1 Homo sapiens 104-107 26721593-4 2016 Srx inhibitor increased the accumulation of sulfinic peroxiredoxins and ROS, which led to oxidative mitochondrial damage and caspase activation, resulting in the death of A549 human lung adenocarcinoma cells. Reactive Oxygen Species 72-75 sulfiredoxin 1 Homo sapiens 0-3 26721593-6 2016 Moreover, Srx inhibitor rendered tumorigenic ovarian cells more susceptible to ROS-mediated death compared with nontumorigenic cells and significantly suppressed the growth of A549 xenografts without acute toxicity. Reactive Oxygen Species 79-82 sulfiredoxin 1 Homo sapiens 10-13 26721593-7 2016 Our results suggest that Srx might serve as a novel therapeutic target for cancer treatment based on ROS-mediated cell death. Reactive Oxygen Species 101-104 sulfiredoxin 1 Homo sapiens 25-28 23830628-5 2013 Here, we describe the methods used to monitor the interplay between NO and H2O2 in the regulation of the Prx/Srx system in immunostimulated macrophages, which produce both reactive oxygen species and NO. Reactive Oxygen Species 172-195 sulfiredoxin 1 Homo sapiens 109-112 22964583-12 2012 NRF2 and SRXN1 genetic polymorphisms are associated with breast cancer risk and survival, implicating that mechanisms associated with reactive oxygen species and NRF2 pathway are involved in breast cancer initiation and progression. Reactive Oxygen Species 134-157 sulfiredoxin 1 Homo sapiens 9-14 27266564-10 2016 CONCLUSIONS: Upregulation of PRDXs and SRXN1 genes may be because of reactive oxygen species (ROS) production and OS in lung tissue of patients after SM exposure. Reactive Oxygen Species 69-92 sulfiredoxin 1 Homo sapiens 39-44 27266564-10 2016 CONCLUSIONS: Upregulation of PRDXs and SRXN1 genes may be because of reactive oxygen species (ROS) production and OS in lung tissue of patients after SM exposure. Reactive Oxygen Species 94-97 sulfiredoxin 1 Homo sapiens 39-44 27266564-11 2016 Expression of SRXN1 and PRDXNs genes, especially I, II, III, and VI is increased in SM-injured lungs, suggesting the induction of cellular responses to increased production of ROS and OS in lung of the patients. Reactive Oxygen Species 176-179 sulfiredoxin 1 Homo sapiens 14-19 25173814-9 2014 Silencing of both Nrf2 and Srx sensitized HT29 cells, leads to ROS overproduction and decreased cell viability. Reactive Oxygen Species 63-66 sulfiredoxin 1 Homo sapiens 27-30 21466852-4 2011 In this study, we addressed the regulation of Srx expression in immunostimulated primary macrophages that produce both reactive oxygen species (ROS) and nitric oxide (NO( )). Reactive Oxygen Species 119-142 sulfiredoxin 1 Homo sapiens 46-49 21466852-4 2011 In this study, we addressed the regulation of Srx expression in immunostimulated primary macrophages that produce both reactive oxygen species (ROS) and nitric oxide (NO( )). Reactive Oxygen Species 144-147 sulfiredoxin 1 Homo sapiens 46-49 21466852-6 2011 We also show that the NO( )/Srx pathway inhibits generation of ROS. Reactive Oxygen Species 63-66 sulfiredoxin 1 Homo sapiens 28-31 34653733-6 2021 The up-regulation of Srxn1 markedly decreased HG-evoked apoptosis, reactive oxygen species (ROS) generation and pro-inflammatory cytokine release in RGCs. Reactive Oxygen Species 92-95 sulfiredoxin 1 Homo sapiens 21-26 32746503-0 2020 SRXN1 stimulates hepatocellular carcinoma tumorigenesis and metastasis through modulating ROS/p65/BTG2 signalling. Reactive Oxygen Species 90-93 sulfiredoxin 1 Homo sapiens 0-5 32975211-8 2020 Sulfiredoxin 1 expression is downregulated by small interfering RNA transfection, which potentiated mitochondrial ROS generation and cell growth arrest in ATO-treated NB4 cells. Reactive Oxygen Species 114-117 sulfiredoxin 1 Homo sapiens 0-14 32746503-8 2020 Mechanistic studies revealed that SRXN1-depleted reactive oxygen species (ROS) modulated migration and invasion of HCC cells. Reactive Oxygen Species 49-72 sulfiredoxin 1 Homo sapiens 34-39 32746503-8 2020 Mechanistic studies revealed that SRXN1-depleted reactive