PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23547261-7 2013 The expression of the master antioxidant regulatory factor Nrf2 (nuclear factor erythroid 2-related factor 2) and its targets, Sesn2, Prdx3, Gclc, and Gclm, was decreased in beta-Bmal1(-/-) islets, which may contribute to the observed increase in ROS accumulation. Reactive Oxygen Species 247-250 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 179-184 27140828-8 2016 The intracellular ROS levels in the ovary on proestrus day and in the oviduct on metestrus day increased significantly in Bmal1-/- mice compared with that of Bmal1+/+ mice. Reactive Oxygen Species 18-21 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 122-127 27140828-9 2016 Deletion of the core biological clock gene Bmal1 significantly decreases oocyte fertilization rate, early embryo development and implantation potential in female mice, and these may be possibly caused by excess ROS levels generated in ovary and oviduct. Reactive Oxygen Species 211-214 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 43-48 30341743-4 2019 In isolated NPCs from Bmal1-/- mice, not only migration velocity and expression pattern of genes involved in detoxification of reactive oxygen species were affected, but also RNA oxidation of catalase was increased and catalase protein levels were decreased. Reactive Oxygen Species 127-150 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 22-27 27824722-1 2016 Bmal1-(brain and muscle ARNT-like protein-1) deficient (Bmal1) mice prematurely age because of an increased reactive oxygen species (ROS) production. Reactive Oxygen Species 108-131 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 0-5 27824722-1 2016 Bmal1-(brain and muscle ARNT-like protein-1) deficient (Bmal1) mice prematurely age because of an increased reactive oxygen species (ROS) production. Reactive Oxygen Species 133-136 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 0-5 27824722-8 2016 Thus, antioxidant treatment normalized cardiac function of Bmal1 mice, probably in part by scavenging ROS. Reactive Oxygen Species 102-105 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 59-64 26142744-2 2015 Mice with targeted deletion of the clock geneBmal1 (Bmal1(-/-)) show disrupted regulation of reactive oxygen species homeostasis, accelerated aging, neurodegeneration and cognitive deficits. Reactive Oxygen Species 93-116 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 45-50 22912383-3 2012 OBJECTIVE: The goals of the present study were to determine whether deletion of a critical component of the circadian clock, Bmal1, can influence endothelial NO synthase coupling and reactive oxygen species levels in arteries from Bmal1-knockout (KO) mice. Reactive Oxygen Species 183-206 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 125-130 22101268-5 2011 Increased sensitivity of Bmal1(-/-) cells to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but not in Bmal1(-/-) cells. Reactive Oxygen Species 130-153 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 25-30 22101268-5 2011 Increased sensitivity of Bmal1(-/-) cells to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but not in Bmal1(-/-) cells. Reactive Oxygen Species 130-153 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 175-180 22101268-5 2011 Increased sensitivity of Bmal1(-/-) cells to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but not in Bmal1(-/-) cells. Reactive Oxygen Species 155-158 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 25-30 22101268-5 2011 Increased sensitivity of Bmal1(-/-) cells to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but not in Bmal1(-/-) cells. Reactive Oxygen Species 155-158 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 175-180 22101268-5 2011 Increased sensitivity of Bmal1(-/-) cells to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but not in Bmal1(-/-) cells. Reactive Oxygen Species 232-235 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 25-30 22101268-5 2011 Increased sensitivity of Bmal1(-/-) cells to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but not in Bmal1(-/-) cells. Reactive Oxygen Species 232-235 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 175-180 32784474-8 2020 Intriguingly, Bmal1/Nrf2/Prdx6 and PhaseII antioxidants showed rhythmic expression in mouse lenses in vivo and were reciprocally linked to ROS levels. Reactive Oxygen Species 139-142 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 14-19 16847346-3 2006 The early aging phenotype correlates with increased levels of reactive oxygen species in some tissues of the Bmal1(-/- )animals. Reactive Oxygen Species 62-85 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 109-114 35236106-12 2022 Further study demonstrated that Bmal1 downregulation in VSMCs increased VSMC migration, monocyte transmigration, reactive oxygen species levels, and VSMCs apoptosis. Reactive Oxygen Species 113-136 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 32-37