PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29066912-6 2017 The top hub genes AR, CDH13, CDKN2A, DAPK1, GSTP1, CD44 and RASSF1 identified from protein-protein interaction network construction using Search Tool for the Retrieval of Interacting Genes contributed to hormonal response, inflammatory response, cell cycle, reactive oxygen species activity and receptor kinase activity, which are related to hallmarks of cancer as revealed by their functional enrichment analysis by Cytoscape. Reactive Oxygen Species 258-281 Ras association domain family member 1 Homo sapiens 60-66 21473856-3 2011 However, the suppressive effect of RASSF1A on K-RasV12-induced ROS increase and DNA damage has not been identified. Reactive Oxygen Species 63-66 Ras association domain family member 1 Homo sapiens 35-42 21473856-4 2011 Here, we show that RASSF1A blocks K-RasV12-triggered ROS production. Reactive Oxygen Species 53-56 Ras association domain family member 1 Homo sapiens 19-26 21473856-6 2011 From the results obtained in this study, we suggest that RASSF1A regulates the cellular ROS levels enhanced by the Ras signaling pathway, and that it may function as a tumor suppressor by suppressing DNA damage caused by activated Ras. Reactive Oxygen Species 88-91 Ras association domain family member 1 Homo sapiens 57-64