oxygen species (ROS) modulated migration and invasion of HCC cells. Reactive Oxygen Species 74-77 sulfiredoxin 1 Homo sapiens 34-39 31504396-9 2019 We demonstrate that SRXN1, an ATP-dependent reductase, is essential for normal responses to GnRH receptor signaling and plays a central role in resolution of ROS induced by GnRH stimulation. Reactive Oxygen Species 158-161 sulfiredoxin 1 Homo sapiens 20-25 31504396-11 2019 Loss of SRXN1 leads to increased basal and GnRH-stimulated ROS levels. Reactive Oxygen Species 59-62 sulfiredoxin 1 Homo sapiens 8-13 31504396-12 2019 We conclude that SRXN1 is essential for normal responses to GnRH stimulation and plays an important role in ROS management. Reactive Oxygen Species 108-111 sulfiredoxin 1 Homo sapiens 17-22 31284950-6 2019 The depletion of Srxn1 by Srxn1 siRNA-mediated gene silencing significantly exacerbated HG-induced apoptosis and the production of reactive oxygen species (ROS), while Srxn1 overexpression attenuated HG-induced apoptosis and ROS production. Reactive Oxygen Species 131-154 sulfiredoxin 1 Homo sapiens 17-22 31284950-6 2019 The depletion of Srxn1 by Srxn1 siRNA-mediated gene silencing significantly exacerbated HG-induced apoptosis and the production of reactive oxygen species (ROS), while Srxn1 overexpression attenuated HG-induced apoptosis and ROS production. Reactive Oxygen Species 156-159 sulfiredoxin 1 Homo sapiens 17-22 31284950-6 2019 The depletion of Srxn1 by Srxn1 siRNA-mediated gene silencing significantly exacerbated HG-induced apoptosis and the production of reactive oxygen species (ROS), while Srxn1 overexpression attenuated HG-induced apoptosis and ROS production. Reactive Oxygen Species 156-159 sulfiredoxin 1 Homo sapiens 26-31 31284950-6 2019 The depletion of Srxn1 by Srxn1 siRNA-mediated gene silencing significantly exacerbated HG-induced apoptosis and the production of reactive oxygen species (ROS), while Srxn1 overexpression attenuated HG-induced apoptosis and ROS production. Reactive Oxygen Species 156-159 sulfiredoxin 1 Homo sapiens 26-31 31284950-6 2019 The depletion of Srxn1 by Srxn1 siRNA-mediated gene silencing significantly exacerbated HG-induced apoptosis and the production of reactive oxygen species (ROS), while Srxn1 overexpression attenuated HG-induced apoptosis and ROS production. Reactive Oxygen Species 225-228 sulfiredoxin 1 Homo sapiens 17-22 29441509-1 2018 Nuclear factor erythroid 2-related factor 2 (NRF2), DJ1 and sulfiredoxin 1 (SRXN1) are transcription factors which protect cells from the oxidative damage caused by reactive oxygen species and, on the other hand, are associated with resistance to cancer treatments. Reactive Oxygen Species 165-188 sulfiredoxin 1 Homo sapiens 60-74 29441509-1 2018 Nuclear factor erythroid 2-related factor 2 (NRF2), DJ1 and sulfiredoxin 1 (SRXN1) are transcription factors which protect cells from the oxidative damage caused by reactive oxygen species and, on the other hand, are associated with resistance to cancer treatments. Reactive Oxygen Species 165-188 sulfiredoxin 1 Homo sapiens 76-81 33531870-1 2020 Introduction: Sulfiredoxin (Srx), which is an endogenous antioxidant substance which could, regulate the signaling pathways of reactive oxygen species. Reactive Oxygen Species 127-150 sulfiredoxin 1 Homo sapiens 14-26 33531870-1 2020 Introduction: Sulfiredoxin (Srx), which is an endogenous antioxidant substance which could, regulate the signaling pathways of reactive oxygen species. Reactive Oxygen Species 127-150 sulfiredoxin 1 Homo sapiens 28-31 31394427-2 2019 Indeed, recent studies have shown that inhibition of sulfiredoxin (Srx), which participates in antioxidant mechanisms, induces ROS-mediated cancer cell death. Reactive Oxygen Species 127-130 sulfiredoxin 1 Homo sapiens 53-65 31394427-2 2019 Indeed, recent studies have shown that inhibition of sulfiredoxin (Srx), which participates in antioxidant mechanisms, induces ROS-mediated cancer cell death. Reactive Oxygen Species 127-130 sulfiredoxin 1 Homo sapiens 67-70