PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18569012-3	2008	25-OH-chol increased the production of reactive oxygen species and opened mitochondrial permeability transition pore, resulting in release of cytochrome c and subsequent activation of caspase-9 and -3.	Reactive Oxygen Species	39-62	caspase 9	Rattus norvegicus	184-200	
22166790-4	2012	In addition, I6-induced reactive oxygen species (ROS) caused the disruption of mitochondria membrane potential (MMP), the release of cytochrome c, the activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase (PARP), resulting in activation of mitochondrial-mediated intrinsic death pathway.	Reactive Oxygen Species	24-47	caspase 9	Rattus norvegicus	165-174	
22166790-4	2012	In addition, I6-induced reactive oxygen species (ROS) caused the disruption of mitochondria membrane potential (MMP), the release of cytochrome c, the activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase (PARP), resulting in activation of mitochondrial-mediated intrinsic death pathway.	Reactive Oxygen Species	49-52	caspase 9	Rattus norvegicus	165-174	
16514665-9	2006	The results showed that Hcy-mediated ROS production preceded the loss of MP, the release of cytochrome-c, and the activation of caspase-9 and -3.	Reactive Oxygen Species	37-40	caspase 9	Rattus norvegicus	128-144	
16514665-14	2006	Our data suggested that Hcy-mediated ROS production promotes endothelial cell death in part by disturbing MP, which results in subsequent release of cytochrome-c and activation of caspase-9 and 3, leading to cell death.	Reactive Oxygen Species	37-40	caspase 9	Rattus norvegicus	180-195	
15135649-9	2004	These results suggest that BR931 can increase generation of ROS, leading to DNA damage and p53 phosphorylation, which, in turn, induces the activation of Bax, release of cytochrome-c from mitochondria and activation of caspases, culminating in cell death.	Reactive Oxygen Species	60-63	caspase 9	Rattus norvegicus	219-227